JP4812223B2 - 多分析対象物測定のためのキット及び方法 - Google Patents

多分析対象物測定のためのキット及び方法 Download PDF

Info

Publication number
JP4812223B2
JP4812223B2 JP2002501026A JP2002501026A JP4812223B2 JP 4812223 B2 JP4812223 B2 JP 4812223B2 JP 2002501026 A JP2002501026 A JP 2002501026A JP 2002501026 A JP2002501026 A JP 2002501026A JP 4812223 B2 JP4812223 B2 JP 4812223B2
Authority
JP
Japan
Prior art keywords
measurement
analytes
analyte
array
luminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002501026A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004510130A (ja
JP2004510130A5 (https=
Inventor
パウラク，ミヒャエル
シック，エギンハルト
アーベル，アンドレアス・ペー
ドゥフェネク，ゲルト・エル
エーラート，マルクス
クレスバッハ，ゲルハルト・エム
シュールマン−マーダー，エヴェリーネ
ボップ，マルティン・アー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Technology Services GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services GmbH filed Critical Bayer Technology Services GmbH
Publication of JP2004510130A publication Critical patent/JP2004510130A/ja
Publication of JP2004510130A5 publication Critical patent/JP2004510130A5/ja
Application granted granted Critical
Publication of JP4812223B2 publication Critical patent/JP4812223B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2002501026A 2000-06-02 2001-05-25 多分析対象物測定のためのキット及び方法 Expired - Fee Related JP4812223B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH20001104/00 2000-06-02
CH11042000 2000-06-02
PCT/EP2001/005995 WO2001092870A2 (de) 2000-06-02 2001-05-25 Kit und verfahren zur multianalytbestimmung

Publications (3)

Publication Number Publication Date
JP2004510130A JP2004510130A (ja) 2004-04-02
JP2004510130A5 JP2004510130A5 (https=) 2008-07-17
JP4812223B2 true JP4812223B2 (ja) 2011-11-09

Family

ID=4557675

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002501026A Expired - Fee Related JP4812223B2 (ja) 2000-06-02 2001-05-25 多分析対象物測定のためのキット及び方法

Country Status (5)

Country Link
US (2) US7396675B2 (https=)
EP (1) EP1287360A2 (https=)
JP (1) JP4812223B2 (https=)
AU (1) AU2001274068A1 (https=)
WO (1) WO2001092870A2 (https=)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7615339B2 (en) 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7175980B2 (en) 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7371562B2 (en) 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7094595B2 (en) * 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
GB0124338D0 (en) 2001-10-10 2001-11-28 Randox Lab Ltd Biochips
WO2003050517A1 (de) * 2001-12-13 2003-06-19 Zeptosens Ag Optisch transparentes trägersubstrat für eine maldi-messanordnung und dessen verwendung
AU2003210523B2 (en) * 2002-01-28 2008-03-20 Sru Biosystems, Inc. A guided mode resonant filter biosensor using a linear grating surface structure
AU2008202728B2 (en) * 2002-01-28 2011-04-07 Sru Biosystems, Inc. A guided mode resonant filter biosensor using a linear grating surface structure
US7074311B1 (en) 2002-05-08 2006-07-11 Sru Biosystems Inc. Biosensor electrophoresis
AU2003242251A1 (en) * 2002-05-13 2003-11-11 Zeptosens Ag Kit for assay development and serial analysis
WO2003104384A1 (en) * 2002-06-05 2003-12-18 Bioprocessors Corporation Reactor systems having a light-interacting component
WO2004023142A1 (de) * 2002-09-03 2004-03-18 Zeptosens Ag Analytische plattform und nachweisverfahren mit den in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
ATE520027T1 (de) * 2002-09-03 2011-08-15 Bayer Technology Services Gmbh Analytische plattform und nachweisverfahren mit gegebenenfalls nach fraktionierung in einer probe nachzuweisenden analyten als immobilisierten spezifischen bindungspartnern
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
US7522762B2 (en) 2003-04-16 2009-04-21 Inverness Medical-Biostar, Inc. Detection, resolution, and identification of arrayed elements
US9317922B2 (en) * 2003-05-16 2016-04-19 Board Of Regents The University Of Texas System Image and part recognition technology
US7413893B2 (en) * 2003-06-09 2008-08-19 Perkinelmer Las, Inc. Methods, apparatus and compositions for improved measurements with optical biosensors
US7545494B2 (en) * 2003-07-23 2009-06-09 Bayer Technology Services Gmbh Analytical system and method for analyzing nonlinear optical signals
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
JP2007510928A (ja) * 2003-11-06 2007-04-26 エス アール ユー バイオシステムズ，インコーポレイテッド 高密度アミン機能化表面
EP1564556A1 (de) * 2004-02-17 2005-08-17 DST Diagnostic Science & Technology GmbH Verfahren und Vorrichtung zur Bestimmung mehrerer Analyten mit simultaner interner Kontrolle
US20050278184A1 (en) 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
US20050197580A1 (en) * 2004-02-19 2005-09-08 Scott Ferguson Synthetic calibration standard for photonic response of tissues
JP2007526460A (ja) * 2004-03-03 2007-09-13 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 細胞集団のタンパク質発現プロファイルの作成のための分析用プラットフォームおよび方法
WO2005118884A1 (en) * 2004-05-28 2005-12-15 The United States Of America As Represented By The Secretary Of The Navy A method for the rapid diagnosis of infectious disease by detection and quantitation of microorganism induced cytokines
US20050266398A1 (en) * 2004-06-01 2005-12-01 Peter Lea Method and device for rapid detection and quantitation of macro and micro matrices
CA2475456A1 (en) 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
US7170050B2 (en) * 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7315019B2 (en) * 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
NZ562794A (en) * 2005-04-12 2010-07-30 Sru Biosystems Inc Proteolipid membrane & lipid membrane biosensor using a titanium surface
US8320728B2 (en) * 2005-09-08 2012-11-27 Georgia Tech Research Corporation Film thin waveguides, methods of fabrication thereof, and detection systems
EP1941276A1 (de) 2005-10-29 2008-07-09 Bayer Technology Services GmbH Verfahren zur bestimmung eines oder mehrerer analyten in komplex zusammengesetzten proben biologischen ursprungs und dessen verwendung
DE102005062377A1 (de) * 2005-12-23 2007-06-28 Bayer Technology Services Gmbh Vorrichtung und Verfahren zum Nachweis von Mykotoxinen
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US20090294677A1 (en) * 2006-05-17 2009-12-03 Siemens Healthcare Diagnostics Inc. Method for signal intensity correction in waveguide sensors
JP2010508520A (ja) * 2006-10-31 2010-03-18 エス アール ユー バイオシステムズ，インコーポレイテッド 官能基が付与された表面上の非特異的タンパク質結合をブロッキングする方法
AU2008242664B2 (en) * 2007-04-19 2011-10-20 Sru Biosystems, Inc. Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
CN101802611A (zh) 2007-07-11 2010-08-11 Sru生物系统公司 鉴别离子通道调节剂的方法
WO2009048833A1 (en) * 2007-10-09 2009-04-16 Siemens Healthcare Diagnostics Inc. Two dimensional imaging of reacted areas on a reagent
MX2010010600A (es) 2008-03-28 2011-03-30 Pacific Biosciences California Inc Composiciones y metodos para secuenciacion de acidos nucleicos.
US8257936B2 (en) * 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
EP2304500A1 (en) * 2008-06-04 2011-04-06 SRU Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8610808B2 (en) * 2008-12-22 2013-12-17 Koninklijke Philips N.V. Color CMOS imager with single photon counting capability
KR20100111098A (ko) * 2009-04-06 2010-10-14 삼성전자주식회사 마이크로어레이의 데이터 스팟의 위치를 검출하는 방법 및 장치
AU2010241641B2 (en) 2009-04-29 2015-05-14 Ldip, Llc Waveguide-based detection system with scanning light source
CA2761114A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of changes in cell populations and mixed cell populations
CN101988893B (zh) 2009-07-31 2012-02-08 长春吉大·小天鹅仪器有限公司 48通道阵列式等吸收波长检测系统
CN102687018B (zh) * 2009-11-16 2015-07-15 硅生物装置有限公司 化验用过滤装置
WO2011127150A2 (en) 2010-04-06 2011-10-13 Massachusetts Institute Of Technology Gene-expression profiling with reduced numbers of transcript measurements
US9538880B2 (en) * 2012-05-09 2017-01-10 Convotherm Elektrogeraete Gmbh Optical quality control system
KR20130127261A (ko) 2012-05-14 2013-11-22 삼성전자주식회사 반도체 장치 및 그 제조 방법
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
JPWO2014196606A1 (ja) * 2013-06-05 2017-02-23 国立研究開発法人物質・材料研究機構 抗体または抗原を固定化した膜型表面応力センサとその製造方法並びにこれを用いた免疫測定方法
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
CN106248224B (zh) * 2015-06-09 2020-04-14 松下知识产权经营株式会社 光检测装置以及光检测系统
TWI794145B (zh) 2015-10-28 2023-03-01 美商加州太平洋生物科學公司 包含整合性帶通濾波器之光學裝置陣列
EP3315963A1 (de) * 2016-10-26 2018-05-02 Fuchs Petrolub SE Probenaufnahmeelement, analysenset und verfahren zur analyse eines liquids, insbesondere einer kühlschmierstoffemulsion
RU2699943C1 (ru) * 2019-01-18 2019-09-11 Общество с ограниченной ответственностью "Метромед" Планшет для тестирования иммуноферментных анализаторов
CN112439393A (zh) * 2020-11-17 2021-03-05 吉林化工学院 一种核酸印迹磁珠的制备方法及其应用
US12429701B2 (en) 2021-12-13 2025-09-30 Samsung Electronics Co., Ltd. Augmented reality device based on curved waveguide, method therefor, augmented reality glasses based on said device
CN116899644B (zh) * 2023-09-12 2023-11-28 微纳动力(北京)科技有限责任公司 一种光电微流控装置及系统

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
IL68506A (en) * 1982-05-04 1988-06-30 Syva Co Simultaneous calibration heterogeneous immunoassay method and device and kit for use therein
DE3380777D1 (en) 1982-08-27 1989-11-30 Roger Philip Ekins Measurement of analyte concentration
WO1986007149A1 (de) * 1985-05-29 1986-12-04 Kurt Tiefenthaler Optischer sensor zum selektiven nachweis von substanzen und zum nachweis von brechzahländerungen in messubstanzen
US5807755A (en) * 1987-08-06 1998-09-15 Multilyte Limited Determination of ambient concentrations of several analytes
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
EP0455067B1 (de) * 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Mikrooptischer Sensor
US5604105B1 (en) * 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
GB9212302D0 (en) * 1992-06-10 1992-07-22 Applied Research Systems Method for improving measurement precision in evanescent wave optical biosensor assays
GB9314991D0 (en) * 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
CN1149335A (zh) 1994-05-27 1997-05-07 希巴-盖吉股份公司 探测短暂受激发光的方法
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
TW302435B (https=) * 1995-05-12 1997-04-11 Ciba Geigy Ag
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
EP0928416A4 (en) * 1996-03-19 2000-03-29 Univ Utah Res Found LENS AND RELATED FLOW CELL
JP2000507350A (ja) * 1996-03-19 2000-06-13 ユニバーシティー オブ ユタ リサーチ ファンデーション 検体の濃度を決定するためのシステム
WO1998022799A2 (de) 1996-11-18 1998-05-28 Novartis Ag Messvorrichtung und deren verwendung
CA2276462C (en) * 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US6485690B1 (en) * 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6653151B2 (en) * 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement

Also Published As

Publication number Publication date
US20080212070A1 (en) 2008-09-04
JP2004510130A (ja) 2004-04-02
US20030148542A1 (en) 2003-08-07
EP1287360A2 (de) 2003-03-05
WO2001092870A2 (de) 2001-12-06
US7645612B2 (en) 2010-01-12
US7396675B2 (en) 2008-07-08
WO2001092870A3 (de) 2002-10-03
AU2001274068A1 (en) 2001-12-11

Similar Documents

Publication Publication Date Title
JP4812223B2 (ja) 多分析対象物測定のためのキット及び方法
US7927868B2 (en) Device and method for determining multiple analytes
US20040058385A1 (en) Kit and method for determining multiple analytes, with provisions for refrencing the density of immobilised recognition elements
JP4599019B2 (ja) フローセル配列及び多重分析対象物測定のためのその利用
AU2013207599B2 (en) Process for determining one or more analytes in samples of biological origin having complex composition, and use thereof
US6534011B1 (en) Device for detecting biochemical or chemical substances by fluorescence excitation
JP2003521684A (ja) 導波板及びセンサプラットフォーム、試料区画の配置構造ならびに前記導波板に基づく分析対象物測定方法
US20020074513A1 (en) Sensor platform and method for the determination of multiple analytes
JP2003533692A (ja) 多重分析対象物測定及びその使用のための格子導波路構造
US20040166508A1 (en) Analytical platform and detection method with the analytes to be determined in a sample as immobilized specific binding partners, optionally after fractionation of said sample
US20040038386A1 (en) Multianalyte determination system and methods
JP2004510130A5 (https=)
JP2002502967A (ja) ルミネッセンスを測定する方法及び装置
US20050163659A1 (en) Kit for assay development and serial analysis
US7429492B2 (en) Multiwell plates with integrated biosensors and membranes
JP2004530125A5 (https=)
US20130203613A1 (en) Device and method for the verification and quantitative analysis of analytes, particularly mycotoxins
US20050059014A1 (en) Analytical platform and detection method with the analytes to be determined in a sample as immobilized specific binding partners
EP1512012B1 (en) Biomolecular kinetics method using a flow-through microarray
JP2007218900A (ja) 標的物質検出用の素子
JP2007101308A (ja) 標的物質検出素子、標的物質検出装置及び標的物質検出方法
JP2004037103A (ja) スポッティング装置の滴下特性測定方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080520

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20080520

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080520

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20100122

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100427

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100709

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100716

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100819

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110427

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110726

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110823

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140902

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140902

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140902

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees