JP4892335B2 - インターロイキン15(il−15)に特異的なヒト抗体 - Google Patents
インターロイキン15(il−15)に特異的なヒト抗体 Download PDFInfo
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- JP4892335B2 JP4892335B2 JP2006502466A JP2006502466A JP4892335B2 JP 4892335 B2 JP4892335 B2 JP 4892335B2 JP 2006502466 A JP2006502466 A JP 2006502466A JP 2006502466 A JP2006502466 A JP 2006502466A JP 4892335 B2 JP4892335 B2 JP 4892335B2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Molecular Biology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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US10/374,932 | 2003-02-26 | ||
US10/374,932 US7329405B2 (en) | 2001-08-23 | 2003-02-26 | Human antibodies specific for interleukin 15 (IL-15) |
US10/379,741 US7247304B2 (en) | 2001-08-23 | 2003-03-05 | Methods of treating using anti-IL-15 antibodies |
US10/379,741 | 2003-03-05 | ||
PCT/IB2004/000484 WO2004076620A2 (en) | 2003-02-26 | 2004-02-25 | Human antibodies specific for interleukin 15 (il-15) |
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JP2007528348A JP2007528348A (ja) | 2007-10-11 |
JP4892335B2 true JP4892335B2 (ja) | 2012-03-07 |
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JP (1) | JP4892335B2 (ru) |
CN (1) | CN1780856A (ru) |
AR (1) | AR043405A1 (ru) |
EA (1) | EA015897B1 (ru) |
RS (1) | RS20050724A (ru) |
ZA (1) | ZA200506724B (ru) |
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PT2769984T (pt) | 2007-05-11 | 2017-10-05 | Altor Bioscience Corp | Moléculas de fusão e variantes de il-15 |
US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
PT2619229T (pt) | 2010-09-21 | 2016-07-13 | Altor Bioscience Corp | Moléculas de fusão de il-15 multiméricas solúveis e métodos de produção e utilização das mesmas |
CN102250243B (zh) * | 2011-07-01 | 2013-08-28 | 华绍炳 | 抗白细胞介素-15抗体 |
KR20230028807A (ko) | 2014-06-30 | 2023-03-02 | 알토 바이오사이언스 코포레이션 | Il-15-베이즈드 분자 및 이의 사용 방법 |
EP2963057A1 (en) * | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
JP2019521981A (ja) * | 2016-06-15 | 2019-08-08 | アムジエン・インコーポレーテツド | セリアック病、非セリアックグルテン過敏症及び難治性セリアック病を治療するための方法及び組成物 |
AU2017345791B2 (en) | 2016-10-21 | 2020-10-22 | Altor Bioscience Corporation | Multimeric IL-15-based molecules |
PE20191497A1 (es) * | 2016-12-21 | 2019-10-21 | Cephalon Inc | Anticuerpos que se unen especificamente a il-15 humana y usos de estos |
CN114786479B (zh) * | 2019-12-25 | 2023-12-15 | 江苏集萃药康生物科技股份有限公司 | 一种il-15人源化小鼠模型及其用途 |
CN114377133A (zh) * | 2022-01-20 | 2022-04-22 | 山东大学 | 靶向肾脏cd8+trm形成与活化在肾小球损伤中的应用 |
CN115362984B (zh) * | 2022-07-07 | 2024-01-16 | 成都中医药大学 | 一种小鼠自身免疫性甲状腺炎模型的构建方法 |
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WO2001002003A1 (en) * | 1999-07-06 | 2001-01-11 | Bulfone Paus Silvia | Method of treating psoriasis with il-15 antagonist |
JP2002520294A (ja) * | 1998-07-10 | 2002-07-09 | ザ マティルダ アンド テレンス ケネディ インスティチュート オブ リューマトロジー | インターロイキン−15拮抗薬によるセリアック病の治療 |
JP4359503B2 (ja) * | 2001-08-23 | 2009-11-04 | ゲンマブ エー/エス | インターロイキン15(il−15)に特異的なヒト抗体 |
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US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
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- 2004-02-25 RS YUP-2005/0724A patent/RS20050724A/sr unknown
- 2004-02-25 ZA ZA200506724A patent/ZA200506724B/en unknown
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JP2002520294A (ja) * | 1998-07-10 | 2002-07-09 | ザ マティルダ アンド テレンス ケネディ インスティチュート オブ リューマトロジー | インターロイキン−15拮抗薬によるセリアック病の治療 |
WO2001002003A1 (en) * | 1999-07-06 | 2001-01-11 | Bulfone Paus Silvia | Method of treating psoriasis with il-15 antagonist |
JP4359503B2 (ja) * | 2001-08-23 | 2009-11-04 | ゲンマブ エー/エス | インターロイキン15(il−15)に特異的なヒト抗体 |
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AR043405A1 (es) | 2005-07-27 |
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EA015897B1 (ru) | 2011-12-30 |
RS20050724A (en) | 2007-11-15 |
ZA200506724B (en) | 2007-03-28 |
CN1780856A (zh) | 2006-05-31 |
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