JP4979157B2 - 置換されたγ−フェニル−Δ−ラクトンおよびそのアナログならびにこれらに関する使用 - Google Patents
置換されたγ−フェニル−Δ−ラクトンおよびそのアナログならびにこれらに関する使用 Download PDFInfo
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- JP4979157B2 JP4979157B2 JP2000568841A JP2000568841A JP4979157B2 JP 4979157 B2 JP4979157 B2 JP 4979157B2 JP 2000568841 A JP2000568841 A JP 2000568841A JP 2000568841 A JP2000568841 A JP 2000568841A JP 4979157 B2 JP4979157 B2 JP 4979157B2
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- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 150000003954 δ-lactams Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9963798P | 1998-09-09 | 1998-09-09 | |
| US12150799P | 1999-02-23 | 1999-02-23 | |
| US14951799P | 1999-08-17 | 1999-08-17 | |
| US60/149,517 | 1999-08-17 | ||
| US60/121,507 | 1999-08-17 | ||
| US60/099,637 | 1999-08-17 | ||
| PCT/CA1999/000819 WO2000014083A1 (en) | 1998-09-09 | 1999-09-09 | SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002524456A JP2002524456A (ja) | 2002-08-06 |
| JP2002524456A5 JP2002524456A5 (enExample) | 2006-11-02 |
| JP4979157B2 true JP4979157B2 (ja) | 2012-07-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568841A Expired - Fee Related JP4979157B2 (ja) | 1998-09-09 | 1999-09-09 | 置換されたγ−フェニル−Δ−ラクトンおよびそのアナログならびにこれらに関する使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6458829B1 (enExample) |
| EP (1) | EP1112262B1 (enExample) |
| JP (1) | JP4979157B2 (enExample) |
| AT (1) | ATE272628T1 (enExample) |
| AU (1) | AU757052B2 (enExample) |
| CA (1) | CA2343732C (enExample) |
| DE (1) | DE69919179T2 (enExample) |
| ES (1) | ES2226422T3 (enExample) |
| WO (1) | WO2000014083A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770658B2 (en) * | 1998-09-09 | 2004-08-03 | Inflazyme Pharmaceuticals Ltd. | Substituted γ-phenyl-Δ-lactams and uses related thereto |
| US9931318B2 (en) * | 2003-04-08 | 2018-04-03 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
| US7868015B2 (en) | 2000-08-10 | 2011-01-11 | Cold Spring Harbor Laboratory | Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit |
| US20040224316A1 (en) | 2000-08-10 | 2004-11-11 | Tully Timothy P. | Augmented cognitive training |
| US8153646B2 (en) | 2000-08-10 | 2012-04-10 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
| KR100439425B1 (ko) * | 2001-03-22 | 2004-07-05 | (주)바이오케어 | 잔토리졸을 포함하는 조성물 및 그 용도 |
| KR20040007583A (ko) * | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 연골 질환의 재생치료용 조성물 |
| US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
| US7041280B2 (en) | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| US7642252B2 (en) * | 2002-07-22 | 2010-01-05 | Chemgenex Pharmaceuticals, Inc. | Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof |
| EP2177626B1 (en) | 2002-08-19 | 2013-12-18 | Dart NeuroScience (Cayman) Ltd | Screening methods for cognitive enhancers |
| ES2213485B1 (es) * | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| JP2007526460A (ja) * | 2004-03-03 | 2007-09-13 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法 |
| WO2006086693A2 (en) * | 2005-02-10 | 2006-08-17 | Chemgenex Pharmaceuticals, Inc. | Medical devices |
| US20080171746A1 (en) * | 2005-03-14 | 2008-07-17 | Thomas Klein | Method for Preventing Cardiovascular Diseases |
| EP2377533A3 (en) | 2006-05-19 | 2012-02-22 | Helicon Therapeutics, Inc. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
| AR065709A1 (es) * | 2007-03-12 | 2009-06-24 | Biolipox Ab | Piperidinonas y composiciones farmaceuticas que las contienen usadas para el tratamiento de la inflamacion. procesos de obtencion. |
| GB0722769D0 (en) * | 2007-11-21 | 2008-01-02 | Biolipox Ab | New compounds |
| AU2008240044B2 (en) * | 2007-04-13 | 2013-09-12 | Teva Pharamceuticals International Gmbh | Oral cephalotaxine dosage forms |
| CN103351390A (zh) * | 2007-11-21 | 2013-10-16 | 解码遗传Ehf公司 | 用于治疗肺部和心血管病症的联芳基pde4 抑制剂 |
| EP2222638A2 (en) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating inflammation |
| WO2011114103A1 (en) | 2010-03-18 | 2011-09-22 | Biolipox Ab | Pyrimidinones for use as medicaments |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| US20150050626A1 (en) * | 2013-03-15 | 2015-02-19 | Dart Neuroscience, Llc | Systems, Methods, and Software for Improving Cognitive and Motor Abilities |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644426A (en) * | 1969-08-15 | 1972-02-22 | Universal Oil Prod Co | Preparation of delta valero-lactones |
| US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
| US3814771A (en) * | 1970-11-19 | 1974-06-04 | T Shen | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones |
| JPS51131870A (en) * | 1975-01-20 | 1976-11-16 | Yoshitomi Pharmaceut Ind Ltd | A process for preparing novel amide compounds |
| JPS52156859A (en) * | 1976-06-18 | 1977-12-27 | Yoshitomi Pharmaceut Ind Ltd | Heterocyclic amide derivatives |
| JPH06279428A (ja) * | 1992-02-07 | 1994-10-04 | Kioritz Corp | 新規化合物及び該化合物を含有するマツノザイセンチュウ殺線虫剤 |
| WO1998032721A1 (en) * | 1997-01-22 | 1998-07-30 | Chisso Corporation | Liquid-crystal compounds, liquid-crystal composition containing the same, and liquid-crystal display element containing the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3607885A (en) * | 1968-08-15 | 1971-09-21 | Universal Oil Prod Co | Preparation of lactones such as substituted delta valerolactones |
| US4616089A (en) * | 1983-08-03 | 1986-10-07 | University Of California | Synthetic anti-inflammatory derivatives of manoalide |
| DE19603477A1 (de) * | 1996-01-31 | 1997-08-07 | Klaus Dr Med Reuter | Tumormittel |
-
1999
- 1999-09-09 WO PCT/CA1999/000819 patent/WO2000014083A1/en not_active Ceased
- 1999-09-09 CA CA002343732A patent/CA2343732C/en not_active Expired - Fee Related
- 1999-09-09 DE DE69919179T patent/DE69919179T2/de not_active Expired - Lifetime
- 1999-09-09 AT AT99941351T patent/ATE272628T1/de active
- 1999-09-09 ES ES99941351T patent/ES2226422T3/es not_active Expired - Lifetime
- 1999-09-09 US US09/786,949 patent/US6458829B1/en not_active Expired - Lifetime
- 1999-09-09 AU AU55009/99A patent/AU757052B2/en not_active Ceased
- 1999-09-09 JP JP2000568841A patent/JP4979157B2/ja not_active Expired - Fee Related
- 1999-09-09 EP EP99941351A patent/EP1112262B1/en not_active Expired - Lifetime
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3644426A (en) * | 1969-08-15 | 1972-02-22 | Universal Oil Prod Co | Preparation of delta valero-lactones |
| US3718743A (en) * | 1970-11-19 | 1973-02-27 | Merck & Co Inc | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation |
| US3814771A (en) * | 1970-11-19 | 1974-06-04 | T Shen | 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones |
| JPS51131870A (en) * | 1975-01-20 | 1976-11-16 | Yoshitomi Pharmaceut Ind Ltd | A process for preparing novel amide compounds |
| JPS52156859A (en) * | 1976-06-18 | 1977-12-27 | Yoshitomi Pharmaceut Ind Ltd | Heterocyclic amide derivatives |
| JPH06279428A (ja) * | 1992-02-07 | 1994-10-04 | Kioritz Corp | 新規化合物及び該化合物を含有するマツノザイセンチュウ殺線虫剤 |
| WO1998032721A1 (en) * | 1997-01-22 | 1998-07-30 | Chisso Corporation | Liquid-crystal compounds, liquid-crystal composition containing the same, and liquid-crystal display element containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2343732C (en) | 2009-06-16 |
| WO2000014083A1 (en) | 2000-03-16 |
| AU757052B2 (en) | 2003-01-30 |
| US6458829B1 (en) | 2002-10-01 |
| AU5500999A (en) | 2000-03-27 |
| EP1112262A1 (en) | 2001-07-04 |
| CA2343732A1 (en) | 2000-03-16 |
| DE69919179T2 (de) | 2005-07-28 |
| ATE272628T1 (de) | 2004-08-15 |
| ES2226422T3 (es) | 2005-03-16 |
| JP2002524456A (ja) | 2002-08-06 |
| DE69919179D1 (de) | 2004-09-09 |
| EP1112262B1 (en) | 2004-08-04 |
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