JP4846665B2 - ピラゾロ［１，５−ａ］ピリミジン化合物 - Google Patents

ピラゾロ［１，５−ａ］ピリミジン化合物 Download PDF

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Publication number
JP4846665B2
JP4846665B2 JP2007175769A JP2007175769A JP4846665B2 JP 4846665 B2 JP4846665 B2 JP 4846665B2 JP 2007175769 A JP2007175769 A JP 2007175769A JP 2007175769 A JP2007175769 A JP 2007175769A JP 4846665 B2 JP4846665 B2 JP 4846665B2
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Japan
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group
chlorophenyl
carbamoyl
pyrimidine
alkyl
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JP2007175769A
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Japanese (ja)
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JP2008285464A5 (enExample
JP2008285464A (ja
Inventor
晃一 谷本
真利子 大井
康範 坪井
恭典 盛谷
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Tanabe Pharma Corp
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Mitsubishi Tanabe Pharma Corp
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Priority to JP2007175769A priority Critical patent/JP4846665B2/ja
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Publication of JP2008285464A5 publication Critical patent/JP2008285464A5/ja
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007175769A 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物 Expired - Fee Related JP4846665B2 (ja)

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JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2006185036 2006-07-05
JP2006185036 2006-07-05
JP2007009706 2007-01-19
JP2007009706 2007-01-19
JP2007059332 2007-03-09
JP2007059332 2007-03-09
JP2007111340 2007-04-20
JP2007111340 2007-04-20
JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Publications (3)

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JP2008285464A JP2008285464A (ja) 2008-11-27
JP2008285464A5 JP2008285464A5 (enExample) 2009-04-09
JP4846665B2 true JP4846665B2 (ja) 2011-12-28

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JP (1) JP4846665B2 (enExample)
TW (2) TWI419889B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30090A1 (es) * 2006-01-16 2007-08-31 Syngenta Participations Ag Insecticidas novedosos
RS53350B (sr) 2008-09-22 2014-10-31 Array Biopharma, Inc. Supstituisana jedinjenja imidazo[1,2-b]piridazina kao inhibitori trk kinaze
HRP20140309T1 (hr) 2008-10-22 2014-05-09 Array Biopharma, Inc. SUPSTITUIRANI SPOJEVI PIRAZOLO[1,5-a]PIRIMIDINA KAO INHIBITORI TRK KINAZE
CN102271515B (zh) * 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
KR102015402B1 (ko) 2010-05-20 2019-08-28 어레이 바이오파마 인크. Trk 키나제 저해제로서의 매크로시클릭 화합물
KR101914161B1 (ko) * 2010-08-31 2018-11-02 (주)아모레퍼시픽 카나비노이드 1 수용체 저해제로 작용하는 신규 화합물
US8796305B2 (en) * 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
JP6914834B2 (ja) 2014-11-16 2021-08-04 アレイ バイオファーマ インコーポレイテッド （Ｓ）−Ｎ−（５−（（Ｒ）−２−（２，５−ジフルオロフェニル）−ピロリジン−１−イル）−ピラゾロ［１，５−ａ］ピリミジン−３−イル）−３−ヒドロキシピロリジン−１−カルボキサミド硫酸水素塩の結晶形
US10160761B2 (en) * 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
TN2018000138A1 (en) 2015-10-26 2019-10-04 Array Biopharma Inc Point mutations in trk inhibitor-resistant cancer and methods relating to the same
AU2017246554B2 (en) 2016-04-04 2022-08-18 Loxo Oncology, Inc. Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
KR102566858B1 (ko) 2016-05-18 2023-08-11 어레이 바이오파마 인크. (s)-n-(5-((r)-2-(2,5-디플루오로페닐)피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복사미드의 제조 방법
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1511751B1 (en) * 2002-06-04 2008-03-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
DE102004008807A1 (de) * 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
WO2005103052A1 (en) * 2004-04-21 2005-11-03 Pfizer Products Inc. Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
KR101071438B1 (ko) * 2005-10-21 2011-10-10 미쓰비시 타나베 파마 코퍼레이션 카나비노이드 수용체 길항제로서의피라졸로[1,5-ａ]피리미딘 화합물
JP4847275B2 (ja) * 2005-10-21 2011-12-28 田辺三菱製薬株式会社 ピラゾロ［１，５−ａ］ピリミジン化合物

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Publication number Publication date
TW201345908A (zh) 2013-11-16
TWI419889B (zh) 2013-12-21
JP2008285464A (ja) 2008-11-27
TW200811177A (en) 2008-03-01

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