JP2006193196A - Packaging material, and outer packaging bag for infusion solution bag using packaging material - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a packaging material which has both oxygen barrier properties and shading properties, and pinhole resistance to inhibit the formation of a pinhole during a transportation process, and to provide an outer packaging bag for an infusion solution bag which outer packaging bag uses the packaging material. <P>SOLUTION: The packaging material is formed by laminating an oriented polypropylene A, a polyethylene B, a film C made by coating an EVOH (ethylene vinyl alcohol copolymer) with an aluminum by vacuum deposition, an adhesive layer D, and a linear low-density polyethylene E in increasing order. With an oriented ethylene vinyl alcohol copolymerized film layer produced by vacuum deposition (VM-EVOH), the packaging material has high shading properties and oxygen properties. The packaging material further contains OPP (oriented polypropylene film layer) in addition to the VM-EVOH, which rids the packaging material of stiffness to give flexibility, thus provides the packaging material with an improvement in pinhole resistance in bending. The packaging material, therefore, prevents the formation of a pinhole due to bending caused by vibrations, thereby offering an improvement in content preservability. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention is a laminated packaging material having oxygen barrier properties and light-shielding properties, and belongs to a light-shielding laminated film having pinhole resistance when packing and transporting an object having a thickness and weight, such as medical, pharmaceutical, food, etc. In this field, it can be used for packaging materials whose quality is easily deteriorated by the ingress of oxygen and light. In particular, it is useful as an exterior bag for protecting an infusion bag in which a flexible plastic container is filled with a liquid agent having a large capacity of 500 ml to 2000 ml.

  In recent years, the one-chamber type and two-chamber type infusion bags filled with a relatively large volume of liquid agent have good handling (handling) properties, weight reduction of infusion bags, volume reduction of garbage, and the like. An increasing number of plastic primary containers are filled (see Patent Document 1).

  Drugs such as amino acid solutions, sugars, and electrolyte solutions filled in infusion bags are significantly altered by oxygen, and vitamins are easily degraded by near-ultraviolet light. On the other hand, since these drugs are directly injected into the body, infusion bags that are in direct contact with these drugs often use containers made of additive-free plastic so that the drugs are not adversely affected. However, the additive-free plastic has almost no oxygen barrier property and near-ultraviolet light shielding property. Therefore, if the infusion bag is left in the atmosphere, sunlight and near-ultraviolet light in fluorescent lamps or oxygen in the atmosphere permeate the infusion bag and alter the drug over time. Therefore, in recent years, secondary packaging has been carried out with an infusion bag having a high oxygen barrier property.

  As described above, this infusion bag exterior bag is required to have a high oxygen barrier property. Therefore, a plastic film coated with PVDC (polyvinylidene chloride), an EVOH (ethylene-vinyl alcohol copolymer) film, Barrier nylon with PVA (polyvinyl alcohol) film, PET (polyester terephthalate) film deposited with aluminum oxide, silicon oxide, etc., stretched nylon film deposited with aluminum oxide, silicon oxide, etc., EVOH layer, MXD6 nylon layer as intermediate layer Laminated packaging materials using the above are widely used (see Patent Documents 2 and 3).

  However, since these oxygen barrier films are transparent and have no light shielding properties, the light shielding properties are imparted by using a plastic film or aluminum foil on which aluminum is deposited.

  Then, the infusion bag filled with the high-calorie infusion consisting of the amino acid, sugar, electrolyte, and vitamin is placed in the infusion bag outer bag for protection, and further packed and packed in cardboard. However, the vibration during the transportation process may cause pinholes in the infusion bag bag. In this case, the oxygen barrier property and the light shielding property cannot be maintained.

There are three types of pinholes depending on the cause. That is, (1) a pinhole due to bending fatigue, (2) a wear pinhole due to wear of the packaging material, and (3) a piercing pinhole due to a piercing of the projection of the packaging material. In pinholes in the transportation process, (1) bending fatigue and (2) wear are considered to be the major causes.
JP 10-314272 A Japanese Patent Laid-Open No. 9-262943 Japanese Patent No. 3202541

  The present invention was made to solve the problems of the prior art, has both oxygen barrier properties and light shielding properties, and has pinhole resistance that suppresses the generation of pinholes during the transportation process. It aims at providing a packaging material and the exterior bag using this packaging material.

  The invention of claim 1 is a packaging material in which an oriented polypropylene film layer (OPP), an oriented ethylene-vinyl alcohol copolymer film layer (VM-EVOH) on which aluminum is deposited, and an unstretched polyolefin layer are laminated in this order. is there.

  According to the invention of claim 2, the oxygen transmission rate is 10.0 ml / m ↑ 2 / day / MPa (JIS K7126 compliant, temperature 30 ° C., humidity 70% RH) or less, and the light transmittance is below the measurement limit. The packaging material according to claim 1.

  In the invention of claim 3, the stretched polypropylene film layer (OPP) and the aluminum-deposited stretched ethylene-vinyl alcohol copolymer film layer (VM-EVOH) are laminated by extrusion lamination using low density polyethylene (LDPE). The stretched ethylene-vinyl alcohol copolymer film layer (VM-EVOH) deposited with aluminum and the unstretched polyolefin layer are laminated by dry lamination using a urethane-based adhesive. The packaging material described.

  Invention of Claim 4 is an exterior bag which packages the infusion bag with which the content comprised from an amino acid, saccharide | sugar, a vitamin, and electrolyte solution is filled, Comprising: One part or all part is any of Claims 1-3 It is comprised from the packaging material as described above, It is an infusion bag exterior bag characterized by the above-mentioned.

  The packaging material according to the first to third aspects of the present invention has a stretched ethylene-vinyl alcohol copolymer film layer (VM-EVOH) deposited with aluminum, and thus has high light shielding properties and oxygen barrier properties. -Since it has EVOH and OPP, the stiffness of the entire packaging material becomes soft, so that pinhole resistance in bending is also improved. For this reason, generation | occurrence | production of the pinhole by the bending | flexion based on a vibration etc. can be prevented, and it becomes possible to improve the content preservation property. Further, since the conventional two layers of the oxygen barrier providing layer and the light shielding layer become one layer, there is an effect of cost reduction.

  Moreover, since the exterior bag which concerns on invention of Claim 4 uses the above packaging materials for the one part or all, it accommodates the infusion bag filled with the chemical | medical agent of about 500 ml-about 2000 ml capacity | capacitance. The contents can be transported without deteriorating.

  The best mode for carrying out the present invention will be specifically described below.

FIG. 1 is a cross-sectional explanatory view of a light-shielding laminated film having pinhole resistance according to the present invention. The structure consists of a stretched polypropylene film layer A, an adhesive layer B, an stretched ethylene-vinyl alcohol copolymer film layer C deposited with aluminum, an adhesive layer D, and an unstretched polyolefin layer E. FIG. 2 is a side view of the infusion bag F filled with the contents. In the figure, G represents a port portion of the infusion bag, and H represents a seal portion (partition) between the first chamber and the second chamber. The seal portion H is configured to be easily peeled off when the infusion solution is used so that the first chamber can communicate with the second chamber.

  The stretched polypropylene film layer (OPP) A needs to be selected as a support for the outer bag and without impairing the flexibility of the entire outer bag. A biaxially stretched propylene film and a uniaxially stretched polypropylene film that have a thickness of 20 μm to 50 μm and are commercially available generally satisfy this condition.

  The adhesive layer B is for adhering the stretched polypropylene film layer A and the stretched ethylene-vinyl alcohol copolymer film layer C. While the low-density polyethylene resin is melt-extruded and coated on one of the films A or C, it does not solidify. And the other film C or A is laminated and adhered. The extruded resin layer B is not particularly limited as long as it is a commercially available low density polyethylene, and the thickness is desirably about 10 to 30 μm. Prior to the melt extrusion coating of the adhesive layer B, an anchor coat layer (AC) may be provided on the extrusion surface of the film.

The stretched ethylene-vinyl alcohol copolymer film layer C deposited with aluminum imparts light shielding properties and oxygen barrier properties to the packaging material, and it is necessary to take care not to impair the flexibility of the entire packaging material. The stretched ethylene-vinyl alcohol copolymer film may have an oxygen permeability of 10.0 ml / m ² / day / MPa (30 ° C., 70% RH) or less according to JIS K7126 in a state where aluminum is vapor-deposited. The thickness is desirably 12 μm to 30 μm.

  Moreover, the aluminum vapor deposition layer provided in the stretched ethylene-vinyl alcohol copolymer film layer imparts light-shielding properties, and the light transmittance measured with a SZ-Σ80 haze meter manufactured by Nippon Denshoku Industries Co., Ltd. is 0. Must be below the measurement limit. The thickness of the vapor deposition layer is desirably 50 nm or more.

  The adhesive layer D adheres the stretched ethylene-vinyl alcohol copolymer film layer C and the unstretched polyolefin layer E, and there is no limitation as long as it is a commercially available two-component curable urethane adhesive, and the thickness is 3 μm. Degree is desirable.

  The unstretched polyolefin layer E serves as a seal layer when making an outer bag, and is not limited as long as it is a polyolefin film having a heat-fusible property on the market, and the thickness is preferably about 40 μm to 100 μm. .

  And this packaging material can be bag-made into a 3-way seal bag, a 4-way seal bag, a gusset bag, etc., and it can be set as the exterior bag based on this invention. Bag making is possible by superimposing the unstretched polyolefin layer E on the inside and heat-sealing the necessary parts. FIG. 3 is an explanatory view showing a state in which the infusion bag F is accommodated in the outer bag thus produced.

<Example 1>
30 μm thick OPP, AC, 15 μm thick polyethylene (PE), 12 μm thick EVOH film (VM-EVOH) with aluminum vacuum, adhesive layer, 60 μm thick linear low density polyethylene (LLDPE) in this order By laminating, a packaging material according to the present invention was produced. In addition, the material of each material is as follows.

OPP: Futamura Chemical Co., Ltd., FOR
AC: Mitsui Takeda Chemical Co., A-3210 / A-3075, solid content 5%, film thickness 1 μm
PE: Nippon Polyethylene Corporation, LC605Y
VM-EVOH: Kuraray Trading Co., Ltd., VM-XL
Adhesive: Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3μ
LLDPE: Tamapoli Co., Ltd., T4-E323B
<Comparative Example 1>
Laminated 30 μm thick OPP, AC, 15 μm thick PE, 25 μm thick oxygen barrier Ny, adhesive, 12 μm thick VM-PET (polyethylene terephthalate film deposited with aluminum), adhesive, 60 μm thick LLDPE in this order The packaging material was manufactured. In addition, the material of each material is as follows.

OPP: Futamura Chemical Co., Ltd., FOR
AC: Mitsui Takeda Chemical Co., A-3210 / A-3075, solid content 5%, film thickness 1 μm
PE: Nippon Polyethylene Corporation, LC605Y
Barrier Ny: Gunze Co., Ltd., HP2
VM-PET: Oike Industry Co., Ltd., MU-V8
Adhesive: Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
LLDPE: Tamapoli Co., Ltd., T4-E323B
<Comparative example 2>
30 μm thick OPP, AC, 15 μm thick PE, 25 μm thick oxygen barrier nylon (Ny), adhesive, 15 μm thick stretched NY (VM-ONy) deposited with aluminum, adhesive, 60 μm thick LDPE Lamination was performed in order to produce a packaging material. In addition, the material of each material is as follows.

OPP: Futamura Chemical Co., Ltd., FOR
AC: Mitsui Takeda Chemical Co., A-3210 / A-3075, solid content 5%, film thickness 1 μm
PE: Nippon Polyethylene Corporation, LC605Y
Barrier Ny: Gunze Co., Ltd., HP2
VM-ONY: Oike Industry Co., Ltd., BCU
Adhesive: Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
LLDPE: Tamapoli Co., Ltd., T4-E323B
<Comparative Example 3>
30 μm thick OPP, AC, 15 μm thick PE, 15 μm thick VM-ONy, adhesive, 15 μm thick VM-ONy, adhesive, and 60 μm thick LDPE were laminated in this order to produce a packaging material. In addition, the material of each material is as follows.

OPP: Futamura Chemical Co., Ltd., FOR
AC: Mitsui Takeda Chemical Co., A-3210 / A-3075, solid content 5%, film thickness 1 μm
PE: Nippon Polyethylene Corporation, LC605Y
VM-ONY: Oike Industry Co., Ltd., BCU
Adhesive: Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
LLDPE: Tamapoli Co., Ltd., T4-E323B
<Example 2>
OPP and AC having a thickness of 30 μm, an adhesive layer, VM-EVOH having a thickness of 12 μm, an adhesive layer, and linear low density polyethylene (LLDPE) having a thickness of 60 μm were laminated in this order to produce a packaging material according to the present invention. In addition, the material of each material is as follows.

OPP: Futamura Chemical Co., Ltd., FOR
VM-EVOH: Kuraray Trading Co., Ltd., VM-XL
Adhesive: Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
LLDPE: Tamapoli Co., Ltd., T4-E323B
The vibration test was conducted in the above comparative example and example.

<Experiment 1>
* Vibration test Vibration conditions: ± 4G (11Hz), total 60 minutes (vertical direction 30 minutes + vertical 15 minutes + horizontal 15 minutes)
Evaluation method: Create a bag of 270mm x 337mm, wrap a Terumo flucalic No. 1 infusion bag (903ml), load and pack it in the same way as the current product, conduct a vibration test under the above conditions, The number of pinholes was counted (10 bags / 1 cardboard). The results are shown in Table 1 together with the oxygen transmission amount. The oxygen permeation amount was measured by MOCON method [ml / m ↑ 2 / day / Mpa] based on JIS K7126 under conditions of a temperature of 30 ° C. and a humidity of 70% RH.

From the above results, it can be seen that Example 1 has reduced pinholes in the vibration test compared to the comparative example. The pinhole generation rate in the actual transportation process is on the order of ppm, and the number of pinholes is zero in all configurations in the vibration test method according to JIS standards. Furthermore, if it is a structure like an Example, the number of pinhole generation | occurrence | production bags is few and it can provide the film which has high oxygen barrier property.

  The present invention provides an infusion bag outer bag that is packaged with an outer bag having a light-shielding property and an oxygen barrier property against contents that easily deteriorate due to the entry of oxygen from the outside and near-ultraviolet light. Useful.

It is a section explanatory view of the present invention. It is side explanatory drawing of the infusion bag which is a content. It is explanatory drawing which shows the state which accommodated the infusion bag F in the exterior bag.

Explanation of symbols

A: Stretched propylene layer B: Extruded resin layer C: Stretched ethylene-vinyl alcohol copolymer film layer D: Adhesive layer E: Unstretched polyolefin layer F: Infusion bag G: Infusion bag port part H: Easy peel layer

Claims (4)

  A packaging material in which an oriented polypropylene film layer (OPP), an oriented ethylene-vinyl alcohol copolymer film layer (VM-EVOH) on which aluminum is deposited, and an unstretched polyolefin layer are laminated in this order.   2. The oxygen transmittance is 10.0 ml / m ↑ 2 / day / MPa (conforming to JIS K7126, temperature 30 ° C., humidity 70% RH) or less, and light transmittance is less than a measurement limit. The packaging material described.   The stretched polypropylene film layer (OPP) and the aluminum-deposited stretched ethylene-vinyl alcohol copolymer film layer (VM-EVOH) are laminated by extrusion lamination using low-density polyethylene (LDPE), and aluminum-deposited stretched ethylene The packaging material according to claim 1 or 2, wherein the vinyl alcohol copolymer film layer (VM-EVOH) and the unstretched polyolefin layer are laminated by a dry laminate using a urethane-based adhesive.   It is an exterior bag which packages the infusion bag with which the content comprised from an amino acid, sugar, a vitamin, and electrolyte solution is filled, Comprising: One part or all part is from the packaging material in any one of Claims 1-3 An infusion bag for an infusion bag, characterized in that it is configured.