JP4996257B2 - イミダゾ［１，２−ｃ］ピリミジニル酢酸誘導体 - Google Patents
イミダゾ［１，２−ｃ］ピリミジニル酢酸誘導体 Download PDFInfo
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- JP4996257B2 JP4996257B2 JP2006550019A JP2006550019A JP4996257B2 JP 4996257 B2 JP4996257 B2 JP 4996257B2 JP 2006550019 A JP2006550019 A JP 2006550019A JP 2006550019 A JP2006550019 A JP 2006550019A JP 4996257 B2 JP4996257 B2 JP 4996257B2
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- Prior art keywords
- imidazo
- formula
- compound
- acid derivative
- pyrimidin
- Prior art date
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- JELCUCXNEYEZOO-UHFFFAOYSA-N 2-imidazo[1,2-c]pyrimidin-2-ylacetic acid Chemical class C1=NC=CC2=NC(CC(=O)O)=CN21 JELCUCXNEYEZOO-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 102000009389 Prostaglandin D receptors Human genes 0.000 claims abstract description 26
- 108050000258 Prostaglandin D receptors Proteins 0.000 claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 24
- 150000003839 salts Chemical class 0.000 claims abstract description 20
- 201000010099 disease Diseases 0.000 claims abstract description 18
- 239000004480 active ingredient Substances 0.000 claims abstract description 14
- 230000000694 effects Effects 0.000 claims abstract description 14
- 238000011282 treatment Methods 0.000 claims abstract description 12
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims abstract description 7
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims abstract description 7
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims abstract description 7
- 206010012438 Dermatitis atopic Diseases 0.000 claims abstract description 7
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims abstract description 7
- 206010039085 Rhinitis allergic Diseases 0.000 claims abstract description 7
- 208000002205 allergic conjunctivitis Diseases 0.000 claims abstract description 7
- 201000010105 allergic rhinitis Diseases 0.000 claims abstract description 7
- 208000006673 asthma Diseases 0.000 claims abstract description 7
- 208000024998 atopic conjunctivitis Diseases 0.000 claims abstract description 7
- 201000008937 atopic dermatitis Diseases 0.000 claims abstract description 7
- 201000009890 sinusitis Diseases 0.000 claims abstract description 7
- 206010052568 Urticaria chronic Diseases 0.000 claims abstract description 6
- 208000024376 chronic urticaria Diseases 0.000 claims abstract description 6
- 208000016557 Acute basophilic leukemia Diseases 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 163
- -1 elixirs Substances 0.000 claims description 84
- 125000000217 alkyl group Chemical group 0.000 claims description 41
- 239000002904 solvent Substances 0.000 claims description 41
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- 239000001257 hydrogen Substances 0.000 claims description 26
- 239000000243 solution Substances 0.000 claims description 23
- 229910052736 halogen Inorganic materials 0.000 claims description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 19
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
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- IMNSAFKHCASFNR-UHFFFAOYSA-N 2-[7-chloro-5-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=C(Cl)N=C1CC(C=C1)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1 IMNSAFKHCASFNR-UHFFFAOYSA-N 0.000 claims description 3
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- ATOWEQWUEYERJH-UHFFFAOYSA-N 2-[5-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=CN=C1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)C(Cl)=C1 ATOWEQWUEYERJH-UHFFFAOYSA-N 0.000 claims description 2
- WZNQTDXNZPDILL-UHFFFAOYSA-N 2-[5-[[4-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=CN=C1CC(C=C1)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1 WZNQTDXNZPDILL-UHFFFAOYSA-N 0.000 claims description 2
- GIGVZCPAYXVQCE-UHFFFAOYSA-N 2-[7-chloro-5-[[4-(naphthalene-2-carbonylamino)phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC=C(C=C3)CC3=NC(Cl)=C(C4=NC=CN43)CC(=O)O)=CC=C21 GIGVZCPAYXVQCE-UHFFFAOYSA-N 0.000 claims description 2
- BNWVGNJHNXVOFY-UHFFFAOYSA-N 2-[7-chloro-5-[[4-[(3,4-dichlorobenzoyl)amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=C(Cl)N=C1CC(C=C1)=CC=C1NC(=O)C1=CC=C(Cl)C(Cl)=C1 BNWVGNJHNXVOFY-UHFFFAOYSA-N 0.000 claims description 2
- ILQOTUDJBVSBHS-BJMVGYQFSA-N 2-[7-chloro-5-[[4-[[(e)-3-(4-chlorophenyl)prop-2-enoyl]amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=C(Cl)N=C1CC(C=C1)=CC=C1NC(=O)\C=C\C1=CC=C(Cl)C=C1 ILQOTUDJBVSBHS-BJMVGYQFSA-N 0.000 claims description 2
- YWPDTUDVAQMTCU-DHZHZOJOSA-N 2-[7-chloro-5-[[4-[[(e)-3-phenylprop-2-enoyl]amino]phenyl]methyl]imidazo[1,2-c]pyrimidin-8-yl]acetic acid Chemical compound N12C=CN=C2C(CC(=O)O)=C(Cl)N=C1CC(C=C1)=CC=C1NC(=O)\C=C\C1=CC=CC=C1 YWPDTUDVAQMTCU-DHZHZOJOSA-N 0.000 claims description 2
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- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
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- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims description 2
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04002144 | 2004-01-31 | ||
| EP04002144.6 | 2004-01-31 | ||
| PCT/EP2005/000475 WO2005073234A2 (en) | 2004-01-31 | 2005-01-19 | Imidazo[1,2-c]pyrimidinylacetic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007519659A JP2007519659A (ja) | 2007-07-19 |
| JP2007519659A5 JP2007519659A5 (https=) | 2011-11-17 |
| JP4996257B2 true JP4996257B2 (ja) | 2012-08-08 |
Family
ID=34814234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006550019A Expired - Fee Related JP4996257B2 (ja) | 2004-01-31 | 2005-01-19 | イミダゾ［１，２−ｃ］ピリミジニル酢酸誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7750014B2 (https=) |
| EP (1) | EP1718649B1 (https=) |
| JP (1) | JP4996257B2 (https=) |
| KR (1) | KR101207428B1 (https=) |
| CN (1) | CN100584844C (https=) |
| AT (1) | ATE433452T1 (https=) |
| AU (1) | AU2005209381B2 (https=) |
| BR (1) | BRPI0507123A (https=) |
| CA (1) | CA2551778C (https=) |
| CY (1) | CY1109274T1 (https=) |
| DE (1) | DE602005014849D1 (https=) |
| DK (1) | DK1718649T3 (https=) |
| ES (1) | ES2326896T3 (https=) |
| IL (1) | IL177083A (https=) |
| MX (1) | MXPA06007674A (https=) |
| NO (1) | NO20063878L (https=) |
| NZ (1) | NZ548396A (https=) |
| PL (1) | PL1718649T3 (https=) |
| PT (1) | PT1718649E (https=) |
| RU (1) | RU2373208C2 (https=) |
| SI (1) | SI1718649T1 (https=) |
| WO (1) | WO2005073234A2 (https=) |
| ZA (1) | ZA200605387B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2369782T3 (es) | 2004-12-27 | 2011-12-05 | Actelion Pharmaceuticals Ltd. | Derivados de 2,3,4,9-tetrahidro-1h-carbazol como antagonistas del receptor crth2. |
| BRPI0715179A2 (pt) | 2006-08-07 | 2013-06-11 | Actelion Pharmaceuticals Ltd | composto, composiÇço farmacÊutica e uso de um composto |
| WO2008125627A1 (en) * | 2007-04-13 | 2008-10-23 | Novartis Ag | Pyridazine-, pyridine- and pyrane-derivatives as gpbar1 agonisis |
| CN103172573A (zh) * | 2007-06-21 | 2013-06-26 | 艾克提麦斯医药品有限公司 | Crth2 拮抗剂的微粒 |
| ATE547407T1 (de) * | 2007-09-25 | 2012-03-15 | Actimis Pharmaceuticals Inc | Alkylthiopyrimidine als crth2-antagonisten |
| WO2009042139A1 (en) * | 2007-09-25 | 2009-04-02 | Actimis Pharmaceuticals, Inc. | 2-s-benzyl substituted pyrimidines as crth2 antagonists |
| EP2257536A4 (en) | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| WO2009145989A2 (en) | 2008-04-02 | 2009-12-03 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl antagonists of prostaglandin d2 receptors |
| CA2735722A1 (en) * | 2008-09-02 | 2010-03-11 | Actimis Pharmaceuticals, Inc. | Isotopically enriched pyrimidin-5-yl acetic acid derivatives as crth2 antagonists |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| PT2558447E (pt) | 2010-03-22 | 2014-11-25 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroarilamino)-1,2,3,4-tetrahidro-9hcarbazol e o seu uso como moduladores do receptor de prostaglandina d2 |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| DE102010031149A1 (de) | 2010-07-09 | 2012-01-12 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimidine und Triazine und ihre Verwendung |
| PE20130779A1 (es) | 2010-07-09 | 2013-06-21 | Bayer Ip Gmbh | Pirimidinas y triazinas condensadas y su uso |
| DE102011003315A1 (de) | 2011-01-28 | 2012-08-02 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimindine und Triazine und ihre Verwendung |
| EP2627178B1 (en) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| DK2697223T3 (en) | 2011-04-14 | 2016-09-05 | Actelion Pharmaceuticals Ltd | 7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor |
| EP2790696A1 (en) | 2011-12-16 | 2014-10-22 | Atopix Therapeutics Limited | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| JP6097765B2 (ja) | 2011-12-21 | 2017-03-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ヘテロシクリル誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用 |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
| WO2014006585A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| AR099767A1 (es) | 2014-03-17 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados del ácido acético azaindol y su uso como moduladores del receptor de prostaglandina d2 |
| KR20160133536A (ko) | 2014-03-18 | 2016-11-22 | 액테리온 파마슈티칼 리미티드 | 아자인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 이의 용도 |
| AU2016323262B2 (en) | 2015-09-15 | 2020-11-19 | Idorsia Pharmaceuticals Ltd | Crystalline forms |
| KR20190103507A (ko) | 2018-02-12 | 2019-09-05 | 김강민 | 지하철 혼잡도 알림 시스템 |
| WO2019139462A2 (ko) * | 2019-02-21 | 2019-07-18 | 엘지전자 주식회사 | 하차 시점 알림 방법 및 사용자 단말 |
| TW202100015A (zh) | 2019-02-28 | 2021-01-01 | 瑞士商先正達農作物保護公司 | 具有含硫取代基之殺有害生物活性雜環衍生物 |
| CN114681438B (zh) * | 2022-05-17 | 2024-03-19 | 中国医学科学院基础医学研究所 | 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| GB9125842D0 (en) | 1991-12-04 | 1992-02-05 | Ici Plc | Heterocyclic derivatives |
| DE60018037T2 (de) * | 1999-11-10 | 2006-01-12 | Ortho-Mcneil Pharmaceutical, Inc. | Substituierte 2-aryl-3-(heteroaryl)-imidazo[1,2-alpha]pyrimidine und ihren verwandten arzneimittel und verfahren |
| JP2001302667A (ja) | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| EP1413306A1 (en) | 2002-10-21 | 2004-04-28 | Warner-Lambert Company LLC | Tetrahydroquinoline derivatives as CRTH2 antagonists |
| ZA200505523B (en) * | 2002-12-20 | 2006-09-27 | Amgen Inc | Asthma and allergic inflammation modulators |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
-
2005
- 2005-01-19 CA CA2551778A patent/CA2551778C/en not_active Expired - Fee Related
- 2005-01-19 NZ NZ548396A patent/NZ548396A/en not_active IP Right Cessation
- 2005-01-19 RU RU2006131304/04A patent/RU2373208C2/ru not_active IP Right Cessation
- 2005-01-19 EP EP05706922A patent/EP1718649B1/en not_active Expired - Lifetime
- 2005-01-19 AU AU2005209381A patent/AU2005209381B2/en not_active Ceased
- 2005-01-19 BR BRPI0507123-2A patent/BRPI0507123A/pt not_active IP Right Cessation
- 2005-01-19 DK DK05706922T patent/DK1718649T3/da active
- 2005-01-19 ES ES05706922T patent/ES2326896T3/es not_active Expired - Lifetime
- 2005-01-19 PL PL05706922T patent/PL1718649T3/pl unknown
- 2005-01-19 CN CN200580010462A patent/CN100584844C/zh not_active Expired - Fee Related
- 2005-01-19 DE DE602005014849T patent/DE602005014849D1/de not_active Expired - Lifetime
- 2005-01-19 SI SI200530724T patent/SI1718649T1/sl unknown
- 2005-01-19 AT AT05706922T patent/ATE433452T1/de active
- 2005-01-19 JP JP2006550019A patent/JP4996257B2/ja not_active Expired - Fee Related
- 2005-01-19 ZA ZA200605387A patent/ZA200605387B/en unknown
- 2005-01-19 MX MXPA06007674A patent/MXPA06007674A/es active IP Right Grant
- 2005-01-19 US US10/585,429 patent/US7750014B2/en not_active Expired - Fee Related
- 2005-01-19 WO PCT/EP2005/000475 patent/WO2005073234A2/en not_active Ceased
- 2005-01-19 PT PT05706922T patent/PT1718649E/pt unknown
-
2006
- 2006-07-25 IL IL177083A patent/IL177083A/en not_active IP Right Cessation
- 2006-08-29 KR KR1020067017478A patent/KR101207428B1/ko not_active Expired - Fee Related
- 2006-08-31 NO NO20063878A patent/NO20063878L/no not_active Application Discontinuation
-
2009
- 2009-08-06 CY CY20091100834T patent/CY1109274T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005209381A1 (en) | 2005-08-11 |
| IL177083A0 (en) | 2006-12-10 |
| BRPI0507123A (pt) | 2007-06-19 |
| DK1718649T3 (da) | 2009-08-24 |
| RU2373208C2 (ru) | 2009-11-20 |
| MXPA06007674A (es) | 2006-09-04 |
| US20090012102A1 (en) | 2009-01-08 |
| ES2326896T3 (es) | 2009-10-21 |
| ATE433452T1 (de) | 2009-06-15 |
| CA2551778A1 (en) | 2005-08-11 |
| NZ548396A (en) | 2010-06-25 |
| EP1718649B1 (en) | 2009-06-10 |
| NO20063878L (no) | 2006-10-11 |
| WO2005073234A3 (en) | 2005-10-06 |
| IL177083A (en) | 2011-10-31 |
| WO2005073234A2 (en) | 2005-08-11 |
| EP1718649A2 (en) | 2006-11-08 |
| CN1938310A (zh) | 2007-03-28 |
| HK1101969A1 (en) | 2007-11-02 |
| AU2005209381B2 (en) | 2011-06-30 |
| SI1718649T1 (sl) | 2009-10-31 |
| CY1109274T1 (el) | 2014-07-02 |
| DE602005014849D1 (de) | 2009-07-23 |
| CA2551778C (en) | 2013-10-22 |
| KR20060130187A (ko) | 2006-12-18 |
| PL1718649T3 (pl) | 2009-11-30 |
| RU2006131304A (ru) | 2008-03-10 |
| JP2007519659A (ja) | 2007-07-19 |
| US7750014B2 (en) | 2010-07-06 |
| ZA200605387B (en) | 2008-05-28 |
| KR101207428B1 (ko) | 2012-12-04 |
| CN100584844C (zh) | 2010-01-27 |
| PT1718649E (pt) | 2009-08-06 |
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