JP4823906B2 - 多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム - Google Patents

多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム Download PDF

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JP4823906B2
JP4823906B2 JP2006523960A JP2006523960A JP4823906B2 JP 4823906 B2 JP4823906 B2 JP 4823906B2 JP 2006523960 A JP2006523960 A JP 2006523960A JP 2006523960 A JP2006523960 A JP 2006523960A JP 4823906 B2 JP4823906 B2 JP 4823906B2
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optical fiber
illumination
irradiation
fiber
laser
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JP2007503851A (ja
JP2007503851A5 (enExample
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アレクサンダー エル． ガエタ
ディミター ジー． ウーズーノブ
ワット ダブリュー． ウェブ
レベッカ エム． ウィリアムズ
ワレン アール． ジップフェル
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コーネル リサーチ ファンデーション インコーポレーティッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning

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  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
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  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
JP2006523960A 2003-08-19 2004-08-16 多光子顕微鏡観察、分光法、および内視鏡観察などの生物学的用途のための光ファイバー送集光システム Expired - Fee Related JP4823906B2 (ja)

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US49624103P 2003-08-19 2003-08-19
US60/496,241 2003-08-19
PCT/US2004/026521 WO2005057244A2 (en) 2003-08-19 2004-08-16 Optical fiber delivery and collection system for biological applications

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JP2007503851A5 JP2007503851A5 (enExample) 2011-06-16
JP4823906B2 true JP4823906B2 (ja) 2011-11-24

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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233554A1 (en) * 2005-04-14 2006-10-19 Siddharth Ramachandran Optical fiber systems for delivering short high power pulses
DE102005021205B4 (de) * 2005-05-07 2007-08-16 Mfd Diagnostics Gmbh Verfahren und Anordnung zur lokalen Erfassung der Vitalität von lebenden Zellen in Zellkulturen oder im Gewebe
US20070073160A1 (en) * 2005-09-13 2007-03-29 Children's Medical Center Corporation Light-guided transluminal catheter
US8954134B2 (en) 2005-09-13 2015-02-10 Children's Medical Center Corporation Light-guided transluminal catheter
US8554035B2 (en) * 2006-10-26 2013-10-08 Cornell Research Foundation, Inc. Production of optical pulses at a desired wavelength using soliton self-frequency shift in higher-order-mode fiber
US20090326385A1 (en) * 2006-12-06 2009-12-31 Koninklijke Philips Electronics N.V. Obtaining optical tissue properties
US8385997B2 (en) * 2007-12-11 2013-02-26 Tokitae Llc Spectroscopic detection of malaria via the eye
US8467842B2 (en) * 2010-02-10 2013-06-18 Tokitae Llc Systems, devices, and methods including multi-harmonic optical detection of hemozoin nanoparticles
JP2011521237A (ja) 2008-05-20 2011-07-21 ユニバーシティー ヘルス ネットワーク 螢光に基づく画像化およびモニタリング用装置ならびにその方法
JP5612608B2 (ja) * 2009-01-30 2014-10-22 コーニンクレッカ フィリップス エヌ ヴェ 検査装置
DE102009028994B3 (de) * 2009-08-28 2011-02-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zum spektroskopischen Nachweis von Molekülen
US9044141B2 (en) 2010-02-10 2015-06-02 Tokitae Llc Systems, devices, and methods including a dark-field reflected-illumination apparatus
US8781184B2 (en) 2010-02-10 2014-07-15 Tokitae Llc Systems, devices, and methods for detection of malaria
WO2012106641A2 (en) 2011-02-04 2012-08-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lightguides to simplify total emission detection for multiphoton microscopy
WO2013175879A1 (ja) * 2012-05-25 2013-11-28 オリンパスメディカルシステムズ株式会社 測定プローブ
US9550072B2 (en) * 2012-08-03 2017-01-24 Cerca Solutions, LLC Diagnostic device, therapeutic device, and uses thereof
US9155474B2 (en) * 2013-08-14 2015-10-13 Omega Optical, Inc. System for multispectral imaging of fluorescence
CN103705201B (zh) * 2014-01-16 2015-11-04 福建师范大学 一种适用于消化道病变检测的多模光谱分析系统
CN107072505B (zh) 2014-04-05 2021-03-12 手术感应设备公司 用于组织氧合的绘制的装置、系统和方法
KR101585011B1 (ko) * 2014-04-11 2016-01-15 한국과학기술원 광섬유 래스터 스캐닝 방식의 멀티 모드 내시현미경 시스템
JP2015227778A (ja) * 2014-05-30 2015-12-17 ソニー株式会社 画像取得装置及び画像取得方法
CN115989999A (zh) 2014-07-24 2023-04-21 大学健康网络 用于诊断目的的数据的收集和分析
EP3288534B1 (en) 2015-04-28 2020-09-23 Symrise AG Compositions comprising valerian extracts
JP7245051B2 (ja) 2016-03-08 2023-03-23 エンスペクトラ・ヘルス・インコーポレイテッド 皮膚の疾患の非侵襲的な検出
GB201701355D0 (en) 2017-01-27 2017-03-15 Renishaw Plc Direct laser writing and chemical etching
WO2018201082A1 (en) 2017-04-28 2018-11-01 Zebra Medical Technologies, Inc. Systems and methods for imaging and measurement of sarcomeres
CN108937824A (zh) * 2018-08-02 2018-12-07 深圳大学 一种内窥成像装置和荧光寿命分布图像的获取方法
US11035794B2 (en) 2018-09-28 2021-06-15 Uchicago Argonne, Llc Scalable, large-area optical sensing platform with compact light delivery and imaging system
WO2020102442A1 (en) 2018-11-13 2020-05-22 Enspectra Health, Inc. Methods and systems for generating depth profiles
CN109758098B (zh) * 2019-01-31 2024-03-19 北京超维景生物科技有限公司 可变焦式腔体内窥镜探测装置及激光扫描腔体内窥镜
CN109656014B (zh) * 2019-01-31 2024-03-19 北京超维景生物科技有限公司 多路荧光收集装置及三维非线性激光扫描腔体内窥镜
CN113854949A (zh) * 2021-11-10 2021-12-31 福建师范大学 基于宫腔镜的光声成像系统及其工作方法
CN117582163B (zh) * 2024-01-12 2024-04-19 武汉迅微光电技术有限公司 一种内窥式照明装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320191B1 (en) * 1998-03-27 2001-11-20 Picometrix, Inc. Dispersive precompensator for use in an electromagnetic radiation generation and detection system
JP2003116775A (ja) * 2001-08-08 2003-04-22 Lucent Technol Inc 多光子内視鏡検査法
US20030100824A1 (en) * 2001-08-23 2003-05-29 Warren William L. Architecture tool and methods of use

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576173A (en) * 1982-06-28 1986-03-18 The Johns Hopkins University Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source
US4592361A (en) * 1982-06-28 1986-06-03 The Johns Hopkins University Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing
US4895156A (en) * 1986-07-02 1990-01-23 Schulze John E Sensor system using fluorometric decay measurements
US5419323A (en) * 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5119815A (en) * 1988-12-21 1992-06-09 Nim, Incorporated Apparatus for determining the concentration of a tissue pigment of known absorbance, in vivo, using the decay characteristics of scintered electromagnetic radiation
SE8900612D0 (sv) * 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5127405A (en) * 1990-02-16 1992-07-07 The Boc Group, Inc. Biomedical fiber optic probe with frequency domain signal processing
US5197470A (en) * 1990-07-16 1993-03-30 Eastman Kodak Company Near infrared diagnostic method and instrument
DE69231614T2 (de) * 1991-02-26 2001-05-03 Massachusetts Institute Of Technology, Cambridge Molekularspektroskopieverfahren und -einrichtungen zur gewebediagnose
CA2042075C (en) 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5323775A (en) * 1991-09-13 1994-06-28 Allergan, Inc. Diagnostic method for determining precorneal retention time of ophthalmic formulations
US5353790A (en) * 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5311013A (en) * 1992-10-15 1994-05-10 Abbott Laboratories Optical fiber distribution system for an optical fiber sensor in a luminescent sensor system
US5333044A (en) * 1992-11-24 1994-07-26 The United States Of America As Represented By The Department Of Energy Fluorescent image tracking velocimeter
US5341805A (en) * 1993-04-06 1994-08-30 Cedars-Sinai Medical Center Glucose fluorescence monitor and method
US5590660A (en) * 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5579773A (en) * 1994-09-30 1996-12-03 Martin Marietta Energy Systems, Inc. Laser-induced differential normalized fluorescence method for cancer diagnosis
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5699795A (en) * 1995-03-31 1997-12-23 Board Of Regents, The University Of Texas System Optical probe for the detection of cervical neoplasia using fluorescence spectroscopy and apparatus incorporating same
IL113333A (en) 1995-04-11 2001-01-28 Yoav Paltieli Fiber-optic endoscope
US5628310A (en) * 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5812729A (en) * 1995-07-21 1998-09-22 Lockheed Martin Energy Systems, Inc. Very high numerical aperture light transmitting device
US6212425B1 (en) * 1995-09-26 2001-04-03 Karl Storz Gmbh & Co., Kg Apparatus for photodynamic diagnosis
JP3796635B2 (ja) * 1996-03-06 2006-07-12 富士写真フイルム株式会社 蛍光検出装置
DE19622359B4 (de) * 1996-06-04 2007-11-22 Carl Zeiss Jena Gmbh Vorrichtung zur Einkopplung der Strahlung von Kurzpulslasern in einem mikroskopischen Strahlengang
US6249630B1 (en) * 1996-12-13 2001-06-19 Imra America, Inc. Apparatus and method for delivery of dispersion-compensated ultrashort optical pulses with high peak power
US5862287A (en) * 1996-12-13 1999-01-19 Imra America, Inc. Apparatus and method for delivery of dispersion compensated ultrashort optical pulses with high peak power
WO1998040007A1 (en) * 1997-03-13 1998-09-17 Biomax Technologies, Inc. Methods and apparatus for detecting the rejection of transplanted tissue
US5995281A (en) * 1997-04-09 1999-11-30 Carl Zeiss Jena Gmbh Device for coupling the radiation of short-pulse lasers in an optical beam path of a microscope
US5986271A (en) * 1997-07-03 1999-11-16 Lazarev; Victor Fluorescence imaging system
US6238348B1 (en) * 1997-07-22 2001-05-29 Scimed Life Systems, Inc. Miniature spectrometer system and method
US6356088B1 (en) * 1997-08-01 2002-03-12 Carl Zeiss Jena Gmbh Highly compact laser scanning microscope with integrated short-pulse laser
DE19833025C2 (de) * 1998-07-23 2001-07-05 Leica Microsystems Optische Anordnung zur Übertragung kurzer Laserpulse in Lichtleitfasern
US6236779B1 (en) * 1999-05-24 2001-05-22 Spectra Physics Lasers, Inc. Photonic crystal fiber system for sub-picosecond pulses
JP2004500197A (ja) * 2000-02-08 2004-01-08 コーネル　リサーチ　ファンデーション　インコーポレーテッド 光ファイバーを通じた蛍光分光用の多光子励起
GB0010950D0 (en) * 2000-05-05 2000-06-28 Univ Bath A nonlinear optical device
US6898367B2 (en) * 2000-06-17 2005-05-24 Leica Microsystems Heidelberg Gmbh Method and instrument for microscopy
DE20122791U1 (de) * 2000-06-17 2007-11-29 Leica Microsystems Cms Gmbh Scanmikroskop
DE10044636A1 (de) * 2000-09-08 2002-03-21 Leica Microsystems Optische Anordnung zur Beleuchtung von Objekten für konfokale Rastermikroskope
US6961599B2 (en) * 2001-01-09 2005-11-01 Childrens Hospital Los Angeles Identifying or measuring selected substances or toxins in a subject using resonant raman signals
EP1442323A1 (en) * 2001-10-09 2004-08-04 Crystal Fibre A/S Hermetically sealed optical fibre with voids or holes, method of its production, and its use
US7116887B2 (en) * 2002-03-19 2006-10-03 Nufern Optical fiber
US20050024716A1 (en) * 2003-07-15 2005-02-03 Johan Nilsson Optical device with immediate gain for brightness enhancement of optical pulses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320191B1 (en) * 1998-03-27 2001-11-20 Picometrix, Inc. Dispersive precompensator for use in an electromagnetic radiation generation and detection system
JP2003116775A (ja) * 2001-08-08 2003-04-22 Lucent Technol Inc 多光子内視鏡検査法
US20030100824A1 (en) * 2001-08-23 2003-05-29 Warren William L. Architecture tool and methods of use

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EP1664854A4 (en) 2009-09-02
WO2005057244A3 (en) 2006-05-11
EP1664854B1 (en) 2015-07-22
JP2007503851A (ja) 2007-03-01
EP1664854A2 (en) 2006-06-07
US7702381B2 (en) 2010-04-20
US20050043636A1 (en) 2005-02-24
AU2004297876A1 (en) 2005-06-23
WO2005057244A2 (en) 2005-06-23
CA2535843A1 (en) 2005-06-23

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