JP4913321B2 - 徐放性医薬組成物 - Google Patents
徐放性医薬組成物 Download PDFInfo
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- JP4913321B2 JP4913321B2 JP2003515226A JP2003515226A JP4913321B2 JP 4913321 B2 JP4913321 B2 JP 4913321B2 JP 2003515226 A JP2003515226 A JP 2003515226A JP 2003515226 A JP2003515226 A JP 2003515226A JP 4913321 B2 JP4913321 B2 JP 4913321B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| AUPR6024 | 2001-06-29 | ||
| AUPR6024A AUPR602401A0 (en) | 2001-06-29 | 2001-06-29 | Sustained release delivery system |
| PCT/AU2002/000866 WO2003009833A1 (en) | 2001-06-29 | 2002-07-01 | Sustained release delivery system |
Publications (3)
| Publication Number | Publication Date |
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| JP2004535473A JP2004535473A (ja) | 2004-11-25 |
| JP2004535473A5 JP2004535473A5 (https=) | 2005-10-27 |
| JP4913321B2 true JP4913321B2 (ja) | 2012-04-11 |
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| JP2003515226A Expired - Fee Related JP4913321B2 (ja) | 2001-06-29 | 2002-07-01 | 徐放性医薬組成物 |
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| Country | Link |
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| US (1) | US8197839B2 (https=) |
| EP (1) | EP1411905A4 (https=) |
| JP (1) | JP4913321B2 (https=) |
| CN (1) | CN1536988A (https=) |
| AU (2) | AUPR602401A0 (https=) |
| BR (1) | BR0210630A (https=) |
| CA (1) | CA2452075C (https=) |
| NZ (1) | NZ529858A (https=) |
| WO (1) | WO2003009833A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
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| NZ581461A (en) * | 2003-11-13 | 2011-04-29 | Psivida Inc | Injectable sustained release delivery devices |
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| US20090005869A1 (en) * | 2006-12-15 | 2009-01-01 | University Of Virginia Patent Foundation | Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof |
| NZ552290A (en) * | 2006-12-21 | 2009-05-31 | Bomac Research Ltd | Tablet fomulation |
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| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| WO2009086416A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Therapeutic cancer treatments |
| AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| US9005649B2 (en) | 2009-07-14 | 2015-04-14 | Board Of Regents, The University Of Texas System | Methods for making controlled delivery devices having zero order kinetics |
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| US20110183948A1 (en) * | 2010-01-15 | 2011-07-28 | Infinity Pharmaceuticals, Inc. | Treatment of fibrotic conditions using hedgehog inhibitors |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
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Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6445318A (en) * | 1987-05-08 | 1989-02-17 | Syntex Inc | Delivery system for administration control of lhrh analogue |
| WO1992007556A1 (en) * | 1990-10-31 | 1992-05-14 | Amgen Inc. | Polyvinyl alcohol coated pellet of growth hormone |
| JPH04230621A (ja) * | 1990-08-22 | 1992-08-19 | Merck & Co Inc | 生体侵食性インプラント |
| JPH04230210A (ja) * | 1990-06-20 | 1992-08-19 | Monsanto Co | 被覆された動物用植込み物 |
| JPH06321803A (ja) * | 1993-05-17 | 1994-11-22 | Kirin Brewery Co Ltd | 水溶性ペプチドホルモンの徐放性製剤 |
| WO1995017881A1 (en) * | 1993-12-27 | 1995-07-06 | Sumitomo Pharmaceuticals Company, Limited | Controlled-release pharmaceutical preparation |
| JPH09225040A (ja) * | 1996-02-23 | 1997-09-02 | Dow Corning Fr Sa | 制御された放出をする装置の製造方法 |
| WO1999015166A1 (en) * | 1997-09-23 | 1999-04-01 | Pfizer Limited | Parasiticidal formulations |
| EP0990450A2 (en) * | 1998-09-30 | 2000-04-05 | Ivy Animal Health, Inc. | Pharmaceutical implants |
| WO2001034112A1 (en) * | 1999-11-10 | 2001-05-17 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release drug formulations for implantation |
| WO2001037811A1 (en) * | 1999-11-22 | 2001-05-31 | Akzo Nobel N.V. | Composition allowing predefined and controlled release of active ingredient, preparation thereof and use |
| JP2001199879A (ja) * | 1999-11-10 | 2001-07-24 | Sumitomo Pharmaceut Co Ltd | 薬物放出製剤 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4013785A (en) * | 1975-03-21 | 1977-03-22 | Bristol-Myers Company | Apap tablet containing fumed silica and process for manufacturing same |
| US4111202A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4331652A (en) * | 1979-09-12 | 1982-05-25 | Eli Lilly And Company | Controlled release parasitic formulations and method |
| US4681583A (en) * | 1982-12-20 | 1987-07-21 | Alza Corporation | System for dispersing drug in biological environment |
| US4578075A (en) * | 1982-12-20 | 1986-03-25 | Alza Corporation | Delivery system housing a plurality of delivery devices |
| DE3681348D1 (de) | 1985-06-11 | 1991-10-17 | Teijin Ltd | Oral-arzneizubereitung mit retardwirkung. |
| SE444801B (sv) | 1985-06-28 | 1986-05-12 | Johan Magnus Ullman | Fender |
| US4786501A (en) | 1985-07-15 | 1988-11-22 | International Minerals & Chemical Corp. | Cylindrical implants for the controlled release of growth hormones |
| US5342622A (en) * | 1986-05-16 | 1994-08-30 | The State Of Victoria | Subdermal biocompatible implants |
| JPH01500899A (ja) * | 1986-05-16 | 1989-03-30 | ザ・ステイト・オブ・ビクトリア | 生物適合性インプラント |
| US5035891A (en) * | 1987-10-05 | 1991-07-30 | Syntex (U.S.A.) Inc. | Controlled release subcutaneous implant |
| US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| JPH0618958B2 (ja) * | 1989-03-08 | 1994-03-16 | 株式会社クラレ | 多層容器および包装体 |
| DK0463061T3 (da) * | 1989-03-17 | 1993-07-12 | Pitman Moore Inc | Controlled-release tilførselsindretning til afgivelse af makromolekylære proteiner |
| FI916066A0 (fi) * | 1989-06-21 | 1991-12-20 | Univ Brown Res Found | Neurologiskt vaordsystem. |
| AU660290B2 (en) | 1990-08-09 | 1995-06-22 | Endocon, Inc. | Multiple drug delivery system |
| US5211951A (en) * | 1991-07-24 | 1993-05-18 | Merck & Co., Inc. | Process for the manufacture of bioerodible poly (orthoester)s and polyacetals |
| KR100210509B1 (ko) * | 1996-01-10 | 1999-07-15 | 성재갑 | 지속성 동물 성장 호르몬 제형 및 이의 제조 방법 |
| AUPP279698A0 (en) * | 1998-04-03 | 1998-04-30 | Sunscape Developments Limited | Sustained release formulation |
| AU752225B2 (en) * | 1998-07-17 | 2002-09-12 | Pacira Pharmaceuticals, Inc. | Biodegradable compositions for the controlled release of encapsulated substances |
| AU5532699A (en) * | 1998-09-05 | 2000-03-27 | Seung Jin Lee | Biodegradable particulate polymeric preparation and process for producing thereof |
| MXPA01002609A (es) * | 1998-09-10 | 2002-04-08 | Sumitomo Pharma | Preparacion de farmaco de liberacion sostenida a largo plazo. |
| WO2000018374A1 (en) | 1998-10-01 | 2000-04-06 | Elan Pharma International, Ltd. | Controlled release nanoparticulate compositions |
| CN1378445B (zh) * | 1999-08-06 | 2013-02-06 | 得克萨斯系统大学评议会 | 药物释放生物可降解纤维植入物 |
| JP4230621B2 (ja) | 1999-08-12 | 2009-02-25 | 住友ゴム工業株式会社 | 空気入りタイヤ |
| US6998137B2 (en) | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| JP4504122B2 (ja) | 2004-07-02 | 2010-07-14 | 株式会社マキタ | 生垣バリカン |
-
2001
- 2001-06-29 AU AUPR6024A patent/AUPR602401A0/en not_active Abandoned
-
2002
- 2002-07-01 NZ NZ529858A patent/NZ529858A/en not_active IP Right Cessation
- 2002-07-01 JP JP2003515226A patent/JP4913321B2/ja not_active Expired - Fee Related
- 2002-07-01 CN CNA028131185A patent/CN1536988A/zh active Pending
- 2002-07-01 AU AU2002344686A patent/AU2002344686B2/en not_active Expired
- 2002-07-01 US US10/482,335 patent/US8197839B2/en active Active
- 2002-07-01 CA CA2452075A patent/CA2452075C/en not_active Expired - Fee Related
- 2002-07-01 BR BR0210630-2A patent/BR0210630A/pt not_active IP Right Cessation
- 2002-07-01 WO PCT/AU2002/000866 patent/WO2003009833A1/en not_active Ceased
- 2002-07-01 EP EP02742516A patent/EP1411905A4/en not_active Withdrawn
Patent Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6445318A (en) * | 1987-05-08 | 1989-02-17 | Syntex Inc | Delivery system for administration control of lhrh analogue |
| JPH04230210A (ja) * | 1990-06-20 | 1992-08-19 | Monsanto Co | 被覆された動物用植込み物 |
| JPH04230621A (ja) * | 1990-08-22 | 1992-08-19 | Merck & Co Inc | 生体侵食性インプラント |
| WO1992007556A1 (en) * | 1990-10-31 | 1992-05-14 | Amgen Inc. | Polyvinyl alcohol coated pellet of growth hormone |
| JPH06321803A (ja) * | 1993-05-17 | 1994-11-22 | Kirin Brewery Co Ltd | 水溶性ペプチドホルモンの徐放性製剤 |
| WO1995017881A1 (en) * | 1993-12-27 | 1995-07-06 | Sumitomo Pharmaceuticals Company, Limited | Controlled-release pharmaceutical preparation |
| JPH09225040A (ja) * | 1996-02-23 | 1997-09-02 | Dow Corning Fr Sa | 制御された放出をする装置の製造方法 |
| WO1999015166A1 (en) * | 1997-09-23 | 1999-04-01 | Pfizer Limited | Parasiticidal formulations |
| EP0990450A2 (en) * | 1998-09-30 | 2000-04-05 | Ivy Animal Health, Inc. | Pharmaceutical implants |
| WO2001034112A1 (en) * | 1999-11-10 | 2001-05-17 | Sumitomo Pharmaceuticals Company, Limited | Sustained-release drug formulations for implantation |
| JP2001199879A (ja) * | 1999-11-10 | 2001-07-24 | Sumitomo Pharmaceut Co Ltd | 薬物放出製剤 |
| WO2001037811A1 (en) * | 1999-11-22 | 2001-05-31 | Akzo Nobel N.V. | Composition allowing predefined and controlled release of active ingredient, preparation thereof and use |
Also Published As
| Publication number | Publication date |
|---|---|
| US20040247643A1 (en) | 2004-12-09 |
| EP1411905A4 (en) | 2008-01-23 |
| WO2003009833A1 (en) | 2003-02-06 |
| CN1536988A (zh) | 2004-10-13 |
| CA2452075C (en) | 2012-08-14 |
| EP1411905A1 (en) | 2004-04-28 |
| AU2002344686B2 (en) | 2008-07-31 |
| BR0210630A (pt) | 2004-07-27 |
| NZ529858A (en) | 2006-02-24 |
| JP2004535473A (ja) | 2004-11-25 |
| AUPR602401A0 (en) | 2001-07-26 |
| CA2452075A1 (en) | 2003-02-06 |
| US8197839B2 (en) | 2012-06-12 |
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