CA2402710A1 - Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease - Google Patents
Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease Download PDFInfo
- Publication number
- CA2402710A1 CA2402710A1 CA002402710A CA2402710A CA2402710A1 CA 2402710 A1 CA2402710 A1 CA 2402710A1 CA 002402710 A CA002402710 A CA 002402710A CA 2402710 A CA2402710 A CA 2402710A CA 2402710 A1 CA2402710 A1 CA 2402710A1
- Authority
- CA
- Canada
- Prior art keywords
- cephalotaxine
- homoharringtonine
- antiproliferative agent
- antiproliferative
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18969900P | 2000-03-15 | 2000-03-15 | |
| US60/189,699 | 2000-03-15 | ||
| PCT/US2001/008480 WO2001068098A2 (en) | 2000-03-15 | 2001-03-15 | Cephalotaxine alkaloid combination compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2402710A1 true CA2402710A1 (en) | 2001-09-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002402710A Abandoned CA2402710A1 (en) | 2000-03-15 | 2001-03-15 | Use of a cephalotaxine and an antiproliferative agent in treating cellular proliferative disease |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6734178B2 (enExample) |
| EP (1) | EP1263440B1 (enExample) |
| JP (1) | JP4929436B2 (enExample) |
| AT (1) | ATE330611T1 (enExample) |
| AU (2) | AU2001245803B8 (enExample) |
| CA (1) | CA2402710A1 (enExample) |
| DE (1) | DE60120928T2 (enExample) |
| DK (1) | DK1263440T3 (enExample) |
| ES (1) | ES2267741T3 (enExample) |
| PT (1) | PT1263440E (enExample) |
| WO (1) | WO2001068098A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1263440E (pt) * | 2000-03-15 | 2006-11-30 | Chemgenex Pharmaceuticals Inc | Composições de combinação do alcalóide cefalotaxina e sua utilização |
| JP2003530431A (ja) | 2000-04-12 | 2003-10-14 | ケムジェネックス・セラピューティクス・インコーポレイテッド | ナフタルイミドおよび抗増殖性剤を含有する組成物 |
| US20060211648A1 (en) * | 2000-04-12 | 2006-09-21 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US7135481B2 (en) * | 2000-04-12 | 2006-11-14 | Chemgenex Pharmaceuticals, Inc. | Naphthalimide compositions and uses thereof |
| US20050170015A1 (en) * | 2000-10-31 | 2005-08-04 | Brown Dennis M. | Antiproliferative colchicine compositions and uses thereof |
| EP1330242A2 (en) * | 2000-10-31 | 2003-07-30 | Chemgenex Therapeutics Inc. | Antiproliferative colchicine compositions and uses thereof |
| AU2003217982A1 (en) * | 2002-03-06 | 2003-09-22 | The Medical Research And Education Trust | Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol |
| WO2004009092A1 (en) * | 2002-07-17 | 2004-01-29 | Chemgenex Pharmaceuticals Limited | Formulations and methods of administration of cephalotaxines, including homoharringtonine |
| US7642252B2 (en) * | 2002-07-22 | 2010-01-05 | Chemgenex Pharmaceuticals, Inc. | Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof |
| CN100396286C (zh) * | 2002-12-30 | 2008-06-25 | 北京大学第一医院 | 高三尖杉酯碱和三尖杉酯碱在制备抑制血管生成药物中的应用 |
| EP1765341A4 (en) * | 2004-06-04 | 2010-04-14 | Chemgenex Pharmaceuticals Inc | PROCESS FOR TREATING PROLIFERATIVE CELL DISEASE USING NAPHTHALIMIDE AND PARP-1 INHIBITORS |
| WO2006086693A2 (en) * | 2005-02-10 | 2006-08-17 | Chemgenex Pharmaceuticals, Inc. | Medical devices |
| AU2008240044B2 (en) * | 2007-04-13 | 2013-09-12 | Teva Pharamceuticals International Gmbh | Oral cephalotaxine dosage forms |
| WO2009148654A2 (en) * | 2008-03-03 | 2009-12-10 | Sloan-Kettering Institute For Cancer Research | Cephalotaxus esters, methods of synthesis, and uses thereof |
| CN118217301B (zh) * | 2024-03-28 | 2025-08-05 | 宁波大学附属人民医院 | 一种协同治疗aml的含有8-氯腺苷和高三尖杉酯碱的药物组合物 |
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| US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
| US4675318A (en) * | 1985-05-28 | 1987-06-23 | Yaguang Liu | Safe antileukemia drug, SAL |
| US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
| PT1263440E (pt) * | 2000-03-15 | 2006-11-30 | Chemgenex Pharmaceuticals Inc | Composições de combinação do alcalóide cefalotaxina e sua utilização |
| JP2003530431A (ja) * | 2000-04-12 | 2003-10-14 | ケムジェネックス・セラピューティクス・インコーポレイテッド | ナフタルイミドおよび抗増殖性剤を含有する組成物 |
-
2001
- 2001-03-15 PT PT01918763T patent/PT1263440E/pt unknown
- 2001-03-15 AT AT01918763T patent/ATE330611T1/de active
- 2001-03-15 US US09/810,527 patent/US6734178B2/en not_active Expired - Lifetime
- 2001-03-15 ES ES01918763T patent/ES2267741T3/es not_active Expired - Lifetime
- 2001-03-15 WO PCT/US2001/008480 patent/WO2001068098A2/en not_active Ceased
- 2001-03-15 AU AU2001245803A patent/AU2001245803B8/en not_active Ceased
- 2001-03-15 DK DK01918763T patent/DK1263440T3/da active
- 2001-03-15 AU AU4580301A patent/AU4580301A/xx active Pending
- 2001-03-15 CA CA002402710A patent/CA2402710A1/en not_active Abandoned
- 2001-03-15 JP JP2001566662A patent/JP4929436B2/ja not_active Expired - Fee Related
- 2001-03-15 EP EP01918763A patent/EP1263440B1/en not_active Expired - Lifetime
- 2001-03-15 DE DE60120928T patent/DE60120928T2/de not_active Expired - Lifetime
-
2004
- 2004-01-30 US US10/769,638 patent/US20040185117A1/en not_active Abandoned
-
2010
- 2010-04-15 US US12/761,251 patent/US20110008307A1/en not_active Abandoned
-
2011
- 2011-12-23 US US13/336,917 patent/US20120207855A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1263440A2 (en) | 2002-12-11 |
| US20120207855A1 (en) | 2012-08-16 |
| HK1052138A1 (en) | 2003-09-05 |
| ATE330611T1 (de) | 2006-07-15 |
| AU2001245803B2 (en) | 2005-12-15 |
| EP1263440B1 (en) | 2006-06-21 |
| DE60120928D1 (de) | 2006-08-03 |
| US20020032190A1 (en) | 2002-03-14 |
| WO2001068098A3 (en) | 2002-06-06 |
| US6734178B2 (en) | 2004-05-11 |
| JP4929436B2 (ja) | 2012-05-09 |
| US20040185117A1 (en) | 2004-09-23 |
| AU2001245803B8 (en) | 2006-02-02 |
| AU4580301A (en) | 2001-09-24 |
| PT1263440E (pt) | 2006-11-30 |
| ES2267741T3 (es) | 2007-03-16 |
| US20110008307A1 (en) | 2011-01-13 |
| DE60120928T2 (de) | 2007-02-08 |
| JP2003526667A (ja) | 2003-09-09 |
| WO2001068098A2 (en) | 2001-09-20 |
| DK1263440T3 (da) | 2006-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |