JP4863881B2 - 電気化学的検出システム、試料アレイ、ハイブリダイゼーションの検出方法、測定実施用キットおよび測定装置の組立方法 - Google Patents

電気化学的検出システム、試料アレイ、ハイブリダイゼーションの検出方法、測定実施用キットおよび測定装置の組立方法 Download PDF

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JP4863881B2
JP4863881B2 JP2006545819A JP2006545819A JP4863881B2 JP 4863881 B2 JP4863881 B2 JP 4863881B2 JP 2006545819 A JP2006545819 A JP 2006545819A JP 2006545819 A JP2006545819 A JP 2006545819A JP 4863881 B2 JP4863881 B2 JP 4863881B2
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry

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JP2006545819A 2003-12-15 2004-12-14 電気化学的検出システム、試料アレイ、ハイブリダイゼーションの検出方法、測定実施用キットおよび測定装置の組立方法 Expired - Fee Related JP4863881B2 (ja)

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US52980003P 2003-12-15 2003-12-15
US60/529,800 2003-12-15
PCT/US2004/041983 WO2005059513A2 (en) 2003-12-15 2004-12-14 Multiplexed electrochemical detection system and method

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CA (1) CA2548577A1 (enExample)
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Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7341834B2 (en) * 2003-12-15 2008-03-11 Geneohn Sciences, Inc. Multiplexed electrochemical detection system and method
US20060216203A1 (en) * 2005-03-28 2006-09-28 Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. Multiwell sample plate with integrated impedance electrodes and connection scheme
FR2884318B1 (fr) * 2005-04-12 2007-12-28 Univ Rennes I Etablissement Pu Procede d'analyse electrochimique par voltametrie, support d'analyse et dispositif pour sa mise en oeuvre.
US7962291B2 (en) * 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
GB2432217A (en) * 2005-11-09 2007-05-16 Seiko Epson Corp Application of biosensor chips
GB2441784A (en) * 2006-09-13 2008-03-19 Rtc North Ltd Device for obtaining and analysing a biological fluid
WO2009128346A1 (ja) * 2008-04-18 2009-10-22 国立大学法人九州工業大学 電極モジュール
JP5176235B2 (ja) * 2008-07-03 2013-04-03 国立大学法人東北大学 電気化学測定装置
WO2010101323A1 (ko) * 2009-03-06 2010-09-10 Lee Yong-Jin 멀티웰이 구비된 시료장착기
WO2011047044A2 (en) * 2009-10-13 2011-04-21 Enrique Saez A miniaturized electroporation-ready microwell array for high-throughput genomic screening
GB0920526D0 (en) 2009-11-23 2010-01-06 Ucl Business Plc Electrochemical detection
FI20100246L (fi) * 2010-06-11 2011-12-12 Sakari Kulmala Menetelmät ja laitteet luminesenssin tuottamiseksi integroiduista elektrodisiruista katodisten ja bipolaaristen pulssien avulla
JP4933657B1 (ja) * 2010-12-28 2012-05-16 日本航空電子工業株式会社 電気化学計測チップ用電極装置
JP4933656B1 (ja) * 2010-12-28 2012-05-16 日本航空電子工業株式会社 電気化学計測チップ用電極装置
US8614087B2 (en) 2011-05-02 2013-12-24 Ibis Biosciences, Inc. Multiple-analyte assay device and system
JP2013220066A (ja) * 2012-04-17 2013-10-28 Hitachi Ltd センサチップ及びそれを用いた測定方法
US9217179B2 (en) 2012-05-24 2015-12-22 The Governing Council Of The University Of Toronto Systems and methods for multiplexed electrochemical detection
US9028662B2 (en) 2012-07-10 2015-05-12 Hewlett-Packard Development Company, L.P. Electrochemical sensing arrays
USD712205S1 (en) * 2012-10-19 2014-09-02 Grace Yoder Holder for coffee k-cup
US10281678B2 (en) 2013-01-04 2019-05-07 Meso Scale Technologies, Llc Assay apparatuses, methods and reagants
AU2015372443A1 (en) * 2014-12-23 2017-06-15 Commonwealth Scientific And Industrial Research Organisation Electrochemical testing system
GB201522323D0 (en) 2015-12-17 2016-02-03 Vrije Universiteit Brussel And Katholieke Universiteit Leuven Systems and methods for conducting electrochemical impedance spectroscopy
US10837936B2 (en) * 2016-03-11 2020-11-17 Panasonic Intellectual Property Management Co., Ltd. Electrochemical measurement system, electrochemical measurement device, and electrochemical measurement method
JP6218199B1 (ja) 2016-10-06 2017-10-25 日本航空電子工業株式会社 電気化学測定装置及びトランスデューサ
US20190017028A1 (en) * 2017-07-12 2019-01-17 The Regents Of The University Of Michigan Systems and methods for cardiomyocyte pacing
CN110118803A (zh) * 2018-02-07 2019-08-13 北京易活生物科技有限公司 样本检测装置
US11336285B2 (en) * 2018-08-10 2022-05-17 Koniku Inc. Stacked integrated platform architecture
WO2020129452A1 (ja) * 2018-12-18 2020-06-25 株式会社ヨコオ 計測装置及び計測方法
JP7148079B2 (ja) * 2019-03-19 2022-10-05 国立研究開発法人物質・材料研究機構 自動電気化学測定システム、および、電気化学特性を自動測定する方法
EP3951374A1 (en) * 2020-08-03 2022-02-09 Consejo Superior de Investigaciones Científicas (CSIC) Biosensor system for multiplexed detection of biomarkers
EP4516402A3 (en) * 2020-12-21 2025-06-04 F. Hoffmann-La Roche AG Sensor assembly
CN113189168A (zh) * 2021-03-31 2021-07-30 广州钰芯传感科技有限公司 一种微电极集成传感芯片及其在水质有机污染物快速检测中的应用
CN113189169A (zh) * 2021-03-31 2021-07-30 广州钰芯传感科技有限公司 一种多个微电极集成传感芯片及其在生化无酶快速检测中的应用
CN113820373A (zh) * 2021-09-30 2021-12-21 广州钰芯传感科技有限公司 一种插卡式微电极集成传感芯片及其在金属离子快速检测中的应用
TWI838739B (zh) * 2022-04-28 2024-04-11 瑞霸生技股份有限公司 連續量測電化學資訊的自動化系統
WO2024010725A1 (en) * 2022-07-06 2024-01-11 The Trustees Of Indiana University Multi-well potentiostat
IL322791A (en) * 2023-02-15 2025-10-01 Meso Scale Technologies Llc Electrochemical cell devices and methods for their manufacture

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
JP2001503856A (ja) * 1996-09-17 2001-03-21 メソ スケール テクノロジーズ,エルエルシー 多重アレイの多重特異的な電気化学発光試験
US20020090649A1 (en) * 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
WO2003001889A2 (en) * 2001-06-29 2003-01-09 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
JP2003156471A (ja) * 2001-08-31 2003-05-30 Toshiba Corp 生体物質検出用素子、生体物質検出方法及び装置
JP2003161730A (ja) * 2001-11-26 2003-06-06 Toshiba Corp 塩基配列検出用チップ、ハイブリダイゼーションモニタリングシステム、ハイブリダイゼーションモニタリング方法
JP2003532116A (ja) * 2000-04-25 2003-10-28 オンコプローブ・リミテッド 電気化学的センシング

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
US4225410A (en) * 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
WO1993021530A1 (de) 1992-04-10 1993-10-28 Messerschmitt-Bölkow-Blohm Gmbh Verfahren und vorrichtung zur empfindlichkeits- und selektivitätssteigerung bei immuno-assays, molekül-rezeptor-, dna-komplementär-dna- und gast-wirtsmolekül-wechselwirkungs-assays
US6468742B2 (en) * 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
EP0821726B1 (en) * 1995-03-10 2014-05-07 Meso Scale Technologies, LLC. Multi-array, multi-specific electrochemiluminescence testing
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6673533B1 (en) * 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
CA2183638C (en) * 1995-03-20 2001-03-20 Tajima Hideji Liquid processing method making use of pipette device and apparatus for same
WO1996036870A1 (en) 1995-05-18 1996-11-21 Igen, Inc. Method for derivitizing electrodes and assay methods using such derivitized electrodes
EP1249705A3 (en) * 1996-12-31 2003-11-05 Genometrix Genomics Incorporated Multiplexed molecular analysis apparatus and its fabrication method
WO1998048266A1 (en) * 1997-04-24 1998-10-29 Daikin Industries, Ltd. Sensor
US6093370A (en) * 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
DE19916921A1 (de) * 1999-04-14 2000-10-19 Fraunhofer Ges Forschung Elektrisches Sensorarray
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
EP1237655A2 (en) 1999-12-09 2002-09-11 Motorola, Inc. Multilayered microfluidic devices for analyte reactions
US6716620B2 (en) * 2000-04-17 2004-04-06 Purdue Research Foundation Biosensor and related method
JP4949589B2 (ja) 2000-05-03 2012-06-13 ガウ,ジェン−ジェイアール 集積センサ・チップを有する生物学的同定システム
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US7198754B2 (en) * 2001-08-31 2007-04-03 Kabushiki Kaisha Toshiba Biological material detection element, biological material detection method and apparatus, charged material moving apparatus
US7258978B2 (en) 2002-11-06 2007-08-21 Geneohm Sciences Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen
US20040086892A1 (en) 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US7341834B2 (en) 2003-12-15 2008-03-11 Geneohn Sciences, Inc. Multiplexed electrochemical detection system and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
JP2001503856A (ja) * 1996-09-17 2001-03-21 メソ スケール テクノロジーズ,エルエルシー 多重アレイの多重特異的な電気化学発光試験
US20020090649A1 (en) * 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
JP2003532116A (ja) * 2000-04-25 2003-10-28 オンコプローブ・リミテッド 電気化学的センシング
WO2003001889A2 (en) * 2001-06-29 2003-01-09 Meso Scale Technologies, Llc. Assay plates reader systems and methods for luminescence test measurements
JP2003156471A (ja) * 2001-08-31 2003-05-30 Toshiba Corp 生体物質検出用素子、生体物質検出方法及び装置
JP2003161730A (ja) * 2001-11-26 2003-06-06 Toshiba Corp 塩基配列検出用チップ、ハイブリダイゼーションモニタリングシステム、ハイブリダイゼーションモニタリング方法

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US20050196776A1 (en) 2005-09-08
AU2004300204A1 (en) 2005-06-30
EP1695064A2 (en) 2006-08-30
US8420313B2 (en) 2013-04-16
WO2005059513A3 (en) 2006-05-26
JP2007514175A (ja) 2007-05-31
WO2005059513A2 (en) 2005-06-30
US20080210573A1 (en) 2008-09-04
US7341834B2 (en) 2008-03-11
EP1695064A4 (en) 2012-06-27
CA2548577A1 (en) 2005-06-30
AU2004300204B2 (en) 2010-06-24

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