JP4786866B2 - クロライドチャンネルオープナーとしてのプロスタグランジンアナログ - Google Patents

クロライドチャンネルオープナーとしてのプロスタグランジンアナログ Download PDF

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Publication number
JP4786866B2
JP4786866B2 JP2003533944A JP2003533944A JP4786866B2 JP 4786866 B2 JP4786866 B2 JP 4786866B2 JP 2003533944 A JP2003533944 A JP 2003533944A JP 2003533944 A JP2003533944 A JP 2003533944A JP 4786866 B2 JP4786866 B2 JP 4786866B2
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JP
Japan
Prior art keywords
compound
prostaglandin
dihydro
alkyl
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP2003533944A
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English (en)
Japanese (ja)
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JP2005504836A (ja
JP2005504836A5 (cg-RX-API-DMAC7.html
Inventor
隆司 上野
ジョン・カッポレッティ
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Sucampo GmbH
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Sucampo GmbH
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Publication of JP2005504836A publication Critical patent/JP2005504836A/ja
Publication of JP2005504836A5 publication Critical patent/JP2005504836A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2003533944A 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ Expired - Lifetime JP4786866B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31591701P 2001-08-31 2001-08-31
US60/315,917 2001-08-31
US37210402P 2002-04-15 2002-04-15
US60/372,104 2002-04-15
PCT/JP2002/008705 WO2003030912A1 (en) 2001-08-31 2002-08-29 Prostaglandin analogs as chloride channel opener

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011001763A Division JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Publications (3)

Publication Number Publication Date
JP2005504836A JP2005504836A (ja) 2005-02-17
JP2005504836A5 JP2005504836A5 (cg-RX-API-DMAC7.html) 2006-01-05
JP4786866B2 true JP4786866B2 (ja) 2011-10-05

Family

ID=26980134

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003533944A Expired - Lifetime JP4786866B2 (ja) 2001-08-31 2002-08-29 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011001763A Expired - Lifetime JP5568021B2 (ja) 2001-08-31 2011-01-07 クロライドチャンネルオープナーとしてのプロスタグランジンアナログ

Country Status (11)

Country Link
US (2) US7064148B2 (cg-RX-API-DMAC7.html)
EP (1) EP1420794B1 (cg-RX-API-DMAC7.html)
JP (2) JP4786866B2 (cg-RX-API-DMAC7.html)
AR (1) AR036391A1 (cg-RX-API-DMAC7.html)
AU (1) AU2002330747B2 (cg-RX-API-DMAC7.html)
BR (1) BR0212233A (cg-RX-API-DMAC7.html)
CA (1) CA2458471C (cg-RX-API-DMAC7.html)
MX (1) MXPA04002006A (cg-RX-API-DMAC7.html)
NZ (1) NZ531503A (cg-RX-API-DMAC7.html)
TW (1) TWI298256B (cg-RX-API-DMAC7.html)
WO (1) WO2003030912A1 (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012031202A (ja) * 2002-12-27 2012-02-16 Sucampo Ag 腹部不快感の処置のためのプロスタグランジン誘導体
WO2015049876A1 (ja) 2013-10-04 2015-04-09 国立大学法人東北大学 腎機能障害の予防又は改善剤
US11376287B2 (en) 2016-10-20 2022-07-05 Biofermin Pharmaceutical Co., Ltd. Agent acting on transcellular ion transporter in intestinal tract, agent for activating chloride channel, agent for preventing or treating renal disease, or agent for promoting defecation

Families Citing this family (31)

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PT1389116E (pt) * 2001-05-18 2008-04-11 Sucampo Ag Composição de indução catártica
AR037524A1 (es) 2001-11-14 2004-11-17 Sucampo Ag Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
US7732487B2 (en) * 2001-11-19 2010-06-08 Sucampo Ag Method for treating a disease or condition responsive to opening of C1C-2 channel
PT1562604E (pt) * 2002-10-23 2012-04-09 Sucampo Ag Compostos de prostaglandina para o tratamento de obesidade
EP1641462B1 (en) * 2003-07-03 2010-11-24 Sucampo AG Enteric coated composition comprising prostaglandin analogs as chloride channel opener
TWI348386B (en) * 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
TWI387454B (zh) * 2004-09-02 2013-03-01 蘇坎波公司 治療胃腸道疾病之方法及組成物
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) * 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US20060281818A1 (en) * 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
ES2371658T3 (es) * 2005-04-12 2012-01-05 Sucampo Ag Uso combinado de compuesto de prostaglandina e inhibidor de la bomba de protones para el tratamiento de trastornos gastrointestinales.
US20070203228A1 (en) * 2006-02-28 2007-08-30 Sucampo Ag Method for treating chronic obstructive pulmonary disease
JP5427029B2 (ja) * 2006-09-06 2014-02-26 スキャンポ・アーゲー 消化管の重炭酸分泌を促進するための方法および組成物
WO2008108322A2 (en) * 2007-02-27 2008-09-12 Sucampo Ag Composition and method for protecting mitochondria
US20090030072A1 (en) * 2007-07-03 2009-01-29 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
WO2009049159A1 (en) 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
CN101318948B (zh) * 2008-04-01 2011-04-27 上海天伟生物制药有限公司 鲁比前列酮晶体、其制备方法及用途
US20110034424A1 (en) * 2009-06-30 2011-02-10 Sucampo Ag Method for the long term nsaid use
AU2010280684B2 (en) * 2009-08-07 2016-07-28 Scipharm Sarl Composition for the treatment of cystic fibrosis
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
EA029760B1 (ru) * 2011-02-07 2018-05-31 Сифарм Сарл ПРИМЕНЕНИЕ КОМПОЗИЦИИ ПРОСТАЦИКЛИНА И ИНГИБИТОРА ФОСФОДИЭСТЕРАЗЫ 4 ИЛИ ИХ АНАЛОГОВ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА И УВЕЛИЧЕНИЯ цАМФ В ЭПИТЕЛИАЛЬНЫХ КЛЕТКАХ
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
EP2717855A4 (en) 2011-06-07 2014-11-12 Parion Sciences Inc PROCESSING METHODS
US10724986B2 (en) 2012-11-29 2020-07-28 Indiana University Research & Technology Corporation Dielectric electrolyte measurement device
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
US20150057351A1 (en) * 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
WO2018065826A1 (en) 2016-10-06 2018-04-12 Sucampo Ag Multilayer beads for pharmaceutical use
US10457623B1 (en) * 2018-07-13 2019-10-29 Chirogate International Inc. Process for the preparation of Lubiprostone and intermediates thereof

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPS56152455A (en) * 1980-04-28 1981-11-26 Ono Pharmaceut Co Ltd Prostaglandin analog, compound, its preparation, and drug composition comprising it
JPH02109A (ja) * 1987-10-02 1990-01-05 Ueno Seiyaku Oyo Kenkyusho:Kk 下剤
JPH03218315A (ja) * 1989-11-22 1991-09-25 Ueno Seiyaku Oyo Kenkyusho:Kk ガス交換機能不全処置剤
WO1999018968A1 (en) * 1997-10-13 1999-04-22 R-Tech Ueno, Ltd. Portal hypertension inhibitor

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CA1322749C (en) 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5221763A (en) 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
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JP2579193B2 (ja) 1988-07-19 1997-02-05 小野薬品工業株式会社 １６，１６−ジフルオロ−１５−オキソ−１５−デオキシｐｇｅ誘導体
CA2030344C (en) 1989-11-22 2000-04-18 Ryuji Ueno Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
TW249226B (cg-RX-API-DMAC7.html) 1990-04-04 1995-06-11 Aderk Ueno Kk
EP0455448B1 (en) * 1990-05-01 1998-12-09 R-Tech Ueno Ltd. Treatment of pancreatic disease with 15-keto-prostaglandin E compounds
CA2150287C (en) 1994-06-03 2004-08-10 Ryuji Ueno Agent for treating hepato-biliary diseases
US6015828A (en) 1996-05-31 2000-01-18 Cuppoletti; John Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
WO1997047595A1 (en) 1996-06-10 1997-12-18 R-Tech Ueno, Ltd. Endothelin antagonist
KR100648868B1 (ko) * 1997-11-28 2006-11-24 가부시키가이샤 아루떼꾸 우에노 엔도텔린 길항제
CN1144588C (zh) * 1998-05-25 2004-04-07 大正制药株式会社 睡眠诱发剂
KR100788226B1 (ko) 2000-03-24 2007-12-26 수캄포 아게 15-케토-프로스타글란딘 또는 이의 유도체를 포함하는세포자연사 억제 조성물
AU4472701A (en) 2000-04-06 2001-10-23 Sucampo Ag Bile secretion promoting composition
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
FR2829293B1 (fr) * 2001-08-31 2003-11-14 Centre Nat Rech Scient Memoire moleculaire et son procede de fabrication

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152455A (en) * 1980-04-28 1981-11-26 Ono Pharmaceut Co Ltd Prostaglandin analog, compound, its preparation, and drug composition comprising it
JPH02109A (ja) * 1987-10-02 1990-01-05 Ueno Seiyaku Oyo Kenkyusho:Kk 下剤
JPH03218315A (ja) * 1989-11-22 1991-09-25 Ueno Seiyaku Oyo Kenkyusho:Kk ガス交換機能不全処置剤
WO1999018968A1 (en) * 1997-10-13 1999-04-22 R-Tech Ueno, Ltd. Portal hypertension inhibitor

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012031202A (ja) * 2002-12-27 2012-02-16 Sucampo Ag 腹部不快感の処置のためのプロスタグランジン誘導体
WO2015049876A1 (ja) 2013-10-04 2015-04-09 国立大学法人東北大学 腎機能障害の予防又は改善剤
US11376287B2 (en) 2016-10-20 2022-07-05 Biofermin Pharmaceutical Co., Ltd. Agent acting on transcellular ion transporter in intestinal tract, agent for activating chloride channel, agent for preventing or treating renal disease, or agent for promoting defecation

Also Published As

Publication number Publication date
WO2003030912A1 (en) 2003-04-17
NZ531503A (en) 2006-01-27
CA2458471C (en) 2012-07-31
JP5568021B2 (ja) 2014-08-06
AU2002330747B2 (en) 2007-07-19
JP2011102313A (ja) 2011-05-26
US7064148B2 (en) 2006-06-20
CA2458471A1 (en) 2003-04-17
JP2005504836A (ja) 2005-02-17
TWI298256B (en) 2008-07-01
AR036391A1 (es) 2004-09-08
US7253295B2 (en) 2007-08-07
EP1420794B1 (en) 2017-12-27
BR0212233A (pt) 2004-10-05
EP1420794A1 (en) 2004-05-26
MXPA04002006A (es) 2004-06-07
US20030130352A1 (en) 2003-07-10
US20060122411A1 (en) 2006-06-08

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