AR043405A1 - Anticuerpos humanos especificos para la interleuquina 15 (il-15) - Google Patents
Anticuerpos humanos especificos para la interleuquina 15 (il-15)Info
- Publication number
- AR043405A1 AR043405A1 ARP040100605A AR043405A1 AR 043405 A1 AR043405 A1 AR 043405A1 AR P040100605 A ARP040100605 A AR P040100605A AR 043405 A1 AR043405 A1 AR 043405A1
- Authority
- AR
- Argentina
- Prior art keywords
- human
- antibodies
- homologous
- human antibodies
- disclosed
- Prior art date
Links
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 abstract 3
- 102000056003 human IL15 Human genes 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 102000003812 Interleukin-15 Human genes 0.000 abstract 1
- 108090000172 Interleukin-15 Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000005215 recombination Methods 0.000 abstract 1
- 230000006798 recombination Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011830 transgenic mouse model Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/374,932 US7329405B2 (en) | 2001-08-23 | 2003-02-26 | Human antibodies specific for interleukin 15 (IL-15) |
US10/379,741 US7247304B2 (en) | 2001-08-23 | 2003-03-05 | Methods of treating using anti-IL-15 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043405A1 true AR043405A1 (es) | 2005-07-27 |
Family
ID=36770634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100605 AR043405A1 (es) | 2003-02-26 | 2004-02-26 | Anticuerpos humanos especificos para la interleuquina 15 (il-15) |
Country Status (6)
Country | Link |
---|---|
JP (1) | JP4892335B2 (ru) |
CN (1) | CN1780856A (ru) |
AR (1) | AR043405A1 (ru) |
EA (1) | EA015897B1 (ru) |
RS (1) | RS20050724A (ru) |
ZA (1) | ZA200506724B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8492118B2 (en) | 2007-05-11 | 2013-07-23 | Altor Bioscience Corporation | Fusion molecules and IL-15 variants |
EP4385570A2 (en) | 2010-09-21 | 2024-06-19 | Altor BioScience, LLC | Multimeric il-15 soluble fusion molecules and methods of making and using same |
US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
CN102250243B (zh) * | 2011-07-01 | 2013-08-28 | 华绍炳 | 抗白细胞介素-15抗体 |
EP3912637A1 (en) | 2014-06-30 | 2021-11-24 | Altor BioScience Corporation | Il-15-based molecules and methods of use thereof |
EP2963057A1 (en) * | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
JP2019521981A (ja) * | 2016-06-15 | 2019-08-08 | アムジエン・インコーポレーテツド | セリアック病、非セリアックグルテン過敏症及び難治性セリアック病を治療するための方法及び組成物 |
CA3041310C (en) | 2016-10-21 | 2023-09-05 | Altor Bioscience Corporation | Multimeric il-15-based molecules |
IL267113B1 (en) * | 2016-12-21 | 2024-05-01 | Cephalon Llc | Antibodies that bind specifically to human IL-15 and their uses |
CN114786479B (zh) * | 2019-12-25 | 2023-12-15 | 江苏集萃药康生物科技股份有限公司 | 一种il-15人源化小鼠模型及其用途 |
CN114377133A (zh) * | 2022-01-20 | 2022-04-22 | 山东大学 | 靶向肾脏cd8+trm形成与活化在肾小球损伤中的应用 |
CN115362984B (zh) * | 2022-07-07 | 2024-01-16 | 成都中医药大学 | 一种小鼠自身免疫性甲状腺炎模型的构建方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
GB9814892D0 (en) * | 1998-07-10 | 1998-09-09 | Kennedy Rheumatology Inst | Treatment of celiac disease |
WO2001002003A1 (en) * | 1999-07-06 | 2001-01-11 | Bulfone Paus Silvia | Method of treating psoriasis with il-15 antagonist |
EA014802B1 (ru) * | 2001-08-23 | 2011-02-28 | Генмаб А/С | АНТИТЕЛА К ИНТЕРЛЕЙКИНУ 15 (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ, ИММУНОКОНЪЮГАТ НА ИХ ОСНОВЕ, ГИБРИДОМА, ТРАНСФЕКТОМА, ТРАНСГЕННОЕ ЖИВОТНОЕ, ЭКСПРЕССИОННЫЙ ВЕКТОР (ВАРИАНТЫ) И НУКЛЕИНОВАЯ КИСЛОТА ДЛЯ ИХ ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ (ВАРИАНТЫ) И СПОСОБ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ, ОПОСРЕДОВАННЫХ ИЛ-15, СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОДУКЦИИ TNF-α И СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОЛИФЕРАЦИИ КЛЕТОК |
-
2004
- 2004-02-25 JP JP2006502466A patent/JP4892335B2/ja not_active Expired - Lifetime
- 2004-02-25 RS YUP-2005/0724A patent/RS20050724A/sr unknown
- 2004-02-25 EA EA200501362A patent/EA015897B1/ru not_active IP Right Cessation
- 2004-02-25 CN CN 200480011288 patent/CN1780856A/zh active Pending
- 2004-02-25 ZA ZA200506724A patent/ZA200506724B/en unknown
- 2004-02-26 AR ARP040100605 patent/AR043405A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1780856A (zh) | 2006-05-31 |
RS20050724A (en) | 2007-11-15 |
EA200501362A1 (ru) | 2006-02-24 |
ZA200506724B (en) | 2007-03-28 |
JP4892335B2 (ja) | 2012-03-07 |
EA015897B1 (ru) | 2011-12-30 |
JP2007528348A (ja) | 2007-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure | ||
FA | Abandonment or withdrawal | ||
FC | Refusal |