JP4866467B2 - 調節性ｔ細胞エピトープ、組成物およびその使用 - Google Patents

調節性ｔ細胞エピトープ、組成物およびその使用 Download PDF

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JP4866467B2
JP4866467B2 JP2009548278A JP2009548278A JP4866467B2 JP 4866467 B2 JP4866467 B2 JP 4866467B2 JP 2009548278 A JP2009548278 A JP 2009548278A JP 2009548278 A JP2009548278 A JP 2009548278A JP 4866467 B2 JP4866467 B2 JP 4866467B2
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tregitope
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JP2010516290A5 (Direct
JP2010516290A (ja
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グルート アン デ
ウィリアム マルティン
ダン リベラ
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エピバックス インコーポレーテッド
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JP2009548278A 2007-01-30 2008-01-29 調節性ｔ細胞エピトープ、組成物およびその使用 Expired - Fee Related JP4866467B2 (ja)

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US89834707P 2007-01-30 2007-01-30
US60/898,347 2007-01-30
PCT/US2008/001148 WO2008094538A2 (en) 2007-01-30 2008-01-29 Regulatory t cell epitopes, compositions and uses thereof

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JP2010516290A JP2010516290A (ja) 2010-05-20
JP2010516290A5 JP2010516290A5 (Direct) 2011-06-16
JP4866467B2 true JP4866467B2 (ja) 2012-02-01

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JP2009548278A Expired - Fee Related JP4866467B2 (ja) 2007-01-30 2008-01-29 調節性ｔ細胞エピトープ、組成物およびその使用
JP2011247226A Expired - Fee Related JP5643739B2 (ja) 2007-01-30 2011-11-11 調節性ｔ細胞エピトープ、組成物およびその使用
JP2014154372A Expired - Fee Related JP6121369B2 (ja) 2007-01-30 2014-07-30 調節性ｔ細胞エピトープ、組成物およびその使用
JP2017064298A Expired - Fee Related JP6472476B2 (ja) 2007-01-30 2017-03-29 調節性ｔ細胞エピトープ、組成物およびその使用
JP2019008352A Pending JP2019089793A (ja) 2007-01-30 2019-01-22 調節性ｔ細胞エピトープ、組成物およびその使用
JP2021011596A Withdrawn JP2021073255A (ja) 2007-01-30 2021-01-28 調節性ｔ細胞エピトープ、組成物およびその使用
JP2021072455A Pending JP2021107444A (ja) 2007-01-30 2021-04-22 調節性ｔ細胞エピトープ、組成物およびその使用
JP2021072446A Pending JP2021107443A (ja) 2007-01-30 2021-04-22 調節性ｔ細胞エピトープ、組成物およびその使用
JP2022155804A Pending JP2022177270A (ja) 2007-01-30 2022-09-29 調節性ｔ細胞エピトープ、組成物およびその使用
JP2024033497A Pending JP2024059975A (ja) 2007-01-30 2024-03-06 調節性ｔ細胞エピトープ、組成物およびその使用

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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2450372B1 (en) 2007-01-30 2015-04-22 Epivax, Inc. Regulatory T cell epitopes, compositions and uses thereof
DE102007030904A1 (de) * 2007-07-03 2009-02-05 Pharis Biotec Gmbh Humanes zirkulierendes antivirales Albumin-Fragment (ALB-408) und seine Verwendung
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
CN110038135B (zh) 2011-03-17 2021-03-05 伯明翰大学 重新定向的免疫治疗
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
SI3682905T1 (sl) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe
RU2620070C2 (ru) * 2011-12-13 2017-05-22 Сантр Насьональ Де Ля Решерш Сьянтифик Модифицированные пептиды и их применение для лечения аутоиммунных заболеваний
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
HK1206601A1 (en) 2012-04-02 2016-01-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
SI2922554T1 (sl) 2012-11-26 2022-06-30 Modernatx, Inc. Terminalno modificirana RNA
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
WO2015085233A1 (en) * 2013-12-06 2015-06-11 The Broad Institute Inc. Formulations for neoplasia vaccines
AU2015249553B2 (en) 2014-04-23 2021-03-04 Modernatx, Inc. Nucleic acid vaccines
US10035823B2 (en) 2014-09-29 2018-07-31 The Regents Of The University Of California Compositions for expanding regulatory T cells (TREG), and treating autoimmune and inflammatory diseases and conditions
US10213482B2 (en) 2014-12-12 2019-02-26 Immupharma France Sa Methods of treating chronic inflammatory diseases
WO2016126611A1 (en) 2015-02-02 2016-08-11 The University Of Birmingham Targeting moiety peptide epitope complexes having a plurality of t-cell epitopes
WO2016178811A1 (en) * 2015-05-04 2016-11-10 Epivax, Inc. Modified h7 hemagluttinin glycoprotein of the influenza a/shanghai/2/2013 h7 sequence
MX2017014146A (es) 2015-05-04 2018-08-14 Epivax Inc Glicoproteína de hemaglutinina h7 modificada de la secuencia de influenza a/shanghai/2/2013 h7.
DK3377103T4 (en) 2015-11-19 2025-05-19 Revitope Ltd Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells
PL238939B1 (pl) * 2016-11-02 2021-10-18 Instytut Immunologii I Terapii Doświadczalnej Polskiej Akademii Nauk Im Ludwika Hirszfelda We Wrocławiu Peptyd immunosupresyjny i jego zastosowania
CA3077084A1 (en) * 2017-10-05 2019-04-11 Epivax, Inc. Regulatory t cell epitopes
EP3622962A1 (en) * 2018-09-14 2020-03-18 advanceCOR GmbH Short cyclic peptides for the treatment of graves' disease
WO2020227233A2 (en) * 2019-05-03 2020-11-12 Richard Guilhem Neoantigens in cancer
KR20220160640A (ko) * 2020-03-27 2022-12-06 에피백스, 인크. 조절 t-세포 에피토프
US20230159610A1 (en) 2020-03-27 2023-05-25 Biotest Ag Protein comprising at least one regulatory t cell activating epitope
CN111856020B (zh) * 2020-06-19 2022-09-27 南方医科大学南方医院 乙型肝炎病毒（hbv）特异性t细胞检测方法及其应用
EP4196232A2 (en) * 2020-08-13 2023-06-21 Epivax, Inc. Regulatory t cell epitopes
MX2023003426A (es) * 2020-09-25 2023-04-27 Epivax Inc Epítopos de celulas t reguladoras retro-inversas.
CA3225927A1 (en) * 2021-07-16 2023-01-19 Vincent Dioszeghy Immunotherapeutic method for increasing cashew tolerance in a subject
KR20260013473A (ko) 2023-05-19 2026-01-28 누맙 세러퓨틱스 아게 면역원성이 감소된 항체 가변 도메인 및 항체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082406A2 (en) * 2005-02-03 2006-08-10 Antitope Limited Human antibodies and proteins

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
FR2556219B1 (fr) 1983-12-07 1987-06-26 Merieux Inst Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines
GB8725529D0 (en) † 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US6162432A (en) 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
FR2686899B1 (fr) † 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5817308A (en) * 1994-02-14 1998-10-06 University Of Rochester Tolerogenic fusion proteins of immunoglobulins and methods for inducing and maintaining tolerance
DE4425115A1 (de) 1994-07-15 1996-01-18 Boehringer Mannheim Gmbh Verfahren zur Modifizierung der Stabilität von Antikörpern
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
DE69729283T2 (de) 1996-03-20 2005-05-25 Immunomedics, Inc. GLYKOSYLIERTE IgG ANTIKÖRPER
AU6054398A (en) * 1997-02-11 1998-08-26 Immunomedics Inc. Stimulation of an immune response with antibodies labeled with the alpha-galactosyl epitope
JP2002505574A (ja) * 1997-04-30 2002-02-19 エンゾン，インコーポレイテッド ポリアルキレンオキシド修飾された単鎖ポリペプチド
US6953675B2 (en) 1997-11-06 2005-10-11 Immunomedics, Inc. Landscaped antibodies and antibody fragments for clinical use
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6445840B1 (en) 1999-05-28 2002-09-03 Omm, Inc. Micromachined optical switching devices
EP1180159B1 (en) 1999-05-28 2008-09-03 Targeted Genetics Corporation Methods and compositions for lowering the level of tumor necrosis factor (tnf) in tnf-associated disorders
ES2529300T3 (es) † 2000-04-12 2015-02-18 Novozymes Biopharma Dk A/S Proteínas de fusión de albúmina
AU2001278898A1 (en) † 2000-07-10 2002-01-21 Xencor Method for disigning protein libraries with altered immunogenicity
CN1496369A (zh) * 2001-03-15 2004-05-12 Ĭ��ר�����޹�˾ 免疫原性减弱的经修饰β干扰素
US6992174B2 (en) † 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
ES2346517T3 (es) * 2001-11-12 2010-10-18 Merck Patent Gmbh Anticuerpo modificado anti-tnf alfa.
DE60229979D1 (Direct) † 2001-12-05 2009-01-02 Circassia Ltd
ES2425738T3 (es) † 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
WO2003059934A2 (en) † 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003066085A1 (en) † 2002-02-07 2003-08-14 Delta Biotechnology Limited Albumin-fused anti-angiogenesis peptides
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
WO2003099853A2 (en) 2002-05-24 2003-12-04 Restoragen, Inc. Petide amidation process
WO2005056606A2 (en) * 2003-12-03 2005-06-23 Xencor, Inc Optimized antibodies that target the epidermal growth factor receptor
EP1578799B8 (en) * 2002-12-02 2011-03-23 Amgen Fremont Inc. Antibodies directed to tumor necrosis factor and uses thereof
CN1511958A (zh) * 2002-12-31 2004-07-14 王小宁 一种筛选人组织相容性抗原(hla)的t细胞表面抗原肽的体系,及其在制备mhc-抗原肽多聚体中的应用
CA2513213C (en) † 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
CA2537055A1 (en) * 2003-08-22 2005-04-21 Medimmune, Inc. Humanization of antibodies
WO2005063815A2 (en) 2003-11-12 2005-07-14 Biogen Idec Ma Inc. Fcϝ receptor-binding polypeptide variants and methods related thereto
ES2643760T3 (es) 2004-02-06 2017-11-24 University Of Massachusetts Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos
ES2567634T3 (es) † 2004-02-09 2016-04-25 Human Genome Sciences, Inc. Proteínas de fusión de albúmina
CA2560278C (en) * 2004-03-19 2012-11-20 Matthew Baker Modified bouganin proteins, cytotoxins and methods and uses thereof
MXPA06011199A (es) * 2004-03-31 2007-04-16 Genentech Inc Anticuerpos anti-tgf-beta humanizados.
BRPI0514052A (pt) 2004-08-03 2008-05-27 Transtech Pharma Inc proteìnas de fusão rage e métodos de utilização
KR20070057818A (ko) 2004-08-03 2007-06-07 트랜스테크 파르마, 인크. Ｒａｇｅ 융합 단백질 및 이의 사용 방법
CU23504A1 (es) * 2004-09-24 2010-04-13 Ct Ingenieria Genetica Biotech Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas
US7488804B2 (en) † 2005-02-02 2009-02-10 The Regents Of The University Of California Modified fusion molecules for treatment of allergic disease
CA2611814A1 (en) 2005-06-20 2007-01-04 Medarex, Inc. Cd19 antibodies and their uses
KR20080071119A (ko) † 2005-08-12 2008-08-01 휴먼 게놈 사이언시즈, 인코포레이티드 알부민 융합 단백질
CN100349921C (zh) * 2005-11-17 2007-11-21 中国人民解放军第四军医大学 破伤风毒素t细胞表位多肽与人b淋巴细胞刺激因子融合蛋白及其制备
KR101398713B1 (ko) * 2005-12-20 2014-06-12 브리스톨-마이어스 스큅 컴퍼니 조성물 및 조성물의 제조 방법
BRPI0709598A8 (pt) * 2006-03-17 2019-01-08 Biogen Idec Inc composições de polipeptídeos estabilizados
GB0605735D0 (en) 2006-03-22 2006-05-03 Immunobiology Ltd Composition and method for mediating an immune response
WO2007146038A2 (en) † 2006-06-07 2007-12-21 Human Genome Sciences, Inc. Albumin fusion proteins
AT503861B1 (de) † 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw Verfahren zur manipulation von t-zell-rezeptoren
US8586006B2 (en) 2006-08-09 2013-11-19 Institute For Systems Biology Organ-specific proteins and methods of their use
EP2450372B1 (en) * 2007-01-30 2015-04-22 Epivax, Inc. Regulatory T cell epitopes, compositions and uses thereof
WO2008151319A2 (en) 2007-06-08 2008-12-11 Dow Global Technologies Inc. Expression of soluble antibody fragment by truncation of ch1 domain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082406A2 (en) * 2005-02-03 2006-08-10 Antitope Limited Human antibodies and proteins

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