JP4929436B2 - セファロタキシンアルカロイド組成物およびその使用 - Google Patents
セファロタキシンアルカロイド組成物およびその使用 Download PDFInfo
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- JP4929436B2 JP4929436B2 JP2001566662A JP2001566662A JP4929436B2 JP 4929436 B2 JP4929436 B2 JP 4929436B2 JP 2001566662 A JP2001566662 A JP 2001566662A JP 2001566662 A JP2001566662 A JP 2001566662A JP 4929436 B2 JP4929436 B2 JP 4929436B2
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- Prior art keywords
- homoharringtonine
- antiproliferative
- drug
- days
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US18969900P | 2000-03-15 | 2000-03-15 | |
| US60/189,699 | 2000-03-15 | ||
| PCT/US2001/008480 WO2001068098A2 (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid combination compositions and uses thereof |
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| JP2003526667A JP2003526667A (ja) | 2003-09-09 |
| JP2003526667A5 JP2003526667A5 (enExample) | 2008-05-08 |
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| CA2402710A1 (en) * | 2000-03-15 | 2001-09-20 | Chemgenex Therapeutics, Inc. | Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease |
| ATE305312T1 (de) * | 2000-04-12 | 2005-10-15 | Chemgenex Pharmaceuticals Inc | Zusammensetzungen welche ein naphthalmid und ein antiproliferatives mittel enthalten |
| US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US7135481B2 (en) | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| US20020123469A1 (en) * | 2000-10-31 | 2002-09-05 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| DE60313754T2 (de) * | 2002-03-06 | 2008-01-24 | The Medical Research and Education Trust, San Diego | Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin |
| AU2003253872A1 (en) * | 2002-07-17 | 2004-02-09 | Chemgenex Pharmaceuticals, Inc. | Formulations and methods of administration of cephalotaxines, including homoharringtonine |
| ES2572145T3 (es) * | 2002-07-22 | 2016-05-30 | Teva Pharmaceuticals Int Gmbh | Inhibición de la angiogénesis mediante alcaloides de cefalotoxina, derivados, composiciones y usos de los mismos |
| CN100396286C (zh) * | 2002-12-30 | 2008-06-25 | 北京大学第一医院 | 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用 |
| US20050288310A1 (en) * | 2004-06-04 | 2005-12-29 | Chemgenex Pharmaceuticals, Inc. | Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors |
| US20060193893A1 (en) * | 2005-02-10 | 2006-08-31 | Chemgenex Pharmaceuticals, Inc. | Medical devices |
| WO2008128191A2 (en) * | 2007-04-13 | 2008-10-23 | Chemgenex Pharmaceuticals, Inc. | Oral cephalotaxine dosage forms |
| EP2260041A4 (en) | 2008-03-03 | 2012-04-25 | Sloan Kettering Inst Cancer | CEPHALOTAXUS ESTERS, METHOD FOR THEIR SYNTHESIS AND USES THEREOF |
| CN118217301B (zh) * | 2024-03-28 | 2025-08-05 | 宁波大学附属人民医院 | 一种协同治疗aml的含有8-氯腺苷和高三尖杉酯碱的药物组合物 |
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| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4675318A (en) * | 1985-05-28 | 1987-06-23 | Yaguang Liu | Safe antileukemia drug, SAL |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| CA2402710A1 (en) * | 2000-03-15 | 2001-09-20 | Chemgenex Therapeutics, Inc. | Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease |
| ATE305312T1 (de) * | 2000-04-12 | 2005-10-15 | Chemgenex Pharmaceuticals Inc | Zusammensetzungen welche ein naphthalmid und ein antiproliferatives mittel enthalten |
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2001
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- 2001-03-15 AU AU2001245803A patent/AU2001245803B8/en not_active Ceased
- 2001-03-15 AT AT01918763T patent/ATE330611T1/de active
- 2001-03-15 US US09/810,527 patent/US6734178B2/en not_active Expired - Lifetime
- 2001-03-15 PT PT01918763T patent/PT1263440E/pt unknown
- 2001-03-15 ES ES01918763T patent/ES2267741T3/es not_active Expired - Lifetime
- 2001-03-15 EP EP01918763A patent/EP1263440B1/en not_active Expired - Lifetime
- 2001-03-15 WO PCT/US2001/008480 patent/WO2001068098A2/en not_active Ceased
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2004
- 2004-01-30 US US10/769,638 patent/US20040185117A1/en not_active Abandoned
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2011
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| EP1263440B1 (en) | 2006-06-21 |
| ES2267741T3 (es) | 2007-03-16 |
| AU2001245803B2 (en) | 2005-12-15 |
| CA2402710A1 (en) | 2001-09-20 |
| AU2001245803B8 (en) | 2006-02-02 |
| JP2003526667A (ja) | 2003-09-09 |
| DK1263440T3 (da) | 2006-10-23 |
| HK1052138A1 (en) | 2003-09-05 |
| WO2001068098A2 (en) | 2001-09-20 |
| US6734178B2 (en) | 2004-05-11 |
| DE60120928T2 (de) | 2007-02-08 |
| ATE330611T1 (de) | 2006-07-15 |
| EP1263440A2 (en) | 2002-12-11 |
| PT1263440E (pt) | 2006-11-30 |
| WO2001068098A3 (en) | 2002-06-06 |
| DE60120928D1 (de) | 2006-08-03 |
| AU4580301A (en) | 2001-09-24 |
| US20120207855A1 (en) | 2012-08-16 |
| US20110008307A1 (en) | 2011-01-13 |
| US20020032190A1 (en) | 2002-03-14 |
| US20040185117A1 (en) | 2004-09-23 |
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