JP4738416B2 - Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス - Google Patents

Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス Download PDF

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JP4738416B2
JP4738416B2 JP2007541425A JP2007541425A JP4738416B2 JP 4738416 B2 JP4738416 B2 JP 4738416B2 JP 2007541425 A JP2007541425 A JP 2007541425A JP 2007541425 A JP2007541425 A JP 2007541425A JP 4738416 B2 JP4738416 B2 JP 4738416B2
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lipase
diyl
lactam
protected
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Japanese (ja)
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JP2008520206A5 (enExample
JP2008520206A (ja
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アンクシュ アルガーデ，
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ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007541425A 2004-11-15 2005-11-15 Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス Expired - Fee Related JP4738416B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62840104P 2004-11-15 2004-11-15
US60/628,401 2004-11-15
PCT/US2005/041276 WO2006055528A2 (en) 2004-11-15 2005-11-15 Process for the preparation of an optically acitive n-carbamate protected beta-lactam by optical resolution employing a candida antarctica lipase

Publications (3)

Publication Number Publication Date
JP2008520206A JP2008520206A (ja) 2008-06-19
JP2008520206A5 JP2008520206A5 (enExample) 2009-01-08
JP4738416B2 true JP4738416B2 (ja) 2011-08-03

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JP2007541425A Expired - Fee Related JP4738416B2 (ja) 2004-11-15 2005-11-15 Ｃａｎｄｉｄａａｎｔａｒｃｔｉｃａリパーゼを使用した光学分割による光学活性Ｎ−カルバメート保護化β−ラクタムを調製するためのプロセス

Country Status (10)

Country Link
US (1) US7459301B2 (enExample)
EP (1) EP1812581B1 (enExample)
JP (1) JP4738416B2 (enExample)
AT (1) ATE421996T1 (enExample)
CA (1) CA2580151C (enExample)
DE (1) DE602005012597D1 (enExample)
DK (1) DK1812581T3 (enExample)
ES (1) ES2320364T3 (enExample)
PT (1) PT1812581E (enExample)
WO (1) WO2006055528A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2566531A1 (en) * 2004-05-18 2005-12-15 Rigel Pharmaceuticals, Inc. Cycloalkyl substituted pyrimidinediamine compounds and their uses
GB2420559B (en) * 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
JP5400388B2 (ja) 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
JP5738196B2 (ja) 2008-12-22 2015-06-17 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼ阻害剤および抗ｃｄ２０抗体の併用
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
US10335494B2 (en) 2013-12-06 2019-07-02 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-CD30 antibodies
US20180207173A1 (en) 2015-07-21 2018-07-26 Millennium Pharmaceuticals, Inc. Administration of aurora kinase inhibitor and chemotherapeutic agents
WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
WO2019201279A1 (zh) * 2018-04-18 2019-10-24 广东东阳光药业有限公司 一种桥环化合物的制备方法
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1095160E (pt) 1998-07-09 2004-06-30 Lonza Ag Processo para a producao de derivados de (1r, 4s)-2-azabiciclo¬2.2.1|hept-5-en-3-ona

Also Published As

Publication number Publication date
WO2006055528A3 (en) 2006-08-31
DK1812581T3 (da) 2009-05-11
DE602005012597D1 (de) 2009-03-19
US20060166308A1 (en) 2006-07-27
CA2580151C (en) 2014-02-04
US7459301B2 (en) 2008-12-02
ES2320364T3 (es) 2009-05-21
ATE421996T1 (de) 2009-02-15
CA2580151A1 (en) 2006-05-26
EP1812581B1 (en) 2009-01-28
WO2006055528A2 (en) 2006-05-26
EP1812581A2 (en) 2007-08-01
JP2008520206A (ja) 2008-06-19
PT1812581E (pt) 2009-04-22

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