JP4954415B2 - 試料のビーズをベースとした同時プロセシングのための基材としての個々のアレイのアレイおよびその製造法 - Google Patents

試料のビーズをベースとした同時プロセシングのための基材としての個々のアレイのアレイおよびその製造法 Download PDF

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JP4954415B2
JP4954415B2 JP2001558715A JP2001558715A JP4954415B2 JP 4954415 B2 JP4954415 B2 JP 4954415B2 JP 2001558715 A JP2001558715 A JP 2001558715A JP 2001558715 A JP2001558715 A JP 2001558715A JP 4954415 B2 JP4954415 B2 JP 4954415B2
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array
beads
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bead
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JP2003522969A5 (enExample
JP2003522969A (ja
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トッド・ディッキンソン
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イルミナ インコーポレイテッド
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    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2001558715A 2000-02-10 2001-02-12 試料のビーズをベースとした同時プロセシングのための基材としての個々のアレイのアレイおよびその製造法 Expired - Lifetime JP4954415B2 (ja)

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US18163100P 2000-02-10 2000-02-10
US60/181,631 2000-02-10
PCT/US2001/004504 WO2001059432A2 (en) 2000-02-10 2001-02-12 Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor

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JP2003522969A JP2003522969A (ja) 2003-07-29
JP2003522969A5 JP2003522969A5 (enExample) 2007-10-04
JP4954415B2 true JP4954415B2 (ja) 2012-06-13

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US (3) US20020039728A1 (enExample)
EP (1) EP1257805B1 (enExample)
JP (1) JP4954415B2 (enExample)
AU (2) AU2001239760B2 (enExample)
CA (1) CA2399908A1 (enExample)
WO (1) WO2001059432A2 (enExample)

Families Citing this family (112)

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Publication number Priority date Publication date Assignee Title
WO1997040385A1 (en) 1996-04-25 1997-10-30 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
AU754952B2 (en) 1998-06-24 2002-11-28 Illumina, Inc. Decoding of array sensors with microspheres
US7612020B2 (en) 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1307743B1 (en) * 2000-05-04 2008-12-24 The Center for Blood Research, INC. Colloid compositions for solid phase biomolecular analytical systems
JP4744778B2 (ja) 2000-06-21 2011-08-10 バイオアレイ ソルーションズ リミテッド 特定のランダム粒子アレイを適用した複数の被検体分子の分析方法
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CA2414618C (en) * 2000-06-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
GB2390155B (en) * 2001-01-03 2004-04-21 Packard Instrument Co Inc Luminescence imager
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6787786B2 (en) * 2001-06-12 2004-09-07 North American Scientific, Inc. Thin radiation source and method of making the same
US7262063B2 (en) * 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
CA2457564C (en) 2001-10-05 2009-04-07 Surmodics, Inc. Particle immobilized coatings and uses thereof
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
ES2712173T3 (es) 2001-10-15 2019-05-09 Bioarray Solutions Ltd Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US20030162178A1 (en) * 2002-02-25 2003-08-28 O'hagan David Variable microarray and methods of detecting one or more anlaytes in a sample
US20030232379A1 (en) * 2002-06-14 2003-12-18 Amorese Douglas A. Methods of performing array based assays and compositions for practicing the same
CN1662807A (zh) * 2002-06-20 2005-08-31 日本瑞翁株式会社 含脂环结构的聚合物树脂制的容器及用该容器的光学分析方法
JP2004028694A (ja) * 2002-06-24 2004-01-29 Canon Inc 核酸プローブ・アレイ基板の温度制御装置、及び、これを用いた遺伝子検出方法
US7923260B2 (en) * 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US6913931B2 (en) 2002-10-03 2005-07-05 3M Innovative Properties Company Devices, methods and systems for low volume microarray processing
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US7364896B2 (en) 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
US20040086869A1 (en) * 2002-10-31 2004-05-06 Schembri Carol T. Device having multiple molecular arrays
ATE540427T1 (de) * 2002-11-13 2012-01-15 Molecular Imprints Inc Ein verfahren um formen von substraten zu modulieren
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
EP1594980B2 (en) 2003-01-29 2017-08-16 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
JP2007525963A (ja) 2003-06-20 2007-09-13 イルミナ インコーポレイテッド 全ゲノム増幅および遺伝型決定のための方法および組成物
US7280727B1 (en) * 2003-09-05 2007-10-09 Schott Corporation Micro-well and methods of fabricating and selectively blackening the same
US20090052850A1 (en) * 2003-09-05 2009-02-26 Loic Barbedette Micro-well plates and methods of fabricating and selectively blackening the same
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
NZ546072A (en) 2003-09-22 2009-08-28 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
JP2007521017A (ja) 2003-10-28 2007-08-02 バイオアレイ ソリューションズ リミテッド 固定化捕捉プローブを用いる遺伝子発現分析法の最適化
JP2007509629A (ja) 2003-10-29 2007-04-19 バイオアレイ ソリューションズ リミテッド 二本鎖ｄｎａの切断による複合核酸分析
US20050136412A1 (en) * 2003-12-22 2005-06-23 Affymetrix, Inc. Light-based detection and manipulation of single molecules
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US20060078983A1 (en) * 2004-08-27 2006-04-13 Applera Corporation Polymer monolith substrate
EP1869615B1 (en) 2004-11-16 2010-03-03 Illumina, Inc. Methods and apparatus for reading coded microbeads
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
CA2640385C (en) 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
EP2038074B1 (en) * 2006-06-29 2014-06-11 Xiaolian Gao Make and use of surface molecules of varied densities
US20080264842A1 (en) * 2006-10-11 2008-10-30 Arcxis Biotechnologies, Llc Disposable micropurification cards, methods, and systems thereof
KR100891095B1 (ko) * 2007-02-13 2009-03-31 삼성전자주식회사 마이크로 어레이 및 그 제조 방법
US8360321B2 (en) * 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
EP2205958B1 (en) * 2007-10-29 2019-04-24 Koninklijke Philips N.V. Frustrated total internal reflection system
US8741815B2 (en) 2008-02-19 2014-06-03 Intelligent Bio Systems, Inc. Methods and devices for amplification of nucleic acid
WO2009105213A1 (en) * 2008-02-19 2009-08-27 Intelligent Bio-Systems, Inc. Non-emulsion methods and masked biomolecules
US20090298131A1 (en) 2008-02-19 2009-12-03 Intelligent Biosystems, Inc. Non-Emulsion Methods And Masked Biomolecules
GB2469424B (en) * 2008-02-19 2013-04-17 Intelligent Bio Systems Inc Non-emulsion methods and masked biomolecules
WO2010019826A1 (en) 2008-08-14 2010-02-18 Nanostring Technologies, Inc Stable nanoreporters
JP5271672B2 (ja) * 2008-11-06 2013-08-21 日立マクセル株式会社 プレート状容器、その成形に用いる鋳型およびそれを用いた処理法
EP2380020A2 (en) * 2008-12-18 2011-10-26 The Texas A&M University System A ph modulation method to detect ligand-receptor binding
ES2892342T3 (es) * 2009-01-08 2022-02-03 It Is International Ltd Sistema óptico para detectar la luz de reacciones en cadena de la polimerasa
EP3236264A3 (en) 2009-10-13 2017-11-08 Nanostring Technologies, Inc Protein detection via nanoreporters
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
EP2516681B1 (en) 2010-02-11 2017-10-18 Nanostring Technologies, Inc Compositions and methods for the detection of preferably small rnas by bridge hybridisation and ligation
JP5856962B2 (ja) * 2010-09-10 2016-02-10 オリンパス株式会社 単一発光粒子の光強度を用いた光分析方法
EP2602612A4 (en) 2010-09-10 2018-05-16 Olympus Corporation Optical analysis method using optical measurement in multiple wavelength bands
EP2631631B1 (en) 2010-11-25 2016-01-20 Olympus Corporation Photometric analysis device and photometric analysis method using wavelength characteristic of light emitted from single illuminant particle
US9285322B2 (en) * 2010-12-01 2016-03-15 The Texas A&M University System pH modulation methods and systems for detecting binding events
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
US10018627B2 (en) 2011-03-08 2018-07-10 Japan Science And Technology Agency Method for sealing substances, method for detecting target molecule, array, kit, and target molecule detection device
US9329174B2 (en) 2011-03-08 2016-05-03 Japan Science And Technology Agency Bead trapping method and method for detecting target molecule
WO2012135340A2 (en) 2011-03-28 2012-10-04 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20150191772A1 (en) 2012-06-29 2015-07-09 Danmarks Tekniske Universitet Method of charging a test carrier and a test carrier
EP2917331A4 (en) 2012-11-09 2016-10-12 Biosystems Inc Aushon METHODS AND SYSTEMS FOR SENSITIVITY OF ENHANCED DETECTION OF ASSAYS
JP6091306B2 (ja) * 2013-04-17 2017-03-08 タツタ電線株式会社 表面プラズモン共鳴センサチップ固定ホルダ
AU2014284584B2 (en) 2013-07-01 2019-08-01 Illumina, Inc. Catalyst-free surface functionalization and polymer grafting
JP2015014507A (ja) * 2013-07-04 2015-01-22 株式会社ニコン 分注装置、バイオチップのスクリーニング装置、分注方法、及びバイオチップのスクリーニング方法
EP3168624B1 (en) 2014-07-08 2020-08-26 Japan Science and Technology Agency Substance sealing method and target molecule detecting method
EP3183577B1 (en) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible surface functionalization
KR102462849B1 (ko) 2014-10-31 2022-11-02 일루미나 케임브리지 리미티드 신규한 폴리머 및 dna 코폴리머 코팅
ES2730898T3 (es) * 2015-04-10 2019-11-13 Mycartis Nv Sistema de análisis con medios separadores
WO2017007753A1 (en) 2015-07-07 2017-01-12 Illumina, Inc. Selective surface patterning via nanoimrinting
EP4368728A3 (en) 2015-07-17 2024-08-07 Bruker Spatial Biology, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
WO2017015097A1 (en) 2015-07-17 2017-01-26 Nanostring Technologies, Inc. Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
WO2018058083A1 (en) * 2016-09-26 2018-03-29 Azure Biosystems, Inc. Methods and devices for photometric analysis
JP6730525B2 (ja) 2016-11-21 2020-07-29 ナノストリング テクノロジーズ，インコーポレイティド 化学組成物とそれを利用する方法
US10241022B2 (en) * 2017-03-30 2019-03-26 Intel Corporation Characterizing a fluid sample based on response of a non-planar structure
CN111108219B (zh) 2017-08-01 2024-12-27 伊鲁米纳公司 使用的水凝胶珠和流动池的遗传物质的空间索引和文库制备
JP7372927B6 (ja) 2018-02-12 2023-11-27 ナノストリング テクノロジーズ，インコーポレイティド 遺伝子およびタンパク質の発現を検出する生体分子プローブおよびその検出方法
DE102018204633A1 (de) 2018-03-27 2019-10-02 Robert Bosch Gmbh Mikrofluidische Vorrichtung und Verfahren zum Prozessieren einer Flüssigkeit
JP7525402B2 (ja) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ，インコーポレイティド 化学的組成物とそれを利用する方法
DE102018130299B4 (de) * 2018-11-29 2020-08-06 Presens Precision Sensing Gmbh Sensoranordnung und Messverfahren
AU2021306281A1 (en) 2020-07-08 2023-01-05 Illumina, Inc. Beads as transposome carriers
EP4587588A1 (en) 2022-09-16 2025-07-23 Illumina, Inc. Nanoparticle with polynucleotide binding site and method of making thereof
CN116106539B (zh) * 2023-04-12 2023-07-04 北京芯迈微生物技术有限公司 一种免疫微流控的多重抗原包被试剂盒及其方法、应用
WO2025024790A1 (en) * 2023-07-26 2025-01-30 The Trustees Of The University Of Pennsylvania Digital assay for single extracellular vesicle, single molecule detection
DE102023122562B4 (de) * 2023-08-23 2025-04-24 Clemens Gmbh Verfahren zur Aufnahme von Fluoreszenzsignalen für ein Laborgerät und Laborgerät

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032000A1 (en) * 1997-01-17 1998-07-23 Smithkline Beecham Corporation Apparatus and process for arraying beads
WO1998040726A1 (en) * 1997-03-14 1998-09-17 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
WO2000039587A1 (en) * 1998-12-28 2000-07-06 Illumina, Inc. Composite arrays utilizing microspheres
WO2000071992A1 (en) * 1999-05-20 2000-11-30 Illumina, Inc. Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200110A (en) * 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4682895A (en) * 1985-08-06 1987-07-28 Texas A&M University Fiber optic probe for quantification of colorimetric reactions
US4798738A (en) * 1986-10-10 1989-01-17 Cardiovascular Devices, Inc. Micro sensor
US4824789B1 (en) * 1986-10-10 1996-08-13 Minnesota Mining & Mfg Gas sensor
US5114864A (en) * 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
US5252494A (en) * 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5143853A (en) * 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US4822746A (en) * 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US5132242A (en) * 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US4785814A (en) * 1987-08-11 1988-11-22 Cordis Corporation Optical probe for measuring pH and oxygen in blood and employing a composite membrane
US4812216A (en) * 1987-08-28 1989-03-14 Bios Corporation Method of handling and transporting a transfer membrane used in a blotting apparatus
US5002867A (en) * 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5575849A (en) * 1988-11-25 1996-11-19 Canon Kabushiki Kaisha Apparatus for producing a substrate having a surface with a plurality of spherical dimples for photoconductive members
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5302509A (en) * 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
EP0557456A4 (en) * 1990-11-14 1995-11-15 Siska Diagnostics Inc Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US5105305A (en) * 1991-01-10 1992-04-14 At&T Bell Laboratories Near-field scanning optical microscope using a fluorescent probe
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5320814A (en) * 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244813A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5380489A (en) * 1992-02-18 1995-01-10 Eastman Kodak Company Element and method for nucleic acid amplification and detection using adhered probes
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
ATE161964T1 (de) * 1991-10-15 1998-01-15 Multilyte Ltd Bindungstest unter benutzung eines markierten reagens
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5888723A (en) * 1992-02-18 1999-03-30 Johnson & Johnson Clinical Diagnostics, Inc. Method for nucleic acid amplification and detection using adhered probes
EP0675966B1 (en) * 1992-02-19 2004-10-06 The Public Health Research Institute Of The City Of New York, Inc. Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
EP0565999A2 (de) * 1992-04-16 1993-10-20 Siemens Aktiengesellschaft Anordnung zur optischen Kopplung von zwei Gruppen von Wellenleitern
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5298741A (en) * 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
JP3302458B2 (ja) * 1993-08-31 2002-07-15 富士通株式会社 集積化光装置及び製造方法
US5494798A (en) * 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
US5496997A (en) * 1994-01-03 1996-03-05 Pope; Edward J. A. Sensor incorporating an optical fiber and a solid porous inorganic microsphere
ATE247716T1 (de) * 1994-02-07 2003-09-15 Beckman Coulter Inc Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5512490A (en) * 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
ATE215993T1 (de) * 1995-05-19 2002-04-15 Abbott Lab Nachweis von nukleinsäuren mit breitem dynamikbereich unter verwendung von aggregat- primer-reihen
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5656241A (en) * 1995-09-07 1997-08-12 Optical Sensors Incorporated Method for manufacturing fiber optic sensors
US5633972A (en) * 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6147205A (en) * 1995-12-15 2000-11-14 Affymetrix, Inc. Photocleavable protecting groups and methods for their use
US5840256A (en) * 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US7041510B2 (en) * 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP0912761A4 (en) * 1996-05-29 2004-06-09 Cornell Res Foundation Inc DETERMINATION OF DIFFERENCES IN THE NUCLEIC ACID SEQUENCE BY MEANS OF A COMBINATION OF LIGASE DETERMINATION AND POLYMERASE CHAIN REACTION
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6703247B1 (en) * 1996-12-23 2004-03-09 American Registry Of Pathology Apparatus and methods for efficient processing of biological samples on slides
EP1249705A3 (en) * 1996-12-31 2003-11-05 Genometrix Genomics Incorporated Multiplexed molecular analysis apparatus and its fabrication method
US6327410B1 (en) * 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
WO1998050583A1 (en) * 1997-05-02 1998-11-12 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
JP2001511361A (ja) * 1997-07-22 2001-08-14 ラピジーン，インコーポレイテッド 核酸アレイ上で行われる増幅および他の酵素反応
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6085004A (en) * 1998-02-03 2000-07-04 3M Innovative Properties Company Optical fiber connector using photocurable adhesive
AU754952B2 (en) * 1998-06-24 2002-11-28 Illumina, Inc. Decoding of array sensors with microspheres
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
US6306643B1 (en) * 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6129896A (en) * 1998-12-17 2000-10-10 Drawn Optical Components, Inc. Biosensor chip and manufacturing method
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6555361B1 (en) * 1999-03-24 2003-04-29 Corning Incorporated Hybridization chamber for high density nucleic acid arrays
US6261523B1 (en) * 1999-04-27 2001-07-17 Agilent Technologies Inc. Adjustable volume sealed chemical-solution-confinement vessel
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US20010053849A1 (en) * 1999-06-16 2001-12-20 Mary Jeanne Kreek Plural biological sample arrays, and preparation and uses thereof
WO2001006244A2 (en) * 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System General signaling protocols for chemical receptors in immobilized matrices
PT1218542E (pt) * 1999-09-13 2004-08-31 Nugen Technologies Inc Metodos e composicoes para amplificacao isotermica linear de sequencias polinucleotidicas
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
DE60136335D1 (de) * 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US6824738B1 (en) * 2000-04-14 2004-11-30 Discovery Partners International, Inc. System and method for treatment of samples on solid supports

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032000A1 (en) * 1997-01-17 1998-07-23 Smithkline Beecham Corporation Apparatus and process for arraying beads
WO1998040726A1 (en) * 1997-03-14 1998-09-17 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
JP2001524208A (ja) * 1997-03-14 2001-11-27 トラスティーズ・オブ・タフツ・カレッジ コード化微小球による光ファイバーセンサー
WO2000039587A1 (en) * 1998-12-28 2000-07-06 Illumina, Inc. Composite arrays utilizing microspheres
JP2004226415A (ja) * 1998-12-28 2004-08-12 Illumina Inc 微小球を利用する複合アレイ
WO2000071992A1 (en) * 1999-05-20 2000-11-30 Illumina, Inc. Method and apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems

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WO2001059432A2 (en) 2001-08-16
WO2001059432A9 (en) 2002-10-17
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