JP5030383B2 - 生物活性化合物を含む表面コーティング - Google Patents

生物活性化合物を含む表面コーティング Download PDF

Info

Publication number
JP5030383B2
JP5030383B2 JP2004546970A JP2004546970A JP5030383B2 JP 5030383 B2 JP5030383 B2 JP 5030383B2 JP 2004546970 A JP2004546970 A JP 2004546970A JP 2004546970 A JP2004546970 A JP 2004546970A JP 5030383 B2 JP5030383 B2 JP 5030383B2
Authority
JP
Japan
Prior art keywords
group
peo
medical device
factor
complement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004546970A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006510396A (ja
JP2006510396A5 (US07459169-20081202-C00003.png
Inventor
ボー ニルソン
ヨナス アンダーソン
カリン カルドウェル
ジェニファー ネフ
Original Assignee
アルヴィヴォ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルヴィヴォ インコーポレイテッド filed Critical アルヴィヴォ インコーポレイテッド
Publication of JP2006510396A publication Critical patent/JP2006510396A/ja
Publication of JP2006510396A5 publication Critical patent/JP2006510396A5/ja
Application granted granted Critical
Publication of JP5030383B2 publication Critical patent/JP5030383B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Electrotherapy Devices (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
JP2004546970A 2002-10-21 2003-10-21 生物活性化合物を含む表面コーティング Expired - Fee Related JP5030383B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42039002P 2002-10-21 2002-10-21
US60/420,390 2002-10-21
PCT/US2003/033348 WO2004037310A2 (en) 2002-10-21 2003-10-21 Surface coating comprising bioactive compound

Publications (3)

Publication Number Publication Date
JP2006510396A JP2006510396A (ja) 2006-03-30
JP2006510396A5 JP2006510396A5 (US07459169-20081202-C00003.png) 2006-12-07
JP5030383B2 true JP5030383B2 (ja) 2012-09-19

Family

ID=32176561

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004546970A Expired - Fee Related JP5030383B2 (ja) 2002-10-21 2003-10-21 生物活性化合物を含む表面コーティング

Country Status (6)

Country Link
US (1) US7459169B2 (US07459169-20081202-C00003.png)
EP (1) EP1553993B1 (US07459169-20081202-C00003.png)
JP (1) JP5030383B2 (US07459169-20081202-C00003.png)
AU (1) AU2003284304B8 (US07459169-20081202-C00003.png)
CA (1) CA2503490C (US07459169-20081202-C00003.png)
WO (1) WO2004037310A2 (US07459169-20081202-C00003.png)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165244A1 (en) * 2003-10-21 2011-07-07 Allvivo Vascular, Inc. Bioresponsive polymer formulations for delivery of bioactive agents
US7858108B2 (en) 2003-10-21 2010-12-28 Richard Nagler Elutable surface coating
WO2005118020A1 (en) * 2004-04-21 2005-12-15 Allvivo, Inc. Surface coating comprising bioactive compound
US20060015057A1 (en) * 2004-07-15 2006-01-19 Ho Chih-Hu Coating for arterial-venous blood tubing set for hemodialysis system
ES2432556T3 (es) 2004-08-04 2013-12-04 Evonik Corporation Métodos para fabricar dispositivos de suministro y sus dispositivos
BRPI0617186A2 (pt) * 2005-10-08 2011-07-19 Potentia Pharmaceuticals Inc uso de análogo de compstatina, implante ocular, micropartìcula ou nanopartìcula, composição, composto multivalente, ácido nucléico, vetor de expressão, célula hospedeira recombinante, proteìna de fusão e método de produção e teste
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
NZ588816A (en) 2007-01-21 2011-11-25 Hemoteq Ag Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses
US8263104B2 (en) * 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
WO2009012162A2 (en) 2007-07-16 2009-01-22 Allvivo Vascular, Inc. Antimicrobial constructs
CN102908690A (zh) 2007-08-31 2013-02-06 密执安州立大学董事会 选择性细胞隔离装置及其相关方法
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
DE102008027133A1 (de) * 2008-05-30 2009-12-03 Ls Medcap Gmbh Vollsynthetisches Albumin-Analogon
US10799593B2 (en) 2008-06-09 2020-10-13 Northwestern University Nanodiamond particle complexes
US20100040672A1 (en) * 2008-06-09 2010-02-18 Northwestern University Delivery of therapeutics
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8500687B2 (en) 2008-09-25 2013-08-06 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
WO2010077646A2 (en) * 2008-12-30 2010-07-08 Bausch & Lomb Incorporated Method of applying renewable polymeric lens coating
US8454689B2 (en) * 2008-12-30 2013-06-04 Bausch & Lomb Incorporated Brush copolymers
WO2010115243A1 (en) * 2009-04-09 2010-10-14 The University Of Queensland Block copolymer blends
WO2011005421A2 (en) 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
JP5933434B2 (ja) 2009-07-17 2016-06-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 薬剤送達バルーンの製造方法
US20110056083A1 (en) * 2009-09-08 2011-03-10 Tsan-Ching Wang Degradable string for string trimmer
WO2011163394A2 (en) 2010-06-22 2011-12-29 Apellis Pharmaceuticals, Inc. Compstatin analogs for treatment of neuropathic pain
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US20130288370A1 (en) 2010-10-15 2013-10-31 Cytopherx, Inc. Cytopheresis cartridges and use thereof
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CA2852220A1 (en) 2011-10-14 2013-07-18 Cytopherx, Inc. Cartridge and method for increasing myocardial function
CA2891673A1 (en) 2012-11-15 2014-05-22 Apellis Pharmaceuticals, Inc. Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
CH708835A1 (de) * 2013-11-14 2015-05-15 Qvanteq Ag Implantat mit verbesserten Oberflächeneigenschaften.
CN117503905A (zh) 2015-10-07 2024-02-06 阿佩利斯制药有限公司 给药方案
CA3059304A1 (en) 2017-04-07 2018-10-11 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
WO2019073992A1 (ja) * 2017-10-11 2019-04-18 国立大学法人京都大学 抗体修飾フィルター
DE102019102597A1 (de) 2019-02-01 2020-08-06 DC Diagnostics Concept UG (haftungsbeschränkt) Behältnis zur Verwahrung einer Körperflüssigkeit

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2433883C2 (de) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Verwendung von physiologisch aktiven Polypeptiden
SE430062B (sv) 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
SE8102194L (sv) 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
JPS6031762A (ja) * 1983-08-03 1985-02-18 テルモ株式会社 人工血管
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
US4975468A (en) * 1989-04-03 1990-12-04 Affinity Biotech, Inc. Fluorinated microemulsion as oxygen carrier
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
WO1997035886A1 (en) * 1996-03-22 1997-10-02 Imutran Limited Surfaces which prevent or reduce complement activation
US5869539A (en) * 1996-04-17 1999-02-09 Board Of Regents, The University Of Texas System Emulsions of perfluoro compounds as solvents for nitric oxide (NO)
US5877263A (en) * 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US6066602A (en) * 1997-08-07 2000-05-23 Becton Dickinson And Company Waterborne non-silicone lubricant comprising phospholipid and polyether
IT1315220B1 (it) * 1999-12-13 2003-02-03 Ipm Ind Plastica Monregalese Telone di foglia pluristrato di materia plastica per pacciamature e/ocome barriera di contenimento di sostanze di trattamento in
JP2003520645A (ja) * 2000-01-25 2003-07-08 エドワーズ ライフサイエンシーズ コーポレイション 人工心臓弁上での組織の過剰増殖を予防する生物活性コーティング
ATE374785T1 (de) * 2000-03-02 2007-10-15 Mitsubishi Pharma Corp Gpib-gebundenes konstrukt und verwendungen davon
AU2002305924A1 (en) * 2001-02-02 2002-10-08 Allvivo, Inc. End group activated polymers with oligonucleotide ligands

Also Published As

Publication number Publication date
AU2003284304B8 (en) 2009-08-06
AU2003284304A1 (en) 2004-05-13
US7459169B2 (en) 2008-12-02
CA2503490A1 (en) 2004-05-06
CA2503490C (en) 2012-04-03
WO2004037310A2 (en) 2004-05-06
EP1553993B1 (en) 2016-03-30
US20040142011A1 (en) 2004-07-22
AU2003284304B2 (en) 2009-07-23
WO2004037310A3 (en) 2004-07-01
EP1553993A2 (en) 2005-07-20
JP2006510396A (ja) 2006-03-30

Similar Documents

Publication Publication Date Title
JP5030383B2 (ja) 生物活性化合物を含む表面コーティング
US8048437B2 (en) Medical device with surface coating comprising bioactive compound
Biran et al. Heparin coatings for improving blood compatibility of medical devices
Jaffer et al. Medical device‐induced thrombosis: what causes it and how can we prevent it?
JP6122052B2 (ja) 固定化生物学的実体
US6143354A (en) One-step method for attachment of biomolecules to substrate surfaces
EP3177332B1 (en) Article coatings including oligomerized polyphenol layer and biological methods of use
JP2002502286A (ja) 生体適合性および／または物理的特性を向上させるための金属表面処理
JP5673525B2 (ja) 抗血液凝固作用を有する親水性高分子化合物
JP2020108864A (ja) 固定された生物学的実体
TW201304755A (zh) 具有抗血栓性之游離血栓捕獲器具
Hertault et al. In vivo evaluation of a pro-healing polydopamine coated stent through an in-stent restenosis rat model
US20110165244A1 (en) Bioresponsive polymer formulations for delivery of bioactive agents
JP5021313B2 (ja) 溶出可能な表面コーティング
CA2392080C (en) Blood-compatible polymer surfaces
Khanna Fabrication of human serum albumin film for enhanced hemocompatibility and mitigation of neointimal hyperplasia under physiologically relevant flow shear conditions
Wnek et al. Heparin-Binding to Improve Biocompatibility/Rolf Larsson
RU2388495C1 (ru) Способ получения тромборезистентных полимерных материалов
CN114522278A (zh) 一种长效抗凝血涂层及其制备方法
JP2020065632A (ja) 医療器具
Aggarwal The antithrombotic properties of polymer-coated, drug eluting coronary stents
Scientific et al. AND DEvices: Huv APPLicovs
JPH06254151A (ja) 抗血栓性材料

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061019

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061019

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100526

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100811

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100818

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101125

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110414

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110421

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110715

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111004

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120206

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120409

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20120406

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120529

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120626

R150 Certificate of patent or registration of utility model

Ref document number: 5030383

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150706

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees