JP4797156B2 - リボヌクレオシドの２’水酸基の脱保護方法 - Google Patents

リボヌクレオシドの２’水酸基の脱保護方法 Download PDF

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Publication number
JP4797156B2
JP4797156B2 JP2005064883A JP2005064883A JP4797156B2 JP 4797156 B2 JP4797156 B2 JP 4797156B2 JP 2005064883 A JP2005064883 A JP 2005064883A JP 2005064883 A JP2005064883 A JP 2005064883A JP 4797156 B2 JP4797156 B2 JP 4797156B2
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Prior art keywords
group
ribonucleoside
hydroxyl group
rna
hydroxyl
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Japanese (ja)
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JP2006248929A (ja
Inventor
光雄 関根
尚郎 實吉
康志 清尾
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Tokyo Institute of Technology NUC
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Tokyo Institute of Technology NUC
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Priority to JP2005064883A priority Critical patent/JP4797156B2/ja
Priority to PCT/JP2006/304399 priority patent/WO2006095739A1/fr
Publication of JP2006248929A publication Critical patent/JP2006248929A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
JP2005064883A 2005-03-09 2005-03-09 リボヌクレオシドの２’水酸基の脱保護方法 Active JP4797156B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2005064883A JP4797156B2 (ja) 2005-03-09 2005-03-09 リボヌクレオシドの２’水酸基の脱保護方法
PCT/JP2006/304399 WO2006095739A1 (fr) 2005-03-09 2006-03-07 Procede de deblocage des groupes 2'-hydroxyle des ribonucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005064883A JP4797156B2 (ja) 2005-03-09 2005-03-09 リボヌクレオシドの２’水酸基の脱保護方法

Publications (2)

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JP2006248929A JP2006248929A (ja) 2006-09-21
JP4797156B2 true JP4797156B2 (ja) 2011-10-19

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JP2005064883A Active JP4797156B2 (ja) 2005-03-09 2005-03-09 リボヌクレオシドの２’水酸基の脱保護方法

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JP (1) JP4797156B2 (fr)
WO (1) WO2006095739A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1995253B1 (fr) * 2006-02-27 2016-12-21 Nippon Shinyaku Co., Ltd. Procede pour detacher un groupe protecteur d'un acide nucleique
CN102344477B (zh) 2010-07-27 2015-04-08 苏州瑞博生物技术有限公司 一种核苷酸和/或寡核苷酸及其制备方法
TWI586684B (zh) 2011-08-25 2017-06-11 Bonac Corp Preparation of thioethers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07126251A (ja) * 1993-09-10 1995-05-16 Taisho Pharmaceut Co Ltd １、４−ジヒドロピリジンモノカルボン酸類の製造方法
US7038027B2 (en) * 2000-06-12 2006-05-02 Avecia Biotechnology, Inc. Method of preventing modification of synthetic oligonucleotides

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WO2006095739A1 (fr) 2006-09-14
JP2006248929A (ja) 2006-09-21

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