JP4872191B2 - Laminated packaging material and laminated packaging bag with reduced generation of pinholes having oxygen barrier properties - Google Patents
Laminated packaging material and laminated packaging bag with reduced generation of pinholes having oxygen barrier properties Download PDFInfo
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本発明は、医療、医薬品や、食品などの分野において、酸素により品質が容易に劣化す
るような、厚みと重みを有する易酸化性内容物を包装・梱包して輸送する目的に使用される酸素バリア性を有するピンホールの発生を低減した積層包装材料および積層包装袋に関する。特に、５００ｍｌ〜１５００ｍｌと大容量の注射剤を柔軟なプラスチック容器に充填してなる、輸液バックの２次外装材料などとして好適に使用される。
The present invention relates to oxygen used for the purpose of packaging, packing and transporting easily oxidizable contents having thickness and weight, such that the quality is easily deteriorated by oxygen in the fields of medicine, pharmaceuticals, foods, etc. The present invention relates to a laminated packaging material and a laminated packaging bag in which occurrence of pinholes having a barrier property is reduced. In particular, it is suitably used as a secondary exterior material for an infusion bag, in which a flexible plastic container is filled with a large volume of 500 ml to 1500 ml of injection.
比較的大容量（５００ｍｌ〜１５００ｍｌ）の注射剤が充填される輸液バックは、近年、ハンドリング（取り扱い）性の良さや、輸液バックの軽量化、ゴミの減容化などの観点から、ガラス瓶、プラスチック成形容器から柔軟なプラスチック包装袋に充填されたものが増えている。 In recent years, infusion bags filled with relatively large volumes (500 ml to 1500 ml) of injections have been recently developed from the viewpoints of ease of handling (handling), weight reduction of infusion bags, volume reduction of garbage, etc. An increasing number of plastic containers are filled from molded containers.
輸液バックに充填されるアミノ酸液や糖・電解質液などの薬液は、酸素によって著しく変質しやすく、更には直接体内に薬液を注入する事からも、薬液が直接接触する輸液バックは無添加のポリオレフィン材料を用いる事が多く、酸素バリア性はほとんど無いに等しい。そのため、輸液バックを大気中に放置しておくと、大気中の酸素が輸液バックを透過し経時的に薬液を変質させてしまい、沈殿物の生成や、薬液の黄変、臭いの発生などの現象が起こり、実際に使用する事ができなくなる。そこで、近年は薬液の充填された輸液バックを酸素バリア性の高い透明包装材料で２次包装することが行われている。 Chemical solutions such as amino acid solution and sugar / electrolyte solution filled in the infusion bag are remarkably easily altered by oxygen. In addition, the infusion bag that is in direct contact with the drug solution is an additive-free polyolefin because it is directly injected into the body. Many materials are used, and there is almost no oxygen barrier property. Therefore, if the infusion bag is left in the atmosphere, oxygen in the atmosphere permeates the infusion bag and changes the chemical solution over time, resulting in the formation of precipitates, yellowing of the chemical solution, generation of odor, etc. A phenomenon occurs and it cannot be used in practice. Therefore, in recent years, infusion bags filled with a chemical solution are secondarily packaged with a transparent packaging material having a high oxygen barrier property.
この輸液バック外装材には上記しているように酸素バリア性が高く要求されるため、Ｐポリ塩化ビニリデン（ＶＤＣ）コートを施したプラスチックフィルムや、エチレン‐ビニルアルコール共重合体（ＥＶＯＨ）フィルム、ポリビニルアルコール（ＰＶＡ）フィルム、酸化アルミニウムや酸化珪素などを蒸着したポリエステルテレフタレート（ＰＥＴ）フィルムなどがバリア層に用いられた積層包装材料が使用されている。 Since the infusion bag exterior material is required to have high oxygen barrier properties as described above, a plastic film coated with P polyvinylidene chloride (VDC), an ethylene-vinyl alcohol copolymer (EVOH) film, A laminated packaging material in which a polyvinyl alcohol (PVA) film, a polyester terephthalate (PET) film on which aluminum oxide, silicon oxide or the like is deposited is used as a barrier layer is used.
通常はアミノ酸などの高カロリー輸液が充填された輸液バックが上記した輸液外装袋に入れられ、更にダンボールに積載梱包され輸送される。しかし、輸送工程中の振動・衝撃により、輸液外装袋にピンホールが生じる問題があり（１００万袋に１袋のｐｐｍオーダー）、そのため内容物の品質を保持する酸素バリア性が得られなくなる。 Usually, an infusion bag filled with a high-calorie infusion solution such as amino acid is put in the above-mentioned infusion bag, and further packed and transported in cardboard. However, there is a problem that pinholes are generated in the infusion outer packaging bag due to vibration and impact during the transportation process (ppm order of one bag per million bag), and therefore, an oxygen barrier property that maintains the quality of the contents cannot be obtained.
一般的にピンホールは３つの要素が加味して発生する事が多く、（１）屈曲疲労による屈曲ピンホール、（２）包装材料同士が摩耗する、及び内容物容器と２次包装材が摩耗する、あるいは２次包装材とダンボールが摩耗する事による摩耗ピンホール、（３）包装材料の突起部が突き刺すことによる突き刺しピンホールに大別される。上記、輸送工程におけるピンホールはこれらの３つの要素が複合して発生すると考えられる。 In general, pinholes often occur due to three factors: (1) bent pinholes due to bending fatigue, (2) wear of packaging materials, and wear of contents containers and secondary packaging materials Or a wear pinhole due to wear of the secondary packaging material and cardboard, and (3) a piercing pinhole due to the piercing of the projection of the packaging material. The above-mentioned pinhole in the transportation process is considered to be generated by combining these three elements.
本発明は、従来、包装袋の輸送工程上での問題点を解決するためになされたものであり、医療、医薬品や、食品などの分野において、酸素により品質が容易に劣化するような、例えば、５００ｍｌ〜１５００ｍｌと大容量の注射剤などのような厚みと重みを有する易酸化性内容物を包装・梱包して輸送する目的に使用される酸素バリア性を有するピンホールの発生を低減した積層包装材料および積層包装袋を提供することを目的とする。 The present invention has heretofore been made to solve the problems in the packaging bag transport process, and in the fields of medicine, pharmaceuticals, foods, etc., the quality is easily deteriorated by oxygen, for example, Lamination with reduced generation of pinholes having oxygen barrier properties used for packaging and packing and transporting easily oxidizable contents having a thickness and weight, such as large volume injections of 500 ml to 1500 ml An object is to provide a packaging material and a laminated packaging bag.
上記課題を解決するために、すなわち、
請求項１に係る発明は、少なくとも、２軸延伸ポリプロピレン（ＯＰＰ）フィルム層、酸素バリア層、多層熱融着（シーラント）層とがこの順序で積層された酸素バリア性を有するピンホールの発生を低減した積層包装材料であって、
前記２軸延伸ポリプロピレンフィルム層と酸素バリア層とは押し出しラミネーション法
によって積層され、前記酸素バリア層と多層熱融着層とはドライラミネーション法によって積層されており、かつ、前記多層熱融着層は少なくとも低密度層と高密度層とを２層以上からなり、その低密度層が酸素バリア層側に配置されて、かつ、少なくともその低密度層に溶液重合法によりメタロセン触媒によって炭素数８個（Ｃ８）のα−オレフィンとエチレンから重合された直鎖状低密度ポリエチレン（ｍ−ＬＬＤＰＥ）を用いることを特徴とする酸素バリア性を有するピンホールの発生を低減した積層包装材料である。
In order to solve the above problem, that is,
The engagement Ru inventions in
The biaxially oriented polypropylene film layer and the oxygen barrier layer are extruded and laminated.
The oxygen barrier layer and the multilayer heat-sealed layer are laminated by a dry lamination method, and the multilayer heat-sealed layer comprises at least a low-density layer and a high-density layer. The low-density layer is arranged on the oxygen barrier layer side, and at least the low-density layer is polymerized from an α-olefin having 8 carbon atoms (C8) and ethylene by a metallocene catalyst by a solution polymerization method. It is a laminated packaging material with reduced generation of pinholes having an oxygen barrier property, characterized by using density polyethylene (m-LLDPE) .
請求項２に係る発明は、
前記多層熱融着層を構成する低密度層と高密度層との密度差が、０．０２６ｇ／ｃｍ ３ であり、酸素バリア層側に配置する低密度層の密度が０．９２０ｇ／ｃｍ３未満で、低密度層の厚さが多層熱融着層総厚の６０％以上であり、一方、高密度層の密度が０．９２０ｇ／ｃｍ３以上で、高密度層の厚さが多層熱融着層総厚の４０％以下であることを特徴と
する請求項１記載の酸素バリア性を有するピンホールの発生を低減した積層包装材料で
ある。
The invention according to
Difference in density between the low density layer and high density layers constituting the multilayer heat sealable layer is a 0.02 6 g / c m 3, the density of the low density layer positioned on the oxygen barrier layer side 0.920g / in cm less than 3, the thickness of the low density layer has a multilayer heat sealable layer total thickness more than 60%, whereas at a density of the high density layer is 0.920 g / cm 3 or more, the thickness of the dense layer The laminated packaging material with reduced generation of pinholes having an oxygen barrier property according to
請求項３に係る発明は、
請求項１または２記載の酸素バリア性を有するピンホールの発生を低減した積層包装材料を用いてなることを特徴とする積層包装袋である。
Is engaged Ru inventions to claim 3,
A laminated packaging bag comprising the laminated packaging material with reduced generation of pinholes having oxygen barrier properties according to
本発明により、医療、医薬品や、食品などの分野において、酸素により品質が容易に劣化するような、厚みと重みを有する易酸化性内容物を包装・梱包して輸送する目的に使用される酸素バリア性を有するピンホールの発生を低減した積層包装材料および積層包装袋を提供することができる。 According to the present invention, oxygen used for the purpose of packaging, packing and transporting easily oxidizable contents having thickness and weight such that quality is easily deteriorated by oxygen in the fields of medicine, pharmaceuticals, foods, etc. It is possible to provide a laminated packaging material and a laminated packaging bag in which occurrence of pinholes having a barrier property is reduced.
本発明のピンホールの発生を低減した積層包装材料および積層包装袋は、例えば、５００ｍｌ〜１５００ｍｌと大容量の注射剤を柔軟なプラスチック容器に充填してなる輸液バックの２次外装材料などととして好適に用いられる。 The laminated packaging material and laminated packaging bag with reduced occurrence of pinholes according to the present invention are, for example, as a secondary packaging material for an infusion bag in which a flexible plastic container is filled with 500 ml to 1500 ml of a large volume injection. Preferably used.
以下、本発明の一実施例としての実施の形態について具体的に説明する。図１は、本発明のピンホールの発生を低減した積層包装材料の一例を示す断面図である。図に示すように、本発明のピンホールの発生を低減した積層包装材料の構成は、２軸延伸ポリプロピレン（ＯＰＰ）フィルム層（ａ）、接着樹脂層（ｂ）、酸素バリア層（ｃ）、接着剤層（ｄ）、多層熱融着（シーラント）層（ｅ）からなり、多層熱融着層（ｅ）が低密度層（ｅ１）と高密度層（ｅ２）とから構成されて、低密度層（ｅ１）が酸素バリア層（ｃ）側に配置されている。 Hereinafter, an embodiment as an example of the present invention will be described in detail. FIG. 1 is a cross-sectional view showing an example of a laminated packaging material with reduced occurrence of pinholes according to the present invention. As shown in the figure, the structure of the laminated packaging material with reduced occurrence of pinholes according to the present invention includes a biaxially oriented polypropylene (OPP) film layer (a), an adhesive resin layer (b), an oxygen barrier layer (c), It consists of an adhesive layer (d) and a multilayer heat sealing (sealant) layer (e), and the multilayer heat sealing layer (e) is composed of a low density layer (e1) and a high density layer (e2), and is low The density layer (e1) is disposed on the oxygen barrier layer (c) side.
本発明における２軸延伸ポリプロピレン（ＯＰＰ）フィルム層（ａ）は、各社ポリプロピレンフィルムメーカーから上市されてい２軸延伸ポリプロピレンフィルムなら特に制限はなく、厚みは３０μｍ以下が望ましい。厚みが、３０μｍを超えると積層包装材料の剛性が増大することで耐屈曲性が減少し、耐ピンホール性が低下する。 The biaxially stretched polypropylene (OPP) film layer (a) in the present invention is not particularly limited as long as it is a biaxially stretched polypropylene film marketed by a polypropylene film manufacturer of each company, and the thickness is desirably 30 μm or less. When the thickness exceeds 30 μm, the rigidity of the laminated packaging material increases, so that the bending resistance decreases and the pinhole resistance decreases.
本発明における接着樹脂層（ｂ）は、押し出しラミネーションで使用可能なポリオレフィン樹脂であるなら各社から上市されているものを使用することができ、密度は０．９２０ｇ／ｃｍ３以下であり、溶融フロー速度は加工適性を考慮して、４〜１５ｇ／１０ｍｉｎ．が望ましい。押し出し樹脂の厚みは３０μｍ以下でありことが望ましい。厚みが、３０μｍを超えると積層包装材料の剛性が増大することで耐屈曲性が減少し、耐ピンホール性が低下する。 As the adhesive resin layer (b) in the present invention, any commercially available polyolefin resin that can be used for extrusion lamination can be used. The density is 0.920 g / cm 3 or less, and the melt flow The speed is 4 to 15 g / 10 min. Is desirable. The thickness of the extruded resin is desirably 30 μm or less. When the thickness exceeds 30 μm, the rigidity of the laminated packaging material increases, so that the bending resistance decreases and the pinhole resistance decreases.
本発明における酸素バリア層（ｃ）は、酸化アルミニウムや、酸化珪素を蒸着したガスバリア性フィルムやエチレン−ビニルアルコール共重合（ＥＶＯＨ）フィルム、ポリビニルアルコール（ＰＶＡ）フィルムなどが使用でき、厚みは１５μｍ前後が望ましい。 As the oxygen barrier layer (c) in the present invention, aluminum oxide, a gas barrier film deposited with silicon oxide, an ethylene-vinyl alcohol copolymer (EVOH) film, a polyvinyl alcohol (PVA) film or the like can be used, and the thickness is about 15 μm. Is desirable.
本発明における接着剤層（ｄ）は、ドライラミネーションに用いられる２液硬化型ウレタン系接着剤ならどれも使用可能であり、乾燥時の塗布量は１．５〜３．５ｇ／ｍ２程度であれば接着強度の観点からも望ましい。 As the adhesive layer (d) in the present invention, any two-component curable urethane adhesive used for dry lamination can be used, and the coating amount when dried is about 1.5 to 3.5 g / m 2 . If present, it is also desirable from the viewpoint of adhesive strength.
本発明における多層熱融着層（ｅ）は、少なくとも低密度層を有し、その低密度層が酸素バリア層側に配置されて、かつ、その低密度層に溶液重合法によりメタロセン触媒によって炭素数８個（Ｃ８）のα−オレフィンとエチレンから重合された直鎖状低密度ポリエチレン（ｍ−ＬＬＤＰＥ）を用いる。少なくとも低密度層と高密度層の２種以上からなる構成の場合は、低密度層と高密度層との密度差が、０．０２６ｇ／ｃｍ ３ であり、酸素バリア層側に配置する低密度層の密度が０．９２０ｇ／ｃｍ３未満で、低密度層の厚さが多層熱融着層総厚の６０％以上であり、一方、高密度層の密度が０．９２０ｇ／ｃｍ３以上で、高密度層の厚さが多層熱融着層総厚の４０％以下である。Ｃ８溶液重合法によって得られるｍ−ＬＬＤＰＥは、Ｃ４、あるいはＣ６気相重合法に比べて柔らかい膜物性が得られることから、高いピンホール耐性を有する。また、多層熱融着層を上記のような構成とすることで、包装材の腰を柔らかく、屈曲ピンホール耐性を持ち、突き刺し、摩耗によるピンホール耐性を維持することができる。 The multilayer heat-sealing layer (e) in the present invention has at least a low-density layer, the low-density layer is disposed on the oxygen barrier layer side, and the low-density layer is carbonized by a metallocene catalyst by a solution polymerization method. Linear low density polyethylene (m-LLDPE) polymerized from several (C8) α-olefins and ethylene is used. At least in the case of the low-density layer and composed of two or more dense layers structure, the density difference between the low-density layer and the dense layer is a 0.02 6 g / c m 3, disposed in the oxygen barrier layer side The density of the low-density layer is less than 0.920 g / cm 3 and the thickness of the low-density layer is 60% or more of the total thickness of the multilayer heat-sealing layer, while the density of the high-density layer is 0.920 g / cm 3. 3 or more, and the thickness of the high-density layer is 40% or less of the total thickness of the multilayer heat-sealing layer. M-LLDPE obtained by the C8 solution polymerization method has a high pinhole resistance because a softer film property is obtained as compared with the C4 or C6 gas phase polymerization method. In addition, by configuring the multilayer heat-sealing layer as described above, the waist of the packaging material is soft, has a bent pinhole resistance, and can maintain the pinhole resistance due to piercing and abrasion.
本発明のピンホールの発生を低減した積層包装材料を用いて、様々の包装形態の積層袋に成形して用いることができる。特に、５００ｍｌ〜１５００ｍｌと大容量の注射剤を柔軟なプラスチック容器に充填してなる、輸液バックの２次外装材料などとして好適に使用される。 Using the laminated packaging material with reduced generation of pinholes of the present invention, it can be molded into laminated bags of various packaging forms. In particular, it is suitably used as a secondary exterior material for an infusion bag, in which a flexible plastic container is filled with a large volume of 500 ml to 1500 ml of injection.
以下、本発明の実施例を具体的に説明する。 Examples of the present invention will be specifically described below.
［実施例１］
下記に示す材料を用いて、図１に示す構成の本発明のピンホールの発生を低減した積層包装材料を作成した。
（ａ）ＯＰＰ層：２軸延伸ポリプロピレン（ＯＰＰ）フィルム（東セロ（株）製「Ｕ１」、厚さ２０μｍ）
（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂「ジェイレクス」（ＬＤＰＥ、密度０．９１８ｇ／ｃｍ３、溶融フロー速度７ｇ／１０ｍｉｎ．、厚さ２０μｍ）（日本ポリオレフィン（株）製「ＪＨ６０７Ｄ」）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（凸版印刷（株）製「ＧＬ−ＡＥＹ」、厚さ１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（三井武田ケミカル（株）製「Ａ５１５」、乾燥塗布量３ｇ／ｍ２）
（ｅ）熱融着層：メタロセン触媒重合ＬＬＤＰＥ（２層、低密度層：Ｃ８溶液重合法、中密度層：Ｃ６気相重合法、総厚６０μｍ）
酸素バリア層側←（密度０．９０５ｇ／ｃｍ３、厚さ４０μｍ‖密度０．９３１ｇ／ｃｍ３、厚さ２０μｍ）
[Example 1]
Using the materials shown below, a laminated packaging material having the configuration shown in FIG.
(A) OPP layer: biaxially oriented polypropylene (OPP) film (“U1” manufactured by Tosero Co., Ltd., thickness 20 μm)
(B) Adhesive resin layer: highly functional extruded laminate resin “JEREX” (LDPE, density 0.918 g / cm 3 , melt flow rate 7 g / 10 min., Thickness 20 μm) (“JH607D” manufactured by Nippon Polyolefin Co., Ltd.)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (“GL-AEY” manufactured by Toppan Printing Co., Ltd., thickness 15 μm)
(D) Adhesive layer: two-component curable urethane-based adhesive (“A515” manufactured by Mitsui Takeda Chemical Co., Ltd., dry coating amount: 3 g / m 2 )
(E) Thermal fusion layer: metallocene catalyst polymerization LLDPE (two layers, low density layer: C8 solution polymerization method, medium density layer: C6 gas phase polymerization method, total thickness 60 μm)
Oxygen barrier layer side ← (density 0.905 g / cm 3 , thickness 40 μm‖density 0.931 g / cm 3 , thickness 20 μm)
［比較例１］
下記に示す材料を用いて、本発明のピンホールの発生を低減した積層包装材料と比較するための積層包装材料を作成した。
（ａ）ＯＰＰ層：２軸延伸ポリプロピレン（ＯＰＰ）フィルム（東セロ（株）製「Ｕ１」
、厚さ２０μｍ）
（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂「ジェイレクス」（ＬＤＰＥ、密度０．９１８ｇ／ｃｍ３、溶融フロー速度７ｇ／１０ｍｉｎ．、２０μｍ）（日本ポリオレフィン（株）製「ＪＨ６０７Ｄ」）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（凸版印刷（株）製「ＧＬ−ＡＥＹ」、１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（三井武田ケミカル（株）製「Ａ５１５」、乾燥塗布量３ｇ／ｍ２）
（ｅ）熱融着層：メタロセン触媒重合ＬＬＤＰＥ（２層、低密度・中密度層：Ｃ６気相重合法、総厚６０μｍ）
酸素バリア層側←（密度０．９０４ｇ／ｃｍ３、厚さ４０μｍ‖密度０．９３１ｇ／ｃｍ３、厚さ２０μｍ）
[Comparative Example 1]
Using the materials shown below, a laminated packaging material for comparison with the laminated packaging material with reduced occurrence of pinholes of the present invention was prepared.
(A) OPP layer: biaxially oriented polypropylene (OPP) film (“U1” manufactured by Tosero Co., Ltd.)
, Thickness 20μm)
(B) Adhesive resin layer: highly functional extruded laminate resin “JEREX” (LDPE, density 0.918 g / cm 3 , melt flow rate 7 g / 10 min., 20 μm) (“JH607D” manufactured by Nippon Polyolefin Co., Ltd.)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (“GL-AEY” manufactured by Toppan Printing Co., Ltd., 15 μm)
(D) Adhesive layer: two-component curable urethane-based adhesive (“A515” manufactured by Mitsui Takeda Chemical Co., Ltd., dry coating amount: 3 g / m 2 )
(E) Thermal fusion layer: metallocene catalyst polymerization LLDPE (two layers, low density / medium density layer: C6 gas phase polymerization method, total thickness 60 μm)
Oxygen barrier layer side ← (density 0.904 g / cm 3, thickness 40μm‖ density 0.931 g / cm 3, a thickness of 20 [mu] m)
［比較例２］
下記材料を用いて、本発明のピンホールの発生を低減した積層包装材料と比較するための積層包装材料を作成した。
（ａ）ＯＰＰ層：２軸延伸ポリプロピレン（ＯＰＰ）フィルム（東セロ（株）製「Ｕ１」、２０μｍ）
（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂「ジェイレクス」（ＬＤＰＥ、密度０．９１８ｇ／ｃｍ３、溶融フロー速度７ｇ／１０ｍｉｎ．、２０μｍ）（日本ポリオレフィン（株）製「ＪＨ６０７Ｄ」）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（凸版印刷（株）製「ＧＬ−ＡＥＹ」、厚さ１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（三井武田ケミカル（株）製「Ａ５１５」、乾燥塗布量３ｇ／ｍ２）
（ｅ）熱融着層：メタロセン触媒重合ＬＬＤＰＥ（単層、低密度層：Ｃ８溶液重合法、総厚６０μｍ）
酸素バリア層側←（密度０．９０５ｇ／ｃｍ３、厚さ６０μｍ）
[Comparative Example 2]
Using the following materials, a laminated packaging material for comparison with the laminated packaging material with reduced occurrence of pinholes of the present invention was prepared.
(A) OPP layer: biaxially oriented polypropylene (OPP) film (“U1”, 20 μm, manufactured by Tosero Co., Ltd.)
(B) Adhesive resin layer: highly functional extruded laminate resin “JEREX” (LDPE, density 0.918 g / cm 3 , melt flow rate 7 g / 10 min., 20 μm) (“JH607D” manufactured by Nippon Polyolefin Co., Ltd.)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (“GL-AEY” manufactured by Toppan Printing Co., Ltd., thickness 15 μm)
(D) Adhesive layer: two-component curable urethane-based adhesive (“A515” manufactured by Mitsui Takeda Chemical Co., Ltd., dry coating amount: 3 g / m 2 )
(E) Heat fusion layer: metallocene catalyst polymerization LLDPE (single layer, low density layer: C8 solution polymerization method, total thickness 60 μm)
Oxygen barrier layer side ← (density 0.905 g / cm 3 , thickness 60 μm)
［比較例３］
本発明のピンホールの発生を低減した積層包装材料と比較するために、ＯＰＰ層（厚さ３０μｍ／ＰＶＡ層（厚さ１２μｍ）／ＬＬＤＰＥ（厚さ９０μｍ）の構成からなる市場品を使用した。
[Comparative Example 3]
In order to compare with the laminated packaging material with reduced occurrence of pinholes of the present invention, a marketed product having a configuration of OPP layer (thickness 30 μm / PVA layer (thickness 12 μm) / LLDPE (thickness 90 μm)) was used.
上記実施例１及び比較例１〜３で得られた積層包装材料を用いて、下記の方法に基づいて耐ピンホール性を評価した。 Using the laminated packaging materials obtained in Example 1 and Comparative Examples 1 to 3 , pinhole resistance was evaluated based on the following method.
＜ピンホール評価方法＞
上記実施例１及び比較例１〜３で得られた積層包装材料をヒートシールした後、輸液バックを充填し残りの一方をヒートシールし輸液外装袋を作成した。作成した輸液外装袋を２行×５段でダンボールに梱包積載し、下記条件で振動試験を行い。ダンボール３箱分（３０袋）の輸液外装袋のピンホール数をカウントした。
<Pinhole evaluation method>
After heat-sealing the laminated packaging materials obtained in Example 1 and Comparative Examples 1 to 3 , an infusion bag was filled and the other one was heat-sealed to prepare an infusion bag. The created infusion outer packaging bag is packed and loaded on cardboard in 2 rows x 5 rows, and a vibration test is performed under the following conditions. The number of pinholes in the infusion outer packaging bag for 3 cardboard boxes (30 bags) was counted.
振動条件：振動加速度±４Ｇ、振動数１１Ｈｚ、垂直方向３０分＋水平方向１５分で２回、計１時間。 Vibration conditions: vibration acceleration ± 4G, vibration frequency 11 Hz, vertical direction 30 minutes + horizontal direction 15 minutes, total 1 hour.
（ａ）：２軸延伸ポリプロピレン（ＯＰＰ）フィルム層
（ｂ）：押し出しラミネーション用接着樹脂層
（ｃ）：酸素バリア層
（ｄ）：ドライラミネーション用接着剤層
（ｅ）：多層熱融着層
（ｅ１）：低密度層
（ｅ２）：高密度層
(A): Biaxially oriented polypropylene (OPP) film layer (b): Adhesive resin layer for extrusion lamination (c): Oxygen barrier layer (d): Adhesive layer for dry lamination (e): Multilayer heat-sealing layer ( e1): Low density layer (e2): High density layer
Claims (3)
前記２軸延伸ポリプロピレンフィルム層と酸素バリア層とは押し出しラミネーション法によって積層され、前記酸素バリア層と多層熱融着層とはドライラミネーション法によって積層されており、かつ、前記多層熱融着層は少なくとも低密度層と高密度層とを２層以上からなり、その低密度層が酸素バリア層側に配置されて、かつ、少なくともその低密度層に溶液重合法によりメタロセン触媒によって炭素数８個（Ｃ８）のα−オレフィンとエチレンから重合された直鎖状低密度ポリエチレン（ｍ−ＬＬＤＰＥ）を用いることを特徴とする酸素バリア性を有するピンホールの発生を低減した積層包装材料。 At least a biaxially oriented polypropylene (OPP) film layer, an oxygen barrier layer, and a multilayer heat-sealing (sealant) layer are laminated packaging materials in which the generation of pinholes having an oxygen barrier property is reduced in this order. ,
The biaxially stretched polypropylene film layer and the oxygen barrier layer are laminated by an extrusion lamination method, the oxygen barrier layer and the multilayer heat fusion layer are laminated by a dry lamination method, and the multilayer heat fusion layer is At least the low-density layer and the high-density layer consist of two or more layers, the low-density layer is disposed on the oxygen barrier layer side, and at least the low-density layer has 8 carbon atoms by a metallocene catalyst by a solution polymerization method ( A laminated packaging material with reduced generation of pinholes having oxygen barrier properties, characterized by using linear low density polyethylene (m-LLDPE) polymerized from an α-olefin of C8) and ethylene.
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| JP2018030313A (en) * | 2016-08-25 | 2018-03-01 | 凸版印刷株式会社 | Laminate film for package |
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| JP4076034B2 (en) * | 1998-05-19 | 2008-04-16 | 大日本印刷株式会社 | Gas barrier multilayer heat seal film and bag body using the same |
| JP4043598B2 (en) * | 1998-05-19 | 2008-02-06 | 大日本印刷株式会社 | Gas barrier multilayer heat seal film and bag body using the same |
| WO2004011252A1 (en) * | 2002-07-25 | 2004-02-05 | Toppan Printing Co., Ltd. | Laminated packaging material and packaging bag |
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