JP4706636B2 - 鎮痛剤 - Google Patents

鎮痛剤 Download PDF

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Publication number
JP4706636B2
JP4706636B2 JP2006542444A JP2006542444A JP4706636B2 JP 4706636 B2 JP4706636 B2 JP 4706636B2 JP 2006542444 A JP2006542444 A JP 2006542444A JP 2006542444 A JP2006542444 A JP 2006542444A JP 4706636 B2 JP4706636 B2 JP 4706636B2
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JP
Japan
Prior art keywords
pain
analgesic
compound
cyclopropylmethyl
morphinan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006542444A
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English (en)
Japanese (ja)
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JPWO2006049248A1 (ja
Inventor
直樹 泉本
邦昭 川村
俊和 駒形
忠俊 橋本
長袋　　洋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
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Publication date
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Priority to JP2006542444A priority Critical patent/JP4706636B2/ja
Publication of JPWO2006049248A1 publication Critical patent/JPWO2006049248A1/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006542444A 2004-11-04 2005-11-04 鎮痛剤 Expired - Fee Related JP4706636B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006542444A JP4706636B2 (ja) 2004-11-04 2005-11-04 鎮痛剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004320583 2004-11-04
JP2004320583 2004-11-04
JP2006542444A JP4706636B2 (ja) 2004-11-04 2005-11-04 鎮痛剤
PCT/JP2005/020297 WO2006049248A1 (ja) 2004-11-04 2005-11-04 鎮痛剤

Publications (2)

Publication Number Publication Date
JPWO2006049248A1 JPWO2006049248A1 (ja) 2008-08-07
JP4706636B2 true JP4706636B2 (ja) 2011-06-22

Family

ID=36319248

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006542444A Expired - Fee Related JP4706636B2 (ja) 2004-11-04 2005-11-04 鎮痛剤

Country Status (13)

Country Link
US (1) US8470845B2 (da)
EP (1) EP1820505A4 (da)
JP (1) JP4706636B2 (da)
KR (1) KR101285645B1 (da)
CN (1) CN101090722B (da)
AR (1) AR053098A1 (da)
CA (1) CA2586181C (da)
HK (1) HK1115808A1 (da)
MX (1) MX2007005336A (da)
NO (1) NO20072832L (da)
PE (1) PE20060723A1 (da)
TW (1) TW200621785A (da)
WO (1) WO2006049248A1 (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11324742B2 (en) 2018-03-08 2022-05-10 Victoria Link Ltd. Treatment of demyelinating diseases

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007055184A1 (ja) * 2005-11-09 2007-05-18 Toray Industries, Inc. 機能性腸障害の治療または予防剤
CN101340911B (zh) 2005-12-21 2013-01-02 东丽株式会社 镇咳剂
FR2902341B1 (fr) 2006-06-16 2011-02-25 Scras Utilisation therapeutique simultanee, separee ou etalee dans le temps d'au moins une neurotoxine botulique, et d'au moins un derive opiace
FR2910327B1 (fr) 2006-12-22 2013-04-26 Scras Utilisation d'au moins une neurotoxine botulique pour traiter la douleur induite par les traitements therapeutiques du virus du sida.
KR101520311B1 (ko) * 2007-05-21 2015-05-14 도레이 카부시키가이샤 특정 유기산을 함유하는 경구 제제, 및 경구 제제의 용출성과 화학적 안정성의 개선 방법
EP2156837B1 (en) 2007-05-21 2017-04-26 Toray Industries, Inc. Crystalline micropowder particles
JP5321454B2 (ja) * 2007-05-21 2013-10-23 東レ株式会社 医薬錠剤の製造法
FR2930447B1 (fr) 2008-04-25 2010-07-30 Sod Conseils Rech Applic Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur dans le cas de la neuropathie diabetique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (da) * 1964-02-03 1966-10-31
JPH11501627A (ja) * 1995-03-03 1999-02-09 アルゴス ファーマシューティカル コーポレーション 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用
WO2004033457A1 (ja) * 2002-10-09 2004-04-22 Toray Industries, Inc. 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体
JP2004522706A (ja) * 2000-10-31 2004-07-29 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3318884A (en) * 1965-07-21 1967-05-09 American Cyanamid Co Substituted 6-amino-6-demethoxythebaine and 6-amino-6-demethoxyoripavine derivatives
NL8102558A (nl) * 1981-05-25 1982-12-16 Alcoa Nederland Bv Lichtmast met versterking van de opening in het onderste gedeelte.
NZ246687A (en) * 1992-01-23 1996-12-20 Toray Industries Morphinan derivative and pharmaceutical compositions thereof
CA2143864C (en) 1993-07-23 2006-01-24 Hiroshi Nagase Morphinan derivatives and pharmaceutical use thereof
KR20020012314A (ko) * 1999-07-19 2002-02-15 히라이 가쯔히꼬 빈뇨 혹은 요실금의 치료 또는 예방제
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
JP4118824B2 (ja) 2004-02-24 2008-07-16 株式会社日立製作所 優先パケットの遅延を最小化するシェーピング装置
JP4118826B2 (ja) 2004-03-01 2008-07-16 リオン株式会社 補聴器用ケースなどの製造方法及びその装置
US7718664B2 (en) 2004-03-30 2010-05-18 Toray Industries, Inc. Anti-itching agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4118823B1 (da) * 1964-02-03 1966-10-31
JPH11501627A (ja) * 1995-03-03 1999-02-09 アルゴス ファーマシューティカル コーポレーション 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用
JP2004522706A (ja) * 2000-10-31 2004-07-29 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
WO2004033457A1 (ja) * 2002-10-09 2004-04-22 Toray Industries, Inc. 頻尿もしくは尿失禁の治療または予防剤および含窒素環状置換基を有するモルヒナン誘導体

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11324742B2 (en) 2018-03-08 2022-05-10 Victoria Link Ltd. Treatment of demyelinating diseases

Also Published As

Publication number Publication date
JPWO2006049248A1 (ja) 2008-08-07
CN101090722B (zh) 2011-12-21
NO20072832L (no) 2007-08-01
US20070299100A1 (en) 2007-12-27
AR053098A1 (es) 2007-04-25
PE20060723A1 (es) 2006-08-29
EP1820505A4 (en) 2010-01-20
KR20070085436A (ko) 2007-08-27
MX2007005336A (es) 2007-06-25
WO2006049248A1 (ja) 2006-05-11
KR101285645B1 (ko) 2013-07-12
TWI356826B (da) 2012-01-21
EP1820505A1 (en) 2007-08-22
CA2586181C (en) 2012-11-27
HK1115808A1 (en) 2008-12-12
US8470845B2 (en) 2013-06-25
TW200621785A (en) 2006-07-01
CN101090722A (zh) 2007-12-19
CA2586181A1 (en) 2006-05-11

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