JP4711391B2 - 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 - Google Patents

新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 Download PDF

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Publication number
JP4711391B2
JP4711391B2 JP2004538781A JP2004538781A JP4711391B2 JP 4711391 B2 JP4711391 B2 JP 4711391B2 JP 2004538781 A JP2004538781 A JP 2004538781A JP 2004538781 A JP2004538781 A JP 2004538781A JP 4711391 B2 JP4711391 B2 JP 4711391B2
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JP
Japan
Prior art keywords
diazabicyclo
nonane
oxadiazol
compound
thiadiazol
Prior art date
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Expired - Fee Related
Application number
JP2004538781A
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English (en)
Japanese (ja)
Other versions
JP2006503062A (ja
JP2006503062A5 (enExample
Inventor
ペータース・ダン
オールセン・グンナー・エム
ニールセン・エルセベート・エスターゴード
イェルゲンセン・ティノ・デュフリング
アーリング・フィリップ・カー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en
Publication of JP2006503062A publication Critical patent/JP2006503062A/ja
Publication of JP2006503062A5 publication Critical patent/JP2006503062A5/ja
Application granted granted Critical
Publication of JP4711391B2 publication Critical patent/JP4711391B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2004538781A 2002-09-30 2003-09-29 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法 Expired - Fee Related JP4711391B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
DKPA200201738 2002-11-11
US42636802P 2002-11-15 2002-11-15
US60/426,368 2002-11-15
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
JP2006503062A JP2006503062A (ja) 2006-01-26
JP2006503062A5 JP2006503062A5 (enExample) 2010-07-15
JP4711391B2 true JP4711391B2 (ja) 2011-06-29

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004538781A Expired - Fee Related JP4711391B2 (ja) 2002-09-30 2003-09-29 新規１，４−ジアザビシクロアルカン誘導体及びその製造方法

Country Status (11)

Country Link
JP (1) JP4711391B2 (enExample)
KR (1) KR20050062575A (enExample)
CN (1) CN1326857C (enExample)
BR (1) BR0314183A (enExample)
IL (1) IL166821A (enExample)
IS (1) IS7829A (enExample)
MX (1) MXPA05003344A (enExample)
NO (1) NO20052124L (enExample)
PT (1) PT1551835E (enExample)
RU (1) RU2323218C2 (enExample)
SI (1) SI1551835T1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2368614C2 (ru) * 2004-02-04 2009-09-27 НьюроСёрч А/С Диазабициклические арильные производные в качестве модуляторов холинергических рецепторов
JO3019B1 (ar) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
MX2008014887A (es) * 2006-05-30 2008-12-05 Neurosearch As Nuevos derivados de 1,4-diaza-biciclo[3.2.2]nonil oxadiazolilo y su uso medico.
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
EP2121688A1 (en) * 2007-02-15 2009-11-25 Argenta Discovery Ltd Heterocyclic derivatives as m3 muscarinic receptors
IN2014KN01075A (enExample) 2011-11-18 2015-10-09 Heptares Therapeutics Ltd
GB201404922D0 (en) 2014-03-19 2014-04-30 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
CN108697709A (zh) * 2015-12-10 2018-10-23 Ptc医疗公司 用于治疗亨廷顿病的方法
CN108727293B (zh) * 2016-09-18 2021-05-11 广西师范大学 1，2，8-氧代二氮杂环壬-9-酮衍生物及其合成方法
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
DE69416869T2 (de) * 1993-12-29 1999-07-01 Pfizer Inc., New York, N.Y. Diazabicyclische neurokinin antagonisten
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr) * 1998-12-04 2001-01-19 Synthelabo Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
PL352432A1 (en) * 1999-07-09 2003-08-25 Ortho Mc Neil Pharmaceutical Neurothrophic pyrolydines and piperidines, their affinite composition and methods of using them
FR2804430B1 (fr) * 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832713B1 (fr) * 2001-11-23 2004-02-13 Sanofi Synthelabo Derives de 4-(1,3,4-thiadiazol-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NO20052124L (no) 2005-06-29
JP2006503062A (ja) 2006-01-26
MXPA05003344A (es) 2005-11-23
PT1551835E (pt) 2007-03-30
NO20052124D0 (no) 2005-04-29
CN1684965A (zh) 2005-10-19
CN1326857C (zh) 2007-07-18
IL166821A0 (en) 2006-01-15
KR20050062575A (ko) 2005-06-23
RU2005105048A (ru) 2005-11-20
IS7829A (is) 2005-04-28
IL166821A (en) 2009-06-15
RU2323218C2 (ru) 2008-04-27
BR0314183A (pt) 2005-08-09
HK1081954A1 (en) 2006-05-26
SI1551835T1 (sl) 2007-06-30

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