NO20063878L - Imidazo[1,2-c]pyrimidinyleddiksyrederivater - Google Patents
Imidazo[1,2-c]pyrimidinyleddiksyrederivaterInfo
- Publication number
- NO20063878L NO20063878L NO20063878A NO20063878A NO20063878L NO 20063878 L NO20063878 L NO 20063878L NO 20063878 A NO20063878 A NO 20063878A NO 20063878 A NO20063878 A NO 20063878A NO 20063878 L NO20063878 L NO 20063878L
- Authority
- NO
- Norway
- Prior art keywords
- diseases
- imidazo
- allergic
- acid derivative
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det beskrives imidazo[1,2-c]pyrimidinyleddiksyrederivater og salter derav som er nyttige som aktive bestanddeler i farmasøytiske preparater. Derivatene ifølge oppfinnelsen har utmerket CRTH2 (G-protein-koblet kjemoattraktantreceptor, uttrykt på Th2 celler) antagonistisk aktivitet og kan benyttes for profylakse og terapi av sykdommer assosiert med CRTH2 aktivitet, særlig for behandling av allergiske sykdommer som astma, allergisk rhinitt, atopisk dermatitt og allergisk konjunktivitt, eosinofilrelaterte sykdommer som Churg-Strauss syndrom og sinusitt; basofilrelatert sykdom som basofilisk leukemi, kronisk urtikaria og basofilisk leukocytose i mennesker eller andre pattedyr og inflammatoriske sykdommer som karakteriseres ved T-lymfocytter og profuse leukocyttinfiltrater som psoriasis, eksem, inflammatorisk tarinsykdom, ulcerativ kolitt, Krohns sykdom, COPD (kronisk obstruktiv pulmonærforstyrrelse) og artritt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04002144 | 2004-01-31 | ||
PCT/EP2005/000475 WO2005073234A2 (en) | 2004-01-31 | 2005-01-19 | Imidazo[1,2-c]pyrimidinylacetic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20063878L true NO20063878L (no) | 2006-10-11 |
Family
ID=34814234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20063878A NO20063878L (no) | 2004-01-31 | 2006-08-31 | Imidazo[1,2-c]pyrimidinyleddiksyrederivater |
Country Status (24)
Country | Link |
---|---|
US (1) | US7750014B2 (no) |
EP (1) | EP1718649B1 (no) |
JP (1) | JP4996257B2 (no) |
KR (1) | KR101207428B1 (no) |
CN (1) | CN100584844C (no) |
AT (1) | ATE433452T1 (no) |
AU (1) | AU2005209381B2 (no) |
BR (1) | BRPI0507123A (no) |
CA (1) | CA2551778C (no) |
CY (1) | CY1109274T1 (no) |
DE (1) | DE602005014849D1 (no) |
DK (1) | DK1718649T3 (no) |
ES (1) | ES2326896T3 (no) |
HK (1) | HK1101969A1 (no) |
IL (1) | IL177083A (no) |
MX (1) | MXPA06007674A (no) |
NO (1) | NO20063878L (no) |
NZ (1) | NZ548396A (no) |
PL (1) | PL1718649T3 (no) |
PT (1) | PT1718649E (no) |
RU (1) | RU2373208C2 (no) |
SI (1) | SI1718649T1 (no) |
WO (1) | WO2005073234A2 (no) |
ZA (1) | ZA200605387B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1833791T3 (da) | 2004-12-27 | 2011-10-24 | Actelion Pharmaceuticals Ltd | 2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister |
AU2007282949B8 (en) | 2006-08-07 | 2012-10-04 | Actelion Pharmaceuticals Ltd. | (3-Amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives |
MX2009010959A (es) * | 2007-04-13 | 2009-10-29 | Novartis Ag | Derivados de piridazina, piridina y pirano como agonistas gpbar1. |
EP2170838A1 (en) * | 2007-06-21 | 2010-04-07 | Actimis Pharmaceuticals, Inc., | Particulates of a crth2 antagonist |
MX2010003178A (es) * | 2007-09-25 | 2010-04-30 | Actimis Pharmaceuticals Inc | Primidinas sustituidas con 2-s-bencilo como antagonistas de crth2. |
TW200922587A (en) * | 2007-09-25 | 2009-06-01 | Actimis Pharmaceuticals Inc | Alkylthio pyrimidines as CRTH2 antagonists |
EP2257536A4 (en) | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
JP2011518130A (ja) | 2008-04-02 | 2011-06-23 | アミラ ファーマシューティカルズ,インク. | プロスタグランジンd2受容体のアミノアルキルフェニルアンタゴニスト |
EP2328876B1 (en) | 2008-09-02 | 2012-11-21 | Actimis Pharmaceuticals, Inc., | Isotopically enriched pyrimidin-5-yl acetic acid derivatives as crth2 antagonists |
WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
TWI562987B (en) | 2010-03-22 | 2016-12-21 | Actelion Pharmaceuticals Ltd | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators |
CA2805452C (en) | 2010-07-05 | 2018-07-31 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
DE102011003315A1 (de) | 2011-01-28 | 2012-08-02 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimindine und Triazine und ihre Verwendung |
DE102010031149A1 (de) | 2010-07-09 | 2012-01-12 | Bayer Schering Pharma Aktiengesellschaft | Annellierte Pyrimidine und Triazine und ihre Verwendung |
EA201390060A1 (ru) | 2010-07-09 | 2013-07-30 | Байер Интеллектуэль Проперти Гмбх | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний |
EP2627178B1 (en) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
EP2697223B1 (en) | 2011-04-14 | 2016-07-13 | Actelion Pharmaceuticals Ltd. | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
US20140328861A1 (en) | 2011-12-16 | 2014-11-06 | Atopix Therapeutics Limited | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis |
CN104011021B (zh) | 2011-12-21 | 2016-08-24 | 埃科特莱茵药品有限公司 | 杂环衍生物及其作为前列腺素d2受体调节剂的用途 |
DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
WO2014006585A1 (en) | 2012-07-05 | 2014-01-09 | Actelion Pharmaceuticals Ltd | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
PL3119779T3 (pl) | 2014-03-17 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Pochodne kwasu azaindolooctowego i ich zastosowanie jako modulatorów receptora prostaglandyny d2 |
JP6484644B2 (ja) | 2014-03-18 | 2019-03-13 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | アザインドール酢酸誘導体及びプロスタグランジンd2受容体調節剤としてのそれらの使用 |
MX2018003202A (es) | 2015-09-15 | 2018-06-08 | Idorsia Pharmaceuticals Ltd | Formas cristalinas. |
KR20190103507A (ko) | 2018-02-12 | 2019-09-05 | 김강민 | 지하철 혼잡도 알림 시스템 |
TW202100015A (zh) | 2019-02-28 | 2021-01-01 | 瑞士商先正達農作物保護公司 | 具有含硫取代基之殺有害生物活性雜環衍生物 |
CN114681438B (zh) * | 2022-05-17 | 2024-03-19 | 中国医学科学院基础医学研究所 | 二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
GB9125842D0 (en) | 1991-12-04 | 1992-02-05 | Ici Plc | Heterocyclic derivatives |
JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
EP1413306A1 (en) | 2002-10-21 | 2004-04-28 | Warner-Lambert Company LLC | Tetrahydroquinoline derivatives as CRTH2 antagonists |
ZA200505523B (en) * | 2002-12-20 | 2006-09-27 | Amgen Inc | Asthma and allergic inflammation modulators |
DE60303238T2 (de) * | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
-
2005
- 2005-01-19 PL PL05706922T patent/PL1718649T3/pl unknown
- 2005-01-19 NZ NZ548396A patent/NZ548396A/en not_active IP Right Cessation
- 2005-01-19 DE DE602005014849T patent/DE602005014849D1/de active Active
- 2005-01-19 JP JP2006550019A patent/JP4996257B2/ja not_active Expired - Fee Related
- 2005-01-19 ZA ZA200605387A patent/ZA200605387B/en unknown
- 2005-01-19 MX MXPA06007674A patent/MXPA06007674A/es active IP Right Grant
- 2005-01-19 US US10/585,429 patent/US7750014B2/en not_active Expired - Fee Related
- 2005-01-19 AT AT05706922T patent/ATE433452T1/de active
- 2005-01-19 AU AU2005209381A patent/AU2005209381B2/en not_active Ceased
- 2005-01-19 RU RU2006131304/04A patent/RU2373208C2/ru not_active IP Right Cessation
- 2005-01-19 BR BRPI0507123-2A patent/BRPI0507123A/pt not_active IP Right Cessation
- 2005-01-19 WO PCT/EP2005/000475 patent/WO2005073234A2/en active Application Filing
- 2005-01-19 DK DK05706922T patent/DK1718649T3/da active
- 2005-01-19 EP EP05706922A patent/EP1718649B1/en not_active Not-in-force
- 2005-01-19 CA CA2551778A patent/CA2551778C/en not_active Expired - Fee Related
- 2005-01-19 PT PT05706922T patent/PT1718649E/pt unknown
- 2005-01-19 CN CN200580010462A patent/CN100584844C/zh not_active Expired - Fee Related
- 2005-01-19 ES ES05706922T patent/ES2326896T3/es active Active
- 2005-01-19 SI SI200530724T patent/SI1718649T1/sl unknown
-
2006
- 2006-07-25 IL IL177083A patent/IL177083A/en not_active IP Right Cessation
- 2006-08-29 KR KR1020067017478A patent/KR101207428B1/ko not_active IP Right Cessation
- 2006-08-31 NO NO20063878A patent/NO20063878L/no not_active Application Discontinuation
-
2007
- 2007-09-14 HK HK07110047.5A patent/HK1101969A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 CY CY20091100834T patent/CY1109274T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR101207428B1 (ko) | 2012-12-04 |
JP4996257B2 (ja) | 2012-08-08 |
ATE433452T1 (de) | 2009-06-15 |
EP1718649A2 (en) | 2006-11-08 |
ES2326896T3 (es) | 2009-10-21 |
DK1718649T3 (da) | 2009-08-24 |
KR20060130187A (ko) | 2006-12-18 |
BRPI0507123A (pt) | 2007-06-19 |
CN100584844C (zh) | 2010-01-27 |
US7750014B2 (en) | 2010-07-06 |
WO2005073234A2 (en) | 2005-08-11 |
AU2005209381A1 (en) | 2005-08-11 |
PL1718649T3 (pl) | 2009-11-30 |
CA2551778C (en) | 2013-10-22 |
ZA200605387B (en) | 2008-05-28 |
CN1938310A (zh) | 2007-03-28 |
NZ548396A (en) | 2010-06-25 |
EP1718649B1 (en) | 2009-06-10 |
PT1718649E (pt) | 2009-08-06 |
JP2007519659A (ja) | 2007-07-19 |
SI1718649T1 (sl) | 2009-10-31 |
CA2551778A1 (en) | 2005-08-11 |
IL177083A (en) | 2011-10-31 |
WO2005073234A3 (en) | 2005-10-06 |
DE602005014849D1 (de) | 2009-07-23 |
CY1109274T1 (el) | 2014-07-02 |
IL177083A0 (en) | 2006-12-10 |
MXPA06007674A (es) | 2006-09-04 |
HK1101969A1 (en) | 2007-11-02 |
RU2373208C2 (ru) | 2009-11-20 |
US20090012102A1 (en) | 2009-01-08 |
AU2005209381B2 (en) | 2011-06-30 |
RU2006131304A (ru) | 2008-03-10 |
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