JP4825194B2 - １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用 - Google Patents
１，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用 Download PDFInfo
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- JP4825194B2 JP4825194B2 JP2007500099A JP2007500099A JP4825194B2 JP 4825194 B2 JP4825194 B2 JP 4825194B2 JP 2007500099 A JP2007500099 A JP 2007500099A JP 2007500099 A JP2007500099 A JP 2007500099A JP 4825194 B2 JP4825194 B2 JP 4825194B2
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- alkyl
- substituted
- alkoxycarbonyl
- trifluoromethyl
- Prior art date
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- 0 *=*(CC1)CC*1C(CN)=O Chemical compound *=*(CC1)CC*1C(CN)=O 0.000 description 6
- PKETXFGBAVBKCU-UHFFFAOYSA-N CC(C(C(C(c(cc1)ccc1C#N)N1)=C(C)N(c2cccc(C(F)(F)F)c2)C1=O)=O)OCc1ccccc1 Chemical compound CC(C(C(C(c(cc1)ccc1C#N)N1)=C(C)N(c2cccc(C(F)(F)F)c2)C1=O)=O)OCc1ccccc1 PKETXFGBAVBKCU-UHFFFAOYSA-N 0.000 description 1
- ZRZMTGMVUGGILU-GAGCMDECSA-N CC(C([C@@H](c(cc1)ccc1C#N)N1)=C(C)N(c2cc(C(F)(F)F)ccc2)C1=O)O Chemical compound CC(C([C@@H](c(cc1)ccc1C#N)N1)=C(C)N(c2cc(C(F)(F)F)ccc2)C1=O)O ZRZMTGMVUGGILU-GAGCMDECSA-N 0.000 description 1
- BMFTVFVJBPREFP-UHFFFAOYSA-N CC(C)(C)OC(CN(C(c(cc1)ccc1C#N)C(C(C(CC1)CCN1C(OC(C)(C)C)=O)=O)=C(C)N1c2cc(C(F)(F)F)ccc2)C1=O)=O Chemical compound CC(C)(C)OC(CN(C(c(cc1)ccc1C#N)C(C(C(CC1)CCN1C(OC(C)(C)C)=O)=O)=C(C)N1c2cc(C(F)(F)F)ccc2)C1=O)=O BMFTVFVJBPREFP-UHFFFAOYSA-N 0.000 description 1
- OSNKRUWWESYONG-UHFFFAOYSA-N CC(C)(C)OC(c1cc(CN(C(c(cc2)ccc2C#N)C(C(C2CCCCC2)=O)=C(C)N2c3cc(C(F)(F)F)ccc3)C2=O)ccc1)=O Chemical compound CC(C)(C)OC(c1cc(CN(C(c(cc2)ccc2C#N)C(C(C2CCCCC2)=O)=C(C)N2c3cc(C(F)(F)F)ccc3)C2=O)ccc1)=O OSNKRUWWESYONG-UHFFFAOYSA-N 0.000 description 1
- GKZMTDSZKWLTTA-UHFFFAOYSA-N CC(N(c1cc(C(F)(F)F)ccc1)C(N(Cc1nc(C(O)=O)c[o]1)C1c(cc2)ccc2C#N)=O)=C1C(C1CCCCC1)=O Chemical compound CC(N(c1cc(C(F)(F)F)ccc1)C(N(Cc1nc(C(O)=O)c[o]1)C1c(cc2)ccc2C#N)=O)=C1C(C1CCCCC1)=O GKZMTDSZKWLTTA-UHFFFAOYSA-N 0.000 description 1
- IAIVBCDXTIKSCE-UHFFFAOYSA-N CC(N(c1cc(C(F)(F)F)ccc1)C(NC1c(cc2)ccc2C#N)=O)=C1C(c(cc1)ccc1Br)=O Chemical compound CC(N(c1cc(C(F)(F)F)ccc1)C(NC1c(cc2)ccc2C#N)=O)=C1C(c(cc1)ccc1Br)=O IAIVBCDXTIKSCE-UHFFFAOYSA-N 0.000 description 1
- HOXAQIYGZSVUFX-UHFFFAOYSA-N CC(N(c1cc(C(F)(F)F)ccc1)C(NC1c(cc2)ccc2C#N)=O)=C1C(c(cc1)ccc1[N+]([O-])=O)=O Chemical compound CC(N(c1cc(C(F)(F)F)ccc1)C(NC1c(cc2)ccc2C#N)=O)=C1C(c(cc1)ccc1[N+]([O-])=O)=O HOXAQIYGZSVUFX-UHFFFAOYSA-N 0.000 description 1
- BBHISLJAQMKEOP-QGZVFWFLSA-N CC(N(c1cc(C(F)(F)F)ccc1)C(N[C@@H]1c(cc2)ccc2C#N)=O)=C1C(O)=O Chemical compound CC(N(c1cc(C(F)(F)F)ccc1)C(N[C@@H]1c(cc2)ccc2C#N)=O)=C1C(O)=O BBHISLJAQMKEOP-QGZVFWFLSA-N 0.000 description 1
- XERLAFZWYABQAT-LJQANCHMSA-N CC(N(c1cc(C(F)(F)F)ccc1)C(N[C@@H]1c(cc2)ccc2C#N)=O)=C1C(OCCO)=O Chemical compound CC(N(c1cc(C(F)(F)F)ccc1)C(N[C@@H]1c(cc2)ccc2C#N)=O)=C1C(OCCO)=O XERLAFZWYABQAT-LJQANCHMSA-N 0.000 description 1
- VDDANIYSDIBFJS-UHFFFAOYSA-N CC(N(c1cccc(C(F)(F)F)c1)C(N(CC(NS(c(cc1)ccc1C#N)(=O)=O)=O)C1c(cc2)ccc2C#N)=O)=C1C(C1CC1)=O Chemical compound CC(N(c1cccc(C(F)(F)F)c1)C(N(CC(NS(c(cc1)ccc1C#N)(=O)=O)=O)C1c(cc2)ccc2C#N)=O)=C1C(C1CC1)=O VDDANIYSDIBFJS-UHFFFAOYSA-N 0.000 description 1
- OTPMOUAVZRNQRG-UHFFFAOYSA-N CC(N(c1cccc(C(F)(F)F)c1)C(NC1c(cc2)ccc2C#N)=O)=C1C(C(CCCC1)N1C(OCc1ccccc1)=O)=O Chemical compound CC(N(c1cccc(C(F)(F)F)c1)C(NC1c(cc2)ccc2C#N)=O)=C1C(C(CCCC1)N1C(OCc1ccccc1)=O)=O OTPMOUAVZRNQRG-UHFFFAOYSA-N 0.000 description 1
- AAOCHJQJPVPDCQ-LJQANCHMSA-N CC(N1c2cc(C(F)(F)F)ccc2)=C(CC(C(O)=O)C(O)=O)[C@@H](c(cc2)ccc2C#N)NC1=O Chemical compound CC(N1c2cc(C(F)(F)F)ccc2)=C(CC(C(O)=O)C(O)=O)[C@@H](c(cc2)ccc2C#N)NC1=O AAOCHJQJPVPDCQ-LJQANCHMSA-N 0.000 description 1
- ULGIVTLZXRBMOX-HXUWFJFHSA-N CC(N1c2cc(C(F)(F)F)ccc2)=C(CCC(O)=O)[C@@H](c(cc2)ccc2C#N)NC1=O Chemical compound CC(N1c2cc(C(F)(F)F)ccc2)=C(CCC(O)=O)[C@@H](c(cc2)ccc2C#N)NC1=O ULGIVTLZXRBMOX-HXUWFJFHSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004314.3 | 2004-02-26 | ||
| EP04004314 | 2004-02-26 | ||
| PCT/EP2005/001486 WO2005082864A1 (en) | 2004-02-26 | 2005-02-15 | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007524696A JP2007524696A (ja) | 2007-08-30 |
| JP2007524696A5 JP2007524696A5 (enExample) | 2008-04-03 |
| JP4825194B2 true JP4825194B2 (ja) | 2011-11-30 |
Family
ID=34895952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007500099A Expired - Fee Related JP4825194B2 (ja) | 2004-02-26 | 2005-02-15 | １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8101615B2 (enExample) |
| EP (1) | EP1723121B1 (enExample) |
| JP (1) | JP4825194B2 (enExample) |
| CA (1) | CA2557271C (enExample) |
| ES (1) | ES2394177T3 (enExample) |
| WO (1) | WO2005082864A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| CA2556463C (en) | 2004-02-19 | 2012-08-14 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| EP1730121B1 (en) * | 2004-02-26 | 2013-08-07 | Bayer Intellectual Property GmbH | 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors |
| WO2006063792A2 (en) * | 2004-12-16 | 2006-06-22 | Bayer Healthcare Ag | Crystal structure of enzyme and uses thereof |
| GB0502258D0 (en) * | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| US7994211B2 (en) | 2005-08-08 | 2011-08-09 | Argenta Discovery Limited | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| DE102006031314A1 (de) * | 2006-07-01 | 2008-01-03 | Bayer Healthcare Aktiengesellschaft | Verwendung von 1,4-Diaryl-dihydropyrimidin-2-on-Derivaten zur Behandlung der pulmonalen arteriellen Hyptertonie |
| WO2008104752A1 (en) * | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
| DE102007019691A1 (de) | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von acyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007019690A1 (de) | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von cyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007027800A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| DE102007027799A1 (de) | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte Furopyrimidine und ihre Verwendung |
| DE102007051762A1 (de) | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituierte Pyrrolotriazine und ihre Verwendung |
| AU2008325288B2 (en) | 2007-11-06 | 2011-12-22 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| DE102007054786A1 (de) | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituierte Furopyrimidine und ihre Verwendung |
| DE102007061766A1 (de) | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | 4-(4-Cyano-2-thioaryl)-dihydropyrimidinone und ihre Verwendung |
| SI2234985T1 (sl) * | 2007-12-20 | 2012-06-29 | Bayer Pharma AG | 4-(4-ciano-2-tioaril)dihidropirimidinoni in njihova uporaba |
| DE102008022521A1 (de) | 2008-05-07 | 2009-11-12 | Bayer Schering Pharma Aktiengesellschaft | 1,4-Diaryl-pyrimidopyridazin-2,5-dione und ihre Verwendung |
| DE102008052013A1 (de) | 2008-10-17 | 2010-04-22 | Bayer Schering Pharma Aktiengesellschaft | 4-(4-Cyano-2-thioaryl)-dihydropyrimidinone und ihre Verwendung |
| DE102008007400A1 (de) | 2008-02-04 | 2009-08-06 | Bayer Healthcare Ag | Substituierte Furane und ihre Verwendung |
| US8642595B2 (en) * | 2008-06-09 | 2014-02-04 | Bayer Intellectual Property Gmbh | Annellated 4-(indazolyl)-1,4-dihydropyridine derivatives and methods of use thereof |
| DE102009004197A1 (de) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| DE102009016553A1 (de) | 2009-04-06 | 2010-10-07 | Bayer Schering Pharma Aktiengesellschaft | Sulfonamid- und Sulfoximin-substituierte Diaryldihydropyrimidinone und ihre Verwendung |
| EP2451817B1 (en) * | 2009-07-10 | 2013-09-04 | Bayer Intellectual Property GmbH | Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof |
| CA2773618A1 (en) | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
| GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
| GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| US20140221335A1 (en) | 2013-02-06 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9115093B2 (en) * | 2013-03-04 | 2015-08-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| CN105705503B (zh) * | 2013-08-28 | 2019-07-09 | 拜耳作物科学股份公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪的丙二酸酯衍生物 |
| AU2014356984B2 (en) * | 2013-11-27 | 2018-01-04 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
| USRE47493E1 (en) | 2014-02-20 | 2019-07-09 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| EP3126339A1 (de) | 2014-04-03 | 2017-02-08 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung |
| US20170114049A1 (en) | 2014-04-03 | 2017-04-27 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases |
| JP2017511319A (ja) | 2014-04-03 | 2017-04-20 | バイエル ファーマ アクチエンゲゼルシャフト | キラル２，５−ジ置換されたシクロペンタンカルボン酸誘導体およびそれの使用 |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9290457B2 (en) * | 2014-07-31 | 2016-03-22 | Boehringer Ingelheim International Gmbh | Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9458113B2 (en) | 2014-07-31 | 2016-10-04 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US10316001B2 (en) * | 2015-03-18 | 2019-06-11 | Ph Pharma Co., Ltd. | Method for producing (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrohydro pyrimidine-5-carbonitrile |
| TWI810220B (zh) | 2017-11-17 | 2023-08-01 | 德商拜耳廠股份有限公司 | 經取代之巨環吲哚衍生物 |
| WO2019166628A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| WO2019166627A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| EP3759073A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Sulfonamide derivates as nlrp3 inhibitors |
| US11530200B2 (en) | 2018-03-02 | 2022-12-20 | Inflazome Limited | Compounds |
| WO2019166629A1 (en) * | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| CA3154761A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| SI4106757T1 (sl) | 2020-04-16 | 2023-11-30 | Mereo Biopharma 4 Limited | Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1 |
| WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
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| CA2556463C (en) | 2004-02-19 | 2012-08-14 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
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- 2005-02-15 JP JP2007500099A patent/JP4825194B2/ja not_active Expired - Fee Related
- 2005-02-15 US US10/590,770 patent/US8101615B2/en not_active Expired - Fee Related
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- 2005-02-15 EP EP05707386A patent/EP1723121B1/en not_active Expired - Lifetime
- 2005-02-15 WO PCT/EP2005/001486 patent/WO2005082864A1/en not_active Ceased
- 2005-02-15 ES ES05707386T patent/ES2394177T3/es not_active Expired - Lifetime
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|---|---|---|---|---|
| JP2006507355A (ja) * | 2002-09-10 | 2006-03-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 急性および慢性炎症、虚血およびリモデリング過程に対する治療剤としてのピリミジノン誘導体 |
| JP2007509074A (ja) * | 2003-10-16 | 2007-04-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、および方法 |
| JP2007509174A (ja) * | 2003-10-24 | 2007-04-12 | ワイス | ５ｈｔ２ｃアゴニストとしてのジヒドロベンゾフラニルアルカンアミン誘導体 |
| JP2007523931A (ja) * | 2004-02-26 | 2007-08-23 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | １，４−ジアリール−ジヒドロピリミジン−２オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080064704A1 (en) | 2008-03-13 |
| WO2005082864A1 (en) | 2005-09-09 |
| CA2557271C (en) | 2012-08-21 |
| EP1723121A1 (en) | 2006-11-22 |
| JP2007524696A (ja) | 2007-08-30 |
| EP1723121B1 (en) | 2012-07-25 |
| US8101615B2 (en) | 2012-01-24 |
| CA2557271A1 (en) | 2005-09-09 |
| ES2394177T3 (es) | 2013-01-23 |
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