JP4751535B2 - 分画方法とそれを用いた血液分析装置 - Google Patents
分画方法とそれを用いた血液分析装置 Download PDFInfo
- Publication number
- JP4751535B2 JP4751535B2 JP2001226382A JP2001226382A JP4751535B2 JP 4751535 B2 JP4751535 B2 JP 4751535B2 JP 2001226382 A JP2001226382 A JP 2001226382A JP 2001226382 A JP2001226382 A JP 2001226382A JP 4751535 B2 JP4751535 B2 JP 4751535B2
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- JP
- Japan
- Prior art keywords
- blood cells
- mature
- population
- blood
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims description 26
- 210000004369 blood Anatomy 0.000 title claims description 24
- 239000008280 blood Substances 0.000 title claims description 24
- 238000005194 fractionation Methods 0.000 title claims description 17
- 239000002245 particle Substances 0.000 claims description 41
- 210000000601 blood cell Anatomy 0.000 claims description 36
- 210000003743 erythrocyte Anatomy 0.000 claims description 16
- 210000000265 leukocyte Anatomy 0.000 claims description 16
- 238000010586 diagram Methods 0.000 claims description 15
- 210000003714 granulocyte Anatomy 0.000 claims description 10
- 210000001995 reticulocyte Anatomy 0.000 claims description 9
- 210000004027 cell Anatomy 0.000 claims description 7
- 230000000366 juvenile effect Effects 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 description 20
- 238000005259 measurement Methods 0.000 description 18
- 239000000523 sample Substances 0.000 description 11
- 210000003651 basophil Anatomy 0.000 description 9
- 230000003287 optical effect Effects 0.000 description 8
- 210000000440 neutrophil Anatomy 0.000 description 7
- 239000002699 waste material Substances 0.000 description 6
- 210000000755 juvenile neutrophil Anatomy 0.000 description 5
- 238000004364 calculation method Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 3
- 210000003979 eosinophil Anatomy 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 239000012192 staining solution Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000013500 data storage Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003219 hemolytic agent Substances 0.000 description 2
- 241000208822 Lactuca Species 0.000 description 1
- 235000003228 Lactuca sativa Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
- G01N2015/014—Reticulocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Ecology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001226382A JP4751535B2 (ja) | 2001-07-26 | 2001-07-26 | 分画方法とそれを用いた血液分析装置 |
| US10/201,930 US6842233B2 (en) | 2001-07-26 | 2002-07-25 | Method of classifying particles on two-dimensional frequency distribution map and blood analyzer utilizing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001226382A JP4751535B2 (ja) | 2001-07-26 | 2001-07-26 | 分画方法とそれを用いた血液分析装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003042936A JP2003042936A (ja) | 2003-02-13 |
| JP2003042936A5 JP2003042936A5 (enExample) | 2008-08-21 |
| JP4751535B2 true JP4751535B2 (ja) | 2011-08-17 |
Family
ID=19059211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001226382A Expired - Fee Related JP4751535B2 (ja) | 2001-07-26 | 2001-07-26 | 分画方法とそれを用いた血液分析装置 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US6842233B2 (enExample) |
| JP (1) | JP4751535B2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7405082B2 (en) * | 2002-09-10 | 2008-07-29 | Sysmex Corporation | Methods and devices for measuring reticulocytes |
| US7551763B2 (en) | 2004-01-14 | 2009-06-23 | Luminex Corporation | Methods for altering one or more parameters of a measurement system |
| JP4417143B2 (ja) * | 2004-03-11 | 2010-02-17 | シスメックス株式会社 | 試料分析装置、プログラムおよびそのプログラムを記録した記録媒体 |
| US8349256B2 (en) * | 2008-11-21 | 2013-01-08 | Sysmex Corporation | Blood cell analyzer, blood cell analyzing method, and computer program product |
| US9522396B2 (en) | 2010-12-29 | 2016-12-20 | S.D. Sight Diagnostics Ltd. | Apparatus and method for automatic detection of pathogens |
| BR112014016072B1 (pt) | 2011-12-29 | 2021-01-12 | Sight Diagnostics Ltd. | método e sistema para detectar uma infecção por plasmodium em uma amostra de sangue |
| CN104781649B (zh) * | 2012-11-16 | 2019-07-05 | 贝克曼考尔特公司 | 流式细胞术数据分割结果的评价系统和方法 |
| EP2999988A4 (en) | 2013-05-23 | 2017-01-11 | S.D. Sight Diagnostics Ltd. | Method and system for imaging a cell sample |
| IL227276A0 (en) | 2013-07-01 | 2014-03-06 | Parasight Ltd | A method and system for preparing a monolayer of cells, particularly suitable for diagnosis |
| EP3039477B1 (en) | 2013-08-26 | 2021-10-20 | S.D. Sight Diagnostics Ltd. | Digital microscopy systems, methods and computer program products |
| WO2016030897A1 (en) | 2014-08-27 | 2016-03-03 | S.D. Sight Diagnostics Ltd | System and method for calculating focus variation for a digital microscope |
| CN106687810B (zh) * | 2014-12-31 | 2019-10-22 | 深圳迈瑞生物医疗电子股份有限公司 | 一种非诊断目的的有核红细胞报警方法、装置及流式细胞分析仪 |
| CN114674825A (zh) | 2015-09-17 | 2022-06-28 | 思迪赛特诊断有限公司 | 用于检测身体样本中实体的方法和设备 |
| US11733150B2 (en) | 2016-03-30 | 2023-08-22 | S.D. Sight Diagnostics Ltd. | Distinguishing between blood sample components |
| CN115266540B (zh) | 2016-05-11 | 2025-11-28 | 思迪赛特诊断有限公司 | 对样品实施的光学测量 |
| EP3455610B1 (en) | 2016-05-11 | 2023-01-04 | S.D. Sight Diagnostics Ltd. | Sample carrier for optical measurements |
| JP6903494B2 (ja) | 2017-06-09 | 2021-07-14 | シスメックス株式会社 | 感染症を識別するための粒子分析方法 |
| CN111788471B (zh) | 2017-11-14 | 2023-12-12 | 思迪赛特诊断有限公司 | 用于光学测量的样品载体 |
| CN111602046B (zh) * | 2018-04-28 | 2024-01-09 | 深圳迈瑞生物医疗电子股份有限公司 | 一种血液分析仪及分析方法 |
| EP4049176A1 (en) | 2019-10-22 | 2022-08-31 | S.D. Sight Diagnostics Ltd. | Accounting for errors in optical measurements |
| MX2022007123A (es) | 2019-12-12 | 2022-07-11 | S D Sight Diagnostics Ltd | Analisis de un analito dispuesto dentro de un medio. |
| CN114787625B (zh) | 2019-12-12 | 2026-01-13 | 思迪赛特诊断有限公司 | 检测血液样品中的血小板 |
| JP7677972B2 (ja) | 2019-12-12 | 2025-05-15 | エス.ディー.サイト ダイアグノスティックス リミテッド | カラー血液スミア画像の人工的な生成 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661913A (en) * | 1984-09-11 | 1987-04-28 | Becton, Dickinson And Company | Apparatus and method for the detection and classification of articles using flow cytometry techniques |
| JP2674705B2 (ja) * | 1988-06-10 | 1997-11-12 | 東亜医用電子株式会社 | 一次元分布分画方法 |
| JP3098273B2 (ja) * | 1991-05-14 | 2000-10-16 | シスメックス株式会社 | 尿中の細胞分析装置 |
| DE69218912T2 (de) * | 1991-08-28 | 1997-10-09 | Becton Dickinson Co | Schwerkraftsattraktionsmaschine zur anpassungsfähigen autoclusterbildung n-dimensionaler datenströme |
| JP3411112B2 (ja) * | 1994-11-04 | 2003-05-26 | シスメックス株式会社 | 粒子画像分析装置 |
| JP3504030B2 (ja) * | 1995-07-04 | 2004-03-08 | シスメックス株式会社 | 粒子判定基準の決定方法およびその装置並びにその判定基準を用いた粒子分析装置 |
| JPH09218147A (ja) * | 1996-02-09 | 1997-08-19 | Toa Medical Electronics Co Ltd | 分布データ計測装置 |
| JP4136017B2 (ja) * | 1996-09-19 | 2008-08-20 | シスメックス株式会社 | 粒子分析装置 |
| US6091843A (en) * | 1998-09-03 | 2000-07-18 | Greenvision Systems Ltd. | Method of calibration and real-time analysis of particulates |
| US6900023B1 (en) * | 1999-09-02 | 2005-05-31 | Sysmex Corporation | Method for classifying and counting leukocytes |
| JP4708605B2 (ja) * | 2000-07-24 | 2011-06-22 | シスメックス株式会社 | 粒子分析装置とその粒子分画方法 |
-
2001
- 2001-07-26 JP JP2001226382A patent/JP4751535B2/ja not_active Expired - Fee Related
-
2002
- 2002-07-25 US US10/201,930 patent/US6842233B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030030784A1 (en) | 2003-02-13 |
| JP2003042936A (ja) | 2003-02-13 |
| US6842233B2 (en) | 2005-01-11 |
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