RU2323218C2 - Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе - Google Patents

Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе Download PDF

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Publication number
RU2323218C2
RU2323218C2 RU2005105048/04A RU2005105048A RU2323218C2 RU 2323218 C2 RU2323218 C2 RU 2323218C2 RU 2005105048/04 A RU2005105048/04 A RU 2005105048/04A RU 2005105048 A RU2005105048 A RU 2005105048A RU 2323218 C2 RU2323218 C2 RU 2323218C2
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RU
Russia
Prior art keywords
diazabicyclo
nonane
oxadiazol
compound
group
Prior art date
Application number
RU2005105048/04A
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English (en)
Russian (ru)
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RU2005105048A (ru
Inventor
Дан ПЕТЕРС (DK)
Дан ПЕТЕРС
Гуннар М. ОЛЬСЕН (DK)
Гуннар М. Ольсен
Элсбет Остергор НИЛЬСЕН (DK)
Элсбет Остергор НИЛЬСЕН
Тино Дюринг ЙОРГЕНСЕН (DK)
Тино Дюринг ЙОРГЕНСЕН
Филип К. АХРИНГ (DK)
Филип К. Ахринг
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НьюроСёрч А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of RU2005105048A publication Critical patent/RU2005105048A/ru
Application granted granted Critical
Publication of RU2323218C2 publication Critical patent/RU2323218C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RU2005105048/04A 2002-09-30 2003-09-29 Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе RU2323218C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
DKPA200201738 2002-11-11
US60/426,368 2002-11-15

Publications (2)

Publication Number Publication Date
RU2005105048A RU2005105048A (ru) 2005-11-20
RU2323218C2 true RU2323218C2 (ru) 2008-04-27

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005105048/04A RU2323218C2 (ru) 2002-09-30 2003-09-29 Новые производные 1,4-диазабициклоалкана и фармацевтическая композиция на их основе

Country Status (12)

Country Link
JP (1) JP4711391B2 (no)
KR (1) KR20050062575A (no)
CN (1) CN1326857C (no)
BR (1) BR0314183A (no)
HK (1) HK1081954A1 (no)
IL (1) IL166821A (no)
IS (1) IS7829A (no)
MX (1) MXPA05003344A (no)
NO (1) NO20052124L (no)
PT (1) PT1551835E (no)
RU (1) RU2323218C2 (no)
SI (1) SI1551835T1 (no)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11773090B2 (en) 2018-06-22 2023-10-03 Heptares Therapeutics Limited Pharmaceutical compounds
US11793817B2 (en) 2011-11-18 2023-10-24 Heptares Therapeutics Limited Muscarinic M1 receptor agonists
US11834407B2 (en) 2016-10-14 2023-12-05 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
US11945801B2 (en) 2018-12-07 2024-04-02 Heptares Therapeutics Limited Bicyclic aza compounds as muscarinic M1 and/or M4 receptor agonists
RU2817018C2 (ru) * 2018-06-22 2024-04-09 Хептерс Терапьютикс Лимитед Оксадиазолы в качестве агонистов мускаринового рецептора m1 и/или m4

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
CA2653769A1 (en) * 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
WO2008016123A1 (fr) * 2006-08-03 2008-02-07 Takeda Pharmaceutical Company Limited INHIBITEUR DE LA GSK-3β
UY30916A1 (es) * 2007-02-15 2008-09-30 Argenta Discovery Ltd Derivados del 1-[sustituido]--3-[sustituido]-1-azona-biciclo[2,2,2]octano y sus enantiomeros
ES2879995T3 (es) * 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
CN108727293B (zh) * 2016-09-18 2021-05-11 广西师范大学 1，2，8-氧代二氮杂环壬-9-酮衍生物及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
JP2003504367A (ja) * 1999-07-09 2003-02-04 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 神経栄養性ピロリジン類およびピペリジン類、並びに関連組成物および方法
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11793817B2 (en) 2011-11-18 2023-10-24 Heptares Therapeutics Limited Muscarinic M1 receptor agonists
US11834407B2 (en) 2016-10-14 2023-12-05 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
US11773090B2 (en) 2018-06-22 2023-10-03 Heptares Therapeutics Limited Pharmaceutical compounds
RU2817018C2 (ru) * 2018-06-22 2024-04-09 Хептерс Терапьютикс Лимитед Оксадиазолы в качестве агонистов мускаринового рецептора m1 и/или m4
US11945801B2 (en) 2018-12-07 2024-04-02 Heptares Therapeutics Limited Bicyclic aza compounds as muscarinic M1 and/or M4 receptor agonists
US11999745B2 (en) 2020-12-18 2024-06-04 Heptares Therapeutics Limited Pharmaceutical compounds

Also Published As

Publication number Publication date
NO20052124D0 (no) 2005-04-29
CN1684965A (zh) 2005-10-19
CN1326857C (zh) 2007-07-18
JP2006503062A (ja) 2006-01-26
BR0314183A (pt) 2005-08-09
KR20050062575A (ko) 2005-06-23
RU2005105048A (ru) 2005-11-20
IL166821A0 (en) 2006-01-15
MXPA05003344A (es) 2005-11-23
JP4711391B2 (ja) 2011-06-29
SI1551835T1 (sl) 2007-06-30
IL166821A (en) 2009-06-15
PT1551835E (pt) 2007-03-30
NO20052124L (no) 2005-06-29
IS7829A (is) 2005-04-28
HK1081954A1 (en) 2006-05-26

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Legal Events

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20110930