JP7412088B2 - Absorbent transparent lid material - Google Patents

Description

The present invention relates to an absorbent transparent lid material.

BACKGROUND ART Conventionally, blister packs have been used as packaging containers for solid preparations such as tablets and capsules containing drugs. This blister pack is made by forming a blister container by forming a concave part called a pocket in a blister container sheet made of a resin sheet, etc., filling the pocket with the contents, and then attaching the lid by heat sealing or the like. It can be formed by joining.

The blister container is made into a blister pack with the contents of the preparation etc. sealed therein by heat-sealing a lid material to the hem part that spreads around the blister container with the preparation etc. housed inside the pocket.

Furthermore, there are various active ingredients in the preparations enclosed in blister packs, including active ingredients with low moisture resistance and active ingredients with strong odors. Therefore, a method has been proposed in which a blister pack after molding has an absorbent function by forming an absorbent layer that absorbs moisture, odors, etc. in advance on a blister container sheet or lid material.

Patent Document 1 discloses a cover foil as a push-through foil for blister packs for packaging moisture-sensitive products, the cover foil comprising an aluminum foil as a barrier layer against water vapor and gas permeation, and a blister pack. and a sealing layer for effecting a seal against the base part, wherein a layer of plastic material containing a moisture-absorbing desiccant is arranged on the side of the aluminum foil provided with the sealing layer. A cover foil is disclosed, characterized in that:

Further, Patent Document 2 describes a film that has extremely high transparency and is useful as a sealing film for organic EL.

Note that methods for producing nanoparticle zeolite are described in Patent Documents 3 and 4.

Special Publication No. 2012-520802 Japanese Patent Application Publication No. 2018-100390 Japanese Patent Application Publication No. 2011-246292 Japanese Patent Application Publication No. 2013-49602

When the package described in Patent Document 1 is used, absorbency is obtained, but since it includes an aluminum foil layer as a barrier layer, it is difficult to determine whether the contents are encapsulated or not, or whether the contents are deteriorated or damaged. It is not possible to check the status of printing, display, etc. from the outside.

Therefore, there is a need to provide a lidding material that has the desired absorbency and allows the contents to be viewed from the outside.

The inventors of the present invention have made extensive studies and have completed the present invention by discovering that the above-mentioned problems can be solved by the following means. That is, the present invention is as follows:
<Aspect 1> An absorbent transparent lid material comprising a transparent barrier base material layer and a transparent absorption layer in this order.
<Aspect 2> The absorbent transparent lid material according to aspect 1, wherein the transparent absorption layer is a transparent moisture absorption layer containing a thermoplastic resin and a moisture absorbent.
<Aspect 3> The absorbent transparent lid material according to aspect 2, wherein the thermoplastic resin is a polyolefin resin.
<Aspect 4> The absorbent transparent lid material according to aspect 2 or 3, wherein the moisture absorbent is zeolite.
<Aspect 5> The absorbent transparent lid material according to aspect 4, wherein the zeolite in the transparent moisture absorbing layer has an average particle diameter D50 of 300 nm or less.
<Aspect 6> The absorbent transparent lid material according to any one of aspects 2 to 5, wherein the transparent moisture absorbing layer further contains an ester compound having an HLB value of 5 or less.
<Aspect 7> The absorbent transparent lid material according to any one of aspects 1 to 6, further comprising a transparent easily peelable layer on the surface of the transparent absorption layer opposite to the transparent barrier base layer. .
<Aspect 8> The absorbent transparent lid material according to any one of aspects 1 to 7, which is for a blister pack.
<Aspect 9> Comprising a content, a blister container, and an absorbent transparent lid material according to any one of aspects 1 to 8,
the blister container has a pocket,
the absorbent transparent lid is adhered to the blister container, thereby sealing the contents within the pocket;
Blister pack with contents.
<Aspect 10> The absorbent transparent lid material according to any one of aspects 1 to 8,
Combination with blister containers with pockets.

According to the present invention, it is possible to provide a lid material that has desired absorbency and allows contents to be visually recognized from the outside.

FIG. 1 is a diagram showing the layer structure of an embodiment of the blister pack of the present invention. FIG. 2 is a diagram showing an opening mechanism of an embodiment of the blister pack of the present invention. FIG. 3 is a diagram showing the opening mechanism of the preferred embodiment (ii) below of the blister pack of the present invention.

《Absorbent transparent lid material》
As shown in FIG. 1, the absorbent transparent lid material 100 of the present invention includes a transparent barrier base material layer 108 and a transparent absorption layer 102 in this order. Further, the absorbent transparent lid material 100 may have transparent skin layers 106 and 106' on one side or both sides of the transparent absorbent layer 102.

Here, in the present invention, "transparent" means that it is sufficiently transparent to visually recognize the characters in the contents, and for example, the total light transmittance is 50% or more, 60% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more, or 100%, and the haze value is 90% or less, 85% or less, 80% or less, 70% or less, It means 60% or less, or 50% or less.

Here, the total light transmittance can be measured in accordance with JIS K 7361. Further, the haze value can be measured in accordance with JIS K7136.

With the above configuration, it is possible to provide a lid material that has desired absorbency and allows the contents to be visually recognized from the outside through at least the transparent lid material.

In addition, from the viewpoint of ensuring easy peelability, the absorbent transparent lid material 100 further includes a transparent easily peelable layer 104 on the surface of the transparent absorbing layer 102 opposite to the transparent barrier base layer 108. preferable.

The transparent lid material of the present invention can be used for various purposes, particularly as a transparent lid material for blister packs.

Each component of the present invention will be explained below.

<Transparent barrier base material layer>
The transparent barrier base material layer is a base material that has transparency and barrier properties.

As the transparent barrier base material layer, for example, a barrier resin layer can be used. As the resin constituting the barrier resin layer, for example, cyclic olefin polymer, ethylene-vinyl alcohol copolymer, polychlorotrifluoroethylene, etc. can be used.

Further, as shown in FIG. 1, the transparent barrier base layer 108 may be a layer having a transparent barrier layer 108a and a transparent base resin layer 108b. In this case, an adhesive layer may be present between the transparent barrier layer and the transparent base resin layer.

(transparent barrier layer)
As the transparent barrier layer, a material that is transparent and capable of suppressing moisture, organic gas, and inorganic gas from outside from permeating into the transparent absorption layer can be used. Such a transparent barrier layer may be, for example, an inorganic vapor-deposited film such as a silica vapor-deposited film, an alumina vapor-deposited film, or a silica/alumina binary vapor-deposited film, or a polyvinylidene chloride coating film, a polychlorotrifluoroethylene coating film, or a polyvinylidene fluoride coating. An organic coating film such as a film can be used. Furthermore, the barrier resin layer described above can also be used as a transparent barrier layer.

When using an inorganic vapor-deposited film or an organic coating film as the transparent barrier layer, the thickness of the transparent barrier layer should be 100 nm or more, 200 nm or more, 300 nm or more, 500 nm or more, 700 nm or more, or 1 μm or more to improve strength and barrier properties. The thickness is preferably 5 μm or less, 4 μm or less, 3 μm or less, or 2 μm or less from the viewpoint of improving handleability as a lid material.

When using a barrier resin layer or an organic coating film as the transparent barrier layer, the thickness of the transparent barrier layer is preferably 7 μm or more, 10 μm or more, or 15 μm or more from the viewpoint of ensuring strength and barrier properties; The thickness is preferably 100 μm or less, 80 μm or less, 60 μm or less, 55 μm or less, 50 μm or less, 45 μm or less, 40 μm or less, or 35 μm or less from the viewpoint of improving handleability as a lid material.

(Transparent base resin layer)
For the transparent base resin layer, thermoplastic resins with excellent impact resistance, abrasion resistance, etc., such as polyolefin resins, vinyl polymers, polyesters, polyamides, etc., may be used alone or in combination of two or more types. Can be used in multiple layers. This resin layer may be a stretched film or a non-stretched film. Further, this resin layer may be present on one or both sides of the transparent barrier layer. This resin layer can protect the transparent barrier layer.

Examples of the polyolefin resin include polyethylene resin, polypropylene resin, and the like.

In this specification, the polyethylene resin is a resin containing more than 50 mol%, 60 mol% or more, 70 mol% or more, or 80 mol% or more of ethylene group repeating units in the main chain of the polymer, and for example, has a low density. Polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), ethylene-acrylic acid copolymer (EAA), ethylene-methacrylic acid copolymer (EMAA) , ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), derivatives thereof, and mixtures thereof.

In this specification, the polypropylene resin is a resin containing more than 50 mol%, 60 mol% or more, 70 mol% or more, or 80 mol% or more of repeating units of propylene groups in the main chain of the polymer, such as polypropylene (PP). Examples include homopolymers, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, acid-modified polypropylene, derivatives thereof, and mixtures thereof.

Examples of vinyl polymers include polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), polychlorotrifluoroethylene, polytetrafluoroethylene, and polyacrylonitrile (PAN).

Examples of the polyester include polyethylene terephthalate (PET) and polybutylene terephthalate.

Examples of the polyamide include nylon such as nylon (registered trademark) 6 and nylon MXD6.

The thickness of the transparent base resin layer is preferably 7 μm or more, 10 μm or more, or 15 μm or more from the viewpoint of good protection of the barrier layer, and preferably 55 μm or less, 50 μm or less, or 45 μm or less. This is preferable from the viewpoint of improving handling properties as a lid material.

<Transparent absorption layer>
The transparent absorption layer is a layer that is transparent and has an absorbent. In this case, the moisture absorbent may be dispersed in the thermoplastic resin. As this thermoplastic resin, the thermoplastic resins mentioned in connection with the transparent base resin layer can be used, and among them, it is preferable to use a polyolefin resin, particularly a polyethylene resin, from the viewpoint of processability and the like.

In particular, the transparent absorption layer may be a transparent moisture absorption layer containing a thermoplastic resin and a moisture absorption agent, or a transparent gas absorption layer containing a thermoplastic resin and a gas absorption agent. good.

The melt flow rate of the resin composition constituting the transparent moisture absorption layer when measured in accordance with JIS K7210 at a temperature of 190°C and a load of 21.18N is 0.3g/10min or more and 30g/10min or less. This is preferable from the viewpoint of making it relatively easy to form into a film by the T-die method or the inflation method, thereby making it easier to manufacture the transparent lid material. This melt flow rate may be 0.5 g/10 min or more, 1.0 g/10 min or more, 3.0 g/10 min or more, or 5.0 g/10 min or more, and 20 g/10 min or less, or 15 g/10 min or less. , 10 g/10 min or less, 8.0 g/10 min or less, or 5.0 g/10 min or less. For example, this melt flow rate may be 0.5 g/10 min or more and 10 g/10 min or less.

The haze of the resin composition constituting the transparent moisture-absorbing layer when measured as a 100 μm thick film before moisture absorption according to JIS K7136 is preferably 50% or less, 40% or less, 30% or less , 20% or less, or 15% or less. For example, the haze may be 3% or more and 25% or less, or 5% or more and 20% or less.

As the hygroscopic agent, physical hygroscopic agents such as hydrophilic zeolite and silica gel, chemical hygroscopic agents such as calcium oxide, magnesium sulfate, calcium chloride, calcium oxide, aluminum oxide, etc. can be used. Among them, it is preferable to use hydrophilic zeolite.

As the hydrophilic zeolite, for example, A-type, X-type, or LSX-type zeolite can be used. These may be used alone or in combination.

When using hydrophilic zeolite as a moisture absorbent, the average particle diameter D50 of the zeolite is preferably 300 nm or less from the viewpoint of imparting appropriate transparency to the composition. Here, the average particle diameter D50 of zeolite is the cumulative value of 50% of the particle size distribution based on the number of particles measured by measuring the long axis of 100 randomly selected particles using a scanning electron microscope (SEM). means the particle size in The average particle diameter D50 of the zeolite may be 250 nm or less, 200 nm or less, 150 nm or less, or 100 nm or less. The average particle diameter D50 of the zeolite may be 10 nm or more, 30 nm or more, 50 nm or more, or 100 nm or more. For example, the average particle diameter D50 of the zeolite may be 10 nm or more and 300 nm or less, or more than 100 nm and 250 nm or less.

When using hydrophilic zeolite as a moisture absorbent, the pore (absorption opening) diameter of the zeolite may be 0.3 nm or more and 1 nm or less, and may be 0.3 nm or more and 0.5 nm or less.

When using hydrophilic zeolite as a moisture absorbent, the value of the atomic ratio of Si to Al (Si/Al) in the zeolite is arbitrary, for example, 1 or more, 2 or more, 3 or more, 5 or more, 10 or more, or It may be 15 or more, for example, 80 or less, 60 or less, 50 or less, 40 or less, or 30 or less.

The zeolite used in the present invention is preferably hydrophilic from the viewpoint of hygroscopicity, and it is particularly preferable to use Na-A type zeolite.

The zeolite used in the present invention can be produced, for example, by the methods described in Patent Documents 3 and 4. Such zeolite may be used with its bulk density adjusted as described in Patent Document 2.

From the perspective of ensuring good absorption capacity, the content of the moisture absorbent is 1% by mass or more, 3% by mass or more, 5% by mass or more, 7% by mass or more, or 10% by mass, based on the mass of the entire absorbent layer. The content is preferably 50% by mass or less, 45% by mass or less, 40% by mass or less, 35% by mass or less, or 30% by mass or less from the viewpoint of ensuring good transparency and film formability. is preferred.

It is preferable that the transparent moisture absorption layer further contains an ester compound having an HLB value of 5 or less from the viewpoint of improving transparency. Here, the HLB value is an index indicating whether it is hydrophilic or lipophilic. The HLB value of an ester compound of 5 or less means that the ester compound has high lipophilicity, and is a value in the range used as an antifoaming agent or an emulsifier for emulsions, for example. This HLB value may be, for example, 4.5 or less, 4.0 or less, or 3.5 or less, and may be, for example, 2.0 or more, 2.5 or more, or 3.0 or more.

The ester compound is, for example, a monoester compound of a polyhydric alcohol and a fatty acid. The polyhydric alcohol may be, for example, glycerin, alkylene glycol, or the like. The fatty acid may be, for example, a saturated or unsaturated fatty acid having 12 or more and 24 or less carbon atoms.

In particular, the ester compound may be a monoester of an alkylene glycol having 2 to 6 carbon atoms and a fatty acid having 15 to 21 carbon atoms. The alkylene glycol may be, for example, ethylene glycol, propylene glycol, diethylene glycol, or the like. The above fatty acid having 15 to 21 carbon atoms may be saturated or unsaturated, and may be, for example, stearic acid, behenic acid, etc.

Specifically, the ester compound may be, for example, propylene glycol monostearate, propylene glycol monobehenate, or the like.

The content of the ester compound in the transparent moisture absorbing layer is not particularly limited as long as it can provide the advantageous effects of the present invention. For example, the content of the ester compound is 2.0% by mass or more and 15% by mass or less, and may be 2.5% by mass or more, 3.0% by mass or more, or 5.0% by mass or more, and 12% by mass or more, 3.0% by mass or more, or 5.0% by mass or more. It may be less than 10% by mass, less than 8.0% by mass, or less than 6.0% by mass. For example, the content of the ester compound may be 2.5% by mass or more and 12% by mass or less, or 3.0% by mass or more and 10% by mass or less.

The transparent moisture absorbing layer may or may not contain an oxide (excluding zeolite) of one or more elements selected from Al, Si, Ti, and Zr, with an average particle diameter D50 of 100 nm or less. It doesn't have to be. The content of such oxides may be, for example, 5% by weight or less, 3% by weight or less, 1% by weight or less, or 0% by weight.

<Transparent easily peelable layer>
After bonding the transparent lid to the blister container, the transparent easily peelable layer is peeled off from the blister container at the interface and/or by causing cohesive failure of the transparent easily peelable layer, so that other layers of the transparent lid can be bonded to the transparent lid. It refers to a layer that can be separated and opened from a blister container.

More specifically, the transparent easily peelable layer is formed by interfacially peeling the transparent easily peelable layer 104 from the blister container 200 as shown in FIG. 2(a), and/or as shown in FIG. 2(b). As such, it is a layer that can cause cohesive failure of the transparent easily peelable layer 104. The transparent easily peelable layer 104 may be a layer that is torn to correspond to the pockets 202 of the blister container 200.

According to this aspect, when opening a blister pack in which opening due to breakage of the lid material is undesirable, for example, a blister pack containing tablets of a soft gel-like substance as contents, the presence of the transparent and easily peelable layer makes it easy to remove the lid material. It is possible to easily open the package and take out the contents without breaking it.

In a preferred embodiment of the transparent easy-peel layer, the transparent easy-peel layer is fused to a blister container having pockets, thereby forming a joint where the blister container and the transparent easy-peel layer join, and a blister. When a non-bonded part corresponding to the pocket of the container and in which the blister container and the transparent easily peelable layer are not bonded is formed, and the transparent lid material is peeled off from the blister container,
(i) as mentioned with respect to FIG. 2(a), the blister container can be interfacially peeled from the transparent easy-peel layer; or (ii) as mentioned with respect to FIG. 2(b), the transparent easy-peel layer The layers can be cohesively exfoliated.

In particular, in the preferred embodiment (ii) above, in the joint part, a part of the transparent easily peelable layer follows the blister container, and in the non-joint part, the entire transparent easily peelable layer follows the lid material. Can follow other layers. This embodiment will be explained with reference to FIG.

As shown in FIG. 3(a), a blister container 200 having a pocket 202 is joined to a lid member 100, and a joint 104a where the blister container 200 and the transparent easily peelable layer 104 are joined, and a blister When a non-bonded part 104b corresponding to the pocket 202 of the container 200 and where the blister container 200 and the transparent easily peelable layer 104 are not bonded is formed, and the lid material 100 is peeled off, a region corresponding to the bonded part 104a is formed. In this step, the transparent easily peelable layer 104 is cohesively peeled off.

In order to realize this cohesive peeling, a non-bonded part 104b' may be further provided between the blister container and the transparent easily peelable layer, and this may be used as a trigger for peeling. In this embodiment, when the peeling surface reaches the boundary between the non-bonded part 104b' and the bonded part 104a, a broken part 144 is formed in the transparent easily peelable layer 104, as shown in FIG. 3(b). In the area corresponding to the joint 104a, a part of the transparent easily peelable layer 104 follows the other layers of the lid material 100, while another part of the transparent easily peelable layer 104 follows the other layers of the blister container 200. The transparent easily peelable layer 104 is cohesively peeled off while remaining on top.

When the transparent easily peelable layer 104 is further coagulated and peeled, the peeled surface eventually reaches the boundary between the bonded part 104a and the non-bonded part 104b, and as shown in FIG. 3(c), the transparent easily peelable layer 104 A broken portion 144 is formed in the non-bonded portion 104b, and the transparent easily peelable layer 104 follows the other layers of the lid material 100, allowing the blister pack to be opened.

As the unsealing is further progressed, the breaking portion 144 reaches the edge on the opposite side of the pocket 202, and the easily peelable layer 104 is separated corresponding to the pocket 202, as shown in FIG. 3(d).

In particular, when the lid material is fused to the innermost resin layer of a single-layer blister container made of polyvinyl chloride or a blister container that has a layer of polyvinyl chloride as the innermost resin layer, transparent The peelable layer contains acrylic-modified polyolefin, which allows it to achieve good melting properties to polyvinyl chloride with good moldability due to its thin film thickness, resulting in cost reduction and good production speed. This is preferable from the viewpoint of bringing about the following.

Examples of the acrylic component include (meth)acrylic acid, methyl (meth)acrylate, ethyl (meth)acrylate, propyl (meth)acrylate, butyl (meth)acrylate, isobutyl acrylate, pentyl (meth)acrylate, hexyl (meth)acrylate, and 2-ethylhexyl (meth)acrylate, and combinations thereof.

In this case, the transparent easily peelable layer contains the maleic acid-modified polyolefin, which is the layer on which the transparent easily peelable layer of the transparent lid material is laminated, that is, the transparent barrier base material layer, the transparent functional layer, or the transparent skin layer. This provides adhesion to the layers, thereby increasing the interlayer strength between these layers and preventing unintended bonding between the transparent and easy peel layers. This is preferable from the viewpoint of suppressing peeling. The maleic acid-modified polyolefin may generally be a polyolefin in which maleic acid is graft-polymerized on the side chain.

The transparent easily peelable layer contains 40% by mass or more, 45% by mass or more, 50% by mass or more, 55% by mass or more, 60% by mass or more, or 65% by mass or more, based on the entire mass of the transparent easily peelable layer. and 90% by mass or less, 85% by mass or less, 80% by mass or less, or 75% by mass or less of acrylic modified polyolefin, and 10% by mass or more, 15% by mass or more, 20% by mass or more, or 25% by mass or more The transparent lid material must contain 60% by mass or less, 55% by mass or less, 50% by mass or less, 45% by mass or less, 40% by mass or less, or 35% by mass or less of maleic acid-modified polyolefin. This is preferable from the viewpoint of achieving good adhesion to the layer on which the transparent easily peelable layer is laminated.

Further, the transparent easily peelable layer may be made of any material that can heat-seal the lid material to the blister container. Such materials are selected depending on the material of the container to be sealed, and include, for example, polyolefin resin, acid-modified polyolefin, ethylene methacrylic acid copolymer (EMAA), ethylene acrylic acid copolymer (EAA), ionomer resin, ethylene acetic acid. Resins such as vinyl copolymers may be used. These resins can be provided in the form of, for example, stretched or unstretched films, molten resins for extrusion lamination, paints for hot melt, and the like.

Moreover, as the transparent easily peelable layer, a commercially available easy-peel resin or easy-peel sealant film that is not composed of these resins may be used.

The thickness of the transparent easily peelable layer can be, for example, 5 μm or more, 7 μm or more, 10 μm or more, 15 μm or more, 20 μm or more, 30 μm or more, or 40 μm or more when it does not contain maleic acid-modified polyolefin. , and can also be 100 μm or less, 90 μm or less, 80 μm or less, 70 μm or less, 60 μm or less, or 50 μm or less.

The thickness of the transparent easily peelable layer containing the maleic acid-modified polyolefin is preferably 0.5 μm or more, 0.7 μm or more, or 1 μm or more from a manufacturing standpoint, and 5 μm or less, 4 μm or less. , 3 μm or less, or 2 μm or less is preferable from the viewpoint of making the transparent easily peelable layer easy to break.

The transparent easily peelable layer may be formed by dry laminating, sand laminating, etc. via an adhesive layer, or by printing means such as gravure printing, offset printing, flexo printing, silk printing, etc. The resin composition constituting the above may be applied to a transparent barrier substrate layer, a transparent absorption layer, or a transparent skin layer.

<Transparent skin layer>
The transparent skin layer is a layer that contains a transparent skin layer resin and can be present on the transparent easily peelable layer side of the transparent absorption layer. A transparent skin layer may further be present on the surface of the transparent absorption layer on the transparent barrier base layer side. Additionally, the transparent skin layer may be fused to the transparent absorbent layer.

In particular, the transparent skin layer can prevent the absorbent contained in the transparent absorbent layer from falling off or coming into contact with the contents. Moreover, in this case, the transparent skin layer may be a layer that does not contain an absorbent. For example, the transparent skin layer may be an absorbent-free layer.

The thickness of the transparent skin layer can be 1 μm or more, 3 μm or more, 5 μm or more, or 7 μm or more, and can be 50 μm or less, 40 μm or less, 30 μm or less, 20 μm or less, or 15 μm or less. When there are multiple transparent skin layers, the thickness of each transparent skin layer may be the same or different.

(Resin for transparent skin layer)
As the resin for the transparent skin layer, the thermoplastic resins listed for the transparent base resin layer can be used alone or in combination. Among them, polyolefin resins, especially polyethylene resins, are preferred because of their workability and other properties. Preferable from this point of view. When skin layers are present on both sides of the transparent absorption layer, the transparent skin layer resins constituting each transparent skin layer may be the same or different.

<Other layers>
The absorbent transparent lidding may have optional other layers. Other layers include, for example, an adhesive layer existing between each layer.

《Blister pack with contents》
As shown in FIG. 1, the blister pack 400 of the present invention includes:
It has a content 300, a blister container 200, and an absorbent transparent lid material 100,
The blister container 200 has a pocket 202,
An absorbent transparent closure 100 is adhered to the blister container 200, thereby sealing the contents 300 within the pocket 202.

The absorbent transparent lid material 100 may be adhered to the blister container 200 via an adhesive layer, or may be fused to the blister container 200.

<Contents>
The contents are those sealed within the pockets of the blister container. Such contents are not limited as long as they can deteriorate due to contact with the outside air, and can include, in addition to drugs, foods, cosmetics, sanitary products, medical equipment, medical instruments, electronic parts, etc. . In addition, drugs include detergents, agricultural chemicals, reagents, etc. in addition to pharmaceutical preparations.

In particular, the configuration of the present invention is more beneficial when the contents are preferably visually recognized, such as pharmaceutical preparations with textual information such as the expiration date attached.

<Blister container>
As the blister container, a blister container having a pocket can be used.

Blister containers can be manufactured, for example, by forming pockets for storing contents in a blister container sheet. Examples of the molding method for forming the pocket include a flat plate pneumatic molding method, a plug-assisted pneumatic molding method, a drum vacuum molding method, a plug molding method, and the like. Among these, a plug molding method using a cylindrical rod (plug material) with a rounded tip made of ultra-high molecular weight polyethylene resin having a viscosity average molecular weight of 1 million or more is preferable for forming the pocket.

As the blister container, a single-layer blister container sheet or a multi-layer blister container sheet in which a plurality of layers are laminated can be used. The single-layer blister container sheet may be composed of a resin that provides appropriate barrier properties and moldability, such as polyolefin resin, polyvinyl chloride, polyvinylidene chloride, polypropylene resin, saturated polyester, polyamide (for example, Nylon (registered trademark), nylon 6, nylon 6,6, nylon MXD6), cyclic polyolefins (COP, COC), fluororesins (e.g., polychlorotrifluoroethylene, polytetrafluoroethylene), etc., and mixtures thereof can be used.

The multilayer blister container sheet may have a base layer and an innermost resin layer. Further, a barrier layer, a reinforcing layer, a functional layer, etc. may be optionally provided between the base material layer and the innermost resin layer, for example, a base material layer, a barrier layer, a reinforcing layer, a functional layer, and the innermost resin layer. It has layers in this order. Examples of methods for bonding adjacent layers include dry lamination, sand lamination, and the like.

The thickness of the blister container sheet can be, for example, 500 μm or less, 400 μm or less, 300 μm or less, 200 μm or less, 150 μm or less, or 100 μm or less, from the viewpoint of appropriate strength, stiffness, barrier properties, etc. as a blister container. , or 50 μm or more, 60 μm or more, or 70 μm or more.

(Innermost resin layer for blister containers)
The innermost resin layer for a blister container is a layer that will be placed on the content side when the blister container is manufactured. Through this layer, the blister container can be fused to the blister pack lid material of the present invention. As the innermost resin layer, for example, the resins mentioned in connection with the single-layer blister container sheet can be used.

The thickness of the innermost resin layer may be 300 μm or less, 200 μm or less, 150 μm or less, 130 μm or less, or 100 μm or less, and 10 μm or more, 20 μm or more, or 30 μm or less, from the viewpoint of imparting appropriate moldability to the blister container sheet. It may be 40 μm or more, or 50 μm or more.

(Base material layer for blister container)
The resin used in the base material layer for blister containers is not particularly limited as long as it provides appropriate barrier properties and moldability to the sheet for blister containers. For example, polyolefin resins, polyvinyl chloride, polyvinylidene chloride, polypropylene resins, saturated polyesters, polyamides (e.g., nylon (registered trademark), nylon 6, nylon 6,6, nylon MXD6), cyclic polyolefins (COP, COC) , fluororesins (for example, polychlorotrifluoroethylene, polytetrafluoroethylene), and mixtures thereof. These may be used in a single layer or in a stack of two or more layers. Preferably, the material is one that prevents moisture from entering from the outside and has excellent moisture resistance, and particularly polypropylene resins, polyamides, and saturated polyesters can be mentioned.

The thickness of the base layer may be 10 μm or more, 20 μm or more, or 30 μm or more, and 300 μm or less, 200 μm or less, or 100 μm or less, from the viewpoint of maintaining barrier properties and imparting strength etc. to the entire blister pack. It's good.

(Barrier layer for blister containers)
Materials used for barrier layers for blister containers include metal foil layers such as copper foil and aluminum foil, barrier resin layers such as cyclic olefin polymers and ethylene-vinyl alcohol copolymers, silica vapor deposited films, aluminum vapor deposited films, and alumina. Examples include vapor-deposited films, inorganic vapor-deposited films such as silica/alumina vapor-deposited films, organic coating films such as vinylidene chloride coating films, polychlorotrifluoroethylene coating films, polyvinylidene fluoride coating films, and combinations thereof.

When using an inorganic vapor-deposited film or an organic coating film as a barrier layer, the thickness of the barrier layer is 100 nm or more, 200 nm or more, 300 nm or more, 500 nm or more, or 700 nm in order to give the blister container sheet appropriate moldability and barrier properties. or more, or 1 μm or more, and may be 5 μm or less, 4 μm or less, 3 μm or less, or 2 μm or less.

When using a metal foil layer, a barrier resin layer, or an organic coating film as a barrier layer, the thickness of the barrier layer is 7 μm or more, 10 μm or more, or 20 μm in order to give the blister container sheet appropriate moldability and barrier properties. or more, and may be 100 μm or less, 80 μm or less, 60 μm or less, 50 μm or less, or 40 μm or less.

In particular, it is preferable for the barrier layer for blister containers to be an opaque barrier layer, such as a metal foil layer, rather than a transparent barrier layer, such as a vapor-deposited film, from the viewpoint of maintaining sufficient barrier properties even after pockets are formed. .

(Reinforcement layer for blister containers)
The reinforcing layer for blister containers is used to improve the moldability of the sheet for blister containers. Examples of the resin used for the reinforcing layer include high-density polyethylene, polyvinyl chloride, polypropylene resin, polyethylene terephthalate, polyamide (for example, nylon (registered trademark), nylon 6, nylon 6,6, nylon MXD6), and the like. Mixtures of these may be mentioned. The thickness of the reinforcing layer may be, for example, 10 μm or more, 15 μm or more, or 25 μm or more, and 60 μm or less, or 50 μm or less.

(other layers)
The multilayer blister container sheet may have optional other layers. Examples of other layers include a functional layer, a skin layer on the functional layer, and an adhesive layer that adheres each layer. The transparent absorption layer of the absorbent transparent lid material and the functional layer of the blister container sheet may be the same, or may differ in layer thickness, type or content of absorbent or resin, etc. may also be used.

"combination"
The combination of the present invention is a combination of the above transparent lid material and a blister container having a pocket. As the blister container, the above blister container can be used.

The present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

《Preparation of lid material》
<Example 1>
By coextrusion molding using a T-die method, a transparent skin layer, a transparent moisture absorbing layer, and a transparent skin layer were arranged in this order to produce two kinds of three-layer transparent moisture absorbing films. As the transparent skin layer, linear low-density polyethylene was used, and as the resin composition for the moisture absorption layer, 48 parts by mass of ethylene-vinyl acetate copolymer (EVA150, Mitsui DuPont Polychemical Co., Ltd.), Na-A type was used. A resin composition prepared by melt-kneading 32 parts by mass of zeolite (average particle diameter D50: 50 nm) and 5 parts by mass of an ester compound (HLB value 3.0) was used. The thickness of each layer was 10 μm for the transparent skin layer, 30 μm for the transparent moisture absorption layer, and 10 μm for the transparent skin layer.

A transparent silica-deposited PET film (GX film, Toppan Printing Co., Ltd., thickness 12 μm) as a barrier transparent base layer was laminated on one skin layer side of the produced transparent moisture-absorbing film using a dry laminating adhesive. Ta.

Next, an acrylic modified polyolefin was applied to the other skin layer side and dried, thereby laminating a transparent easily peelable layer to produce the lid material of Example 1.

<Comparative example 1>
By applying acrylic modified polyolefin to the aluminum foil side of a laminate having a layer structure of PET (12 μm)//aluminum foil (9 μm) (where "//" represents a dry lamination adhesive) and drying it. A lid material of Comparative Example 1 was produced in the same manner as in Example 1, except that a transparent easily peelable layer was laminated and used as the lid material.

<Comparative example 2>
Except that a transparent easily peelable layer was laminated by applying an acrylic modified polyolefin to a transparent silica-deposited PET film (GX film, Toppan Printing Co., Ltd., thickness 12 μm) and drying it, which was used as a lid material. A lid material of Comparative Example 2 was produced in the same manner as Example 1.

<Comparative example 3>
As the resin composition for the moisture absorption layer in the lid material, a resin composition prepared by melt-kneading 53 parts by mass of hydrophilic zeolite (Molecular Sieve 3A, Union Showa Co., Ltd.) and 47 parts by mass of ethylene-methacrylic acid copolymer was used. A lid material of Comparative Example 3 was produced in the same manner as in Example 1, except that a non-transparent hygroscopic film was produced.

"evaluation"
<Peeling test>
The easily peelable layer side of each of the produced lid materials was heat-sealed to the PVC layer side of a blister container sheet having a layer structure of nylon (25 μm)//aluminum foil (40 μm)//PVC (60 μm). The heat sealing conditions were as follows: temperature on the blister pack lid side was 150°C, temperature on the blister container sheet side was 40°C, time was 1.5 seconds, and pressure was 0.2 MPa.

Next, the heat-sealed blister pack lid material and blister container sheet were cut to a width of 15 mm, and subjected to T-peeling at a tensile speed of 300 mm/min using a tensile tester in accordance with JIS K 6854-3. The peelability of the lid material was evaluated by measuring the heat seal strength. The evaluation criteria are as follows.
○: Peel strength was 2N to 10N.
×: Peel strength did not reach 2N to 10N.

<Visibility>
A blister container sheet having a layered structure of nylon (25 μm)//aluminum foil (40 μm)//PVC (60 μm) was used to form pockets in the sheet using a press to produce a blister container.

A tablet with a diameter of 7 mm and a thickness of 3 mm with the words "6 Test" marked in 6-point MS Gothic font was placed in the prepared blister container, and then the transparent easily peelable layer side of the lid material and the blister container were heated. By sealing, a blister pack with contents was prepared. The heat sealing conditions were as follows: temperature on the blister pack lid side was 150°C, temperature on the blister container sheet side was 40°C, time was 1.5 seconds, and pressure was 0.2 MPa.

Visual evaluation was conducted to determine whether the characters attached to the contents could be identified from the outside of the blister pack containing the contents. The evaluation criteria are as follows:
○: Characters attached to the contents could be identified.
Δ: Although the letters attached to the contents could not be identified, their presence or absence could be confirmed.
×: Characters attached to the contents could not be visually recognized.

<Moisture absorption test>
Each of the produced lid materials was cut into a size of 100 mm x 100 mm to prepare a sample for a moisture absorption test, and the mass of this sample was measured.

The above sample was exposed to an environment of a temperature of 60° C. and a relative humidity of 100% RH for 6 hours, and then left for one day or more in an environment of 23° C. and 50% RH, and then the mass of the sample was measured.

The difference in mass before and after treatment was calculated, and the obtained mass value was converted into mass per 1 m ² .

The evaluation criteria are as follows:
○: Moisture absorption amount is 1 g/m ² or more.
×: Moisture absorption amount is less than 1 g/m ² .

Table 1 shows the configurations and evaluation results of Examples and Comparative Examples.

From Table 1, it can be seen that the lid material of Example 1 using the transparent moisture absorption layer had good visibility and moisture absorption.

On the other hand, in Comparative Example 1, the lid material contains aluminum foil, so it is opaque and visibility is not good, and the lid material does not have a moisture absorbing layer, so it does not have good moisture absorption. There wasn't.

Moreover, in Comparative Example 2, the lid material did not have a moisture absorbing layer, so the moisture absorbing property was not good.

In addition, in Comparative Example 3, the lid material had a moisture absorption layer, so the hygroscopicity was good, but this moisture absorption layer was opaque, so the lid material was opaque, and as a result, visual The characteristics were not good.

Examples of the transparent hygroscopic layer and easily peelable layer that can be used in the present invention will be shown below with reference to reference examples.

《Reference example A: Example of transparent moisture absorbing layer》
<Manufacturing example>
Thermoplastic resin, Na-A type zeolite (average particle size D50: 50 nm), and ester compound (HLB value 3.0) were mixed at 160°C for 10 minutes using a Banbury mixer in the formulations shown in Tables 2 and 3. The resin compositions of each example were obtained by melt-kneading.

<evaluation>
(melt flow rate)
The resin composition of each example was cut into measurable sizes. The melt flow rate (MFR) of the cut resin composition was measured using a melt indexer (Techno Seven Co., Ltd.) under conditions of a temperature of 190°C and a load of 21.18N in accordance with JIS K7210. .

(Haze)
The resin composition was cut to a predetermined weight, and a film with a thickness of 100 μm was produced by hot press molding. Here, the pressing conditions were a temperature of 160° C., a pressure of 40 to 60 MPa, and 2 minutes. The film thus obtained was cut into 50 mm squares, and the haze was measured in accordance with JIS K7105 using a haze measuring device (Murakami Color Research Institute, HR-100). Regarding the haze after moisture absorption, the film was left standing in an environment of 23° C. and 50%, allowed to absorb moisture until the weight change after moisture absorption became constant, and then measured in the same manner as above.

<result>
The configuration and evaluation results of each example are shown in Tables 2 and 3.

Referring to Table 2, it was found that as the zeolite content increased, the melt flow rate of the resin composition decreased significantly. This tendency can also be confirmed in Reference Examples A3 and A4. In Reference Comparative Example A1, the melt flow rate was reduced to such an extent that molding by the T-die method or the inflation method was impossible.

Referring to Table 3, it was found that as the content of the ester compound decreased, the melt flow rate of the resin composition decreased significantly and the haze increased. In Reference Comparative Example A2, the melt flow rate was reduced to such an extent that molding by the T-die method or the inflation method was impossible, and the transparency was also reduced.

<Reference example B: Example of easily peelable layer>
<Preparation of lid material for blister pack>
(Reference example B1)
A skin layer, an absorbent layer as a functional layer, and a skin layer were arranged in this order to produce two kinds of three-layer absorbent films by coextrusion molding using air-cooled inflation. As the skin layer, linear low density polyethylene was used, and as the resin for the absorbent layer, a resin prepared by melt-kneading hydrophilic zeolite and ethylene-methacrylic acid copolymer (EMAA) was used. The thickness of each layer was 10 μm for the skin layer, 30 μm for the absorption layer, and 10 μm for the skin layer.

Next, the wettability of the surface of one skin layer of the fabricated absorbent film was confirmed, corona treatment was performed as necessary, and PET (12 μm) // aluminum foil ( The aluminum foil side of the laminate (9 μm) was laminated using a dry laminating adhesive.

Next, on the other skin layer side, 47.8 parts by mass of acrylic modified polyolefin and 52.2 parts by mass of maleic acid modified polyolefin were mixed, and this was applied and dried to form an easily peelable layer. A blister pack lid material of Reference Example B1 was produced.

(Reference Examples B2 to B5 and Reference Comparative Example B1)
Blister pack lid materials of Reference Examples B2 to B5 and Reference Comparative Example B1 were produced in the same manner as Reference Example B1, except that an easily peelable layer having the configuration shown in Table 4 was used as the easily peelable layer. .

<Reference comparative example B2>
A blister pack lid material of Reference Comparative Example B2 was produced in the same manner as Reference Example B1 except that the easily peelable layer was not laminated.

"evaluation"
<Peeling test>
The easily peelable layer or skin layer side of the produced blister pack lid material was heated to the PVC layer side of a blister container sheet having a layer structure of nylon (25 μm) // aluminum foil (40 μm) // PVC (60 μm). I sealed it. The heat sealing conditions were as follows: temperature on the blister pack lid side was 150°C, temperature on the blister container sheet side was 40°C, time was 3 seconds, and pressure was 0.2 MPa.

Next, the heat-sealed blister pack lid material and blister container sheet were cut to a width of 15 mm, and subjected to T-peeling at a tensile speed of 300 mm/min using a tensile tester in accordance with JIS K 6854-3. The peelability of the lid material was evaluated by measuring the heat seal strength.

<Moisture absorption test>
The produced blister pack lid material was cut into a 100 mm x 100 mm sample to be used as a moisture absorption test sample, and the mass of this sample was measured.

The mass of the sample was measured after exposing the sample to an environment of a temperature of 60° C. and a relative humidity of 100% RH for 6 hours.

The difference in mass before and after treatment was calculated, and the obtained mass value was converted into mass per 1 m ² .

The evaluation criteria are as follows:
○: Moisture absorption amount is 1 g/m ² or more.
×: Moisture absorption amount is less than 1 g/m ² .

The results are shown in Table 4.

From Table 4, the blister pack lid materials of Reference Examples B1 to B4 in which the easily peelable layer contains an acrylic modified polyolefin and an acid modified polyolefin are compared to Reference Example B5 and Reference Comparison, which do not contain at least one of these. It can be seen that good sealing strength was obtained compared to the blister pack lid materials of Examples B1 and B2.

Similarly, from Table 4, it can be seen that the functionality of the blister pack lid materials of Reference Examples B1 to B4 was not impaired.

DESCRIPTION OF SYMBOLS 100 Absorbent transparent lid material 102 Transparent absorption layer 104 Transparent easily peelable layer 104a Joint part 104b, 104b' Non-joint part 106, 106' Transparent skin layer 108 Transparent barrier base material layer 108a Transparent barrier layer 108b Transparent base resin layer 144 Broken part 200 Blister container 202 Pocket 300 Contents 400 Blister pack with contents

Claims (8)

It comprises a transparent barrier base material layer and a transparent moisture absorption layer in this order,
The transparent moisture absorbing layer contains a polyolefin resin, a zeolite having an average particle diameter D50 of 300 nm or less, and an ester compound having an HLB value of 5 or less, and the transparent moisture absorbing layer has an average particle diameter D50 of 100 nm or less. The content of oxides of one or more elements selected from Al, Si, Ti, and Zr (excluding zeolite) is 0% by mass,
Absorbent transparent lid material. The resin composition constituting the transparent moisture absorbing layer has a melt flow rate of 1.0 g /10 min or more when measured in accordance with JIS K7210 at a temperature of 190° C. and a load of 21.18 N. Item 1. Absorbent transparent lid material according to item 1. The absorbent transparent lid material according to claim 1 or 2, wherein the content of the zeolite is 40% by mass or less based on the mass of the entire transparent moisture absorbing layer. The absorbent transparent lid material according to any one of claims 1 to 3, wherein the content of the ester compound is 5.0% by mass or more based on the mass of the entire transparent moisture absorbing layer. The absorbent transparent lid material according to any one of claims 1 to 4, further comprising a transparent easily peelable layer on the surface of the transparent absorbent layer opposite to the transparent barrier base layer. The absorbent transparent lid material according to any one of claims 1 to 5, which is for a blister pack. comprising a content, a blister container, and an absorbent transparent lid material according to any one of claims 1 to 6,
the blister container has a pocket,
the absorbent transparent lid is adhered to the blister container, thereby sealing the contents within the pocket;
Blister pack with contents. The absorbent transparent lid material according to any one of claims 1 to 6,
Combination with blister containers with pockets.

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