JP5069119B2 - 血管内皮成長因子（ｖｅｇｆ）受容体キナーゼインヒビターとしてのニコチンアミドピリジンウレア - Google Patents
血管内皮成長因子（ｖｅｇｆ）受容体キナーゼインヒビターとしてのニコチンアミドピリジンウレア Download PDFInfo
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- JP5069119B2 JP5069119B2 JP2007538358A JP2007538358A JP5069119B2 JP 5069119 B2 JP5069119 B2 JP 5069119B2 JP 2007538358 A JP2007538358 A JP 2007538358A JP 2007538358 A JP2007538358 A JP 2007538358A JP 5069119 B2 JP5069119 B2 JP 5069119B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04090420A EP1655297A1 (fr) | 2004-11-03 | 2004-11-03 | Pyridineurées de nicotinamide commes inhibiteurs du recepteur kinase du facteur de croissance endothéliale vasculaire (VEGF) |
| EP04090420.3 | 2004-11-03 | ||
| PCT/EP2005/011709 WO2006048249A1 (fr) | 2004-11-03 | 2005-10-28 | Nicotinamide pyridinureas utiles comme inhibiteurs de kinase dans le recepteur du facteur de croissance de l'endothelium vasculaire (vegf) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008518893A JP2008518893A (ja) | 2008-06-05 |
| JP5069119B2 true JP5069119B2 (ja) | 2012-11-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538358A Expired - Fee Related JP5069119B2 (ja) | 2004-11-03 | 2005-10-28 | 血管内皮成長因子（ｖｅｇｆ）受容体キナーゼインヒビターとしてのニコチンアミドピリジンウレア |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP1655297A1 (fr) |
| JP (1) | JP5069119B2 (fr) |
| KR (1) | KR20070085609A (fr) |
| CN (1) | CN101056870A (fr) |
| AU (1) | AU2005300734A1 (fr) |
| BR (1) | BRPI0515725A (fr) |
| CA (1) | CA2586265C (fr) |
| ES (1) | ES2394324T3 (fr) |
| IL (1) | IL182335A0 (fr) |
| MX (1) | MX2007005340A (fr) |
| NO (1) | NO20072803L (fr) |
| RU (1) | RU2007120691A (fr) |
| WO (1) | WO2006048249A1 (fr) |
| ZA (1) | ZA200705003B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2663984C (fr) | 2006-10-18 | 2012-02-21 | Pfizer Products Inc. | Composes d'uree de bisaryle ether |
| AU2009287152B2 (en) * | 2008-08-27 | 2014-09-25 | Leo Pharma A/S | Pyridine derivatives as VEGFR-2 receptor and protein tyrosine kinase inhibitors |
| IL295518B2 (en) | 2009-10-06 | 2023-11-01 | Millennium Pharm Inc | Heterocyclic compounds used as PDK1 inhibitors |
| US9723840B2 (en) | 2013-11-11 | 2017-08-08 | Syngenta Limited | 1-(pyridazin-3-yl)-imidazolidin-2-one derivatives as herbicides |
| CA2935880A1 (fr) * | 2014-01-10 | 2015-07-16 | Aurigene Discovery Technologies Limited | Composes d'imidazole utilisables en tant qu'inhibiteurs de l'irak4 |
| SG11201605486WA (en) | 2014-01-13 | 2016-08-30 | Aurigene Discovery Tech Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
| PL3600270T3 (pl) | 2017-03-31 | 2023-09-25 | Aurigene Oncology Limited | Związki i kompozycje do leczenia zaburzeń hematologicznych |
| IL274248B2 (en) | 2017-10-31 | 2024-06-01 | Curis Inc | Compounds and preparations for the treatment of hematological disorders |
| CN109942544B (zh) * | 2017-12-21 | 2021-06-11 | 中国科学院合肥物质科学研究院 | 一类新型吲唑类衍生物激酶抑制剂 |
| CN108467360B (zh) * | 2018-06-22 | 2021-04-30 | 江苏美迪克化学品有限公司 | 一种阿帕替尼的制备方法及其中间体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71587C2 (uk) * | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
| GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| KR20030094395A (ko) * | 2001-05-08 | 2003-12-11 | 쉐링 악티엔게젤샤프트 | Ｖｅｇｆｒ-2 및 ｖｅｇｆｒ-3의 억제제로서의 선택적안트라닐아미드 피리딘 아미드 |
| DE50206476D1 (de) * | 2001-05-08 | 2006-05-24 | Schering Ag | Cyanoanthranylamid-derivate und deren verwendung als arzneimittel |
| CA2493026C (fr) * | 2002-07-31 | 2011-05-24 | Schering Aktiengesellschaft | Anthranylamidopyrimidines inhibant vegfr-2 et vegfr-3 |
| EP1657241A1 (fr) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Nouveaux urées d' anthranylamide pyridine ayant une activité inhibitrice de kinase du récepteur de VEGF |
| EP1655295A1 (fr) * | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Anthranilamide pyridinurées comme inhibiteurs de kinase du récepteur VEGF |
-
2004
- 2004-11-03 EP EP04090420A patent/EP1655297A1/fr not_active Withdrawn
-
2005
- 2005-10-28 WO PCT/EP2005/011709 patent/WO2006048249A1/fr active Application Filing
- 2005-10-28 KR KR1020077012381A patent/KR20070085609A/ko not_active Application Discontinuation
- 2005-10-28 ES ES05806225T patent/ES2394324T3/es active Active
- 2005-10-28 MX MX2007005340A patent/MX2007005340A/es not_active Application Discontinuation
- 2005-10-28 RU RU2007120691/04A patent/RU2007120691A/ru unknown
- 2005-10-28 JP JP2007538358A patent/JP5069119B2/ja not_active Expired - Fee Related
- 2005-10-28 EP EP05806225A patent/EP1807416B1/fr active Active
- 2005-10-28 CA CA2586265A patent/CA2586265C/fr not_active Expired - Fee Related
- 2005-10-28 BR BRPI0515725-0A patent/BRPI0515725A/pt not_active IP Right Cessation
- 2005-10-28 CN CNA2005800381303A patent/CN101056870A/zh active Pending
- 2005-10-28 AU AU2005300734A patent/AU2005300734A1/en not_active Abandoned
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2007
- 2007-03-29 IL IL182335A patent/IL182335A0/en unknown
- 2007-06-01 NO NO20072803A patent/NO20072803L/no not_active Application Discontinuation
- 2007-06-01 ZA ZA200705003A patent/ZA200705003B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007120691A (ru) | 2008-12-10 |
| CA2586265A1 (fr) | 2006-05-11 |
| NO20072803L (no) | 2007-08-02 |
| BRPI0515725A (pt) | 2008-08-05 |
| EP1807416B1 (fr) | 2012-08-29 |
| IL182335A0 (en) | 2007-07-24 |
| ES2394324T3 (es) | 2013-01-30 |
| EP1655297A1 (fr) | 2006-05-10 |
| JP2008518893A (ja) | 2008-06-05 |
| CA2586265C (fr) | 2013-08-06 |
| KR20070085609A (ko) | 2007-08-27 |
| CN101056870A (zh) | 2007-10-17 |
| WO2006048249A1 (fr) | 2006-05-11 |
| AU2005300734A1 (en) | 2006-05-11 |
| ZA200705003B (en) | 2008-09-25 |
| EP1807416A1 (fr) | 2007-07-18 |
| MX2007005340A (es) | 2007-08-17 |
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