JP4954083B2 - Ｈｓｐ９０活性を調節するトリアゾール化合物 - Google Patents

Ｈｓｐ９０活性を調節するトリアゾール化合物 Download PDF

Info

Publication number
JP4954083B2
JP4954083B2 JP2007543263A JP2007543263A JP4954083B2 JP 4954083 B2 JP4954083 B2 JP 4954083B2 JP 2007543263 A JP2007543263 A JP 2007543263A JP 2007543263 A JP2007543263 A JP 2007543263A JP 4954083 B2 JP4954083 B2 JP 4954083B2
Authority
JP
Japan
Prior art keywords
optionally substituted
triazole
phenyl
mercapto
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2007543263A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008520702A5 (fr
JP2008520702A (ja
Inventor
イン，ウェイウェン
ジェームズ，デイビッド
チャン，シーチエ
プルツェウロカ，テレサ
チャエ，チュンヒュン
チマナマダ，ディネシュ，ユー．
イー，チ−ワン
コスティック，エレナ
ング，ハワード，ピー．
フォーリー，ケビン
ドゥ，チェンチアン
バースーム，ジェイムス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
Original Assignee
Synta Phamaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35966006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4954083(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of JP2008520702A publication Critical patent/JP2008520702A/ja
Publication of JP2008520702A5 publication Critical patent/JP2008520702A5/ja
Application granted granted Critical
Publication of JP4954083B2 publication Critical patent/JP4954083B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007543263A 2004-11-18 2005-11-17 Ｈｓｐ９０活性を調節するトリアゾール化合物 Active JP4954083B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US62897904P 2004-11-18 2004-11-18
US60/628,979 2004-11-18
US70935805P 2005-08-18 2005-08-18
US60/709,358 2005-08-18
US72504405P 2005-10-06 2005-10-06
US60/725,044 2005-10-06
PCT/US2005/041779 WO2006055760A1 (fr) 2004-11-18 2005-11-17 Composes triazole modulant l'activite de hsp90

Publications (3)

Publication Number Publication Date
JP2008520702A JP2008520702A (ja) 2008-06-19
JP2008520702A5 JP2008520702A5 (fr) 2009-01-08
JP4954083B2 true JP4954083B2 (ja) 2012-06-13

Family

ID=35966006

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007543263A Active JP4954083B2 (ja) 2004-11-18 2005-11-17 Ｈｓｐ９０活性を調節するトリアゾール化合物

Country Status (21)

Country Link
US (4) US7825148B2 (fr)
EP (3) EP2298748B1 (fr)
JP (1) JP4954083B2 (fr)
KR (2) KR20140006070A (fr)
CN (2) CN101072759B (fr)
AU (1) AU2005306484C1 (fr)
BR (1) BRPI0518315B8 (fr)
CA (1) CA2586612C (fr)
DK (1) DK1817295T3 (fr)
ES (2) ES2399241T3 (fr)
HK (1) HK1107700A1 (fr)
HR (1) HRP20130095T1 (fr)
IL (1) IL183108A (fr)
ME (1) ME01498B (fr)
MX (1) MX2007005940A (fr)
NZ (1) NZ555158A (fr)
PL (1) PL1817295T3 (fr)
PT (1) PT1817295E (fr)
RS (1) RS52642B (fr)
TW (1) TWI380983B (fr)
WO (1) WO2006055760A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009538320A (ja) * 2006-05-25 2009-11-05 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005063222A1 (ja) * 2003-12-26 2007-07-19 協和醗酵工業株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
EP2298748B1 (fr) 2004-11-18 2016-07-20 Synta Pharmaceuticals Corp. Composés triazole modulant l'activité de HSP90
DE102005007304A1 (de) * 2005-02-17 2006-08-24 Merck Patent Gmbh Triazolderivate
US8399464B2 (en) 2005-03-09 2013-03-19 Nippon Kayaku Kabushiki Kaisha HSP90 inhibitor
JP5044730B2 (ja) * 2005-03-09 2012-10-10 日本化薬株式会社 新規なｈｓｐ９０阻害剤
JP5154406B2 (ja) 2005-04-13 2013-02-27 アステックス、セラピューティックス、リミテッド 医薬化合物
AU2006279794B2 (en) 2005-08-12 2011-04-07 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
US8629285B2 (en) 2005-08-18 2014-01-14 Synta Pharmaceuticals Corp. Imidazole compounds that modulate HSP90 activity
AU2006338265B2 (en) * 2005-08-18 2011-04-14 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US20070250391A1 (en) * 2006-04-05 2007-10-25 Prade Hendrik D Merchandising system and method for food and non-food items for a meal kit
JP5181347B2 (ja) 2006-05-18 2013-04-10 日本化薬株式会社 ポドフィロトキシン類の高分子結合体
CA2653336C (fr) 2006-05-25 2014-10-28 Synta Pharmaceuticals Corp. Methode pour traiter un lymphome non hodgkinien
TW200800260A (en) 2006-05-25 2008-01-01 Synta Pharmaceuticals Corp Method for treating proliferative disorders associated with protooncogene products
CA2653332A1 (fr) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Composes de triazole qui modulent l'activite de la hsp90
AU2012200157B2 (en) * 2006-05-25 2014-08-21 Synta Pharmaceuticals Corp. Method for treating proliferative disorders associated with protooncogene products
JP5441691B2 (ja) * 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
TW200806637A (en) * 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
US20080027047A1 (en) * 2006-05-25 2008-01-31 Weiwen Ying Compounds that modulate HSP90 activity and methods for identifying same
WO2008021364A2 (fr) * 2006-08-17 2008-02-21 Synta Pharmaceuticals Corp. Composés de triazole modulant l'activité de la hsp90
JP5548364B2 (ja) 2006-10-03 2014-07-16 日本化薬株式会社 レゾルシノール誘導体の高分子結合体
WO2008044054A2 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Composés pharmaceutiques
WO2008044045A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
WO2008044041A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
GB0620259D0 (en) * 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US20110046125A1 (en) * 2006-10-19 2011-02-24 Synta Pharmaceuticals Corp. Method for treating infections
FR2907453B1 (fr) 2006-10-24 2008-12-26 Sanofi Aventis Sa Nouveaux derives du fluorene,compositions les contenant et utilisation
WO2008057246A2 (fr) * 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Procédé de traitement de troubles inflammatoires
WO2008056596A1 (fr) 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
WO2008056654A1 (fr) 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
DE102007002715A1 (de) * 2007-01-18 2008-07-24 Merck Patent Gmbh Triazolderivat
CN101679319B (zh) 2007-02-08 2014-07-09 辛塔医药品有限公司 用于治疗增生性病症如癌症的三唑类化合物
TW200904417A (en) * 2007-02-20 2009-02-01 Synta Pharmaceuticals Corp Triazole compounds that modulate Hsp90 activity
US8993608B2 (en) * 2007-03-12 2015-03-31 Synta Pharmaceuticals Corp. Method for inhibiting topoisomerase II
WO2008153730A2 (fr) * 2007-05-25 2008-12-18 Synta Pharmaceuticals Corp. Méthode de traitement des maladies prolifératives associées à des mutations dans c-met
CA2695995C (fr) * 2007-08-13 2015-09-29 Synta Pharmaceuticals Corp. Composes de triazole qui modulent l'activite de hsp90
EP2206502B1 (fr) 2007-09-28 2018-09-12 Nippon Kayaku Kabushiki Kaisha Conjugué polymère-stéroïde
WO2009049305A2 (fr) * 2007-10-12 2009-04-16 Arqule, Inc. Composés de tétrazole substitués et leurs utilisations
GB0722680D0 (en) * 2007-11-19 2007-12-27 Topotarget As Therapeutic compounds and their use
KR100947696B1 (ko) * 2007-11-23 2010-03-16 재단법인서울대학교산학협력재단 1,2,4-트리아졸 유도체를 함유하는 Ｈｓｐ９０ 억제제 및이를 이용한 항암제
JP5525456B2 (ja) 2008-02-04 2014-06-18 マーキュリー セラピューティクス，インコーポレイテッド Ａｍｐｋ調節因子
FR2928645A1 (fr) * 2008-03-14 2009-09-18 Sanofi Aventis Sa Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
CN101977631A (zh) 2008-03-18 2011-02-16 日本化药株式会社 生理活性物质的高分子量偶联物
EP2284209B1 (fr) 2008-05-08 2016-08-31 Nippon Kayaku Kabushiki Kaisha Conjugué de polymère avec l'acide folique ou un dérivé de l'acide folique
WO2009139916A1 (fr) * 2008-05-16 2009-11-19 Synta Pharmaceuticals Corp. Composés triazoles tricycliques modulant l'activité hsp90
WO2009148599A1 (fr) 2008-06-04 2009-12-10 Synta Pharmaceuticals Corp. Composés de pyrrole qui modulent l’activité de la hsp90
WO2009158026A1 (fr) 2008-06-27 2009-12-30 Synta Pharmaceuticals Corp. Composés d’hydrazonamide modulant l’activité des hsp90
EP2323737A2 (fr) 2008-08-08 2011-05-25 Synta Pharmaceuticals Corp. Composés de triazole qui modulent l'activité hsp90
WO2010017479A1 (fr) * 2008-08-08 2010-02-11 Synta Pharmaceuticals Corp. Composés de triazole qui modulent l’activité hsp90
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
AR077405A1 (es) * 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
KR20120093970A (ko) 2009-10-19 2012-08-23 신타 파마슈티칼스 코프. 에이취에스피90 억제 화합물을 이용한 조합 항암 요법
WO2011133521A2 (fr) 2010-04-19 2011-10-27 Synta Pharmaceuticals Corp. Traitement anticancéreux utilisant une combinaison de composés inhibiteurs de hsp90 et un inhibiteur de vegf
EP2560640A1 (fr) * 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Thérapie anticancéreuse à l'aide d'une combinaison d'un composé inhibiteur de hsp90 et d'un inhibiteur d'egfr
WO2011146803A1 (fr) 2010-05-20 2011-11-24 Synta Pharmaceuticals Corp. Méthode de traitement d'adénocarcinomes pulmonaires par composés inhibiteurs de hsp90
US20130172333A1 (en) 2010-05-20 2013-07-04 Synta Pharmaceuticals Corp. Formulation and dosing of hsp90 inhibitory compounds
WO2011149824A1 (fr) 2010-05-24 2011-12-01 Synta Pharmaceuticals Corp. Traitement anticancéreux utilisant une combinaison d'un composé inhibiteur de hsp90 et d'un inhibiteur de la topoisomérase ii
WO2012026433A1 (fr) * 2010-08-23 2012-03-01 第一三共株式会社 Dérivé pyrazolopyrimidine tricyclique sous forme cristalline libre
WO2012037072A1 (fr) 2010-09-13 2012-03-22 Synta Pharmaceuticals Corporation Inhibiteurs de hsp90 pour le traitement de cancers du poumon non à petites cellules chez des patients présentant un egfr et/ou kras de type sauvage
WO2012067138A1 (fr) 2010-11-17 2012-05-24 日本化薬株式会社 Nouveau dérivé polymère d'antagoniste de métabolisme de cytidine
EP2640384A1 (fr) 2010-11-18 2013-09-25 Synta Pharmaceuticals Corp. Présélection de patients pour un traitement thérapeutique fondé sur un état hypoxique, avec des agents sensibles à l'oxygène
US20120128665A1 (en) 2010-11-18 2012-05-24 Synta Pharmaceuticals Corp. Preselection of subjects for therapeutic treatment based on hypoxic status
EP2648708A2 (fr) 2010-12-08 2013-10-16 Synta Pharmaceuticals Corp. Traitement combinatoire du cancer du sein avec des composés inhibiteurs d'hsp90
SI2655345T1 (sl) 2010-12-20 2015-06-30 Sigma-Tau Research Switzerland S.A. Aril triazol spojine s protitumorsko aktivnostjo
WO2012096919A1 (fr) 2011-01-11 2012-07-19 Synta Pharmaceuticals Corp. Plurithérapie associant des composés inhibiteurs de hsp90 à des inhibiteurs du protéasome
WO2012116061A1 (fr) 2011-02-23 2012-08-30 Synta Pharmaceuticals Corp. Polythérapie associant des composés inhibiteurs de hsp90 à une radiothérapie
CA2827739A1 (fr) 2011-02-24 2012-10-18 Synta Pharmaceuticals Corp. Traitement du cancer de la prostate avec des composes inhibiteurs de hsp90
US20140045908A1 (en) 2011-02-25 2014-02-13 Synta Pharmaceuticals Corp. Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers
US20140228418A1 (en) * 2011-05-23 2014-08-14 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with mek inhibitors
US20140315943A1 (en) * 2011-05-24 2014-10-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with mtor/p13k inhibitors
EP2714033A1 (fr) * 2011-05-26 2014-04-09 Synta Pharmaceuticals Corp. Polythérapie de composés inhibiteurs de hsp90 avec inhibiteurs de chk
CA2840986A1 (fr) 2011-07-07 2013-01-10 Synta Pharmaceuticals Corp. Traitement du cancer au moyen de composes inhibiteurs de hsp90
CA2844809A1 (fr) * 2011-08-19 2013-02-28 Synta Pharmaceuticals Corp. Polytherapie anticancereuse d'inhibiteur de hsp90 comprenant un anti-metabolite
JP5711378B2 (ja) 2011-09-11 2015-04-30 日本化薬株式会社 ブロック共重合体の製造方法
EP2773345A1 (fr) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Thérapie anticancéreuse utilisant une combinaison d'inhibiteurs de hsp 90 et d'inhibiteurs de topoisomérase i
EP2776025A1 (fr) 2011-11-02 2014-09-17 Synta Pharmaceuticals Corp. Polythérapie d'inhibiteurs de hsp 90 avec des agents contenant du platine
JP2014533299A (ja) 2011-11-14 2014-12-11 シンタ ファーマシューティカルズ コーポレーション Ｂｒａｆ阻害剤とｈｓｐ９０阻害剤の組合せ療法
AU2013239663A1 (en) * 2012-03-28 2014-10-09 Synta Pharmaceuticals Corp. Triazole derivatives as HSP90 inhibitors
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
WO2013170159A1 (fr) 2012-05-10 2013-11-14 Synta Pharmaceuticals Corp. Traitement du cancer avec des composés inhibiteurs de hsp90
WO2013177241A1 (fr) 2012-05-22 2013-11-28 Trustees Of Dartmouth College Procédé permettant de synthétiser des cycloalcanyl[b]indoles, des cycloalcanyl[b]benzofuranes, des cycloalcanyl[b]benzothiophènes, composés et procédés d'utilisation
AU2013331070A1 (en) * 2012-10-19 2015-05-07 Synta Pharmaceuticals Corp. Treating polycystic kidney disease with HSP90 inhibitory compounds
WO2015038649A1 (fr) 2013-09-10 2015-03-19 Synta Pharmaceuticals Corp. Thérapeutique ciblée
WO2015066053A2 (fr) * 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Thérapies ciblées
WO2015134464A2 (fr) 2014-03-03 2015-09-11 Synta Pharmaceuticals Corp. Thérapies ciblées
KR101711732B1 (ko) * 2014-04-30 2017-03-02 경북대학교 산학협력단 3-아릴-1,2,4-트라이아졸 유도체 및 이의 용도
WO2015167211A1 (fr) * 2014-04-30 2015-11-05 경북대학교 산학협력단 Dérivé de 3-aryl-1,2,4-triazole et utilisation correspondante
LT3179991T (lt) 2014-08-11 2021-11-10 Acerta Pharma B.V. Terapiniai btk inhibitoriaus ir bcl-2 inhibitoriaus deriniai
WO2016024228A1 (fr) 2014-08-11 2016-02-18 Acerta Pharma B.V. Combinaisons thérapeutiques associant un inhibiteur de btk, un inhibiteur de pi3k, un inhibiteur de jak-2, un inhibiteur de pd-1 et/ou un inhibiteur de pd-l1
TW201618773A (zh) 2014-08-11 2016-06-01 艾森塔製藥公司 Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、及／或ｃｄｋ４／６抑制劑的治療組合物
AU2016208863B2 (en) * 2015-01-22 2020-01-16 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Resorcinol derivative as HSP90 inhibitor
EP3256161A1 (fr) 2015-02-09 2017-12-20 Synta Pharmaceuticals Corp. Polythérapie d'inhibiteurs de hsp90 et d'inhibiteurs de pd-1 pour traiter un cancer
SI3300500T1 (sl) 2015-05-20 2020-07-31 Amgen Inc. Triazolni agonisti receptorja APJ
CN106349233B (zh) * 2015-07-15 2021-06-01 上海翰森生物医药科技有限公司 3,4-二苯基-4h-1,2,4-三唑衍生物及其制备方法和应用
US10626096B2 (en) 2015-11-24 2020-04-21 Sanford Burnham Prebys Medical Discovery Institute Azole derivatives as apelin receptor agonist
US11154538B2 (en) 2016-02-29 2021-10-26 Synta Pharmaceuticals Corporation Combination therapy for treatment of ovarian cancer
US9988369B2 (en) 2016-05-03 2018-06-05 Amgen Inc. Heterocyclic triazole compounds as agonists of the APJ receptor
WO2018093580A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
EP3541804A1 (fr) 2016-11-16 2019-09-25 Amgen Inc. Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
EP3541805B1 (fr) 2016-11-16 2020-10-14 Amgen Inc. Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
EP3541810B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés phényle triazole en tant qu'agonistes du récepteur apj
WO2018093576A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
CN109666022B (zh) * 2017-10-17 2021-06-15 中国科学院上海药物研究所 三氮唑衍生物及其制备方法和用途
EP3704122B1 (fr) 2017-11-03 2021-09-01 Amgen Inc. Agonistes de triazole fusionnés du récepteur apj
WO2019213006A1 (fr) 2018-05-01 2019-11-07 Amgen Inc. Pyrimidinones substituées en tant qu'agonistes du récepteur apj
EP3653611A1 (fr) * 2018-11-15 2020-05-20 Centre National De La Recherche Scientifique Inhibiteurs de metallo-beta-lactamases
CN113874015B (zh) 2018-12-21 2024-05-24 细胞基因公司 Ripk2的噻吩并吡啶抑制剂
JP2022527821A (ja) * 2019-04-03 2022-06-06 ターベダ セラピューティクス インコーポレイテッド Ｈｓｐ９０結合コンジュゲート及びその製剤

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928919A (en) * 1960-08-16 1963-06-19 Bellon Labor Sa Roger Triazole derivatives and a process for their preparation
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4178253A (en) * 1977-04-05 1979-12-11 Ciba-Geigy Corporation Corrosion inhibited lubricant compositions
US4269846A (en) * 1979-10-29 1981-05-26 Usv Pharmaceutical Corporation Heterocyclic compounds useful as anti-allergy agents
JPS5770820A (en) 1980-10-20 1982-05-01 Haruo Ogura Immunoregulating agent
JPS5910574A (ja) 1982-07-07 1984-01-20 Fujisawa Pharmaceut Co Ltd トリアゾ−ル誘導体およびその製造法
FR2546887B1 (fr) 1983-05-30 1985-08-30 Paris 7 Universite Procede de preparation de dihydro-2,4 triazol-1,2,4 thiones-3 disubstituees en positions 4 et 5 et nouveaux composes pouvant etre prepares par ce procede
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4624995A (en) * 1985-04-09 1986-11-25 Minnesota Mining And Manufacturing Company Triazolinethione-containing polymer
US4740568A (en) * 1985-04-09 1988-04-26 Minnesota Mining And Manufacturing Company Triazolinethione-containing polymer
US5436252A (en) * 1986-12-19 1995-07-25 Merrell Dow Pharmaceuticals Inc. 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
DE3729070A1 (de) * 1987-09-01 1989-03-09 Bayer Ag Substituierte triazolinone
US5241074A (en) * 1988-05-09 1993-08-31 Bayer Aktiengesellschaft Sulphonylaminocarbonyltriazolinones
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5219722A (en) * 1990-09-21 1993-06-15 Konica Corporation Silver halide color photographic light-sensitive material
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
CA2129146A1 (fr) * 1992-03-13 1993-09-16 Victor Giulio Matassa Derives de l'imidazole, du triazole et du tetrazole
TW218017B (fr) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
DE4222771A1 (de) * 1992-07-10 1994-01-13 Bayer Ag Heterocyclyltriazolinone
DE4234801A1 (de) * 1992-10-15 1994-04-21 Bayer Ag Sulfonylaminocarbonyltriazolinone
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
DE4303376A1 (de) * 1993-02-05 1994-08-11 Bayer Ag Substituierte Triazolinone
DE4303676A1 (de) * 1993-02-09 1994-08-11 Bayer Ag 1-Aryltriazolin(thi)one
DE4411913A1 (de) * 1994-04-07 1995-10-12 Bayer Ag Substituierte Sulfonylaminocarbonyltriazolinone
US5538988A (en) * 1994-04-26 1996-07-23 Martinez; Gregory R. Benzocycloalkylazolethione derivatives
US5489598A (en) 1994-06-08 1996-02-06 Warner-Lambert Company Cytoprotection utilizing aryltriazol-3-thiones
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
JP3372365B2 (ja) * 1994-08-19 2003-02-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料およびそれを用いた画像形成方法
DE19502579A1 (de) * 1995-01-27 1996-08-01 Bayer Ag Sulfonylamino(thio)carbonyl-triazolin(thi)one
US6080772A (en) 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
DE19521162A1 (de) * 1995-06-09 1996-12-12 Bayer Ag N-Aryl-1,2,4-triazolin-5-one
DE19525162A1 (de) * 1995-07-11 1997-01-16 Bayer Ag Sulfonylamino(thio)carbonylverbindungen
US6114334A (en) 1995-07-13 2000-09-05 Knoll Aktiengesellschaft Piperazine derivatives as therapeutic agents
DE19540737A1 (de) * 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
DE19609059A1 (de) * 1996-03-08 1997-09-11 Bayer Ag Substituierte Arylsulfonylamino(thio)carbonyl-triazolin(thi)one
US6274171B1 (en) 1996-03-25 2001-08-14 American Home Products Corporation Extended release formulation of venlafaxine hydrochloride
ZA974703B (en) * 1996-05-30 1997-12-30 Bayer Ag Substituted sulfonylamino(thio)carbonyl compounds.
TW467902B (en) * 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
DE19632945A1 (de) * 1996-08-16 1998-02-19 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
EP0938487A2 (fr) * 1996-11-12 1999-09-01 Sepracor, Inc. DERIVES DE 2$i(R),4$i(S),$i(R),$i(S) ET 2$i(S),4$i(R),$i(R),$i(S)-HYDROXYITRACONAZOLE ET HYDROXYSAPERCONAZOLE
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
JP3788676B2 (ja) * 1997-11-11 2006-06-21 富士写真フイルム株式会社 有機エレクトロルミネツセンス素子材料およびそれを使用した有機エレクトロルミネツセンス素子
EP1062208A1 (fr) * 1998-03-09 2000-12-27 Basf Aktiengesellschaft Benzylphenylethers a substitution hetaryle, leur procede de preparation et leur utilisation pour lutter contre les champignons parasites et les parasites animaux
US6185567B1 (en) * 1998-05-29 2001-02-06 The Trustees Of The University Of Pennsylvania Authenticated access to internet based research and data services
IT1302034B1 (it) * 1998-08-31 2000-07-20 Enirisorse Spa Catalizzatori superacidi solidi per l'isomerizzazione di idrocarburi eprocedimento sol-gel per il loro ottenimento
JP2000100570A (ja) 1998-09-25 2000-04-07 Toray Ind Inc 発光素子
JP2000284412A (ja) 1999-03-30 2000-10-13 Fuji Photo Film Co Ltd 熱現像写真材料
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US20040110684A1 (en) * 1999-08-02 2004-06-10 Universite Catholique De Louvain Novel pharmaceutical compositions for modulating angiogenesis
EP1265913A4 (fr) * 2000-03-24 2004-07-14 Univ Duke Caracterisation d'interactions ligands-grp94 et methodes de purification, de criblage et de traitement associees
US20030216385A1 (en) * 2000-05-19 2003-11-20 Takahiko Tobe Triazole derivatives
RU2002133666A (ru) * 2000-05-19 2007-05-10 Мерк Патент ГмбХ (DE) Производные триазола
WO2002002123A1 (fr) * 2000-06-29 2002-01-10 Trustees Of Boston University Emploi de la geldanamycine et de composes associes pour la prophylaxie ou le traitement de troubles fibrogeniques
KR20030046397A (ko) * 2000-07-28 2003-06-12 슬로안-케테링인스티튜트퍼캔서리서치 세포증식성 질환 및 바이러스 감염의 치료 방법
EP2308515A1 (fr) 2000-11-02 2011-04-13 Sloan-Kettering Institute For Cancer Research Methode permettant d'amelioer l'efficacite d'agents cytotoxiques a l'aide d'inhibiteurs de HSP90
WO2002066447A1 (fr) 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. Derives de 4h-1,2,4-triazole-3(2h)-thione tenant lieu d'inhibiteurs de sphingomyelinase
AU2002252179A1 (en) 2001-03-01 2002-09-19 Conforma Therapeutics Corp. Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors
US20040235813A1 (en) * 2001-05-03 2004-11-25 Erich Wanker Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation
US7825094B2 (en) * 2001-05-23 2010-11-02 Sloan-Kettering Institute For Cancer Research Method of treatment for cancers associated with elevated HER 2 levels
JP4102124B2 (ja) 2001-08-01 2008-06-18 富士フイルム株式会社 ハロゲン化銀乳剤およびハロゲン化銀写真感光材料
EP1420747A4 (fr) 2001-08-06 2010-06-02 Kosan Biosciences Inc Ansamycine benzoquinone
HUP0402489A3 (en) 2001-11-28 2009-09-28 Sod Conseils Rech Applic 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as medicine
JP2005520795A (ja) 2001-12-12 2005-07-14 コンフォーマ・セラピューティクス・コーポレイション Ｈｓｐ９０阻害活性を有するプリン類似体
ATE374753T1 (de) 2001-12-21 2007-10-15 Vernalis Cambridge Ltd 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung
MXPA04007719A (es) 2002-02-07 2005-09-08 Univ Missouri Compuestos 4-(3hidroxifenil) o 4-(3-alcoxifenil)-1,2,4-triazol activos del receptor opioide.
GB0207362D0 (en) 2002-03-28 2002-05-08 Univ Liverpool Chemotherapy
WO2004082676A1 (fr) 2003-03-13 2004-09-30 Conforma Therapeutics Corporation Preparations medicamenteuses contenant des triglycerides a longue chaine et a chaine moyenne
GB0208516D0 (en) 2002-04-15 2002-05-22 Univ Liverpool Chemotherapy
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
CN1771235B (zh) 2003-02-11 2010-04-28 弗奈利斯(剑桥)有限公司 异噁唑化合物
EP1457499A1 (fr) 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibiteurs de protéine de choc thermique (HSP90) extracellulaire
WO2004082876A1 (fr) 2003-03-17 2004-09-30 Seco Tools Ab Plaquette de coupe
BR0301799A (pt) 2003-04-09 2005-03-22 Elzo Ferreira Uso do processo de extração do extrato, da seiva, da tintura, da massa e dos produtos deles derivados, originários da planta xaxim - dicksonia sellowiana - presl - hooker 1844 pertencente à famìlia das dicksoniaceae para emprego nas seguintes áreas e setores: quìmica humana, industrial, farmacológica, biologia humana e animal, medicinal, fitomedicinal, fitoterápica, alopata, alimentìcia, nutricêutico, vitamìnico, dermatológica, cosmética e veterinária
JP2006522750A (ja) 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
WO2004089415A2 (fr) 2003-04-11 2004-10-21 Novo Nordisk A/S Therapie combinatoire utilisant un inhibiteur de 11$g(b)-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides pour minimiser les effets secondaires associes a la therapie a base d'agoniste du recepteur de glucocorticoides
EP1615637A1 (fr) * 2003-04-11 2006-01-18 Novo Nordisk A/S Utilisation pharmaceutique de 1,2,4-triazoles substituees
SE0301232D0 (sv) 2003-04-25 2003-04-25 Astrazeneca Ab Novel use
GB0309637D0 (en) 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
US20050020557A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
US20050054625A1 (en) * 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors
US20050020556A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
US20050026893A1 (en) * 2003-05-30 2005-02-03 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants
US7691838B2 (en) * 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
US20050020534A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites
US20050054589A1 (en) * 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics
GB0315111D0 (en) * 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
DE602004012578T2 (de) 2003-08-15 2008-12-11 Vertex Pharmaceuticals Inc., Cambridge Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
JP2005084612A (ja) 2003-09-11 2005-03-31 Fuji Photo Film Co Ltd ハロゲン化銀乳剤、ハロゲン化銀感光材料、および熱現像感光材料
WO2005028452A1 (fr) * 2003-09-22 2005-03-31 Pfizer Limited Derives de triazoles substitues en tant qu'antagonistes de l'oxytocine
AU2004273615B2 (en) 2003-09-23 2009-01-15 Novartis Ag Combination of a VEGF receptor inhibitor with a chemotherapeutic agent
CA2539726A1 (fr) 2003-09-24 2005-05-06 Vertex Pharmaceuticals Incorporated Compositions d'imidazole utilisees comme inhibiteurs des proteines kinases
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
EP1677786A1 (fr) 2003-10-18 2006-07-12 Bayer HealthCare AG Derives de 2-(phenylmethyl)thio-4-phenyl-4h-1,2,4-triazole substitues en 5 et composes associes utilises en tant que gaba-agonistes dans le traitement de l'incontinence urinaire et des maladies associees
WO2005044194A2 (fr) 2003-10-28 2005-05-19 Pharmacia Corporation Traitement ou prevention de la neoplasie a l'aide d'un inhibiteur de la proteine hsp90
JP2007509968A (ja) 2003-10-28 2007-04-19 ファルマシア・コーポレーション 新形成を治療または予防するためのｈｓｐ９０阻害剤およびホスホジエステラーゼ阻害剤を含む組み合わせ
WO2005087750A1 (fr) * 2004-03-08 2005-09-22 Wyeth Modulateurs de canaux ioniques
JP2007530589A (ja) * 2004-03-26 2007-11-01 アンフォラ ディスカバリー コーポレーション 特定のトリアゾールを基礎とする化合物、組成物、およびそれらの使用
DE102004039280A1 (de) 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
DE102004049078A1 (de) 2004-10-08 2006-04-13 Merck Patent Gmbh Phenylpyrazole
EP2298748B1 (fr) * 2004-11-18 2016-07-20 Synta Pharmaceuticals Corp. Composés triazole modulant l'activité de HSP90
DE102005007304A1 (de) 2005-02-17 2006-08-24 Merck Patent Gmbh Triazolderivate
JP5044730B2 (ja) 2005-03-09 2012-10-10 日本化薬株式会社 新規なｈｓｐ９０阻害剤
JP2008137894A (ja) 2005-03-22 2008-06-19 Nippon Kayaku Co Ltd 新規なアセチレン誘導体
US7473784B2 (en) 2005-08-01 2009-01-06 Bristol-Myers Squibb Company Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
AU2006279794B2 (en) * 2005-08-12 2011-04-07 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
AU2006338265B2 (en) * 2005-08-18 2011-04-14 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US8629285B2 (en) * 2005-08-18 2014-01-14 Synta Pharmaceuticals Corp. Imidazole compounds that modulate HSP90 activity
CA2653336C (fr) * 2006-05-25 2014-10-28 Synta Pharmaceuticals Corp. Methode pour traiter un lymphome non hodgkinien
JP5441691B2 (ja) * 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
CA2653222A1 (fr) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Composes de triazole qui modulent l'activite de la hsp90
TW200800260A (en) * 2006-05-25 2008-01-01 Synta Pharmaceuticals Corp Method for treating proliferative disorders associated with protooncogene products
US20080027047A1 (en) * 2006-05-25 2008-01-31 Weiwen Ying Compounds that modulate HSP90 activity and methods for identifying same
CA2653332A1 (fr) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Composes de triazole qui modulent l'activite de la hsp90
WO2008021364A2 (fr) 2006-08-17 2008-02-21 Synta Pharmaceuticals Corp. Composés de triazole modulant l'activité de la hsp90
US20110046125A1 (en) 2006-10-19 2011-02-24 Synta Pharmaceuticals Corp. Method for treating infections
WO2008057246A2 (fr) 2006-10-26 2008-05-15 Synta Pharmaceuticals Corp. Procédé de traitement de troubles inflammatoires
CN101679319B (zh) 2007-02-08 2014-07-09 辛塔医药品有限公司 用于治疗增生性病症如癌症的三唑类化合物
TW200904417A (en) 2007-02-20 2009-02-01 Synta Pharmaceuticals Corp Triazole compounds that modulate Hsp90 activity
US8993608B2 (en) 2007-03-12 2015-03-31 Synta Pharmaceuticals Corp. Method for inhibiting topoisomerase II
ES2395114T3 (es) 2007-03-27 2013-02-08 Synta Pharmaceuticals Corporation Derivados de triazinona y de diazinona útiles como inhibidores de Hsp90
WO2008153730A2 (fr) 2007-05-25 2008-12-18 Synta Pharmaceuticals Corp. Méthode de traitement des maladies prolifératives associées à des mutations dans c-met
CA2695995C (fr) 2007-08-13 2015-09-29 Synta Pharmaceuticals Corp. Composes de triazole qui modulent l'activite de hsp90
US8548104B2 (en) * 2010-11-23 2013-10-01 Siano Mobile Silicon Ltd. Receiver with configurable clock frequencies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009538320A (ja) * 2006-05-25 2009-11-05 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物

Also Published As

Publication number Publication date
RS52642B (en) 2013-06-28
WO2006055760A9 (fr) 2006-09-21
CN103554042B (zh) 2016-08-10
WO2006055760A1 (fr) 2006-05-26
EP2295416B1 (fr) 2016-01-27
EP2295416A2 (fr) 2011-03-16
IL183108A0 (en) 2007-09-20
AU2005306484B2 (en) 2010-03-18
AU2005306484A1 (en) 2006-05-26
CN103554042A (zh) 2014-02-05
TWI380983B (zh) 2013-01-01
HK1107700A1 (en) 2008-04-11
AU2005306484C1 (en) 2015-07-23
EP2295416A3 (fr) 2011-05-04
KR101374553B1 (ko) 2014-03-17
IL183108A (en) 2016-05-31
US7825148B2 (en) 2010-11-02
EP1817295A1 (fr) 2007-08-15
JP2008520702A (ja) 2008-06-19
EP2298748A2 (fr) 2011-03-23
DK1817295T3 (da) 2013-02-18
US20120330009A1 (en) 2012-12-27
KR20070086353A (ko) 2007-08-27
NZ555158A (en) 2010-09-30
US20060167070A1 (en) 2006-07-27
US20110105749A1 (en) 2011-05-05
US9090569B2 (en) 2015-07-28
US20110009397A1 (en) 2011-01-13
EP1817295B1 (fr) 2012-11-07
ME01498B (me) 2014-04-20
KR20140006070A (ko) 2014-01-15
US8362055B2 (en) 2013-01-29
CN101072759B (zh) 2013-06-19
BRPI0518315B8 (pt) 2021-05-25
PL1817295T3 (pl) 2013-04-30
ES2399241T3 (es) 2013-03-26
BRPI0518315A2 (pt) 2008-11-11
CA2586612A1 (fr) 2006-05-26
TW200637831A (en) 2006-11-01
US8901308B2 (en) 2014-12-02
MX2007005940A (es) 2007-06-19
ES2594874T3 (es) 2016-12-23
BRPI0518315B1 (pt) 2020-11-17
CN101072759A (zh) 2007-11-14
EP2298748B1 (fr) 2016-07-20
EP2298748A3 (fr) 2011-04-27
PT1817295E (pt) 2013-02-18
HRP20130095T1 (hr) 2013-03-31
CA2586612C (fr) 2016-10-11

Similar Documents

Publication Publication Date Title
JP4954083B2 (ja) Ｈｓｐ９０活性を調節するトリアゾール化合物
US8921407B2 (en) Pyrazole compounds that modulate HSP90 activity
US8063083B2 (en) Method for treating non-Hodgkin's lymphoma
EP1951679B1 (fr) Dérivés d'imidazole modulant l'activité de hsp90
US20140221375A1 (en) Method for treating proliferative disorders associated with mutations in c-met
US20140363830A1 (en) Compounds that modulate hsp90 activity and methods for identifying same
US20080004266A1 (en) Method for treating proliferative disorders associated with protooncogene products
KR20090127402A (ko) 암과 같은 증식성 질환의 치료에 유용한 트라이아졸 화합물
AU2006338265A1 (en) Triazole compounds that modulate HSP90 activity

Legal Events

Date Code Title Description
A529 Written submission of copy of amendment under article 34 pct

Free format text: JAPANESE INTERMEDIATE CODE: A529

Effective date: 20070703

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110913

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20110914

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111208

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120106

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120116

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120210

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120302

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120313

R150 Certificate of patent or registration of utility model

Ref document number: 4954083

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150323

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R157 Certificate of patent or utility model (correction)

Free format text: JAPANESE INTERMEDIATE CODE: R157

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250