JP4966958B2 - カリウムチャネル調節剤及び医療における使用 - Google Patents
カリウムチャネル調節剤及び医療における使用 Download PDFInfo
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- JP4966958B2 JP4966958B2 JP2008501279A JP2008501279A JP4966958B2 JP 4966958 B2 JP4966958 B2 JP 4966958B2 JP 2008501279 A JP2008501279 A JP 2008501279A JP 2008501279 A JP2008501279 A JP 2008501279A JP 4966958 B2 JP4966958 B2 JP 4966958B2
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- Prior art keywords
- pyrazol
- quinazolin
- amine
- dimethyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 29
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66114905P | 2005-03-14 | 2005-03-14 | |
| US60/661,149 | 2005-03-14 | ||
| DKPA200500366 | 2005-03-14 | ||
| DKPA200500366 | 2005-03-14 | ||
| PCT/EP2006/060643 WO2006097441A1 (en) | 2005-03-14 | 2006-03-13 | Potassium channel modulating agents and their medical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008533087A JP2008533087A (ja) | 2008-08-21 |
| JP2008533087A5 JP2008533087A5 (OSRAM) | 2009-04-16 |
| JP4966958B2 true JP4966958B2 (ja) | 2012-07-04 |
Family
ID=36600224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501279A Expired - Fee Related JP4966958B2 (ja) | 2005-03-14 | 2006-03-13 | カリウムチャネル調節剤及び医療における使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8252806B2 (OSRAM) |
| EP (1) | EP1861388B1 (OSRAM) |
| JP (1) | JP4966958B2 (OSRAM) |
| AU (1) | AU2006224605B2 (OSRAM) |
| CA (1) | CA2601527A1 (OSRAM) |
| MX (1) | MX2007010991A (OSRAM) |
| NZ (1) | NZ556248A (OSRAM) |
| WO (1) | WO2006097441A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132439B2 (en) | 2002-05-13 | 2006-11-07 | Icagen, Inc. | Bis-benzimidazoles and related compounds as potassium channel modulators |
| AU2007217099A1 (en) | 2006-02-17 | 2007-08-30 | Janssen Pharmaceutica N.V. | Pyrazolylquinazolinones as potassium channel openers |
| JP2010502674A (ja) * | 2006-09-07 | 2010-01-28 | ノイロサーチ アクティーゼルスカブ | カリウムチャンネル調節剤として有用なピリジニル−ピリミジン誘導体 |
| AU2007304195A1 (en) | 2006-10-03 | 2008-04-10 | Neurosearch A/S | Indazolyl derivatives useful as potassium channel modulating agents |
| EP2114916A2 (en) * | 2007-02-02 | 2009-11-11 | NeuroSearch A/S | Pyridinyl-pyrazole derivatives and their use as potassium channel modulators |
| EP2142547A1 (en) * | 2007-03-28 | 2010-01-13 | NeuroSearch A/S | Purinyl derivatives and their use as potassium channel modulators |
| EP2203436A1 (en) | 2007-09-17 | 2010-07-07 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| CN102177154A (zh) * | 2008-09-02 | 2011-09-07 | 神经研究公司 | 吡唑基-嘧啶衍生物及其作为钾通道调节剂的应用 |
| KR101123292B1 (ko) * | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
| US20110237607A1 (en) * | 2008-09-26 | 2011-09-29 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034707A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| EP3575288B1 (en) | 2009-09-03 | 2021-10-27 | Bristol-Myers Squibb Company | Quinazolines as potassium ion channel inhibitors |
| JP6223443B2 (ja) | 2012-06-26 | 2017-11-01 | サニオナ・エイピイエス | フェニルトリアゾール誘導体及びｇａｂａａ受容体複合体を調節するための該フェニルトリアゾール誘導体の使用 |
| US9242966B2 (en) | 2013-03-11 | 2016-01-26 | Bristol-Myers Squibb Company | Phthalazines as potassium ion channel inhibitors |
| JP2016516691A (ja) * | 2013-03-11 | 2016-06-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | カリウムイオンチャネル阻害剤としてのイソキノリン |
| CA2969839A1 (en) * | 2014-12-05 | 2016-06-09 | Subramaniam Ananthan | Heterocyclic compounds as biogenic amine transport modulators |
| WO2016090299A1 (en) | 2014-12-05 | 2016-06-09 | Subramaniam Ananthan | Novel quinazolines as biogenic amine transport modulators |
| BR112018006873A2 (pt) * | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
| US10774064B2 (en) | 2016-06-02 | 2020-09-15 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| HRP20220079T1 (hr) | 2017-01-23 | 2022-04-15 | Cadent Therapeutics, Inc. | Modulatori kalijevih kanala |
| JP7457505B2 (ja) | 2017-05-10 | 2024-03-28 | ユニバーシティー オブ ロチェスター | 神経精神障害を処置する方法 |
| FR3066761B1 (fr) * | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| CA3116339A1 (en) | 2018-10-22 | 2020-04-30 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
| WO2024191106A1 (ko) * | 2023-03-13 | 2024-09-19 | 주식회사 미토이뮨테라퓨틱스 | 뇌전증 예방 또는 치료용 약학적 조성물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3340260A (en) * | 1962-12-03 | 1967-09-05 | Ciba Geigy Corp | 4-amino-pyrimidines |
| IL88507A (en) | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| JP2657760B2 (ja) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| US5539895A (en) * | 1994-05-12 | 1996-07-23 | International Business Machines Corporation | Hierarchical computer cache system |
| US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| AU2002250394A1 (en) | 2001-03-23 | 2002-10-08 | Bayer Corporation | Rho-kinase inhibitors |
| WO2004065392A1 (en) * | 2003-01-24 | 2004-08-05 | Smithkline Beecham Corporation | Condensed pyridines and pyrimidines and their use as alk-5 receptor ligands |
| CL2004000409A1 (es) | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| EP1742634B1 (en) * | 2004-04-13 | 2010-10-27 | ICAgen, Inc. | Polycyclic pyrimidines as potassium ion channel modulators |
| JP2008526734A (ja) | 2004-12-31 | 2008-07-24 | エスケー ケミカルズ カンパニー リミテッド | 糖尿及び肥満治療予防に有効なキナゾリン誘導体 |
| US20090036475A1 (en) | 2005-03-22 | 2009-02-05 | Neurosearch A/S | Pyrazolyl-Pyrimidines as Potassium Channel Modulating Agents and Their Medical Use |
-
2006
- 2006-03-13 US US11/886,341 patent/US8252806B2/en active Active
- 2006-03-13 CA CA002601527A patent/CA2601527A1/en not_active Abandoned
- 2006-03-13 MX MX2007010991A patent/MX2007010991A/es active IP Right Grant
- 2006-03-13 WO PCT/EP2006/060643 patent/WO2006097441A1/en not_active Ceased
- 2006-03-13 EP EP06725016.7A patent/EP1861388B1/en active Active
- 2006-03-13 AU AU2006224605A patent/AU2006224605B2/en not_active Ceased
- 2006-03-13 NZ NZ556248A patent/NZ556248A/en not_active IP Right Cessation
- 2006-03-13 JP JP2008501279A patent/JP4966958B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007010991A (es) | 2007-11-07 |
| US20080275045A1 (en) | 2008-11-06 |
| US8252806B2 (en) | 2012-08-28 |
| WO2006097441A1 (en) | 2006-09-21 |
| CA2601527A1 (en) | 2006-09-21 |
| AU2006224605B2 (en) | 2012-03-01 |
| EP1861388A1 (en) | 2007-12-05 |
| EP1861388B1 (en) | 2017-07-05 |
| JP2008533087A (ja) | 2008-08-21 |
| AU2006224605A1 (en) | 2006-09-21 |
| NZ556248A (en) | 2010-06-25 |
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