JP4917753B2 - 離散した非混合液滴に複数の薬剤を有するプロテーゼ - Google Patents
離散した非混合液滴に複数の薬剤を有するプロテーゼ Download PDFInfo
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- JP4917753B2 JP4917753B2 JP2004551918A JP2004551918A JP4917753B2 JP 4917753 B2 JP4917753 B2 JP 4917753B2 JP 2004551918 A JP2004551918 A JP 2004551918A JP 2004551918 A JP2004551918 A JP 2004551918A JP 4917753 B2 JP4917753 B2 JP 4917753B2
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- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
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- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
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Description
市販の二部量エポキシ調合物の成分を、噴射プロセスによって混合し、表面に塗布して被覆を形成する。イリノイ州レイクブラフのBuehler社によって製造される調合では、一方の部分は、4,4’−イソプロピリデンジフェノールエピクロロヒドリン樹脂およびブチルグリシジルエーテルを含有する液体「エポキシ樹脂」である。第2の部分は、ジエチレントリアミン、トリエチレンテトラミン、およびポリオキシプロピレンジアミンを含有する液体「硬化剤」である。この噴射プロセスでは、一方の試薬噴射システム(A)に、エポキシ樹脂を装填し、第2の噴射システム(B)に、硬化剤を装填する。各システムから放出される液滴が、空中で混合され、標的デバイスまで移動して2〜8時間の硬化時間後に架橋された被覆を形成するように、2つの噴射システムを整列させる。噴射システムAから放出される液滴の容量は、噴射システムBから放出される液滴の容量の5倍とし、各噴射システムから分与される液滴の総数をほぼ等しくする。
市販の二部量エポキシ調合物の成分を、噴射プロセスによって混合し、表面に塗布して被覆を形成する。イリノイ州レイクブラフのBuehler社によって製造される市販の二部量調合物では、一方の部分は、4,4’−イソプロピリデンジフェノールエピクロロヒドリン樹脂およびブチルグリシジルエーテルを含有する液体「エポキシ樹脂」である。第2の部分は、ジエチレントリアミン、トリエチレンテトラミン、およびポリオキシプロピレンジアミンを含有する液体「硬化剤」である。この噴射プロセスでは、一方の試薬噴射システム(A)に、エポキシ樹脂を装填し、第2の噴射システム(B)に、硬化剤を装填する。各システムから放出される液滴が、空中で混合され、標的デバイスまで移動して2〜8時間の硬化時間後に架橋された被覆を形成するように、2つの噴射システムを整列させる。噴射システムAから放出される液滴の容量は、噴射システムBから放出される液滴の容量の4倍とし、各噴射システムから分与される液滴の総数をほぼ等しくする。この被覆は、例1に記載の被覆よりも速い速度で硬化する。
市販の二部量エポキシ調合物の成分を、噴射プロセスによって混合し、表面に塗布して被覆を形成する。イリノイ州レイクブラフのBuehler社によって製造される市販の二部量調合物では、一方の部分は、4,4’−イソプロピリデンジフェノールエピクロロヒドリン樹脂およびブチルグリシジルエーテルを含有する液体「エポキシ樹脂」である。第2の部分は、ジエチレントリアミン、トリエチレンテトラミン、およびポリオキシプロピレンジアミンを含有する液体「硬化剤」である。この噴射プロセスでは、一方の試薬噴射システム(A)に、エポキシ樹脂を装填し、第2の噴射システム(B)に、硬化剤を装填する。各システムから放出される液滴が、空中で混合され、標的デバイスまで移動して2〜8時間の硬化時間後に架橋された被覆を形成するように、2つの噴射システムを整列させる。噴射システムAから放出される液滴の容量は、噴射システムBから放出される液滴の容量とほぼ等しくするが、噴射システムAから分与される液滴の総数は、噴射システムBからの液滴の総数の4倍とする。
一方の試薬噴射システム(A)に、液体エポキシ樹脂と、該エポキシ樹脂に対して20重量%の薬物、つまりパクリタキセルの可溶化された調合物とを装填する。第2の噴射システム(B)には、等しい重量または少ない重量の生体適合性高分子と混合された例1で記載された硬化剤と同様の硬化剤を装填する。このような化学種の一例は、一般式poly(MPCw:LMAx:HPMAy:TSMAz)のホスホリルコリン架橋高分子である。ここでMPCは、2−メタクリオイロキシエチルホスホリルコリンであり、LMAは、ラウリルメタクリレートであり、HPMAは、ヒドロキシプロピルメタクリレートであり、TSMAは、トリメトキシリルプロピルメタクリレートである。この高分子を、クロロホルムなどの溶剤中で溶解する。各システムから放出される液滴が、空中で混合され、標的デバイスまで移動して、薬物および高分子を取り込む架橋された被覆を形成するように、2つの噴射システムを整列させる。噴射システムAから放出される液滴の容量は、噴射システムBから放出される液滴の容量の5倍とし、各噴射システムから分与される液滴の総数をほぼ等しくする。この被覆を、70℃4時間加熱し、トリメトキシシラン基を用いて、それ自身が占有的なホスホリルコリン結合高分子の架橋を生じさせると同時に、硬化剤を用いてエポキシ樹脂の硬化を加速させる。
一方の試薬噴射システム(A)に、エタノールに溶解したラパマイシンを装填する。第2の噴射システムに、水を装填する。噴射システムAから放出される1滴の液滴容量を、50plとし、噴射システムBから放出される1滴の液滴容量を、150plとする。各噴射システムから放出される液滴が、空中で混合され、標的デバイスまで移動するように、両噴射システムを整列させる。液滴が混合される間、ラパマイシンは液滴内で沈殿し、微小沈殿物として標的表面上に付着する。
実施可能性を実証するために、ABT−578を20mg/ml、およびホスホリルコリン結合メタクリレート高分子(PC)4mg/mlをイソブタノール中で混合して噴射用原液を調整した。テキサス州プラノのMicroFab Technologies社製の流体噴射システムを、線形mm当たり5μgの面密度を得るように、1.4×11mmのOC Biodiv Ysioステント上に75μgの薬物が一様に噴射されるようにプログラムした。イソブタノール10mlが入ったバイアルに21888滴を噴射して、278nmにおいて分光光度計で決定されるように77μgのABT−578が得られた。このような条件下で、1滴は、170〜180plとし、直径は67〜70μとした。ステントは、ホスホリルコリン結合高分子(PC)のベースコーティングを含む。ステントと同軸の中心軸周囲で回転(θ)を制御するマンドレル、およびステントの軸に沿って側方回転(X)を行うステージ備えた冶具上にステントを設置した。ステントを全体で720度回転させるように、運動制御を設定した。回転するステントの軸に対して直交方向で観察したところ、ステントの外面に接する点の内側約50μに、接線方向に軸が外れた可能性のある位置が2ヵ所あった。一方は回転の中心線の各側にあり、噴射の軌道が、少なくとも1つのステントの構造要素に衝突しないであろう例は比較的ほとんどなかった。薬物の装填を開始するために、このような軸が外れた位置の1つをまず選択した。噴射された液滴の軌道が、この軸が外れた場所でステントストラットに当たるように、マンドレルに設置されたステントを位置決めした。X方向にステントを軸方向に移動させるようにモーションコントローラを設定し、噴射の軌道がステントの端部から外れる位置で、動作を開始させた。モーションコントローラは、所定の速度まで加速し、X軸に沿った動作が一定速度に達し、かつステントストラットの端部が噴射ヘッドの直下の位置に来ると同時に、噴射ヘッドをオンした。ステントが、X方向のこの軸が外れた経路に沿って噴射ヘッドの下を完全に通過する毎に、モーションコントローラは、減速し、停止し、ステントを5度回転させる。直線方向は反転し、次の通過が行われた。360度に達した後、(72回の通過)テーブルを、他方の軸の外れた位置までステントの内径(1 ID)にぼ等しい距離並進させた。73回以上360°回転させた。このように、各ステントに2回噴射を行いその薬物装填を行った。
同様の実施可能性を実証するために、11mmのOCステントに使用した約3Xで59904滴を分与するように、テキサス州プラノのMicroFab Technologies社製の流体噴射システムをプログラムした。このような抹消血管ステント(SFA)は、5×30mmとし、より大きな寸法の回転冶具上に設置した。ステントのマトリクスは、OC冠動脈ステントの場合よりも一層開いていた。しかし、良好な補足効率が得られた。
ホスホリルコリン結合メタクリレート高分子(PC)の10mg/ml溶液を、イソブタノール中で作成した。先の例で用いた条件下で、ステントの軸方向寸法に沿って計288回、1440°の回転を超えて通過させたところ、線形mm当たり5μgのオーバーコーティングが得られた。
ホスホリルコリン結合メタクリレート高分子(PC)10mg/ml溶液を、イソブタノール中で作成した。ステント長の最初の25%、およびステント長の終わりの25%の間で、噴射ヘッド下のステントの線形移動速度を、50%遅くなるようにプログラムした。ステントの長さにわたって噴射速度は変えなかった。ステントの軸方向寸法に沿って計288回の通過、および1440°の回転を超えて行った。このような条件下では、ステントは、中間部分と比較してステントの両端上でPCの量は増大する。
ABT−578を20mg/ml、およびホスホリルコリン結合メタクリレート高分子(PC)4mg/mlをイソブタノール中で混合して噴射用原液を調整した。ステント長の最初の25%、およびステント長の終わりの25%の間で、噴射ヘッド下のステントの線形移動速度を、50%速くなるようにプログラムした。ステントの長さにわたって噴射速度は変えなかった。ステントの軸方向寸法に沿って計144回の通過、720°の回転を超えて行った。このような条件下では、ステントは、中間部分と比較してステントの両端上でABT−578の量は低下した。
Claims (13)
- インターベンショナルデバイスであって、
管腔内に配置されかつ表面を有するプロテーゼと、
プロテーゼの表面上に装填される第1の有益な薬剤とを含み、プロテーゼの表面上の第1の有益な薬剤が微小沈殿物の形で存在しており、
微小沈殿物は、プロテーゼの表面上への第1の有益な薬剤の装填プロセス中、または、プロテーゼの表面上に第1の有益な薬剤が装填された後、第1の有益な薬剤が第1の溶剤中で溶解され、第1の溶剤中で溶解された第1の有益な薬剤が第2の有益な薬剤と組み合わされることによって生じたものであり、第2の有益な薬剤が、第1の有益な薬剤を第1の溶剤から沈殿させて微小沈殿物を形成する、前記インターベンショナルデバイス。 - 第1の有益な薬剤が、第1の制御された軌道に沿って装填され、第2の有益な薬剤が、第2の制御された軌道に沿って装填され、第1の制御された軌道および第2の制御された軌道が、プロテーゼの表面上に装填される前に、第1の有益な薬剤および第2の有益な薬剤を混合できるように構成される、請求項1に記載のインターベンショナルデバイス。
- 第1の有益な薬剤および第2の有益な薬剤が、プロテーゼの表面上で混合される、請求項1に記載のインターベンショナルデバイス。
- 第1の有益な薬剤および第2の有益な薬剤の少なくとも一方が、プロテーゼ上に装填される前に結合剤と混合される、請求項1に記載のインターベンショナルデバイス。
- 結合剤が、ホスホリルコリン結合高分子である、請求項4に記載のインターベンショナルデバイス。
- 第1の有益な薬剤が、第1の有益な薬剤の送達に関する第1の放出速度を有する結合剤と混合される、請求項4に記載のインターベンショナルデバイス。
- プロテーゼが、プロテーゼの中に画定された少なくとも1つの空洞を含み、少なくとも1つの空洞には少なくとも部分的に基材が装填され、かつ、さらに第1の有益な薬剤および第2の有益な薬剤が、基材に装填される、請求項1に記載のインターベンショナルデバイス。
- プロテーゼが、少なくとも1つの空洞を含み、少なくとも1つの空洞が、第1の断面寸法を有する口部および第2の断面寸法を有するリザーバを画定し、第2の断面寸法が、第1の断面寸法よりも大きい、請求項1に記載のインターベンショナルデバイス。
- プロテーゼの表面上に装填される第3の有益な薬剤をさらに含む、請求項1に記載のインターベンショナルデバイス。
- 第1の有益な薬剤が、ラパマイシンの類似体である3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)−9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a−ヘキサデカヒドロ−9,27−ジヒドロキシ−3−[(1R)−2−[(1S,3R,4R)−3−メトキシ−4−テトラゾール−1−yl]シクロヘキシル]−1−メチルエチル]−10,21−ジメトキシ−6,8,12,14,20,26−ヘキサメチル−23,27−エポキシ−3H−ピリド[2,1−c][1,4]オクサアガシクロヘントリアコンチン−1,5,11,28,29(4H,6H,31H)−ペントン;23,27−エポキシ−3H−ピリド[2,1−c][1,4]オクサアガシクロヘントリアコンチン−1,5,11,28,29(4H,6H,31H)−ペントンである、請求項9に記載のインターベンショナルデバイス。
- 第1の有益な薬剤および第2の有益な薬剤のうちすくなくとも一方が、抗血栓剤、抗凝血剤、抗血小板剤、抗脂質剤、血栓溶解剤、抗増殖剤、抗炎症薬、過形成を抑制する薬剤、平滑筋細胞抑制剤、抗生物質、成長因子阻害剤、細胞接着阻害剤、細胞接着促進剤、細胞分裂抑制薬、抗線溶剤、酸化防止剤、抗新生物薬、内皮細胞の修復を促進する薬剤、抗アレルギー薬、放射線不透過性物質、ウイルスベクター、アンチセンス化合物、オリゴヌクレオチド、細胞浸透エンハンサー、血管形成剤、パクリタキセル、ラパマイシン、エベロリムス、ヘパリン、エストラジオール、デキサメタゾン、これらの類似体、ラパマイシンの類似体である3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)−9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a−ヘキサデカヒドロ−9,27−ジヒドロキシ−3−[(1R)−2−[(1S,3R,4R)−3−メトキシ−4−テトラゾール−1−yl]シクロヘキシル]−1−メチルエチル]−10,21−ジメトキシ−6,8,12,14,20,26−ヘキサメチル−23,27−エポキシ−3H−ピリド[2,1−c][1,4]オクサアガシクロヘントリアコンチン−1,5,11,28,29(4H,6H,31H)−ペントン;23,27−エポキシ−3H−ピリド[2,1−c][1,4]オクサアガシクロヘントリアコンチン−1,5,11,28,29(4H,6H,31H)−ペントン、およびこれらの混合物から成る群から選択される、請求項1に記載のインターベンショナルデバイス。
- 表面の少なくとも一部分の上に塗布されたオーバーコートをさらに含む、請求項1に記載のインターベンショナルデバイス。
- 有益な薬剤が、各々制御された軌道を有する離散した液滴として有益な薬剤を分与することのできる分与要素を有する流体噴射ディスペンサを用いて、プロテーゼに塗布される、請求項1に記載のインターベンショナルデバイス。
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JP2004551918A Expired - Fee Related JP4917753B2 (ja) | 2002-11-07 | 2003-11-07 | 離散した非混合液滴に複数の薬剤を有するプロテーゼ |
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IT202200017178A1 (it) * | 2022-08-11 | 2024-02-11 | Nuova Ompi S R L Unipersonale | Apparato per rivestire un dispositivo medico per iniezione e relativo metodo |
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