JP4994387B2 - 歯肉縁下ポケット感染症の治療 - Google Patents
歯肉縁下ポケット感染症の治療 Download PDFInfo
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- JP4994387B2 JP4994387B2 JP2008541814A JP2008541814A JP4994387B2 JP 4994387 B2 JP4994387 B2 JP 4994387B2 JP 2008541814 A JP2008541814 A JP 2008541814A JP 2008541814 A JP2008541814 A JP 2008541814A JP 4994387 B2 JP4994387 B2 JP 4994387B2
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- subgingival
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Description
Holt and Ebersole、Periodontol 2000.2005;38:72−122 Socransky and Haffajee、 Periodontol 2000. 2005;38:135−87 Califano J.V. et al、 Infection and Immunity、Sept.1996,p.3908−3910 Lu et al、Infect Immun 1993 Jun;61(6):2400−7 Quinn S. et al、Infect.Immun.64:2500−2505 Van Winkelhoff A.J. and Slots J. Periodontol. 2000 1999;20:122−135 Chan EC, McLaughlin R. Oral Microbiol Immunol 2000;15:1−9 Takeuchi Y、 Umeda M、 Sakamoto M. et al. J Periodontol 2001;72:1354−1363 Langendijk−Genevaux PS et al. J Clin Periodontol 2001;28:1151−1157 Shiloah J. et al. J Periodontol 2000;71:562−567 Collaert et al、 Scand J Dent Res 1994;102:17−25 Etienne、 Oral Dis.2003;9 Suppl 1:45−50
式中、R1は、モルホリノ環の2位もしくは3位に存在し、8〜16個の炭素原子を含む、直鎖型もしくは分岐鎖型アルキル基であり、R2は、2〜10個の炭素原子を含み、かつα位を除きヒドロキシ基で置換されている、直鎖型もしくは分岐鎖型アルキル基である。
請求項に記載のモルホリノ化合物そのものは、化合物として既知であり、既知のいずれかの方法、たとえば本明細書において参照として援用される、米国特許第5,082,653号および国際公開第90/14342号に開示されている方法により製造可能である。
この実施例では、2年間にわたり、治療を行ってきた患者の治療に、すすぎ剤としてデルモピノールを使用した。彼女は、クローン病(Morbus Crohn)、および、重篤な歯肉病変および歯肉腫大を伴う口腔合併症と診断されていた。彼女は、口腔感染症を抑えるためにそれまでに抗生物質(ジスロマックス)の投与治療を受け、病原菌のコロニー再形成を調節するためにクロルヘキシジン0.12%のすすぎ液を常用していた。クロルヘキシジンは、他の口腔衛生手段の補助手段として、歯肉感染症/炎症を抑えるために常用される。しかし、クロルヘキシジンには、歯の汚れ、味覚の喪失および灼熱感などの副作用がある。クロルヘキシジン溶液におけるアルコール分もまた、患者に何らかの問題を引き起こす。灼熱感はこの場合問題であり、該患者はクロルヘキシジンによるすすぎに協力的ではなかった。
1.患者は、臨床医にデルモピノールによるすすぎが好ましいと伝え、2週間の間、副作用としての歯の汚れや灼熱感がないことが報告された。
2.触診時の出血量の低下および、目視診察時の歯肉の腫大の緩和と潰瘍の欠如によって明らかなように、歯肉の炎症の度合いは、臨床的には軽減していた。
Claims (14)
- 前記モルホリノ化合物のR 1 基およびR 2 基における炭素原子の総和が、少なくとも10個であることを特徴とする、請求項1に記載の治療用薬剤。
- 前記モルホルノ化合物のR 2 基が前記ヒドロキシ基で終端することを特徴とする、請求項1もしくは2に記載の治療用薬剤。
- 前記モルホリノ化合物が、3−(4−プロピル−ヘプチル)−4−(2−ヒドロキシエチル)モルホリンであることを特徴とする、請求項1〜3のいずれか1項に記載の治療用薬剤。
- 前記感染した歯肉縁下ポケットが、細菌複合体であるレッドコンプレックスによる感染であることを特徴とする、請求項1〜4のいずれか1項に記載の治療用薬剤。
- 前記感染した歯肉縁下ポケットに、Tannerella forsythensis、 Porphyromonas gingivalis、Treponema denticolaもしくはActinobacillus actinomycetemcomitansのいずれかが含まれていることを特徴とする、請求項1〜5のいずれか1項に記載の治療用薬剤。
- 前記感染した歯肉縁下ポケットが歯周炎であることを特徴とする、請求項1〜6のいずれか1項に記載の治療用薬剤。
- 前記感染した歯肉縁下ポケットが慢性歯周炎であることを特徴とする、請求項1〜7のいずれか1項に記載の治療用薬剤。
- 前記薬剤に、さらに抗菌剤が含まれていることを特徴とする、請求項1〜8のいずれか1項に記載の治療用薬剤。
- 前記薬剤に、さらに抗炎症剤が含まれていることを特徴とする、請求項1〜9のいずれか1項に記載の治療用薬剤。
- 前記薬剤が水性であることを特徴とする、請求項1〜10のいずれか1項に記載の治療用薬剤。
- 前記薬剤が、うがい薬、練り歯磨き、ジェルもしくはガムの形態であることを特徴とする、請求項1〜11のいずれか1項に記載の治療用薬剤。
- 請求項1〜4に記載の化合物と、前記化合物が前記感染の治療のために使用されるものである旨の説明書とを含む、歯肉縁下ポケットにおける感染を治療するためのキット。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0523745.8A GB0523745D0 (en) | 2005-11-22 | 2005-11-22 | Method |
GB0523745.8 | 2005-11-22 | ||
GB0600324A GB0600324D0 (en) | 2006-01-09 | 2006-01-09 | Method |
GB0600324.8 | 2006-01-09 | ||
PCT/GB2006/004348 WO2007060413A1 (en) | 2005-11-22 | 2006-11-22 | Treatment of sub-gingival pocket infections |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009516731A JP2009516731A (ja) | 2009-04-23 |
JP2009516731A5 JP2009516731A5 (ja) | 2012-02-09 |
JP4994387B2 true JP4994387B2 (ja) | 2012-08-08 |
Family
ID=37636121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008541814A Active JP4994387B2 (ja) | 2005-11-22 | 2006-11-22 | 歯肉縁下ポケット感染症の治療 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20080287443A1 (ja) |
EP (2) | EP3184150B1 (ja) |
JP (1) | JP4994387B2 (ja) |
CY (1) | CY1118964T1 (ja) |
DK (2) | DK3184150T3 (ja) |
ES (2) | ES2625110T3 (ja) |
HU (1) | HUE032665T2 (ja) |
LT (1) | LT1951374T (ja) |
PL (2) | PL1951374T3 (ja) |
PT (1) | PT1951374T (ja) |
WO (1) | WO2007060413A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0502046D0 (en) | 2005-02-01 | 2005-03-09 | Sinclair Pharmaceuticals Ltd | Method |
GB0714338D0 (en) * | 2007-07-23 | 2007-09-05 | Sinclair Pharmaceuticals Ltd | method |
CA2861199C (en) * | 2012-03-20 | 2020-03-24 | Sinclair Pharmaceuticals Limited | Treatment of microbial infections with delmopinol and cetylpyridinium |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE439011B (sv) * | 1980-03-21 | 1985-05-28 | Ferrosan Ab | Morfolinoforeningar, kompositioner innehallande dessa och anvendning derav |
US4894221A (en) * | 1981-03-19 | 1990-01-16 | Ab Ferrosan | Method of treating plaque using morpholine compounds |
US4846200A (en) * | 1983-01-17 | 1989-07-11 | Wiley Larry J | Periodontal pocket cleaner |
ES2053195T3 (es) | 1989-05-24 | 1994-07-16 | Pharmacia Ab | Isoxazolidinas e isoxazolinas sustituidas. |
US5147632A (en) * | 1990-10-31 | 1992-09-15 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and chelating agent |
US5082653A (en) | 1990-10-31 | 1992-01-21 | Warner-Lambert Company | Anti-plaque compositions comprising a combination of morpholinoamino alcohol and antibiotic |
AU8879591A (en) * | 1990-11-09 | 1992-06-11 | Warner-Lambert Company | Improved anti-plaque compositions comprising a combination of morpholinoamino alcohol and anti-microbial agent |
US5755572A (en) * | 1992-08-10 | 1998-05-26 | Novadent Ltd. | Oral hygiene irrigator syringe bulb |
US5736175A (en) * | 1996-02-28 | 1998-04-07 | Nabisco Technology Co. | Chewing gums containing plaque disrupting ingredients and method for preparing it |
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2006
- 2006-11-22 ES ES06808626.3T patent/ES2625110T3/es active Active
- 2006-11-22 DK DK16199408.2T patent/DK3184150T3/da active
- 2006-11-22 PL PL06808626T patent/PL1951374T3/pl unknown
- 2006-11-22 US US12/091,784 patent/US20080287443A1/en not_active Abandoned
- 2006-11-22 PT PT68086263T patent/PT1951374T/pt unknown
- 2006-11-22 LT LTEP06808626.3T patent/LT1951374T/lt unknown
- 2006-11-22 HU HUE06808626A patent/HUE032665T2/en unknown
- 2006-11-22 EP EP16199408.2A patent/EP3184150B1/en active Active
- 2006-11-22 DK DK06808626.3T patent/DK1951374T3/en active
- 2006-11-22 ES ES16199408T patent/ES2744345T3/es active Active
- 2006-11-22 PL PL16199408T patent/PL3184150T3/pl unknown
- 2006-11-22 WO PCT/GB2006/004348 patent/WO2007060413A1/en active Application Filing
- 2006-11-22 JP JP2008541814A patent/JP4994387B2/ja active Active
- 2006-11-22 EP EP06808626.3A patent/EP1951374B1/en active Active
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- 2017-05-05 CY CY20171100503T patent/CY1118964T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL1951374T3 (pl) | 2017-07-31 |
ES2625110T3 (es) | 2017-07-18 |
PL3184150T3 (pl) | 2020-03-31 |
HUE032665T2 (en) | 2017-10-30 |
PT1951374T (pt) | 2017-06-08 |
DK1951374T3 (en) | 2017-04-10 |
ES2744345T3 (es) | 2020-02-24 |
EP3184150A1 (en) | 2017-06-28 |
EP3184150B1 (en) | 2019-06-19 |
EP1951374B1 (en) | 2017-03-01 |
WO2007060413A1 (en) | 2007-05-31 |
DK3184150T3 (da) | 2019-09-02 |
JP2009516731A (ja) | 2009-04-23 |
US20080287443A1 (en) | 2008-11-20 |
CY1118964T1 (el) | 2018-01-10 |
LT1951374T (lt) | 2017-05-10 |
EP1951374A1 (en) | 2008-08-06 |
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