JP4812070B2 - 質量分析計 - Google Patents
質量分析計 Download PDFInfo
- Publication number
- JP4812070B2 JP4812070B2 JP2004207641A JP2004207641A JP4812070B2 JP 4812070 B2 JP4812070 B2 JP 4812070B2 JP 2004207641 A JP2004207641 A JP 2004207641A JP 2004207641 A JP2004207641 A JP 2004207641A JP 4812070 B2 JP4812070 B2 JP 4812070B2
- Authority
- JP
- Japan
- Prior art keywords
- ion
- ion source
- chamber
- ions
- reaction chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims description 296
- 238000006243 chemical reaction Methods 0.000 claims description 85
- 238000012360 testing method Methods 0.000 claims description 72
- 239000003153 chemical reaction reagent Substances 0.000 claims description 51
- 238000005070 sampling Methods 0.000 claims description 30
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 29
- 238000000132 electrospray ionisation Methods 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 21
- 230000005684 electric field Effects 0.000 claims description 17
- 239000006199 nebulizer Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 239000007921 spray Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 6
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 4
- 238000005040 ion trap Methods 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 3
- 230000009471 action Effects 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
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- 238000004891 communication Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 51
- 239000012491 analyte Substances 0.000 description 50
- 239000007789 gas Substances 0.000 description 43
- 238000004458 analytical method Methods 0.000 description 21
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 19
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 19
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 19
- 229960003147 reserpine Drugs 0.000 description 19
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 19
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 17
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 description 12
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 11
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 8
- 238000002552 multiple reaction monitoring Methods 0.000 description 8
- 229960001722 verapamil Drugs 0.000 description 8
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 238000013467 fragmentation Methods 0.000 description 6
- 238000006062 fragmentation reaction Methods 0.000 description 6
- 229960002899 hydroxyprogesterone Drugs 0.000 description 6
- 238000004811 liquid chromatography Methods 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000000451 chemical ionisation Methods 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 238000011067 equilibration Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
- H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/168—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission field ionisation, e.g. corona discharge
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB-0316628.7 | 2003-07-16 | ||
| GB0316628A GB0316628D0 (en) | 2003-07-16 | 2003-07-16 | Mass spectrometer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005135897A JP2005135897A (ja) | 2005-05-26 |
| JP2005135897A5 JP2005135897A5 (enExample) | 2011-01-27 |
| JP4812070B2 true JP4812070B2 (ja) | 2011-11-09 |
Family
ID=27763920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004207641A Expired - Fee Related JP4812070B2 (ja) | 2003-07-16 | 2004-07-14 | 質量分析計 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4812070B2 (enExample) |
| CA (1) | CA2474836C (enExample) |
| DE (3) | DE202004011017U1 (enExample) |
| GB (2) | GB0316628D0 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005041655B4 (de) * | 2005-09-02 | 2010-05-20 | Bruker Daltonik Gmbh | Erzeugung mehrfach geladener Ionen für die Tandem Massenspektrometrie |
| CN103069538B (zh) | 2010-08-19 | 2016-05-11 | 莱克公司 | 具有软电离辉光放电和调节器的质谱仪 |
| TWI488216B (zh) * | 2013-04-18 | 2015-06-11 | Univ Nat Sun Yat Sen | 多游離源的質譜游離裝置及質譜分析系統 |
| JP2013254752A (ja) * | 2013-09-25 | 2013-12-19 | Shimadzu Corp | 液体クロマトグラフ質量分析装置 |
| US20220208539A1 (en) * | 2019-04-29 | 2022-06-30 | Ohio State Innovation Foundation | Method and apparatus for mass spectrometry |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA928199A (en) * | 1971-06-25 | 1973-06-12 | I. Schiff Harold | Method of gas analysis |
| JPH077660B2 (ja) * | 1984-05-16 | 1995-01-30 | 株式会社日立製作所 | 大気圧イオン化質量分析計 |
| JPS63193454A (ja) * | 1987-02-03 | 1988-08-10 | Hitachi Ltd | 質量分析装置 |
| JP2834136B2 (ja) * | 1988-04-27 | 1998-12-09 | 株式会社日立製作所 | 質量分析計 |
| GB8826966D0 (en) * | 1988-11-18 | 1988-12-21 | Vg Instr Group Plc | Gas analyzer |
| JP2902197B2 (ja) * | 1992-02-04 | 1999-06-07 | 株式会社日立製作所 | 大気圧イオン化質量分析装置 |
| JPH06302295A (ja) * | 1993-04-14 | 1994-10-28 | Hitachi Ltd | 質量分析装置および差動排気装置 |
| JPH06310091A (ja) * | 1993-04-26 | 1994-11-04 | Hitachi Ltd | 大気圧イオン化質量分析計 |
| DE19608963C2 (de) * | 1995-03-28 | 2001-03-22 | Bruker Daltonik Gmbh | Verfahren zur Ionisierung schwerer Moleküle bei Atmosphärendruck |
| US6458597B1 (en) * | 1999-03-22 | 2002-10-01 | Analytica Of Branford, Inc. | Direct flow injection analysis nebulization electrospray and apci mass spectrometry |
| US6573510B1 (en) * | 1999-06-18 | 2003-06-03 | The Regents Of The University Of California | Charge exchange molecular ion source |
| US6545419B2 (en) * | 2001-03-07 | 2003-04-08 | Advanced Technology Materials, Inc. | Double chamber ion implantation system |
| GB0107311D0 (en) * | 2001-03-23 | 2001-05-16 | Secr Defence | Corona ionisation source |
| JP3660279B2 (ja) * | 2001-07-23 | 2005-06-15 | 株式会社日立製作所 | 試料イオン化装置及び質量分析計 |
-
2003
- 2003-07-16 GB GB0316628A patent/GB0316628D0/en not_active Ceased
-
2004
- 2004-07-14 JP JP2004207641A patent/JP4812070B2/ja not_active Expired - Fee Related
- 2004-07-14 DE DE200420011017 patent/DE202004011017U1/de not_active Expired - Lifetime
- 2004-07-14 DE DE102004033993A patent/DE102004033993B4/de not_active Expired - Fee Related
- 2004-07-14 GB GB0415777A patent/GB2406703B/en not_active Expired - Fee Related
- 2004-07-14 DE DE102004064078A patent/DE102004064078B4/de not_active Expired - Fee Related
- 2004-07-16 CA CA2474836A patent/CA2474836C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB2406703A (en) | 2005-04-06 |
| JP2005135897A (ja) | 2005-05-26 |
| GB2406703B (en) | 2005-11-30 |
| DE102004033993A1 (de) | 2005-02-24 |
| CA2474836A1 (en) | 2005-01-16 |
| GB0316628D0 (en) | 2003-08-20 |
| CA2474836C (en) | 2013-05-14 |
| DE202004011017U1 (de) | 2004-11-18 |
| GB0415777D0 (en) | 2004-08-18 |
| DE102004033993B4 (de) | 2010-11-25 |
| DE102004064078B4 (de) | 2010-12-02 |
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