JP4980716B2 - 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 - Google Patents

遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 Download PDF

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JP4980716B2
JP4980716B2 JP2006533810A JP2006533810A JP4980716B2 JP 4980716 B2 JP4980716 B2 JP 4980716B2 JP 2006533810 A JP2006533810 A JP 2006533810A JP 2006533810 A JP2006533810 A JP 2006533810A JP 4980716 B2 JP4980716 B2 JP 4980716B2
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seq
sequence
hbv
rna
expression
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JP2007503474A5 (https=
JP2007503474A (ja
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キャサリン・ジェイ・パチュク
シー・サティシュチャンドラン
ビンセント・アール・ズロースキ・ジュニア
リアット・ミンツ
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Alnylam Pharmaceuticals Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2006533810A 2003-06-12 2004-06-10 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 Expired - Fee Related JP4980716B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47807603P 2003-06-12 2003-06-12
US60/478,076 2003-06-12
PCT/US2004/019229 WO2005014806A2 (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

Related Child Applications (1)

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JP2011148461A Division JP5593279B2 (ja) 2003-06-12 2011-07-04 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列

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JP2007503474A JP2007503474A (ja) 2007-02-22
JP2007503474A5 JP2007503474A5 (https=) 2007-07-26
JP4980716B2 true JP4980716B2 (ja) 2012-07-18

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JP2011148461A Expired - Lifetime JP5593279B2 (ja) 2003-06-12 2011-07-04 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列

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US (1) US8350021B2 (https=)
EP (4) EP3470518A1 (https=)
JP (2) JP4980716B2 (https=)
CN (1) CN1836042A (https=)
AU (1) AU2004263832B2 (https=)
BR (1) BRPI0411219A (https=)
CA (2) CA3040025C (https=)
DK (1) DK2270162T3 (https=)
HU (1) HUE042261T2 (https=)
IL (1) IL172268A0 (https=)
SG (1) SG173218A1 (https=)
SI (1) SI2270162T1 (https=)
WO (1) WO2005014806A2 (https=)

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HUE042261T2 (hu) 2019-06-28
SG173218A1 (en) 2011-08-29
EP1631670A2 (en) 2006-03-08
EP2270162A3 (en) 2012-05-30
EP2284268A2 (en) 2011-02-16
AU2004263832B2 (en) 2010-07-01
EP2270162B1 (en) 2018-10-03
BRPI0411219A (pt) 2006-07-18
CA2528510A1 (en) 2005-02-17
US8350021B2 (en) 2013-01-08
DK2270162T3 (en) 2019-01-21
CN1836042A (zh) 2006-09-20
AU2004263832A1 (en) 2005-02-17
WO2005014806A2 (en) 2005-02-17
EP2270162A2 (en) 2011-01-05
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SI2270162T1 (sl) 2019-03-29
CA3040025C (en) 2023-01-10
JP5593279B2 (ja) 2014-09-17
WO2005014806A3 (en) 2005-12-01
JP2011224013A (ja) 2011-11-10
JP2007503474A (ja) 2007-02-22
US20080070854A1 (en) 2008-03-20
EP1631670B1 (en) 2012-08-08

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