JP4817600B2 - 常磁性錯体への可逆性結合による基質画像診断の増強 - Google Patents

常磁性錯体への可逆性結合による基質画像診断の増強 Download PDF

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Publication number
JP4817600B2
JP4817600B2 JP2003536219A JP2003536219A JP4817600B2 JP 4817600 B2 JP4817600 B2 JP 4817600B2 JP 2003536219 A JP2003536219 A JP 2003536219A JP 2003536219 A JP2003536219 A JP 2003536219A JP 4817600 B2 JP4817600 B2 JP 4817600B2
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Japan
Prior art keywords
methyl
tetraazacyclododecane
acid
citrate
lactate
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Expired - Fee Related
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JP2003536219A
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Japanese (ja)
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JP2005508965A (ja
JP2005508965A5 (https=
Inventor
テッレノ，エンツォ
アイメ，シルヴィオ
ボッタ，マウロ
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Bracco Imaging SpA
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Bracco Imaging SpA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2003536219A 2001-10-11 2002-10-09 常磁性錯体への可逆性結合による基質画像診断の増強 Expired - Fee Related JP4817600B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01124440.7 2001-10-11
EP01124440A EP1302465A1 (en) 2001-10-11 2001-10-11 Enhanced substrate imaging by reversible binding to a paramagnetic complex
PCT/EP2002/011271 WO2003033479A1 (en) 2001-10-11 2002-10-09 Enhanced substrate imaging by reversible binding to a paramagnetic complex

Publications (3)

Publication Number Publication Date
JP2005508965A JP2005508965A (ja) 2005-04-07
JP2005508965A5 JP2005508965A5 (https=) 2006-01-05
JP4817600B2 true JP4817600B2 (ja) 2011-11-16

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ID=8178947

Family Applications (1)

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JP2003536219A Expired - Fee Related JP4817600B2 (ja) 2001-10-11 2002-10-09 常磁性錯体への可逆性結合による基質画像診断の増強

Country Status (6)

Country Link
US (1) US7608249B2 (https=)
EP (2) EP1302465A1 (https=)
JP (1) JP4817600B2 (https=)
AT (1) ATE439350T1 (https=)
DE (1) DE60233338D1 (https=)
WO (1) WO2003033479A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1331012A1 (en) 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
EP1716870A1 (en) * 2005-04-29 2006-11-02 Bracco Imaging S.p.A. MRI contrast agents endowed with concentration independent responsiveness
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
CA2675638C (en) 2007-01-16 2015-11-24 Ipintl, Llc Composition comprising serotonin for treating metabolic syndrome
CA2666036C (en) 2008-05-16 2017-09-12 Chien-Hung Chen Novel compositions and methods for treating hyperproliferative diseases
US20110217241A1 (en) * 2008-11-14 2011-09-08 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
US20120156139A1 (en) * 2009-08-31 2012-06-21 Rachel Katz-Brull Isotopically labeled neurochemical agents and uses therof for diagnosing conditions and disorders
FR3025317B1 (fr) * 2014-08-26 2022-09-23 Imabiotech Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse
US12569170B2 (en) * 2021-06-10 2026-03-10 Yale University Paramagnetic sodium NMR macrocyclic-based biosensors, and associated methods

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6452764A (en) * 1987-04-24 1989-02-28 Squibb & Sons Inc 1-substituted 1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane and analogue
WO1996011189A1 (fr) * 1994-10-05 1996-04-18 L'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
WO1999005145A1 (en) * 1997-07-25 1999-02-04 Bracco S.P.A. 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
WO2000038738A1 (en) * 1998-12-23 2000-07-06 Bracco Imaging S.P.A. Blood pool agents for nuclear magnetic resonance diagnostics
WO2001046202A1 (fr) * 1999-12-22 2001-06-28 L'air Liquide Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Polyazacycloalcanes, complexes organometalliques les incorporant comme ligands ainsi que utilisation desdits composes a l'extraction de metaux lourds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933441A (en) * 1987-01-27 1990-06-12 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6452764A (en) * 1987-04-24 1989-02-28 Squibb & Sons Inc 1-substituted 1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecane and analogue
WO1996011189A1 (fr) * 1994-10-05 1996-04-18 L'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
WO1999005145A1 (en) * 1997-07-25 1999-02-04 Bracco S.P.A. 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
WO2000038738A1 (en) * 1998-12-23 2000-07-06 Bracco Imaging S.P.A. Blood pool agents for nuclear magnetic resonance diagnostics
WO2001046202A1 (fr) * 1999-12-22 2001-06-28 L'air Liquide Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Polyazacycloalcanes, complexes organometalliques les incorporant comme ligands ainsi que utilisation desdits composes a l'extraction de metaux lourds

Also Published As

Publication number Publication date
US20040258618A1 (en) 2004-12-23
JP2005508965A (ja) 2005-04-07
US7608249B2 (en) 2009-10-27
EP1434768B1 (en) 2009-08-12
DE60233338D1 (de) 2009-09-24
EP1434768A1 (en) 2004-07-07
ATE439350T1 (de) 2009-08-15
WO2003033479A1 (en) 2003-04-24
EP1302465A1 (en) 2003-04-16

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