JP4757632B2 - ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 - Google Patents

２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 Download PDF

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Publication number
JP4757632B2
JP4757632B2 JP2005501990A JP2005501990A JP4757632B2 JP 4757632 B2 JP4757632 B2 JP 4757632B2 JP 2005501990 A JP2005501990 A JP 2005501990A JP 2005501990 A JP2005501990 A JP 2005501990A JP 4757632 B2 JP4757632 B2 JP 4757632B2
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chloro
aryl
alkyl
sulfonyl
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Japanese (ja)
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JP2006508183A (ja
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ジェイ． ロビンス、モリス
ジャネバ、ズラトコ
フランカム、ポーラ
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Brigham Young University
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Brigham Young University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
JP2005501990A 2002-09-25 2003-09-25 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 Expired - Fee Related JP4757632B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41391502P 2002-09-25 2002-09-25
US60/413,915 2002-09-25
US41632902P 2002-10-04 2002-10-04
US60/416,329 2002-10-04
PCT/US2003/030386 WO2004028462A2 (en) 2002-09-25 2003-09-25 Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011051093A Division JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

Publications (2)

Publication Number Publication Date
JP2006508183A JP2006508183A (ja) 2006-03-09
JP4757632B2 true JP4757632B2 (ja) 2011-08-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2005501990A Expired - Fee Related JP4757632B2 (ja) 2002-09-25 2003-09-25 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法
JP2011051093A Pending JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

Family Applications After (1)

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JP2011051093A Pending JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

Country Status (7)

Country Link
US (2) US7572909B2 (https=)
EP (1) EP1556400B1 (https=)
JP (2) JP4757632B2 (https=)
AU (1) AU2003275267A1 (https=)
CA (1) CA2540158C (https=)
ES (1) ES2405825T3 (https=)
WO (1) WO2004028462A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2405825T3 (es) 2002-09-25 2013-06-03 Brigham Young University Método para la preparación de compuestos 2-halo-2'-desoxiadenosina a partir de 2'-desoxiguanosina
EP3332789B1 (en) 2004-12-22 2022-04-06 Merck Serono SA Cladribine regimen for treating multiple sclerosis
AU2007253254B2 (en) 2006-05-24 2013-01-17 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
DE602006009282D1 (de) 2006-12-15 2009-10-29 Explora Lab Sa Verfahren zur Herstellung von Cladribin
RU2324699C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
RU2649828C1 (ru) * 2017-06-07 2018-04-04 Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения города Москвы Способ лечения волосатоклеточного лейкоза
EP3713582A1 (en) 2017-11-24 2020-09-30 Merck Patent GmbH Cladribine regimen for use intreating progressive forms of multiple sclerosis
CA3194812A1 (en) 2020-09-10 2022-03-17 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
US20240077481A1 (en) 2021-03-03 2024-03-07 Ares Trading S.A. Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods
TW202541818A (zh) 2023-12-14 2025-11-01 瑞士商亞利斯貿易公司 用於治療重症肌無力之克拉屈濱(cladribine)療程

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61106594A (ja) * 1984-08-06 1986-05-24 ブリガム　ヤング　ユニヴア−シテイ プリン誘導体およびその製造法
JPH05255378A (ja) * 1991-12-18 1993-10-05 Ortho Pharmaceut Corp ２−クロル−２′−デオキシアデノシンの製造法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760137A (en) 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
DE3924424A1 (de) 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
US6252061B1 (en) 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US6541626B2 (en) * 2001-04-17 2003-04-01 Isis Pharmaceuticals, Inc. Process for selective N-acylation of purine nucleosides
ES2405825T3 (es) 2002-09-25 2013-06-03 Brigham Young University Método para la preparación de compuestos 2-halo-2'-desoxiadenosina a partir de 2'-desoxiguanosina

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61106594A (ja) * 1984-08-06 1986-05-24 ブリガム　ヤング　ユニヴア−シテイ プリン誘導体およびその製造法
JPH05255378A (ja) * 1991-12-18 1993-10-05 Ortho Pharmaceut Corp ２−クロル−２′−デオキシアデノシンの製造法

Also Published As

Publication number Publication date
AU2003275267A1 (en) 2004-04-19
EP1556400B1 (en) 2013-05-01
ES2405825T3 (es) 2013-06-03
JP2011116782A (ja) 2011-06-16
US20070032645A1 (en) 2007-02-08
EP1556400A4 (en) 2009-11-18
US8466275B2 (en) 2013-06-18
JP2006508183A (ja) 2006-03-09
WO2004028462A2 (en) 2004-04-08
CA2540158C (en) 2011-07-05
US7572909B2 (en) 2009-08-11
WO2004028462A3 (en) 2004-06-10
AU2003275267A8 (en) 2004-04-19
WO2004028462A9 (en) 2010-08-26
EP1556400A2 (en) 2005-07-27
US20090270604A1 (en) 2009-10-29
CA2540158A1 (en) 2004-04-08

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