JP5013865B2 - 2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 - Google Patents
2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 Download PDFInfo
- Publication number
- JP5013865B2 JP5013865B2 JP2006516047A JP2006516047A JP5013865B2 JP 5013865 B2 JP5013865 B2 JP 5013865B2 JP 2006516047 A JP2006516047 A JP 2006516047A JP 2006516047 A JP2006516047 A JP 2006516047A JP 5013865 B2 JP5013865 B2 JP 5013865B2
- Authority
- JP
- Japan
- Prior art keywords
- deoxy
- gluconate
- dehydro
- ribose
- nucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WPAMZTWLKIDIOP-WVZVXSGGSA-N 2-dehydro-3-deoxy-D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)CC(=O)C(O)=O WPAMZTWLKIDIOP-WVZVXSGGSA-N 0.000 title claims 8
- 239000002243 precursor Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 28
- 244000005700 microbiome Species 0.000 claims 15
- 230000000694 effects Effects 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108010071778 Benzoylformate decarboxylase Proteins 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000006114 decarboxylation reaction Methods 0.000 claims 5
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108030003207 2-dehydro-3-deoxy-D-gluconate aldolases Proteins 0.000 claims 3
- 241000589220 Acetobacter Species 0.000 claims 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 3
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 claims 3
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 claims 3
- 108091022917 Gluconate dehydratase Proteins 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 3
- 241001464778 Zymobacter Species 0.000 claims 3
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 3
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 claims 3
- 102000020233 phosphotransferase Human genes 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000589158 Agrobacterium Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 2
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 2
- 241000589776 Pseudomonas putida Species 0.000 claims 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 241000588902 Zymomonas mobilis Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 238000006911 enzymatic reaction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101710125669 D-galactonate dehydratase family member RspA Proteins 0.000 claims 1
- 101710095404 D-gluconate dehydratase Proteins 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 244000253724 Saccharomyces cerevisiae S288c Species 0.000 claims 1
- 235000004905 Saccharomyces cerevisiae S288c Nutrition 0.000 claims 1
- 241000588901 Zymomonas Species 0.000 claims 1
- 229950006191 gluconic acid Drugs 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000004224 potassium gluconate Substances 0.000 claims 1
- 235000013926 potassium gluconate Nutrition 0.000 claims 1
- 239000000176 sodium gluconate Substances 0.000 claims 1
- 235000012207 sodium gluconate Nutrition 0.000 claims 1
- MSXHSNHNTORCAW-GGLLEASOSA-M sodium;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].O[C@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O MSXHSNHNTORCAW-GGLLEASOSA-M 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03013457.1 | 2003-06-24 | ||
| EP20030013457 EP1491549A1 (en) | 2003-06-24 | 2003-06-24 | Production of 2'-deoxynucleosides and 2'-deoxynucleoside precursors from 2-dehydro-3-deoxy-D-gluconate |
| EP03027750 | 2003-12-02 | ||
| EP03027750.3 | 2003-12-02 | ||
| PCT/EP2004/006848 WO2004113358A1 (en) | 2003-06-24 | 2004-06-24 | Production of 2'-deoxynucleosides and 2'-deoxynucleoside precursors from 2-dehydro-3-deoxy-d-gluconate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012005561A Division JP5766624B2 (ja) | 2003-06-24 | 2012-01-13 | 2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007527855A JP2007527855A (ja) | 2007-10-04 |
| JP2007527855A5 JP2007527855A5 (enExample) | 2011-08-18 |
| JP5013865B2 true JP5013865B2 (ja) | 2012-08-29 |
Family
ID=33542545
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006516047A Expired - Fee Related JP5013865B2 (ja) | 2003-06-24 | 2004-06-24 | 2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 |
| JP2012005561A Expired - Fee Related JP5766624B2 (ja) | 2003-06-24 | 2012-01-13 | 2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012005561A Expired - Fee Related JP5766624B2 (ja) | 2003-06-24 | 2012-01-13 | 2−デヒドロ−3−デオキシ−d−グルコネートからの2’−デオキシヌクレオシド及び2’−デオキシヌクレオシド前駆体の製造 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7858775B2 (enExample) |
| EP (1) | EP1636246B1 (enExample) |
| JP (2) | JP5013865B2 (enExample) |
| KR (1) | KR100817462B1 (enExample) |
| DK (1) | DK1636246T3 (enExample) |
| WO (1) | WO2004113358A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005068642A2 (en) | 2003-10-01 | 2005-07-28 | Board Of Trustees Operating Michigan State University | Bacterial synthesis of 1,2,4-butanetriol enantiomers |
| US20090246841A1 (en) * | 2008-03-26 | 2009-10-01 | Jamieson Andrew C | Methods and compositions for production of acetaldehyde |
| JP5848028B2 (ja) * | 2010-05-21 | 2016-01-27 | 三井化学株式会社 | 2’−デオキシヌクレオシドの製造方法 |
| EP3794116A2 (en) | 2018-05-17 | 2021-03-24 | BP Corporation North America Inc. | Production of 2-keto-3-deoxy-d-gluconic acid in filamentous fungi |
| WO2020044379A1 (en) | 2018-08-29 | 2020-03-05 | Matis Ohf. | Methods for enzymatic processing of polysaccharides from brown algae |
| EP3963067A1 (en) * | 2019-07-11 | 2022-03-09 | BP Corporation North America Inc. | Gluconate dehydratase enzymes and recombinant cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3312683A (en) * | 1964-06-09 | 1967-04-04 | Hoffmann La Roche | Process for producing derivatives of d-glucose |
| JPH02195870A (ja) * | 1989-01-24 | 1990-08-02 | Shinenerugii Sogo Kaihatsu Kiko | ザイモモナス・モビリスの新菌株並びにその菌株を使用するレバンの製法 |
| US5759825A (en) * | 1991-09-20 | 1998-06-02 | The Scripps Research Institute | Method for synthesizing 2-ketoaldonic acids |
| FR2749307B1 (fr) | 1996-05-29 | 1998-09-04 | Roquette Freres | Procede de preparation de d-arabitol |
| FR2749306B1 (fr) * | 1996-06-03 | 1998-08-28 | Roquette Freres | Procede de decarboxylation des acides 2-cetoaldoniques |
| DE60042209D1 (de) * | 1999-08-20 | 2009-06-25 | Pasteur Institut | Enzymatische synthese von deoxyribonucleotiden |
| AU2002353763B2 (en) * | 2001-05-04 | 2007-01-04 | University Of Florida Research Foundation, Inc | Cloning and sequencing of pyruvate decarboxylase (PDC) genes from bacteria and uses therefor |
| WO2003070959A2 (en) * | 2002-02-22 | 2003-08-28 | Dsm Ip Assets B.V. | Process for producing levodione |
| DK1546596T3 (da) * | 2002-07-05 | 2006-03-20 | Technip France | Fleksibel rörledning med anti-turbulenskarkasse til transport af hydrocarboner |
| EP1589021A1 (en) * | 2002-12-26 | 2005-10-26 | Mitsui Chemicals, Inc. | Process for producing 2-deoxyaldose compound |
| JP4391328B2 (ja) * | 2003-07-10 | 2009-12-24 | 三井化学株式会社 | 新規グルコン酸脱水酵素 |
-
2004
- 2004-06-24 JP JP2006516047A patent/JP5013865B2/ja not_active Expired - Fee Related
- 2004-06-24 US US10/560,760 patent/US7858775B2/en not_active Expired - Fee Related
- 2004-06-24 EP EP04740261.5A patent/EP1636246B1/en not_active Expired - Lifetime
- 2004-06-24 DK DK04740261.5T patent/DK1636246T3/en active
- 2004-06-24 KR KR1020057024851A patent/KR100817462B1/ko not_active Expired - Fee Related
- 2004-06-24 WO PCT/EP2004/006848 patent/WO2004113358A1/en not_active Ceased
-
2012
- 2012-01-13 JP JP2012005561A patent/JP5766624B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004113358A1 (en) | 2004-12-29 |
| EP1636246A1 (en) | 2006-03-22 |
| KR100817462B1 (ko) | 2008-03-31 |
| US7858775B2 (en) | 2010-12-28 |
| JP2012082221A (ja) | 2012-04-26 |
| KR20060091716A (ko) | 2006-08-21 |
| JP5766624B2 (ja) | 2015-08-19 |
| US20070212759A1 (en) | 2007-09-13 |
| DK1636246T3 (en) | 2015-11-23 |
| EP1636246B1 (en) | 2015-08-19 |
| JP2007527855A (ja) | 2007-10-04 |
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