JP5066974B2 - Shading packaging material - Google Patents

Description

  The present invention is a laminated packaging material having oxygen barrier properties and light-shielding properties, and belongs to a light-shielding laminated film having pinhole resistance when packing and transporting an object having a thickness and weight, such as medical, pharmaceutical, food, etc. In this field, it can be used for packaging materials whose quality is easily deteriorated by the ingress of oxygen and light. In particular, the present invention relates to a light-shielding packaging material useful as an outer bag for an infusion bag, in which a flexible plastic container is filled with a liquid agent having a large capacity of 500 ml to 2000 ml.

  In recent years, the one-chamber type and two-chamber type infusion bags filled with a relatively large volume of liquid agent have been improved from the viewpoint of good handling (handling), weight reduction of the infusion bag, volume reduction of garbage, etc. An increasing number of plastic primary containers are filled (Patent Document 1, etc.).

  Drugs such as amino acid solution and sugar / electrolyte solution filled in the infusion bag are remarkably altered by oxygen, and vitamins are easily deteriorated by near-ultraviolet light. Furthermore, since the drug is directly injected into the body, an additive-free plastic container is often used as the primary container, and there is almost no oxygen barrier property and near ultraviolet light shielding property. Therefore, if the infusion bag is left in the atmosphere, sunlight, near-ultraviolet light in a fluorescent lamp, and oxygen in the atmosphere permeate the infusion bag and alter the drug over time. Therefore, in recent years, secondary packaging of an infusion bag with a packaging material having a high oxygen barrier property has been performed.

  Since this infusion bag outer bag is required to have a high oxygen barrier property as described above, a plastic film coated with PVDC (polyvinylidene chloride), EVOH (ethylene-vinyl alcohol copolymer) film, PVA (Polyvinyl alcohol) film, PET (polyester terephthalate) film deposited with aluminum oxide or silicon oxide, stretched nylon film deposited with aluminum oxide or silicon oxide, EVOH layer, barrier nylon with MXD6 nylon layer as intermediate layer, etc. Laminated packaging materials in which are used are widely used.

  However, since the oxygen barrier film described above is transparent, it does not have a light shielding property, and an aluminum-deposited plastic film and an aluminum foil laminate film are used to provide the light shielding property.

  Usually, a bag filled with a high-calorie infusion solution consisting of amino acids, sugars, electrolytes and vitamins is placed in the above-mentioned infusion bag and further packed and transported in cardboard. Due to vibration during the transportation process, pinholes may occur in the infusion outer packaging bag, so that the oxygen barrier property and the light shielding property cannot be maintained.

  Pinholes often occur due to three factors: (1) pinholes caused by bending fatigue, (2) wear pinholes caused by wear of packaging materials, and (3) protrusions of packaging materials pierce The pinholes are roughly divided into two, and in the pinholes in the transportation process, the combined cause of (1) bent pinholes and (2) wear pinholes is a major cause. Furthermore, although the laminated film laminated with the aluminum foil does not reach the complete through hole due to bending fatigue, the aluminum foil is cracked and has a large possibility of partially impairing the light shielding property.

As a packaging material in which an infusion bag is stored and pinholes are unlikely to occur, a laminated film is proposed in Patent Document 2, Patent Document 3, and the like. This laminated film is a packaging material with reduced pinholes due to its configuration, packaging form, heat sealing method, etc., and unlike light shielding packaging materials having both light shielding properties, oxygen barrier properties, and pinhole resistance, There is a demand for a light shielding packaging material having both oxygen barrier properties and pinhole resistance.
JP 10-314272 A Japanese Patent Laid-Open No. 9-262943 Japanese Patent No. 3202541

  The present invention has been made to solve the problems of the prior art, has both oxygen barrier properties and light shielding properties, and has excellent pinhole resistance and light shielding properties even when the packaging material is bent and fatigued. It is an object to provide a light-shielding packaging material that can be maintained.

As means for solving the above problems,
The invention according to claim 1 is a light shielding packaging material comprising a laminated film having oxygen barrier properties and light shielding properties,
Stretched polypropylene film, black polyolefin film, nylon film on which inorganic metal such as aluminum oxide (alumina) or silicon oxide (silica) is deposited, and polyolefin film are laminated in order, and bending degradation with an adhesive layer between each layer It is a light-shielding packaging material characterized by little pinhole resistance.

In the invention according to claim 2, the oxygen barrier property is such that the oxygen permeation amount is 5.0 ml / m ² / day / MPa or less (under the conditions of temperature 30 ° C. and humidity 70% RH in accordance with JIS K7126). The light-shielding packaging material according to claim 1, wherein the light-shielding property has a light transmittance (Nippon Denshoku Industries Co., Ltd., SZ-Σ80) of 0.1% or less.

  The invention according to claim 3 is the light-shielding packaging material according to claim 1 or 2, wherein the black polyolefin film contains 3% by weight or more of carbon black and has a thickness of at least 15 μm or more. .

  The invention according to claim 4 is an oxygen barrier for an infusion bag in which the light-shielding packaging material according to any one of claims 1 to 3 is filled with a content composed of an amino acid, a sugar, a vitamin, and an electrolyte. The light-shielding packaging material is characterized by being used as a part of a conductive outer bag.

  For laminated packaging materials filled with easily oxidizable and light-degradable contents of about 500ml to 2000ml, such as infusion bags, it is possible to provide light shielding and oxygen barrier properties by using vapor deposited nylon film and black polyolefin. It becomes. Furthermore, since the light shielding property is imparted without using an aluminum foil, the discardability is simple, and a good packaging material can be provided from the environmental aspect.

  When aluminum foil or aluminum vapor deposition film is used, cracks occur in the aluminum during bending motion, making it difficult to maintain light shielding properties. However, the use of black polyethylene solves such problems, and even light shielding properties through bending motion. Can be provided.

  By having a stretched polypropylene film layer (OPP) as the outermost layer, even if the packaging material undergoes repeated bending motions in transportation tests, vibration tests, etc., it provides a light-shielding packaging material that is less likely to generate complete through holes (pinholes) it can.

By using a transparent vapor-deposited nylon film for the intermediate layer, it is possible to provide a light-shielding packaging material that hardly generates pinholes.

  The best mode for carrying out the present invention will be specifically described below. FIG. 1 is a cross-sectional view of a light-shielding packaging material with little bending deterioration of the present invention. The structure consists of (A) a stretched polypropylene layer, (B) a black polyolefin film, (C) a deposited nylon film layer, (D) a polyolefin film, and (E) an adhesive layer. FIG. 2 is a front view of the primary container filled with the contents.

  (A) The stretched polypropylene layer may be a biaxially stretched propylene film or a uniaxially stretched polypropylene film, and the thickness is desirably 20 μm to 50 μm. (B) The black polyolefin layer should contain 3% by weight or more of carbon black and have a thickness of 15 μm or more. A polyolefin film made of black low density polyethylene or black linear low density polyethylene can also be used. Alternatively, the above-mentioned resin can be used by extrusion lamination. The thickness is desirably about 15 μm to 30 μm. The (C) vapor-deposited nylon film layer is not particularly limited as long as it is a nylon film on which an inorganic metal such as aluminum oxide (alumina) or silicon oxide (silica) is vapor-deposited, and the thickness of nylon is preferably about 15 μm to 30 μm. (D) The polyolefin film is not limited as long as it is a polyolefin film having a heat-fusible property on the market, and the thickness is desirably about 40 μm to 100 μm. (E) The adhesive layer is not limited as long as it is a commercially available two-component curable urethane adhesive for dry laminating or an adhesive for extrusion laminating, and the thickness is preferably about 1 μm to 3 μm.

  Hereinafter, the present invention will be described with reference to specific examples.

<Example 1>
<OPP30μ / Ad / Black LLDPE30μ / Ad / Vapor deposited Ny film 15μ / Ad / LLDPE60μ>
・ OPP30μ: manufactured by Nimura Chemical Co., Ltd. ・ Ad (adhesive): manufactured by Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
Black LLDPE 30μ: manufactured by Tamapoly Co., Ltd., UB-1 black vapor-deposited nylon film 15μ: manufactured by Toppan Printing Co., Ltd., GL-AEYBC
・ LLDPE 60μ: Tamapoly Co., Ltd., TTY

<Comparative Example 1>
<OPP30μ / Ad / Aluminum foil 9μ / Ad / Barrier Ny25μ / Ad / LLDPE60μ>
・ OPP30μ: manufactured by Nimura Chemical Co., Ltd. ・ Ad (adhesive): manufactured by Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
・ Aluminum foil 9μ: manufactured by Sun Aluminum Co., Ltd., 1N30
-Barrier nylon film 25μ: Gunze Co., Ltd., HP2
・ LLDPE 60μ: Tamapoly Co., Ltd., TTY

<Comparative example 2>
<OPP30μ / Ad / Barrier Ny25μ / Ad / Aluminum-deposited PET12μ / Ad / LLDPE60μ>
・ OPP30μ: manufactured by Nimura Chemical Industry Co., Ltd.
Ad (adhesive): manufactured by Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%,
Film thickness 3μ
-Barrier nylon film 25μ: Gunze Co., Ltd., HP2
Aluminum vapor deposition PET12μ: manufactured by Oike Industry Co., Ltd., MU-V8
・ LLDPE 60μ: Tamapoly Co., Ltd., TTY

<Comparative Example 3>
<OPP30μ / Ad / Barrier Ny25μ / Ad / Aluminum-deposited nylon 15μ / Ad / LLDPE60μ>
・ OPP30μ: manufactured by Nimura Chemical Co., Ltd. ・ Ad (adhesive): manufactured by Mitsui Takeda Chemical Co., Ltd., A-525 / A-52, solid content 30%, film thickness 3 μm
-Barrier nylon film 25μ: Gunze Co., Ltd., HP2
Aluminum vapor-deposited nylon 15μ: manufactured by Oike Industry Co., Ltd., BCU
・ LLDPE 60μ: Tamapoly Co., Ltd., TTY
The light shielding packaging material made of the laminated film obtained in Example 1 and Comparative Examples 1 to 3 is subjected to a bending test based on the following evaluation method 1, and the number of pinholes after the bending test and before and after the bending test. The light transmittance was measured. The results are shown in Table 1.

<Evaluation method 1>
* Bending test (BE-1006, manufactured by Tester Sangyo Co., Ltd.)
Bending test: 440-degree torsion x 3.5 inches straight + 2.5 inches straight Sample size: 205 mm x 290 mm
Method: The sample was reciprocated 2000 times in an environment of 5 ° C., and the number of pinholes was counted with a penetrant (total number of N = 2).
* Light transmittance measurement (Nippon Denshoku Co., Ltd., SZ-Σ80)
The light transmittance before and after the bending test was measured.

  From Table 1, it can be seen that Example 1 has fewer pinholes in the bending test than Comparative Examples 1 to 3, and has the lowest light transmittance after the bending test. Actually, the required light-shielding properties differ depending on the contents, and the pinholes generated differ depending on the packaging form. However, the light-shielding packaging material of the present invention obtained in Example 1 can provide a light-shielding packaging material that is excellent in pinhole resistance and can maintain the light-shielding property even when bending fatigued.

  Moreover, the oxygen permeation amount was measured based on the following evaluation method 2 for the light-shielding packaging material composed of the laminated films obtained in Example 1 and Comparative Examples 1 to 3. The results are shown in Table 2.

<Evaluation method 2>
* Oxygen permeation amount Measured by MOCON method [ml / m ² / day / Mpa] under the conditions of temperature 30 ° C. and humidity 70% RH in accordance with JIS K7126.

From Table 2, the oxygen permeation amount is generally 5.0 ml / m ² / day / Mpa in order to satisfy a storage period of 3 years at room temperature in an infusion bag made of vitamins, amino acids, sugars and electrolytes. The light shielding packaging material of the present invention obtained in Example 1 has a sufficiently low oxygen permeation amount.

  INDUSTRIAL APPLICABILITY The present invention is useful for an infusion bag exterior bag that is packaged with an exterior bag having a light-shielding property and an oxygen barrier property against contents that easily deteriorate due to the entry of oxygen and light from the outside. is there.

It is sectional drawing which shows an example of the light shielding packaging material of this invention. It is a top view which shows an example of the infusion bag exterior material using the light shielding packaging material of this invention.

Explanation of symbols

1: Light shielding packaging material 2: Infusion bag A: Stretched propylene layer B: Black polyolefin layer C: Vaporized nylon film layer D: Polyolefin film E: Adhesive layer G: Infusion back port part H: Easy peel layer I: First chamber J : Room 2 K: Room 3

Claims (4)

In a light shielding packaging material comprising a laminated film having oxygen barrier properties and light shielding properties,
Stretched polypropylene film, black polyolefin film, nylon film on which inorganic metal such as aluminum oxide (alumina) or silicon oxide (silica) is deposited, and polyolefin film are laminated in order, and bending degradation with an adhesive layer between each layer Light-shielding packaging material characterized by little pinhole resistance. The oxygen barrier property is an oxygen transmission amount of 5.0 ml / m ² / day / MPa or less (according to JIS K7126, under conditions of a temperature of 30 ° C. and a humidity of 70% RH), and the light shielding property is a light transmittance. (Nippon Denshoku Industries Co., Ltd., SZ-Σ80) is 0.1% or less.   3. The light-shielding packaging material according to claim 1, wherein the black polyolefin film contains 3% by weight or more of carbon black and has a thickness of at least 15 μm or more.   Use of the light-shielding packaging material according to any one of claims 1 to 3 as a part of an oxygen barrier outer packaging bag of an infusion bag filled with contents composed of amino acids, sugars, vitamins, and an electrolyte solution A light-shielding packaging material.

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