KR20130038409A - 카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및 6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 - Google Patents
카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및 6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 Download PDFInfo
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- KR20130038409A KR20130038409A KR1020137005469A KR20137005469A KR20130038409A KR 20130038409 A KR20130038409 A KR 20130038409A KR 1020137005469 A KR1020137005469 A KR 1020137005469A KR 20137005469 A KR20137005469 A KR 20137005469A KR 20130038409 A KR20130038409 A KR 20130038409A
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- South Korea
- Prior art keywords
- indole
- carboxylic acid
- mmol
- phenylsulfanyl
- acid amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- KPOWODVZVBAOQC-UHFFFAOYSA-N tert-butyl n-[(2-carbamoyl-1h-indol-6-yl)methyl]carbamate Chemical compound CC(C)(C)OC(=O)NCC1=CC=C2C=C(C(N)=O)NC2=C1 KPOWODVZVBAOQC-UHFFFAOYSA-N 0.000 description 1
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- DKZBBWMURDFHNE-UHFFFAOYSA-N trans-coniferylaldehyde Natural products COC1=CC(C=CC=O)=CC=C1O DKZBBWMURDFHNE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60338004P | 2004-08-19 | 2004-08-19 | |
| US60/603,380 | 2004-08-19 | ||
| PCT/US2005/029053 WO2006023467A1 (en) | 2004-08-19 | 2005-08-16 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Iϵ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077003922A Division KR20070043012A (ko) | 2004-08-19 | 2005-08-16 | 카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130038409A true KR20130038409A (ko) | 2013-04-17 |
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| KR1020137005469A Withdrawn KR20130038409A (ko) | 2004-08-19 | 2005-08-16 | 카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및 6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 |
| KR1020077003922A Abandoned KR20070043012A (ko) | 2004-08-19 | 2005-08-16 | 카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 |
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| KR1020077003922A Abandoned KR20070043012A (ko) | 2004-08-19 | 2005-08-16 | 카제인 키나제 Ｉε의 억제제로서 3-치환된-5- 및6-아미노알킬 인돌-2-카복실산 아미드 및 관련된 유사체 |
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|---|---|
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| EP (1) | EP1794122B1 (enExample) |
| JP (1) | JP4843608B2 (enExample) |
| KR (2) | KR20130038409A (enExample) |
| CN (1) | CN101006055B (enExample) |
| AR (1) | AR050919A1 (enExample) |
| AT (1) | ATE508112T1 (enExample) |
| AU (1) | AU2005277523B2 (enExample) |
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| CA (1) | CA2577667C (enExample) |
| DE (1) | DE602005027858D1 (enExample) |
| GT (1) | GT200500214A (enExample) |
| IL (1) | IL181156A (enExample) |
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| MA (1) | MA28863B1 (enExample) |
| MX (1) | MX2007001382A (enExample) |
| NO (1) | NO20071466L (enExample) |
| NZ (1) | NZ552800A (enExample) |
| PA (1) | PA8642901A1 (enExample) |
| PE (1) | PE20060498A1 (enExample) |
| RU (1) | RU2369599C2 (enExample) |
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| TW (1) | TWI357897B (enExample) |
| UY (1) | UY29078A1 (enExample) |
| WO (1) | WO2006023467A1 (enExample) |
| ZA (1) | ZA200700651B (enExample) |
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| JP4748823B2 (ja) * | 2009-02-12 | 2011-08-17 | 株式会社ファルマデザイン | カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤 |
| SG175210A1 (en) * | 2009-04-17 | 2011-11-28 | Cylene Pharmaceuticals Inc | Method of treating disorders associated with protein kinase ck2 activity |
| CA2877589C (en) | 2012-06-27 | 2019-11-26 | 4Sc Ag | Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders |
| JP2021511364A (ja) | 2018-01-29 | 2021-05-06 | カディラ ヘルスケア リミティド | 抗菌剤として有用な複素環式化合物 |
| WO2022006377A2 (en) | 2020-07-02 | 2022-01-06 | Mbq Pharma | Heterocyclic inhibitors of rho gtpases for the treatment of disease |
| US12209078B2 (en) | 2021-10-06 | 2025-01-28 | Mbq Pharma | Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease |
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| US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| KR100722176B1 (ko) | 1999-06-08 | 2007-05-29 | 아벤티스 파마슈티칼스 인크. | 일주기 리듬 단백질을 변화시키기 위한 스크리닝 방법 |
| TWI310035B (en) * | 2000-04-28 | 2009-05-21 | Acadia Pharm Inc | Muscarinic agonists |
| CA2494962C (en) * | 2002-08-09 | 2011-06-14 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| CN100439367C (zh) * | 2003-12-11 | 2008-12-03 | 安万特药物公司 | 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物 |
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- 2005-08-16 AR ARP050103442A patent/AR050919A1/es not_active Application Discontinuation
- 2005-08-16 KR KR1020137005469A patent/KR20130038409A/ko not_active Withdrawn
- 2005-08-16 KR KR1020077003922A patent/KR20070043012A/ko not_active Abandoned
- 2005-08-16 RU RU2007109783/04A patent/RU2369599C2/ru not_active IP Right Cessation
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- 2005-08-16 JP JP2007527928A patent/JP4843608B2/ja not_active Expired - Fee Related
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- 2005-08-19 TW TW094128283A patent/TWI357897B/zh not_active IP Right Cessation
- 2005-08-19 UY UY29078A patent/UY29078A1/es unknown
- 2005-08-19 PA PA20058642901A patent/PA8642901A1/es unknown
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2007
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- 2007-02-04 IL IL181156A patent/IL181156A/en not_active IP Right Cessation
- 2007-02-13 US US11/674,385 patent/US7629376B2/en not_active Expired - Lifetime
- 2007-03-14 MA MA29757A patent/MA28863B1/fr unknown
- 2007-03-19 NO NO20071466A patent/NO20071466L/no not_active Application Discontinuation
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2008
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