JP4843608B2 - カゼイン・キナーゼＩε阻害剤としての３−置換−５−及び６−アミノアルキルインドール−２−カルボン酸アミド及び関連する類似化合物 - Google Patents

カゼイン・キナーゼＩε阻害剤としての３−置換−５−及び６−アミノアルキルインドール−２−カルボン酸アミド及び関連する類似化合物 Download PDF

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JP4843608B2
JP4843608B2 JP2007527928A JP2007527928A JP4843608B2 JP 4843608 B2 JP4843608 B2 JP 4843608B2 JP 2007527928 A JP2007527928 A JP 2007527928A JP 2007527928 A JP2007527928 A JP 2007527928A JP 4843608 B2 JP4843608 B2 JP 4843608B2
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indole
phenylsulfanyl
carboxylic acid
acid amide
methyl
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JP2008510017A (ja
JP2008510017A5 (enExample
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ウィリアム・アーサー・メッツ・ジュニア
ファー−シアーン・ディン
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アベンティス・ファーマスーティカルズ・インコーポレイテツド
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2007527928A 2004-08-19 2005-08-16 カゼイン・キナーゼＩε阻害剤としての３−置換−５−及び６−アミノアルキルインドール−２−カルボン酸アミド及び関連する類似化合物 Expired - Fee Related JP4843608B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19
US60/603,380 2004-08-19
PCT/US2005/029053 WO2006023467A1 (en) 2004-08-19 2005-08-16 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Iϵ

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JP2008510017A JP2008510017A (ja) 2008-04-03
JP2008510017A5 JP2008510017A5 (enExample) 2008-09-04
JP4843608B2 true JP4843608B2 (ja) 2011-12-21

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JP2007527928A Expired - Fee Related JP4843608B2 (ja) 2004-08-19 2005-08-16 カゼイン・キナーゼＩε阻害剤としての３−置換−５−及び６−アミノアルキルインドール−２−カルボン酸アミド及び関連する類似化合物

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US (2) US7629376B2 (enExample)
EP (1) EP1794122B1 (enExample)
JP (1) JP4843608B2 (enExample)
KR (2) KR20130038409A (enExample)
CN (1) CN101006055B (enExample)
AR (1) AR050919A1 (enExample)
AT (1) ATE508112T1 (enExample)
AU (1) AU2005277523B2 (enExample)
BR (1) BRPI0514380A (enExample)
CA (1) CA2577667C (enExample)
DE (1) DE602005027858D1 (enExample)
GT (1) GT200500214A (enExample)
IL (1) IL181156A (enExample)
JO (1) JO2724B1 (enExample)
MA (1) MA28863B1 (enExample)
MX (1) MX2007001382A (enExample)
NO (1) NO20071466L (enExample)
NZ (1) NZ552800A (enExample)
PA (1) PA8642901A1 (enExample)
PE (1) PE20060498A1 (enExample)
RU (1) RU2369599C2 (enExample)
SV (1) SV2006002192A (enExample)
TW (1) TWI357897B (enExample)
UY (1) UY29078A1 (enExample)
WO (1) WO2006023467A1 (enExample)
ZA (1) ZA200700651B (enExample)

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JP4748823B2 (ja) * 2009-02-12 2011-08-17 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
SG175210A1 (en) * 2009-04-17 2011-11-28 Cylene Pharmaceuticals Inc Method of treating disorders associated with protein kinase ck2 activity
CA2877589C (en) 2012-06-27 2019-11-26 4Sc Ag Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders
JP2021511364A (ja) 2018-01-29 2021-05-06 カディラ ヘルスケア リミティド 抗菌剤として有用な複素環式化合物
WO2022006377A2 (en) 2020-07-02 2022-01-06 Mbq Pharma Heterocyclic inhibitors of rho gtpases for the treatment of disease
US12209078B2 (en) 2021-10-06 2025-01-28 Mbq Pharma Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501074A (ja) * 1999-06-08 2003-01-14 アベンティス・ファーマスーティカルズ・インコーポレイテツド 概日リズムタンパク質の変化に関するスクリーニング方法
WO2004014851A2 (en) * 2002-08-09 2004-02-19 Merck & Co., Inc. Tyrosine kinase inhibitors

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
TWI310035B (en) * 2000-04-28 2009-05-21 Acadia Pharm Inc Muscarinic agonists
CN100439367C (zh) * 2003-12-11 2008-12-03 安万特药物公司 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003501074A (ja) * 1999-06-08 2003-01-14 アベンティス・ファーマスーティカルズ・インコーポレイテツド 概日リズムタンパク質の変化に関するスクリーニング方法
WO2004014851A2 (en) * 2002-08-09 2004-02-19 Merck & Co., Inc. Tyrosine kinase inhibitors

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Publication number Publication date
EP1794122A1 (en) 2007-06-13
CN101006055A (zh) 2007-07-25
CN101006055B (zh) 2011-06-22
US7629376B2 (en) 2009-12-08
HK1105196A1 (en) 2008-02-06
IL181156A0 (en) 2007-07-04
JP2008510017A (ja) 2008-04-03
AU2005277523A1 (en) 2006-03-02
BRPI0514380A (pt) 2008-06-10
SV2006002192A (es) 2006-06-28
EP1794122B1 (en) 2011-05-04
GT200500214A (es) 2006-03-27
DE602005027858D1 (de) 2011-06-16
CA2577667C (en) 2011-01-04
NZ552800A (en) 2010-11-26
TW200621711A (en) 2006-07-01
RU2007109783A (ru) 2008-09-27
MX2007001382A (es) 2007-04-19
RU2369599C2 (ru) 2009-10-10
IL181156A (en) 2011-09-27
PE20060498A1 (es) 2006-07-10
US7923466B2 (en) 2011-04-12
AU2005277523B2 (en) 2011-09-29
ATE508112T1 (de) 2011-05-15
WO2006023467A1 (en) 2006-03-02
KR20070043012A (ko) 2007-04-24
US20090082340A1 (en) 2009-03-26
NO20071466L (no) 2007-04-19
CA2577667A1 (en) 2006-03-02
ZA200700651B (en) 2008-09-25
KR20130038409A (ko) 2013-04-17
TWI357897B (en) 2012-02-11
PA8642901A1 (es) 2006-05-16
US20080027124A1 (en) 2008-01-31
MA28863B1 (fr) 2007-09-03
AR050919A1 (es) 2006-12-06
JO2724B1 (en) 2013-09-15
UY29078A1 (es) 2006-03-31

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