IL166821A

IL166821A - 1,4-diazabicyloalkane derivatives, their preparation and use

1,4-diazabicyloalkane derivatives, their preparation and use

Info

Publication number: IL166821A
Authority: IL; Israel
Prior art keywords: nonane; diazabicyclo; oxadiazol; compound; thiadiazol
Prior art date: 2002-09-30

Application number

IL166821A

Other languages

English (en)

Other versions

IL166821A0 (en

Original Assignee

Neurosearch As

Priority date

2002-09-30

Filing date

2005-02-10

Publication date

2009-06-15

2003-09-29 Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en

2005-02-10 Application filed by Neurosearch As filed Critical Neurosearch As

2006-01-15 Publication of IL166821A0 publication Critical patent/IL166821A0/xx

2009-06-15 Publication of IL166821A publication Critical patent/IL166821A/en

Links

238000002360 preparation method Methods 0.000 title description 7
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208000035475 disorder Diseases 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 37
150000003839 salts Chemical class 0.000 claims description 35
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 22
238000011282 treatment Methods 0.000 claims description 22
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125000003118 aryl group Chemical group 0.000 claims description 17
229910052736 halogen Inorganic materials 0.000 claims description 13
150000002367 halogens Chemical class 0.000 claims description 13
125000001424 substituent group Chemical group 0.000 claims description 13
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CPRRHERYRRXBRZ-SRVKXCTJSA-N methyl n-[(2s)-1-[[(2s)-1-hydroxy-3-[(3s)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate Chemical compound COC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CO)C[C@@H]1CCNC1=O CPRRHERYRRXBRZ-SRVKXCTJSA-N 0.000 claims description 5
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CIXOTBSLQRANKM-UHFFFAOYSA-N 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-5-(1,2,4-thiadiazol-3-yl)-1,3,4-oxadiazole Chemical compound C1CN(CC2)CCC1N2C(O1)=NN=C1C=1N=CSN=1 CIXOTBSLQRANKM-UHFFFAOYSA-N 0.000 description 3
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