ES2267741T3 - Composiciones combinadas de alcaloides de cefalotaxina y de los mismos. - Google Patents

Composiciones combinadas de alcaloides de cefalotaxina y de los mismos. Download PDF

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Publication number
ES2267741T3
ES2267741T3 ES01918763T ES01918763T ES2267741T3 ES 2267741 T3 ES2267741 T3 ES 2267741T3 ES 01918763 T ES01918763 T ES 01918763T ES 01918763 T ES01918763 T ES 01918763T ES 2267741 T3 ES2267741 T3 ES 2267741T3
Authority
ES
Spain
Prior art keywords
cephalotaxin
antiproliferative
homoharringtonin
medication
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01918763T
Other languages
English (en)
Spanish (es)
Inventor
Dennis M. Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChemGenex Pharmaceuticals Inc
Original Assignee
ChemGenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ChemGenex Pharmaceuticals Inc filed Critical ChemGenex Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2267741T3 publication Critical patent/ES2267741T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES01918763T 2000-03-15 2001-03-15 Composiciones combinadas de alcaloides de cefalotaxina y de los mismos. Expired - Lifetime ES2267741T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18969900P 2000-03-15 2000-03-15
US189699P 2000-03-15

Publications (1)

Publication Number Publication Date
ES2267741T3 true ES2267741T3 (es) 2007-03-16

Family

ID=22698410

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01918763T Expired - Lifetime ES2267741T3 (es) 2000-03-15 2001-03-15 Composiciones combinadas de alcaloides de cefalotaxina y de los mismos.

Country Status (11)

Country Link
US (4) US6734178B2 (enExample)
EP (1) EP1263440B1 (enExample)
JP (1) JP4929436B2 (enExample)
AT (1) ATE330611T1 (enExample)
AU (2) AU4580301A (enExample)
CA (1) CA2402710A1 (enExample)
DE (1) DE60120928T2 (enExample)
DK (1) DK1263440T3 (enExample)
ES (1) ES2267741T3 (enExample)
PT (1) PT1263440E (enExample)
WO (1) WO2001068098A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402710A1 (en) * 2000-03-15 2001-09-20 Chemgenex Therapeutics, Inc. Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease
ATE305312T1 (de) * 2000-04-12 2005-10-15 Chemgenex Pharmaceuticals Inc Zusammensetzungen welche ein naphthalmid und ein antiproliferatives mittel enthalten
US20060211648A1 (en) * 2000-04-12 2006-09-21 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
US7135481B2 (en) 2000-04-12 2006-11-14 Chemgenex Pharmaceuticals, Inc. Naphthalimide compositions and uses thereof
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
US20020123469A1 (en) * 2000-10-31 2002-09-05 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
DE60313754T2 (de) * 2002-03-06 2008-01-24 The Medical Research and Education Trust, San Diego Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin
AU2003253872A1 (en) * 2002-07-17 2004-02-09 Chemgenex Pharmaceuticals, Inc. Formulations and methods of administration of cephalotaxines, including homoharringtonine
ES2572145T3 (es) * 2002-07-22 2016-05-30 Teva Pharmaceuticals Int Gmbh Inhibición de la angiogénesis mediante alcaloides de cefalotoxina, derivados, composiciones y usos de los mismos
CN100396286C (zh) * 2002-12-30 2008-06-25 北京大学第一医院 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用
US20050288310A1 (en) * 2004-06-04 2005-12-29 Chemgenex Pharmaceuticals, Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
US20060193893A1 (en) * 2005-02-10 2006-08-31 Chemgenex Pharmaceuticals, Inc. Medical devices
WO2008128191A2 (en) * 2007-04-13 2008-10-23 Chemgenex Pharmaceuticals, Inc. Oral cephalotaxine dosage forms
EP2260041A4 (en) 2008-03-03 2012-04-25 Sloan Kettering Inst Cancer CEPHALOTAXUS ESTERS, METHOD FOR THEIR SYNTHESIS AND USES THEREOF
CN118217301B (zh) * 2024-03-28 2025-08-05 宁波大学附属人民医院 一种协同治疗aml的含有8-氯腺苷和高三尖杉酯碱的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
US4675318A (en) * 1985-05-28 1987-06-23 Yaguang Liu Safe antileukemia drug, SAL
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
CA2402710A1 (en) * 2000-03-15 2001-09-20 Chemgenex Therapeutics, Inc. Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease
ATE305312T1 (de) * 2000-04-12 2005-10-15 Chemgenex Pharmaceuticals Inc Zusammensetzungen welche ein naphthalmid und ein antiproliferatives mittel enthalten

Also Published As

Publication number Publication date
EP1263440B1 (en) 2006-06-21
AU2001245803B2 (en) 2005-12-15
CA2402710A1 (en) 2001-09-20
AU2001245803B8 (en) 2006-02-02
JP2003526667A (ja) 2003-09-09
DK1263440T3 (da) 2006-10-23
HK1052138A1 (en) 2003-09-05
WO2001068098A2 (en) 2001-09-20
US6734178B2 (en) 2004-05-11
DE60120928T2 (de) 2007-02-08
ATE330611T1 (de) 2006-07-15
EP1263440A2 (en) 2002-12-11
PT1263440E (pt) 2006-11-30
WO2001068098A3 (en) 2002-06-06
DE60120928D1 (de) 2006-08-03
AU4580301A (en) 2001-09-24
US20120207855A1 (en) 2012-08-16
US20110008307A1 (en) 2011-01-13
US20020032190A1 (en) 2002-03-14
US20040185117A1 (en) 2004-09-23
JP4929436B2 (ja) 2012-05-09

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