DE60233338D1 - Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex - Google Patents

Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Info

Publication number
DE60233338D1
DE60233338D1 DE60233338T DE60233338T DE60233338D1 DE 60233338 D1 DE60233338 D1 DE 60233338D1 DE 60233338 T DE60233338 T DE 60233338T DE 60233338 T DE60233338 T DE 60233338T DE 60233338 D1 DE60233338 D1 DE 60233338D1
Authority
DE
Germany
Prior art keywords
reversible binding
substrate formation
improved substrate
paramagnetic complex
paramagnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60233338T
Other languages
German (de)
English (en)
Inventor
Enzo Terreno
Silvio Aime
Mauro Botta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Application granted granted Critical
Publication of DE60233338D1 publication Critical patent/DE60233338D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
DE60233338T 2001-10-11 2002-10-09 Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex Expired - Lifetime DE60233338D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01124440A EP1302465A1 (en) 2001-10-11 2001-10-11 Enhanced substrate imaging by reversible binding to a paramagnetic complex
PCT/EP2002/011271 WO2003033479A1 (en) 2001-10-11 2002-10-09 Enhanced substrate imaging by reversible binding to a paramagnetic complex

Publications (1)

Publication Number Publication Date
DE60233338D1 true DE60233338D1 (de) 2009-09-24

Family

ID=8178947

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60233338T Expired - Lifetime DE60233338D1 (de) 2001-10-11 2002-10-09 Verbesserte substratabbildung durch reversible bindung an einen paramagnetischen komplex

Country Status (6)

Country Link
US (1) US7608249B2 (https=)
EP (2) EP1302465A1 (https=)
JP (1) JP4817600B2 (https=)
AT (1) ATE439350T1 (https=)
DE (1) DE60233338D1 (https=)
WO (1) WO2003033479A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1331012A1 (en) 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
EP1716870A1 (en) 2005-04-29 2006-11-02 Bracco Imaging S.p.A. MRI contrast agents endowed with concentration independent responsiveness
EP2051739A2 (en) * 2006-08-18 2009-04-29 GE Healthcare AS Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
ES2660173T3 (es) 2007-01-16 2018-03-21 Ipintl, Llc Nueva composición para el tratamiento del síndrome metabólico
CA2666036C (en) 2008-05-16 2017-09-12 Chien-Hung Chen Novel compositions and methods for treating hyperproliferative diseases
WO2010056590A2 (en) * 2008-11-14 2010-05-20 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
EP2473199A1 (en) * 2009-08-31 2012-07-11 Brain Watch Ltd. Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders
FR3025317B1 (fr) * 2014-08-26 2022-09-23 Imabiotech Methode de caracterisation d'un echantillon par imagerie par spectrometrie de masse
US12569170B2 (en) * 2021-06-10 2026-03-10 Yale University Paramagnetic sodium NMR macrocyclic-based biosensors, and associated methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4933441A (en) * 1987-01-27 1990-06-12 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
US5597548A (en) * 1990-07-18 1997-01-28 Board Of Regents, The University Of Texas System 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling
FR2725449B1 (fr) * 1994-10-05 1996-12-27 Air Liquide Derives de polyazacycloalcanes, leurs complexes metalliques et produits pharmaceutiques incorporant ces complexes
IT1293778B1 (it) * 1997-07-25 1999-03-10 Bracco Spa 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
CA2249173C (en) * 1997-10-06 2008-12-16 Tokyo Gas Co., Ltd. Diagnostic agent for liver function
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
FR2802928B1 (fr) * 1999-12-22 2003-01-31 Air Liquide Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds

Also Published As

Publication number Publication date
US20040258618A1 (en) 2004-12-23
JP4817600B2 (ja) 2011-11-16
EP1434768A1 (en) 2004-07-07
EP1302465A1 (en) 2003-04-16
US7608249B2 (en) 2009-10-27
ATE439350T1 (de) 2009-08-15
JP2005508965A (ja) 2005-04-07
EP1434768B1 (en) 2009-08-12
WO2003033479A1 (en) 2003-04-24

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Legal Events

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