JP4738172B2 - 抗感染薬 - Google Patents

抗感染薬 Download PDF

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Publication number
JP4738172B2
JP4738172B2 JP2005502238A JP2005502238A JP4738172B2 JP 4738172 B2 JP4738172 B2 JP 4738172B2 JP 2005502238 A JP2005502238 A JP 2005502238A JP 2005502238 A JP2005502238 A JP 2005502238A JP 4738172 B2 JP4738172 B2 JP 4738172B2
Authority
JP
Japan
Prior art keywords
alkyl
group
alkenyl
oxo
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2005502238A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006509042A (ja
Inventor
プラツト，ジヨン・ケイ
ベテベナー，デイビツド・エイ
ドナー，パメラ・エル
グリーン，ブライアン・イー
ケンプ，デイル・ジエイ
マクダニエル，キース・エフ
マーリング，クラレンス・ジエイ
ストール，ビンセント・エス
チヤン，ロン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/285,714 external-priority patent/US20040097492A1/en
Priority claimed from US10/625,121 external-priority patent/US20040162285A1/en
Priority claimed from US10/679,881 external-priority patent/US20050075331A1/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority claimed from PCT/US2003/034707 external-priority patent/WO2004041818A1/en
Publication of JP2006509042A publication Critical patent/JP2006509042A/ja
Application granted granted Critical
Publication of JP4738172B2 publication Critical patent/JP4738172B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2005502238A 2002-11-01 2003-10-31 抗感染薬 Expired - Fee Related JP4738172B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10/285,714 2002-11-01
US10/285,714 US20040097492A1 (en) 2002-11-01 2002-11-01 Anti-infective agents
US10/410,853 US20040087577A1 (en) 2002-11-01 2003-04-10 Anti-infective agents
US10/410,853 2003-04-10
US10/625,121 2003-07-23
US10/625,121 US20040162285A1 (en) 2002-11-01 2003-07-23 Anti-infective agents
US10/679,881 2003-10-06
US10/679,881 US20050075331A1 (en) 2003-10-06 2003-10-06 Anti-infective agents
PCT/US2003/034707 WO2004041818A1 (en) 2002-11-01 2003-10-31 Anti-infective agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011033491A Division JP5250649B2 (ja) 2002-11-01 2011-02-18 抗感染薬

Publications (2)

Publication Number Publication Date
JP2006509042A JP2006509042A (ja) 2006-03-16
JP4738172B2 true JP4738172B2 (ja) 2011-08-03

Family

ID=43426110

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2005502238A Expired - Fee Related JP4738172B2 (ja) 2002-11-01 2003-10-31 抗感染薬
JP2011033491A Expired - Fee Related JP5250649B2 (ja) 2002-11-01 2011-02-18 抗感染薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011033491A Expired - Fee Related JP5250649B2 (ja) 2002-11-01 2011-02-18 抗感染薬

Country Status (6)

Country Link
JP (2) JP4738172B2 (enExample)
AT (1) ATE493408T1 (enExample)
DE (1) DE60335564D1 (enExample)
DK (1) DK1560827T3 (enExample)
PT (1) PT1560827E (enExample)
SI (1) SI1560827T1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA100120C2 (en) * 2007-04-03 2012-11-26 Анадис Фармасьютикалз, Инк. 5,6-dihydro-1h-pyridin-2-one compounds
GB0800855D0 (en) * 2008-01-17 2008-02-27 Syngenta Ltd Herbicidal compounds
US20090257979A1 (en) * 2008-04-15 2009-10-15 Intermune, Inc. Novel Inhibitors of Hepatitis C Virus Replication
WO2010049270A1 (de) * 2008-10-29 2010-05-06 Basf Se Substituierte pyridine mit herbizider wirkung
CA2752443A1 (en) * 2009-03-06 2010-09-10 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
EP2560636A4 (en) * 2010-04-23 2013-11-27 Kineta Inc ANTIVIRAL CONNECTIONS
US8815847B2 (en) * 2011-06-07 2014-08-26 Anadys Pharmaceuticals, Inc. [1,2,4]thiadiazine 1,1-dioxide compounds for lowering serum uric acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1292310A1 (en) * 2000-05-10 2003-03-19 SmithKline Beecham Corporation Novel anti-infectives
AR036081A1 (es) * 2001-06-07 2004-08-11 Smithkline Beecham Corp Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos
WO2003059356A2 (en) * 2001-10-30 2003-07-24 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
JP5250649B2 (ja) 2013-07-31
SI1560827T1 (sl) 2011-04-29
DK1560827T3 (da) 2011-04-18
JP2011144183A (ja) 2011-07-28
PT1560827E (pt) 2011-03-17
DE60335564D1 (de) 2011-02-10
ATE493408T1 (de) 2011-01-15
JP2006509042A (ja) 2006-03-16

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