JP2002536023A5 - - Google Patents
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- Publication number
- JP2002536023A5 JP2002536023A5 JP2000598656A JP2000598656A JP2002536023A5 JP 2002536023 A5 JP2002536023 A5 JP 2002536023A5 JP 2000598656 A JP2000598656 A JP 2000598656A JP 2000598656 A JP2000598656 A JP 2000598656A JP 2002536023 A5 JP2002536023 A5 JP 2002536023A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- monoclonal antibody
- population
- cell
- nerve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 description 92
- 238000000034 method Methods 0.000 description 58
- 210000002569 neuron Anatomy 0.000 description 21
- 210000005036 nerve Anatomy 0.000 description 16
- 239000000203 mixture Substances 0.000 description 13
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 9
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 9
- 239000001963 growth medium Substances 0.000 description 8
- 210000000130 stem cell Anatomy 0.000 description 8
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 7
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 7
- 108010046018 leukocyte inhibitory factor Proteins 0.000 description 6
- 102000013925 CD34 antigen Human genes 0.000 description 5
- 108050003733 CD34 antigen Proteins 0.000 description 5
- 239000003102 growth factor Substances 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 210000003061 neural cell Anatomy 0.000 description 5
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 4
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 4
- 108010013709 Leukocyte Common Antigens Proteins 0.000 description 4
- 102000017095 Leukocyte Common Antigens Human genes 0.000 description 4
- 102100038081 Signal transducer CD24 Human genes 0.000 description 4
- 210000003169 central nervous system Anatomy 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 4
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 3
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 3
- 229940126864 fibroblast growth factor Drugs 0.000 description 3
- 238000012606 in vitro cell culture Methods 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108010071965 CD24 Antigen Proteins 0.000 description 2
- 102000007645 CD24 Antigen Human genes 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 208000029028 brain injury Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 229940116977 epidermal growth factor Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000012679 serum free medium Substances 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11972599P | 1999-02-12 | 1999-02-12 | |
| US09/422,844 US6468794B1 (en) | 1999-02-12 | 1999-10-21 | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| US16840799P | 1999-12-01 | 1999-12-01 | |
| US09/422,844 | 1999-12-01 | ||
| US60/168,407 | 1999-12-01 | ||
| US60/119,725 | 1999-12-01 | ||
| PCT/US2000/003592 WO2000047762A2 (en) | 1999-02-12 | 2000-02-11 | Enriched central nervous system cell populations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010173169A Division JP2010252808A (ja) | 1999-02-12 | 2010-07-30 | 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536023A JP2002536023A (ja) | 2002-10-29 |
| JP2002536023A5 true JP2002536023A5 (cg-RX-API-DMAC10.html) | 2007-03-29 |
| JP5007003B2 JP5007003B2 (ja) | 2012-08-22 |
Family
ID=46844555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598656A Expired - Lifetime JP5007003B2 (ja) | 1999-02-12 | 2000-02-11 | 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 |
| JP2010173169A Withdrawn JP2010252808A (ja) | 1999-02-12 | 2010-07-30 | 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010173169A Withdrawn JP2010252808A (ja) | 1999-02-12 | 2010-07-30 | 富化された中枢神経系の幹細胞および始原細胞の集団、ならびにこのような集団を同定、単離、および富化するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070238171A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP1900811B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP5007003B2 (cg-RX-API-DMAC10.html) |
| AT (2) | ATE377652T1 (cg-RX-API-DMAC10.html) |
| AU (2) | AU780256B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2361249C (cg-RX-API-DMAC10.html) |
| DE (2) | DE60044655D1 (cg-RX-API-DMAC10.html) |
| DK (2) | DK1900811T3 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2351170T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2000047762A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| DE60044655D1 (de) * | 1999-02-12 | 2010-08-19 | Stemcells California Inc | Angereicherte Zellpopulationen des zentralen Nervensystems |
| US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
| US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
| EP1287116A2 (en) | 2000-05-17 | 2003-03-05 | Geron Corporation | Neural progenitor cell populations |
| WO2002097069A1 (en) * | 2001-06-01 | 2002-12-05 | University Of Sydney | Purification of lineage-specific cells and uses therefor |
| AUPR540301A0 (en) * | 2001-06-01 | 2001-06-28 | Walter And Eliza Hall Institute Of Medical Research, The | A method of purification of cells |
| ATE371018T1 (de) | 2001-06-22 | 2007-09-15 | Stemcells Inc | Le-zellen (liver engrafting cells), assays und verwendungen davon |
| US7381561B2 (en) | 2002-08-27 | 2008-06-03 | Stemcells California, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| JP4481706B2 (ja) * | 2004-03-31 | 2010-06-16 | 独立行政法人科学技術振興機構 | 脳梗塞疾患モデルマウス |
| WO2008064408A1 (en) * | 2006-11-27 | 2008-06-05 | The University Of Queensland | Generation of enriched populations of neural progenitor cells and their progeny |
| DK2114167T3 (en) * | 2007-01-16 | 2018-09-17 | Univ Rochester | NON-HUMAN ANIMALS WITH HUMAN GLIAKIMARY BRAIN |
| JP5035928B2 (ja) * | 2009-12-15 | 2012-09-26 | 独立行政法人産業技術総合研究所 | ヒト神経幹細胞のスクリーニング方法 |
| JP4997613B2 (ja) * | 2009-12-15 | 2012-08-08 | 独立行政法人産業技術総合研究所 | ヒト神経幹細胞に選択的なモノクローナル抗体及びこれを用いたスクリーニング方法 |
| JP6090735B2 (ja) * | 2012-03-02 | 2017-03-08 | 国立大学法人山口大学 | 消化器系がん幹細胞を培養するための無血清培地、及びそれを用いた消化器系がん幹細胞の増殖方法 |
| ES2927175T3 (es) | 2013-02-12 | 2022-11-03 | Reneuron Ltd | Método de producción de micropartículas |
| TWI482782B (zh) * | 2013-05-31 | 2015-05-01 | Univ Nat Chiao Tung | 架接抗體之雙乳化核殼奈米結構 |
| EP4526433A4 (en) * | 2022-05-20 | 2026-05-06 | Univ Leland Stanford Junior | METHODS FOR ISOLATING NUAL AND PROGENITOR STEM CELLS FROM THE DEVELOPING HUMAN BRAIN |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| JPH08500245A (ja) * | 1992-07-27 | 1996-01-16 | カリフォルニア インスティテュート オブ テクノロジー | 哺乳動物の多能性神経幹細胞 |
| IT1264903B1 (it) | 1993-06-30 | 1996-10-17 | Sniaricerche S C P A | Cristalli liquidi metallo-organici in una matrice polimerica |
| US5843633A (en) * | 1996-04-26 | 1998-12-01 | Amcell Corporation | Characterization of a human hematopoietic progenitor cell antigen |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| CA2294737A1 (en) * | 1997-07-04 | 1999-01-14 | University Of Utah Research Foundation | Neuron-restricted precursor cells |
| US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6852533B1 (en) * | 1998-01-23 | 2005-02-08 | Cornell Research Foundation, Inc. | Purified populations of stem cells |
| US6451306B1 (en) * | 1998-04-15 | 2002-09-17 | The Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
| WO2000012683A2 (en) * | 1998-08-31 | 2000-03-09 | New York University | Stem cells bearing an fgf receptor on the cell surface |
| DE60044655D1 (de) * | 1999-02-12 | 2010-08-19 | Stemcells California Inc | Angereicherte Zellpopulationen des zentralen Nervensystems |
| US7037719B1 (en) * | 1999-02-12 | 2006-05-02 | Stemcells California, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| US6468794B1 (en) * | 1999-02-12 | 2002-10-22 | Stemcells, Inc. | Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations |
| US7105150B2 (en) * | 1999-02-12 | 2006-09-12 | Stemcells California, Inc. | In vivo screening methods using enriched neural stem cells |
-
2000
- 2000-02-11 DE DE60044655T patent/DE60044655D1/de not_active Expired - Lifetime
- 2000-02-11 ES ES07021550T patent/ES2351170T3/es not_active Expired - Lifetime
- 2000-02-11 DK DK07021550.4T patent/DK1900811T3/da active
- 2000-02-11 AU AU33618/00A patent/AU780256B2/en not_active Expired
- 2000-02-11 CA CA2361249A patent/CA2361249C/en not_active Expired - Lifetime
- 2000-02-11 ES ES00911779T patent/ES2295012T3/es not_active Expired - Lifetime
- 2000-02-11 EP EP07021550A patent/EP1900811B1/en not_active Expired - Lifetime
- 2000-02-11 EP EP00911779A patent/EP1144671B1/en not_active Expired - Lifetime
- 2000-02-11 AT AT00911779T patent/ATE377652T1/de active
- 2000-02-11 DE DE60037007T patent/DE60037007T2/de not_active Expired - Lifetime
- 2000-02-11 DK DK00911779T patent/DK1144671T3/da active
- 2000-02-11 WO PCT/US2000/003592 patent/WO2000047762A2/en not_active Ceased
- 2000-02-11 AT AT07021550T patent/ATE473273T1/de active IP Right Revival
- 2000-02-11 JP JP2000598656A patent/JP5007003B2/ja not_active Expired - Lifetime
-
2005
- 2005-06-10 AU AU2005202534A patent/AU2005202534B2/en not_active Expired
-
2006
- 2006-10-31 US US11/590,686 patent/US20070238171A1/en not_active Abandoned
-
2010
- 2010-07-30 JP JP2010173169A patent/JP2010252808A/ja not_active Withdrawn
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