JP5007003B2 - 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 - Google Patents

富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 Download PDF

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JP5007003B2
JP5007003B2 JP2000598656A JP2000598656A JP5007003B2 JP 5007003 B2 JP5007003 B2 JP 5007003B2 JP 2000598656 A JP2000598656 A JP 2000598656A JP 2000598656 A JP2000598656 A JP 2000598656A JP 5007003 B2 JP5007003 B2 JP 5007003B2
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pta
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JP2002536023A5 (cg-RX-API-DMAC10.html
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デイビッド ダブリュー. バック,
ノブコ ウチダ,
アービング ウェイスマン,
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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JP2000598656A 1999-02-12 2000-02-11 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 Expired - Lifetime JP5007003B2 (ja)

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Application Number Priority Date Filing Date Title
US11972599P 1999-02-12 1999-02-12
US09/422,844 US6468794B1 (en) 1999-02-12 1999-10-21 Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US16840799P 1999-12-01 1999-12-01
US09/422,844 1999-12-01
US60/168,407 1999-12-01
US60/119,725 1999-12-01
PCT/US2000/003592 WO2000047762A2 (en) 1999-02-12 2000-02-11 Enriched central nervous system cell populations

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JP2010173169A Withdrawn JP2010252808A (ja) 1999-02-12 2010-07-30 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE60044655D1 (de) * 1999-02-12 2010-08-19 Stemcells California Inc Angereicherte Zellpopulationen des zentralen Nervensystems
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
EP1287116A2 (en) 2000-05-17 2003-03-05 Geron Corporation Neural progenitor cell populations
WO2002097069A1 (en) * 2001-06-01 2002-12-05 University Of Sydney Purification of lineage-specific cells and uses therefor
AUPR540301A0 (en) * 2001-06-01 2001-06-28 Walter And Eliza Hall Institute Of Medical Research, The A method of purification of cells
ATE371018T1 (de) 2001-06-22 2007-09-15 Stemcells Inc Le-zellen (liver engrafting cells), assays und verwendungen davon
US7381561B2 (en) 2002-08-27 2008-06-03 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
JP4481706B2 (ja) * 2004-03-31 2010-06-16 独立行政法人科学技術振興機構 脳梗塞疾患モデルマウス
WO2008064408A1 (en) * 2006-11-27 2008-06-05 The University Of Queensland Generation of enriched populations of neural progenitor cells and their progeny
DK2114167T3 (en) * 2007-01-16 2018-09-17 Univ Rochester NON-HUMAN ANIMALS WITH HUMAN GLIAKIMARY BRAIN
JP5035928B2 (ja) * 2009-12-15 2012-09-26 独立行政法人産業技術総合研究所 ヒト神経幹細胞のスクリーニング方法
JP4997613B2 (ja) * 2009-12-15 2012-08-08 独立行政法人産業技術総合研究所 ヒト神経幹細胞に選択的なモノクローナル抗体及びこれを用いたスクリーニング方法
JP6090735B2 (ja) * 2012-03-02 2017-03-08 国立大学法人山口大学 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法
ES2927175T3 (es) 2013-02-12 2022-11-03 Reneuron Ltd Método de producción de micropartículas
TWI482782B (zh) * 2013-05-31 2015-05-01 Univ Nat Chiao Tung 架接抗體之雙乳化核殼奈米結構
EP4526433A4 (en) * 2022-05-20 2026-05-06 Univ Leland Stanford Junior METHODS FOR ISOLATING NUAL AND PROGENITOR STEM CELLS FROM THE DEVELOPING HUMAN BRAIN

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001159A1 (en) * 1997-07-04 1999-01-14 University Of Utah Research Foundation Lineage-restricted neuronal precursors
WO1999037751A1 (en) * 1998-01-23 1999-07-29 Imclone Systems Incorporated Purified populations of stem cells

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞
IT1264903B1 (it) 1993-06-30 1996-10-17 Sniaricerche S C P A Cristalli liquidi metallo-organici in una matrice polimerica
US5843633A (en) * 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6451306B1 (en) * 1998-04-15 2002-09-17 The Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
WO2000012683A2 (en) * 1998-08-31 2000-03-09 New York University Stem cells bearing an fgf receptor on the cell surface
DE60044655D1 (de) * 1999-02-12 2010-08-19 Stemcells California Inc Angereicherte Zellpopulationen des zentralen Nervensystems
US7037719B1 (en) * 1999-02-12 2006-05-02 Stemcells California, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US6468794B1 (en) * 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7105150B2 (en) * 1999-02-12 2006-09-12 Stemcells California, Inc. In vivo screening methods using enriched neural stem cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999001159A1 (en) * 1997-07-04 1999-01-14 University Of Utah Research Foundation Lineage-restricted neuronal precursors
WO1999037751A1 (en) * 1998-01-23 1999-07-29 Imclone Systems Incorporated Purified populations of stem cells

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ATE473273T1 (de) 2010-07-15
DE60044655D1 (de) 2010-08-19
EP1144671A2 (en) 2001-10-17
WO2000047762A9 (en) 2002-04-11
ES2351170T3 (es) 2011-02-01
ES2295012T3 (es) 2008-04-16
CA2361249C (en) 2011-05-10
EP1144671B1 (en) 2007-11-07
AU3361800A (en) 2000-08-29
WO2000047762A3 (en) 2000-12-21
DK1900811T3 (da) 2010-10-25
JP2010252808A (ja) 2010-11-11
US20070238171A1 (en) 2007-10-11
EP1900811B1 (en) 2010-07-07
EP1900811A1 (en) 2008-03-19
DK1144671T3 (da) 2008-03-17
CA2361249A1 (en) 2000-08-17
AU2005202534A1 (en) 2005-07-07
WO2000047762A2 (en) 2000-08-17
AU780256B2 (en) 2005-03-10
AU2005202534B2 (en) 2008-05-08
ATE377652T1 (de) 2007-11-15
DE60037007D1 (de) 2007-12-20
JP2002536023A (ja) 2002-10-29

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