JP4385689B2 - Laminate with suppressed generation of pinholes and infusion bag package using the laminate - Google Patents
Laminate with suppressed generation of pinholes and infusion bag package using the laminate Download PDFInfo
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- JP4385689B2 JP4385689B2 JP2003316379A JP2003316379A JP4385689B2 JP 4385689 B2 JP4385689 B2 JP 4385689B2 JP 2003316379 A JP2003316379 A JP 2003316379A JP 2003316379 A JP2003316379 A JP 2003316379A JP 4385689 B2 JP4385689 B2 JP 4385689B2
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- 238000001802 infusion Methods 0.000 title claims description 23
- 239000010410 layer Substances 0.000 claims description 65
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 30
- 239000001301 oxygen Substances 0.000 claims description 30
- 229910052760 oxygen Inorganic materials 0.000 claims description 30
- 230000004888 barrier function Effects 0.000 claims description 28
- 229920000092 linear low density polyethylene Polymers 0.000 claims description 17
- 239000004707 linear low-density polyethylene Substances 0.000 claims description 17
- 238000004806 packaging method and process Methods 0.000 claims description 13
- 230000004927 fusion Effects 0.000 claims description 12
- 239000004743 Polypropylene Substances 0.000 claims description 10
- -1 polypropylene Polymers 0.000 claims description 10
- 229920001155 polypropylene Polymers 0.000 claims description 10
- 239000012790 adhesive layer Substances 0.000 claims description 9
- 239000004840 adhesive resin Substances 0.000 claims description 8
- 229920006223 adhesive resin Polymers 0.000 claims description 8
- 229920006284 nylon film Polymers 0.000 claims description 7
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims description 7
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000012793 heat-sealing layer Substances 0.000 claims description 4
- 229910052814 silicon oxide Inorganic materials 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- 238000009820 dry lamination Methods 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 238000003475 lamination Methods 0.000 claims description 3
- 239000012968 metallocene catalyst Substances 0.000 claims description 3
- 239000012476 oxidizable substance Substances 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 9
- 239000005022 packaging material Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229920000098 polyolefin Polymers 0.000 description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Description
本発明は、内容物が易酸化性物質であるために酸素バリア性を有する積層透明包装材料において、厚みと重みのある物を包装・梱包して輸送した際に、ピンホールの発生を抑制した積層体およびその積層体を用いた積層包装袋に関する。さらに、詳細には、本発明の積層体は、医療、医薬品、食品などの分野において、酸素の侵入により品質を容易に劣化させるような内容物が収納されている包装材料に利用することができ、とりわけ、５００ｍｌ〜１５００ｍｌと大容量の注射剤を柔軟なプラスチック容器に充填してなる、輸液バックの２次外装材料として有用である。 In the laminated transparent packaging material having oxygen barrier properties because the contents are an easily oxidizable substance, the present invention suppresses the occurrence of pinholes when packaging and packing with thickness and weight. The present invention relates to a laminated body and a laminated packaging bag using the laminated body. More specifically, the laminate of the present invention can be used in packaging materials that contain contents that easily deteriorate in quality due to oxygen intrusion in the fields of medicine, pharmaceuticals, foods, and the like. In particular, it is useful as a secondary exterior material for an infusion bag in which a flexible plastic container is filled with 500 ml to 1500 ml of a large volume of injection.
比較的大容量（５００ｍｌ〜１５００ｍｌ）の注射剤が充填される輸液バックは、近年、ハンドリング（取り扱い）性の良さや、輸液バックの軽量化、ゴミの減容化などの観点から、ガラス瓶、プラスチック成形容器から柔軟なプラスチック包装袋に充填されたものが増えている。 In recent years, infusion bags filled with relatively large volumes (500 ml to 1500 ml) of injections have been recently developed from the viewpoints of ease of handling (handling), weight reduction of infusion bags, volume reduction of garbage, etc. An increasing number of plastic containers are filled from molded containers.
輸液バックに充填されるアミノ酸液や糖・電解質液などの薬液は、酸素によって著しく変質しやすく、更には直接体内に薬液を注入することからも、薬液が直接接触する輸液バックは無添加のポリオレフィン材料を用いることが多く、酸素バリア性はほとんど無いに等しい。そのため、輸液バックを大気中に放置しておくと、大気中の酸素が輸液バックを透過し経時的に薬液を変質させてしまい、沈殿物の生成や、薬液の黄変、臭いの発生などの現象が起こる。そこで、近年は薬液の充填された輸液バックを酸素バリア性の高い透明包装材料で２次包装することが行われている。 Chemical solutions such as amino acid solution and sugar / electrolyte solution filled in the infusion bag are easily changed by oxygen, and since the medicinal solution is directly injected into the body, the infusion bag that is in direct contact with the solution is an additive-free polyolefin Many materials are used, and there is almost no oxygen barrier property. Therefore, if the infusion bag is left in the atmosphere, oxygen in the atmosphere permeates the infusion bag and changes the chemical solution over time, resulting in the formation of precipitates, yellowing of the chemical solution, generation of odor, etc. A phenomenon occurs. Therefore, in recent years, infusion bags filled with a chemical solution are secondarily packaged with a transparent packaging material having a high oxygen barrier property.
この輸液バック外装材には上記しているように、酸素バリア性が高く要求されるため、ポリ塩化ビニリデン（ＰＶＤＣ）コートを施したプラスチックフィルムや、エチレン‐ビニルアルコール共重合体（ＥＶＯＨ）フィルム、ポリビニルアルコール（ＰＶＡ）フィルム、酸化アルミニウムや酸化珪素などを蒸着したポリエステルテレフタレート（ＰＥＴ）フィルムなどがバリア層に用いられた積層包装材料が使用されている。 As described above, since the oxygen barrier property is required to be high for this infusion bag exterior material, a plastic film coated with polyvinylidene chloride (PVDC), an ethylene-vinyl alcohol copolymer (EVOH) film, A laminated packaging material in which a polyvinyl alcohol (PVA) film, a polyester terephthalate (PET) film on which aluminum oxide, silicon oxide or the like is deposited is used as a barrier layer is used.
通常は、アミノ酸などの高カロリー輸液が充填された輸液バックが上記した輸液外装袋に入れられ、更にダンボールに積載梱包され輸送される。輸送工程中の振動・衝撃により、輸液外装袋にピンホールが生じることがあり（１００万袋に１袋のｐｐｍオーダー）、そのため酸素バリア性が維持できなくなる。 Usually, an infusion bag filled with a high-calorie infusion such as amino acids is placed in the above-described infusion bag, and further packed and transported in cardboard. Due to vibrations and impacts during the transportation process, pinholes may occur in the infusion outer packaging bag (ppm order of one bag per million bag), and oxygen barrier properties cannot be maintained.
一般的に、ピンホールは３つの要素が加味して発生することが多く、（１）屈曲疲労による屈曲ピンホール、（２）包装材料同士が摩耗することによる摩耗ピンホール、（３）包装材料の突起部が突き刺すことによる突き刺しピンホールに大別される。上記、輸送工程におけるピンホールはこれらの３つの要素が複合して発生すると考えられる。 Generally, pinholes are often generated by taking into account three factors: (1) bent pinholes caused by bending fatigue, (2) worn pinholes caused by wear of packaging materials, and (3) packaging materials. It is roughly classified into a piercing pinhole by the piercing of the protruding portion. The above-mentioned pinhole in the transportation process is considered to be generated by combining these three elements.
本発明は、輸送工程上での実情を鑑みて、従来技術の問題点を解決するためになされたものであり、輸送工程において包装材料にピンホールが生じることによる、内容液の変質を防ぐ、ピンホールの発生を抑制した積層体およびその積層体を用いた包装袋を提供することを課題とする。 The present invention has been made in order to solve the problems of the prior art in view of the actual situation on the transportation process, and prevents alteration of the content liquid due to the occurrence of pinholes in the packaging material in the transportation process. It aims at providing the laminated body which suppressed generation | occurrence | production of a pinhole, and the packaging bag using the laminated body.
上記課題を解決するために、請求項１記載の発明は、２軸延伸ポリプロピレンフィルムからなる延伸フィルム基材上に、２軸延伸ナイロンフィルムを具備する酸素バリア層、密度勾配を持った２層以上の多層構成の直鎖状低密度ポリエチレンからなる熱融着層とが、この順序で積層された易酸化性物質を収納する酸素バリア性を有する積層体であって、
前記延伸フィルム基材と酸素バリア層とは接着樹脂層を介して押出ラミネーションによって積層され、酸素バリア層と熱融着層とは２液硬化型ウレタン接着剤からなる接着剤層を介してドライラミネーションによって積層され、前記熱融着層は、密度が低い直鎖状低密度ポリエチレンからなる層を酸素バリア層側に配置していることを特徴とするピンホールの発生を抑制した積層体である。
In order to solve the above-mentioned problems, the invention according to claim 1 is characterized in that an oxygen barrier layer comprising a biaxially stretched nylon film on a stretched film substrate made of a biaxially stretched polypropylene film , two or more layers having a density gradient And a heat-sealing layer composed of a linear low-density polyethylene having a multilayer structure, and a laminate having an oxygen barrier property containing the oxidizable substances laminated in this order,
The stretched film substrate and the oxygen barrier layer are laminated by extrusion lamination via an adhesive resin layer, and the oxygen barrier layer and the heat fusion layer are dry lamination via an adhesive layer made of a two-component curable urethane adhesive. The thermal fusion layer is a laminate that suppresses the generation of pinholes, characterized in that a layer made of linear low density polyethylene having a low density is disposed on the oxygen barrier layer side .
請求項２記載の発明は、前記酸素バリア層は、酸化アルミニウムや、酸化珪素を蒸着した２軸延伸ナイロンフィルムからなることを特徴とするピンホールの発生を抑制した積層体である。
According to a second aspect of the present invention, the oxygen barrier layer is made of a biaxially stretched nylon film on which aluminum oxide or silicon oxide is vapor-deposited .
請求項３記載の発明は、前記熱融着層は、密度が低い直鎖状低密度ポリエチレンからなる層が６０％以上占めていることを特徴とするピンホールの発生を抑制した積層体である。
The invention according to claim 3 is a laminate that suppresses the generation of pinholes , characterized in that the heat- sealing layer occupies 60% or more of a linear low-density polyethylene layer having a low density. .
請求項４記載の発明は、前記熱融着層は、メタロセン触媒を用いて重合した直鎖状低密度ポリエチレンフィルムからなることを特徴とするピンホールの発生を抑制した積層体である。
Fourth aspect of the present invention, the heat-fusible layer is a laminate of pinholes characterized that you made of linear low density polyethylene film obtained by polymerization using the metallocene catalyst.
請求項５記載の発明は、前記積層体を２次外装材料に用いた外装袋により、輸液バッグを充填包装したことを特徴とする輸液バッグ包装体である。 The invention according to claim 5 is an infusion bag package characterized in that an infusion bag is filled and packaged with an exterior bag using the laminate as a secondary exterior material .
本発明により、輸送工程において包装材料にピンホールが生じることによる、内容液の変質を防ぐ、ピンホールの発生を抑制した積層体およびその積層体を用いた包装袋を提供することができる。 By this invention, the laminated body which suppressed generation | occurrence | production of the content liquid by suppressing the generation | occurrence | production of a pinhole by the pinhole arising in a packaging material in a transport process, and the packaging bag using the laminated body can be provided.
また、本発明のピンホールの発生を抑制した積層体およびその積層体を用いた包装袋は、医療、医薬品、食品などの分野において、酸素の侵入により品質を容易に劣化させるような内容物が収納されている包装材料に利用することができ、とりわけ、５００ｍｌ〜１５００ｍｌと大容量の注射剤を柔軟なプラスチック容器に充填してなる、輸液バックの２次外装材料として好適に用いられる。 In addition, the laminate and the packaging bag using the laminate that suppresses the occurrence of pinholes according to the present invention have contents that easily deteriorate in quality due to oxygen intrusion in fields such as medicine, pharmaceuticals, and foods. It can be used as a packaging material that is housed, and is particularly suitably used as a secondary exterior material for an infusion bag in which a flexible plastic container is filled with a large volume of an injection of 500 ml to 1500 ml.
以下に、本発明の実施の形態の一例について具体的に説明する。図１は、本発明のピンホールの発生を抑制した積層包装袋の側断面図であり、その構成は（ａ）延伸フィルム層、（ｂ）接着性樹脂層、（ｃ）酸素バリア層、（ｄ）接着剤層、（ｅ）熱融着層からなる。 Hereinafter, an example of the embodiment of the present invention will be specifically described. FIG. 1 is a side sectional view of a laminated packaging bag in which the occurrence of pinholes of the present invention is suppressed, and the constitution thereof is (a) stretched film layer, (b) adhesive resin layer, (c) oxygen barrier layer, ( d) It consists of an adhesive layer and (e) a heat fusion layer.
（ａ）延伸フィルム層は、各社ポリプロピレンフィルムメーカーから上市されてい２軸延伸ポリプロピレンフィルムなら特に制限はなく、厚みは３０μｍ以下が望ましい。（ｃ）酸素バリア層は、酸化アルミニウムや、酸化珪素を蒸着したガスバリア性フィルムやエチレン−ビニルアルコール共重合（ＥＶＯＨ）フィルム、ポリビニルアルコール（ＰＶＡ）フィルムなどが使用でき、厚みは１５μｍ前後が望ましい。（ｅ）熱融着層は、各社フィルムメーカから上市されている直鎖状低密度ポリエチレン（ＬＬＤＰＥ）であれば特に制限はなく、密度勾配を持った２層以上の多層構成からなり、密度０．９２ｇ／ｃｍ3以下の低密度層と密度０．９２〜０．９５ｇ／ｃｍ3の中密度層の少なくとも２層以上から構成される。さらには、ＬＬＤＰＥもメタロセン触媒を用いて重合したメタロセンＬＬＤＰＥが有用であり、熱融着層の６０％以上を上記低密度層が占めるのが望ましい。（ｂ）接着樹脂層は、押し出しラミネーションで用いられるポリオレフィン系樹脂であるなら各社から上市されているのもを使用することが可能である。密度は０．８８〜０．９２［ｇ
／ｃｍ3］、溶融フロー速度（ＭＦＲ）は６〜１４［ｇ／１０分］、押し出し樹脂の厚みは、３０μｍ以下であることが加工適性上望ましい。（ｄ）接着剤層は、ドライラミネーションに用いられる２液硬化型ウレタン系接着剤ならどれも使用可能であり、乾燥時の塗布量は１．５〜３．５ｇ／ｍ2程度であれば接着強度の観点からも望ましい。
(A) The stretched film layer is not particularly limited as long as it is a biaxially stretched polypropylene film marketed by each manufacturer's polypropylene film manufacturer, and the thickness is desirably 30 μm or less. (C) As the oxygen barrier layer, aluminum oxide, a gas barrier film deposited with silicon oxide, an ethylene-vinyl alcohol copolymer (EVOH) film, a polyvinyl alcohol (PVA) film, or the like can be used, and the thickness is preferably about 15 μm. (E) The heat-sealing layer is not particularly limited as long as it is a linear low density polyethylene (LLDPE) marketed by a film manufacturer of each company, and has a multi-layer structure having two or more layers having a density gradient, and has a density of 0. It is composed of at least two layers of a low density layer having a density of 0.92 g / cm 3 or less and a medium density layer having a density of 0.92 to 0.95 g / cm 3 . Further, a metallocene LLDPE polymerized using a metallocene catalyst is also useful as the LLDPE, and it is desirable that the low density layer occupies 60% or more of the heat fusion layer. (B) As the adhesive resin layer, if it is a polyolefin resin used in extrusion lamination, it is possible to use those marketed by various companies. Density is 0.88-0.92 [g
/ Cm 3 ], the melt flow rate (MFR) is 6 to 14 [g / 10 min], and the thickness of the extruded resin is desirably 30 μm or less in view of workability. (D) As the adhesive layer, any two-component curable urethane adhesive used for dry lamination can be used. If the coating amount at the time of drying is about 1.5 to 3.5 g / m 2 , the adhesive layer is bonded. It is also desirable from the viewpoint of strength.
（ａ）延伸フィルム層：２軸延伸ポリプロピレン（ＯＰＰ）フィルム（Ｕ１，東セロ（株）、２０μｍ）
（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂ジェイレクス（ＪＨ６０７Ｄ、日本ポリオレフィン（株）、２０μｍ）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（ＧＬ−ＡＥＹ、凸版印刷（株）、１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（乾燥塗布量３ｇ／ｍ2）
（ｅ）熱融着層：メタロセンＬＬＤＰＥ（多層、６０μｍ）
酸素バリア層側←（密度０．９０５ｇ／ｃｍ3、厚み４０μｍ／密度０．９３１ｇ／ｃｍ3、厚み２０μｍ）
上記の（ａ）／（ｂ）／（ｃ）／（ｄ）／（ｅ）からなる構成の本発明のピンホールの発生を抑制した積層体を得た。
(A) Stretched film layer: Biaxially stretched polypropylene (OPP) film (U1, Tosero Co., Ltd., 20 μm)
(B) Adhesive resin layer: highly functional extruded laminate resin J-Rex (JH607D, Nippon Polyolefin Co., Ltd., 20 μm)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (GL-AEY, Toppan Printing Co., Ltd., 15 μm)
(D) Adhesive layer: Two-component curable urethane adhesive (dry coating amount 3 g / m 2 )
(E) Thermal fusion layer: metallocene LLDPE (multilayer, 60 μm)
Oxygen barrier layer side ← (density 0.905 g / cm 3 , thickness 40 μm / density 0.931 g / cm 3 , thickness 20 μm)
The laminated body which suppressed generation | occurrence | production of the pinhole of this invention of the structure which consists of said (a) / (b) / (c) / (d) / (e) was obtained.
（ａ）延伸フィルム層：２軸延伸ポリプロピレン（ＯＰＰ）フィルム（Ｕ１，東セロ（株）、２０μｍ）
（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂ジェイレクス（ＪＨ６０７Ｄ、日本ポリオレフィン（株）、２０μｍ）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（ＧＬ−ＡＥＹ、凸版印刷（株）、１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（乾燥塗布量３ｇ／ｍ2）
（ｅ）熱融着層：メタロセンＬＬＤＰＥ（単層、６０μｍ）
酸素バリア層側←（密度０．９０５ｇ／ｃｍ3、厚み６０μｍ）
上記の（ａ）／（ｂ）／（ｃ）／（ｄ）／（ｅ）からなる構成の本発明のピンホールの発生を抑制した積層体を得た。
(A) Stretched film layer: Biaxially stretched polypropylene (OPP) film (U1, Tosero Co., Ltd., 20 μm)
(B) Adhesive resin layer: highly functional extruded laminate resin J-Rex (JH607D, Nippon Polyolefin Co., Ltd., 20 μm)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (GL-AEY, Toppan Printing Co., Ltd., 15 μm)
(D) Adhesive layer: Two-component curable urethane adhesive (dry coating amount 3 g / m 2 )
(E) Thermal fusion layer: metallocene LLDPE (single layer, 60 μm)
Oxygen barrier layer side ← (density 0.905 g / cm 3 , thickness 60 μm)
The laminated body which suppressed generation | occurrence | production of the pinhole of this invention of the structure which consists of said (a) / (b) / (c) / (d) / (e) was obtained.
（ａ）延伸フィルム層：２軸延伸ナイロン（ＯＮｙ）フィルム（東洋紡（株）、１５μ）（ｂ）接着樹脂層：高機能性押し出しラミネート樹脂（ＪＨ６０７Ｄ、日本ポリオレフィン（株）、２０μｍ）
（ｃ）酸素バリア層：酸化アルミニウム蒸着２軸延伸ナイロンフィルム（ＧＬ−ＡＥＹ、凸版印刷（株）、１５μｍ）
（ｄ）接着剤層：２液硬化型ウレタン系接着剤（乾燥塗布量３ｇ／ｍ2）
（ｅ）熱融着層：メタロセンＬＬＤＰＥ（多層、６０μｍ）
酸素バリア層側←（密度０．９０５ｇ／ｃｍ3、厚み４０μｍ／密度０．９３１ｇ／ｃｍ3、厚み２０μｍ）
上記の（ａ）／（ｂ）／（ｃ）／（ｄ）／（ｅ）からなる構成の本発明のピンホールの発生を抑制した積層体を得た。
(A) Stretched film layer: Biaxially stretched nylon (ONy) film (Toyobo Co., Ltd., 15 μ) (b) Adhesive resin layer: High-functional extruded laminate resin (JH607D, Nippon Polyolefin Co., Ltd., 20 μm)
(C) Oxygen barrier layer: Aluminum oxide vapor-deposited biaxially stretched nylon film (GL-AEY, Toppan Printing Co., Ltd., 15 μm)
(D) Adhesive layer: Two-component curable urethane adhesive (dry coating amount 3 g / m 2 )
(E) Thermal fusion layer: metallocene LLDPE (multilayer, 60 μm)
Oxygen barrier layer side ← (density 0.905 g / cm 3 , thickness 40 μm / density 0.931 g / cm 3 , thickness 20 μm)
The laminated body which suppressed generation | occurrence | production of the pinhole of this invention of the structure which consists of said (a) / (b) / (c) / (d) / (e) was obtained.
ピンホールを評価する方法として、屈曲試験、摩耗試験、振動試験などを行い、その評価検体のピンホール数を調べる方法があるが、輸送工程の実情を鑑みると振動試験を行うことが適当であり、上記の実施例１〜３で得られた積層体について、下記の振動試験に基づいてピンホール数を評価した。その結果を表１に示す。
＜振動試験評価方法＞
上記実施例で作成した積層フィルムをヒートシールした後、輸液バックを充填し残りの一方をヒートシールし輸液外装袋を作成する。作成した輸液外装袋を２行×５段でダンボールに梱包積載し、下記条件で振動試験を行い。輸液外装袋のピンホール数をカウントした。振動条件：振動加速度±４Ｇ、振動数１１Ｈｚ、垂直方向３０分＋水平方向１５分）の２回合計１時間。
As a method of evaluating pinholes, there are methods such as bending test, wear test, vibration test, etc., and examining the number of pinholes in the evaluation specimen, but it is appropriate to perform a vibration test in view of the actual situation of the transportation process. And about the laminated body obtained in said Examples 1-3, the number of pinholes was evaluated based on the following vibration test. The results are shown in Table 1.
<Vibration test evaluation method>
After heat-sealing the laminated film prepared in the above example, the infusion bag is filled and the other one is heat-sealed to prepare an infusion bag. The created infusion outer packaging bag is packed and loaded on cardboard in 2 rows x 5 rows, and a vibration test is performed under the following conditions. The number of pinholes in the infusion outer packaging bag was counted. Vibration conditions: vibration acceleration ± 4G, vibration frequency 11 Hz, vertical direction 30 minutes + horizontal direction 15 minutes), total 1 hour.
上記の結果からも、本発明におけるラミネート方法を用い、かつ、最表層には延伸ポリプロピレンフィルムを使用し、さらには熱融着層に密度勾配を持った多層ＬＬＤＰＥを使用することで、輸送工程においてピンホールの発生を抑制した積層体およびその積層体を用いた積層包装袋として好適に用いられるものである。 From the above results, in the transportation process, using the laminating method in the present invention, using a stretched polypropylene film as the outermost layer, and further using a multilayer LLDPE having a density gradient in the heat fusion layer. It is suitably used as a laminate in which the generation of pinholes is suppressed and a laminate packaging bag using the laminate.
本発明のピンホールの発生を抑制した積層体およびその積層体を用いた包装袋は、特に医療、医薬品、食品などの分野において、輸送工程において包装材料にピンホールが生じることによる、内容液の変質を防ぐ、ピンホールの発生を抑制した積層体およびその積層体を用いた包装袋として好適に使用できる。 The laminated body and the packaging bag using the laminated body in which the occurrence of pinholes according to the present invention is suppressed, especially in the fields of medical, pharmaceuticals, foods, etc. It can use suitably as a laminated body which prevented generation | occurrence | production, and suppressed generation | occurrence | production of a pinhole, and a packaging bag using the laminated body.
（ａ）：延伸フィルム層（延伸ポリプロピレンフィルム）
（ｂ）：接着樹脂層
（ｃ）：酸素バリア層
（ｄ）：接着剤層
（ｅ）：熱融着層（多層ＬＬＤＰＥ）
(A): Stretched film layer (stretched polypropylene film)
(B): Adhesive resin layer (c): Oxygen barrier layer (d): Adhesive layer (e): Thermal fusion layer (multilayer LLDPE)
Claims (5)
前記延伸フィルム基材と酸素バリア層とは接着樹脂層を介して押出ラミネーションによって積層され、酸素バリア層と熱融着層とは２液硬化型ウレタン接着剤からなる接着剤層を介してドライラミネーションによって積層され、前記熱融着層は、密度が低い直鎖状低密度ポリエチレンからなる層を酸素バリア層側に配置していることを特徴とするピンホールの発生を抑制した積層体。 On a stretched film substrate composed of a biaxially stretched polypropylene film, an oxygen barrier layer comprising a biaxially stretched nylon film, and a heat fusion layer composed of a linear low-density polyethylene having a multi-layer structure of two or more layers having a density gradient And a laminated body having an oxygen barrier property that accommodates oxidizable substances laminated in this order,
The stretched film substrate and the oxygen barrier layer are laminated by extrusion lamination via an adhesive resin layer, and the oxygen barrier layer and the heat fusion layer are dry lamination via an adhesive layer made of a two-component curable urethane adhesive. A layered product that suppresses the generation of pinholes, characterized in that a layer of linear low density polyethylene having a low density is disposed on the oxygen barrier layer side .
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| JP2017024377A (en) * | 2015-07-28 | 2017-02-02 | スタープラスチック工業株式会社 | Film for package, and package |
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| JP5066974B2 (en) * | 2007-03-29 | 2012-11-07 | 凸版印刷株式会社 | Shading packaging material |
| JP5151237B2 (en) * | 2007-05-07 | 2013-02-27 | 凸版印刷株式会社 | Easy-cut packaging material and its packaging container |
| JP5678571B2 (en) * | 2010-10-20 | 2015-03-04 | 大日本印刷株式会社 | Laminate for packaging materials |
| JP2020128069A (en) * | 2019-02-12 | 2020-08-27 | 凸版印刷株式会社 | Laminate for packaging material, and packaging bag using the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2017024377A (en) * | 2015-07-28 | 2017-02-02 | スタープラスチック工業株式会社 | Film for package, and package |
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