JP5095414B2 - 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 - Google Patents

眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 Download PDF

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JP5095414B2
JP5095414B2 JP2007548380A JP2007548380A JP5095414B2 JP 5095414 B2 JP5095414 B2 JP 5095414B2 JP 2007548380 A JP2007548380 A JP 2007548380A JP 2007548380 A JP2007548380 A JP 2007548380A JP 5095414 B2 JP5095414 B2 JP 5095414B2
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seq
sequence
interfering rna
antisense
nucleotides
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アラン アール． シェパード，
イオク−ホウ パン，
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007548380A 2004-12-23 2005-12-19 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害 Expired - Fee Related JP5095414B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63870504P 2004-12-23 2004-12-23
US60/638,705 2004-12-23
PCT/US2005/046064 WO2006069037A1 (en) 2004-12-23 2005-12-19 Rnai inhibition of ctgf for treatment of ocular disorders

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JP2008525460A JP2008525460A (ja) 2008-07-17
JP2008525460A5 JP2008525460A5 (enExample) 2009-02-12
JP5095414B2 true JP5095414B2 (ja) 2012-12-12

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JP2012029499A Withdrawn JP2012097119A (ja) 2004-12-23 2012-02-14 眼の障害を処置するためのＣＴＧＦのＲＮＡｉ阻害

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US (4) US7622454B2 (enExample)
EP (2) EP1827503A1 (enExample)
JP (2) JP5095414B2 (enExample)
KR (1) KR20070091337A (enExample)
CN (1) CN101160138B (enExample)
AR (1) AR052172A1 (enExample)
AU (1) AU2005319279B2 (enExample)
BR (1) BRPI0516377A (enExample)
CA (1) CA2591611A1 (enExample)
MX (1) MX2007007654A (enExample)
TW (1) TWI386225B (enExample)
WO (1) WO2006069037A1 (enExample)
ZA (1) ZA200704932B (enExample)

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CN101160138A (zh) 2008-04-09
US7622454B2 (en) 2009-11-24
ZA200704932B (en) 2008-11-26
CA2591611A1 (en) 2006-06-29
AU2005319279A1 (en) 2006-06-29
US20110028534A1 (en) 2011-02-03
AR052172A1 (es) 2007-03-07
CN101160138B (zh) 2013-05-15
US20100035969A1 (en) 2010-02-11
US20140094502A1 (en) 2014-04-03
US20060166919A1 (en) 2006-07-27
AU2005319279B2 (en) 2011-08-18
EP1827503A1 (en) 2007-09-05
BRPI0516377A (pt) 2008-09-02
JP2012097119A (ja) 2012-05-24
US7838507B2 (en) 2010-11-23
TW200626721A (en) 2006-08-01
MX2007007654A (es) 2007-11-09
TWI386225B (zh) 2013-02-21

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