JP4711391B2 - 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 - Google Patents

新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 Download PDF

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Publication number
JP4711391B2
JP4711391B2 JP2004538781A JP2004538781A JP4711391B2 JP 4711391 B2 JP4711391 B2 JP 4711391B2 JP 2004538781 A JP2004538781 A JP 2004538781A JP 2004538781 A JP2004538781 A JP 2004538781A JP 4711391 B2 JP4711391 B2 JP 4711391B2
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JP
Japan
Prior art keywords
diazabicyclo
nonane
oxadiazol
compound
thiadiazol
Prior art date
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Expired - Fee Related
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JP2004538781A
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English (en)
Japanese (ja)
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JP2006503062A5 (no
JP2006503062A (ja
Inventor
ペータース・ダン
オールセン・グンナー・エム
ニールセン・エルセベート・エスターゴード
イェルゲンセン・ティノ・デュフリング
アーリング・フィリップ・カー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
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Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en
Publication of JP2006503062A publication Critical patent/JP2006503062A/ja
Publication of JP2006503062A5 publication Critical patent/JP2006503062A5/ja
Application granted granted Critical
Publication of JP4711391B2 publication Critical patent/JP4711391B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2004538781A 2002-09-30 2003-09-29 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 Expired - Fee Related JP4711391B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15
US60/426,368 2002-11-15
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
JP2006503062A JP2006503062A (ja) 2006-01-26
JP2006503062A5 JP2006503062A5 (no) 2010-07-15
JP4711391B2 true JP4711391B2 (ja) 2011-06-29

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004538781A Expired - Fee Related JP4711391B2 (ja) 2002-09-30 2003-09-29 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法

Country Status (12)

Country Link
JP (1) JP4711391B2 (no)
KR (1) KR20050062575A (no)
CN (1) CN1326857C (no)
BR (1) BR0314183A (no)
HK (1) HK1081954A1 (no)
IL (1) IL166821A (no)
IS (1) IS7829A (no)
MX (1) MXPA05003344A (no)
NO (1) NO20052124L (no)
PT (1) PT1551835E (no)
RU (1) RU2323218C2 (no)
SI (1) SI1551835T1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
CA2653769A1 (en) * 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
WO2008016123A1 (fr) * 2006-08-03 2008-02-07 Takeda Pharmaceutical Company Limited INHIBITEUR DE LA GSK-3β
UY30916A1 (es) * 2007-02-15 2008-09-30 Argenta Discovery Ltd Derivados del 1-[sustituido]--3-[sustituido]-1-azona-biciclo[2,2,2]octano y sus enantiomeros
JP6083818B2 (ja) 2011-11-18 2017-02-22 ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ ムスカリンｍ１受容体アゴニスト
ES2879995T3 (es) * 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
CN108727293B (zh) * 2016-09-18 2021-05-11 广西师范大学 1，2，8-氧代二氮杂环壬-9-酮衍生物及其合成方法
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01156979A (ja) * 1987-09-10 1989-06-20 Merck Sharp & Dohme Ltd 老人性痴呆症治療用のオキサジアゾリルーアザビシクロヘプタン類
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO2001092259A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.22]nonane-phenylisoxazole, leur preparation et leur application en therapeutique
WO2001092260A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane, leur preparation et leur application en therapeutique
JP2005509679A (ja) * 2001-11-23 2005-04-14 サノフィ−アベンティス ４−（１，３，４−チアジアゾール−２−イル）−１，４−ジアザビシクロ−［３．２．２］ノナン誘導体、それらの製造およびそれらの治療的使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
JP2003504367A (ja) * 1999-07-09 2003-02-04 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経栄養性ピロリジン類およびピペリジン類、並びに関連組成物および方法
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01156979A (ja) * 1987-09-10 1989-06-20 Merck Sharp & Dohme Ltd 老人性痴呆症治療用のオキサジアゾリルーアザビシクロヘプタン類
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
WO2001092259A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 1,4-diazabicyclo[3.22]nonane-phenylisoxazole, leur preparation et leur application en therapeutique
WO2001092260A1 (fr) * 2000-05-31 2001-12-06 Sanofi-Synthelabo Derives de 4-(2-phenylthiazol-5-yl)-1,4-diazabicyclo-[3.2.2]nonane, leur preparation et leur application en therapeutique
JP2005509679A (ja) * 2001-11-23 2005-04-14 サノフィ−アベンティス ４−（１，３，４−チアジアゾール−２−イル）−１，４−ジアザビシクロ−［３．２．２］ノナン誘導体、それらの製造およびそれらの治療的使用

Also Published As

Publication number Publication date
NO20052124D0 (no) 2005-04-29
CN1684965A (zh) 2005-10-19
CN1326857C (zh) 2007-07-18
JP2006503062A (ja) 2006-01-26
BR0314183A (pt) 2005-08-09
KR20050062575A (ko) 2005-06-23
RU2005105048A (ru) 2005-11-20
IL166821A0 (en) 2006-01-15
MXPA05003344A (es) 2005-11-23
RU2323218C2 (ru) 2008-04-27
SI1551835T1 (sl) 2007-06-30
IL166821A (en) 2009-06-15
PT1551835E (pt) 2007-03-30
NO20052124L (no) 2005-06-29
IS7829A (is) 2005-04-28
HK1081954A1 (en) 2006-05-26

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