JP4658331B2 - 耐負荷型インプラント、その製造方法、及びそれを用いた骨の調製方法 - Google Patents

耐負荷型インプラント、その製造方法、及びそれを用いた骨の調製方法 Download PDF

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JP4658331B2
JP4658331B2 JP2000600712A JP2000600712A JP4658331B2 JP 4658331 B2 JP4658331 B2 JP 4658331B2 JP 2000600712 A JP2000600712 A JP 2000600712A JP 2000600712 A JP2000600712 A JP 2000600712A JP 4658331 B2 JP4658331 B2 JP 4658331B2
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bone
bone implant
load
particles
composition
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Expired - Fee Related
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Japanese (ja)
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JP2002537073A5 (enExample
JP2002537073A (ja
Inventor
エム ボイス，トッド
エイ シンプ，ローレンス
マンリキュー，アルバート
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オステオテック インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000600712A 1999-02-23 2000-02-22 耐負荷型インプラント、その製造方法、及びそれを用いた骨の調製方法 Expired - Fee Related JP4658331B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/256,447 1999-02-23
US09/256,447 US6294187B1 (en) 1999-02-23 1999-02-23 Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
PCT/US2000/004408 WO2000050102A1 (en) 1999-02-23 2000-02-22 Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

Publications (3)

Publication Number Publication Date
JP2002537073A JP2002537073A (ja) 2002-11-05
JP2002537073A5 JP2002537073A5 (enExample) 2007-04-12
JP4658331B2 true JP4658331B2 (ja) 2011-03-23

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JP2000600712A Expired - Fee Related JP4658331B2 (ja) 1999-02-23 2000-02-22 耐負荷型インプラント、その製造方法、及びそれを用いた骨の調製方法

Country Status (10)

Country Link
US (2) US6294187B1 (enExample)
EP (1) EP1152777B1 (enExample)
JP (1) JP4658331B2 (enExample)
KR (1) KR100754814B1 (enExample)
AU (1) AU758828B2 (enExample)
CA (1) CA2363153C (enExample)
DE (1) DE60027698T2 (enExample)
ES (1) ES2261191T3 (enExample)
TR (1) TR200102480T2 (enExample)
WO (1) WO2000050102A1 (enExample)

Families Citing this family (423)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US6998135B1 (en) * 1998-02-27 2006-02-14 Musculoskeletal Transplant Foundation Demineralized corticocancellous bone sheet
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US7019192B2 (en) * 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US20080077251A1 (en) * 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6025538A (en) * 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US6383519B1 (en) * 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US20070233272A1 (en) * 1999-02-23 2007-10-04 Boyce Todd M Shaped load-bearing osteoimplant and methods of making same
US6241770B1 (en) * 1999-03-05 2001-06-05 Gary K. Michelson Interbody spinal fusion implant having an anatomically conformed trailing end
AU6406700A (en) * 1999-03-16 2000-10-04 Regeneration Technologies, Inc. Molded implants for orthopedic applications
US6767928B1 (en) 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6558422B1 (en) * 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
CA2363562C (en) 1999-05-05 2010-08-03 Gary Karlin Michelson Nested interbody spinal fusion implants
US6258124B1 (en) * 1999-05-10 2001-07-10 C. R. Bard, Inc. Prosthetic repair fabric
US6960249B2 (en) * 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US7270705B2 (en) * 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US6840995B2 (en) * 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
EP1210038A1 (de) 1999-08-20 2002-06-05 Peter Metz-Stavenhagen Wirbelsäulensegment
US6830763B2 (en) * 1999-09-03 2004-12-14 Lifenet Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
US20050059953A1 (en) 1999-09-03 2005-03-17 Lifenet Apparatus for demineralizing osteoinductive bone
WO2001022989A2 (en) * 1999-09-30 2001-04-05 Kaken Pharmaceutical Co., Ltd. Method to enhance healing of sternum after sternotomy
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US20010032017A1 (en) 1999-12-30 2001-10-18 Alfaro Arthur A. Intervertebral implants
US7635390B1 (en) 2000-01-14 2009-12-22 Marctec, Llc Joint replacement component having a modular articulating surface
US6702821B2 (en) 2000-01-14 2004-03-09 The Bonutti 2003 Trust A Instrumentation for minimally invasive joint replacement and methods for using same
JP4280445B2 (ja) * 2000-03-10 2009-06-17 ウォーソー・オーソペディック・インコーポレーテッド 補強した合成椎骨体間融合インプラント
AR027685A1 (es) 2000-03-22 2003-04-09 Synthes Ag Forma de tejido y metodo para realizarlo
US6350283B1 (en) 2000-04-19 2002-02-26 Gary K. Michelson Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof
US7462195B1 (en) 2000-04-19 2008-12-09 Warsaw Orthopedic, Inc. Artificial lumbar interbody spinal implant having an asymmetrical leading end
US20020111680A1 (en) * 2000-06-13 2002-08-15 Michelson Gary K. Ratcheted bone dowel
WO2001095837A1 (en) * 2000-06-13 2001-12-20 Michelson Gary K Manufactured major long bone ring implant shaped to conform to a prepared intervertebral implantation space
DK1294414T3 (da) * 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
US6332779B1 (en) 2000-07-03 2001-12-25 Osteotech, Inc. Method of hard tissue repair
US6863694B1 (en) 2000-07-03 2005-03-08 Osteotech, Inc. Osteogenic implants derived from bone
TR200400527T4 (tr) * 2000-07-03 2004-07-21 Osteotech Inc. Kemikten türetilmiş osteojenik implantlar
US7156915B2 (en) * 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US7182928B2 (en) * 2000-07-13 2007-02-27 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US7001551B2 (en) * 2000-07-13 2006-02-21 Allograft Research Technologies, Inc. Method of forming a composite bone material implant
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
AU2001275999B2 (en) * 2000-07-19 2007-03-29 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US6638312B2 (en) 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
US6739112B1 (en) * 2000-08-21 2004-05-25 Nu Vasive, Inc. Bone allograft packaging system
US20050064041A1 (en) * 2000-09-05 2005-03-24 Lifenet Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
JP4430302B2 (ja) * 2000-09-19 2010-03-10 アルデコア、エドアルド アニトウア チタンやその他素材のインプラント及びプロテーゼの表面処理
DE60122027T2 (de) * 2000-10-11 2007-03-01 Michael D. Dover Mason Wirbelfusionsvorrichtung
AU1086201A (en) * 2000-10-13 2002-04-29 Osteotech Inc Volume maintaining osteoinductive/oesteoconductive compositions
US20030120274A1 (en) 2000-10-20 2003-06-26 Morris John W. Implant retaining device
ES2384405T3 (es) * 2000-10-24 2012-07-04 Warsaw Orthopedic, Inc. Dispositivos para fusionar vértebras
CA2423603C (en) 2000-11-03 2010-05-04 Osteotech, Inc. Spinal intervertebral implant and method of making
US6692498B1 (en) * 2000-11-27 2004-02-17 Linvatec Corporation Bioabsorbable, osteopromoting fixation plate
AU2002245092A1 (en) * 2000-12-08 2002-07-30 Todd M. Boyce Implant for orthopedic applications
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2438033A1 (en) 2001-02-14 2002-08-22 Osteotech, Inc. Implant derived from bone
US20030045935A1 (en) * 2001-02-28 2003-03-06 Angelucci Christopher M. Laminoplasty implants and methods of use
US6776800B2 (en) * 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
IL141813A (en) * 2001-03-05 2010-04-15 Hadasit Med Res Service Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders
US6989031B2 (en) 2001-04-02 2006-01-24 Sdgi Holdings, Inc. Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite
US6749636B2 (en) 2001-04-02 2004-06-15 Gary K. Michelson Contoured spinal fusion implants made of bone or a bone composite material
US6890355B2 (en) 2001-04-02 2005-05-10 Gary K. Michelson Artificial contoured spinal fusion implants made of a material other than bone
US7122057B2 (en) * 2001-04-12 2006-10-17 Therics, Llc Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications
DE10126085A1 (de) * 2001-05-29 2002-12-05 Tutogen Medical Gmbh Knochenimplantat
AU2002316694B2 (en) 2001-07-16 2007-09-06 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US8092529B2 (en) 2001-07-16 2012-01-10 Depuy Products, Inc. Meniscus regeneration device
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
JP4302515B2 (ja) 2001-07-16 2009-07-29 デピュイ・プロダクツ・インコーポレイテッド 単体型外科装置および方法
JP4197157B2 (ja) * 2001-07-16 2008-12-17 デピュイ・プロダクツ・インコーポレイテッド 軟骨修復再生装置および方法
US20030032961A1 (en) * 2001-07-16 2003-02-13 Pelo Mark Joseph Devices from naturally occurring biologically derived materials
US7858679B2 (en) * 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
US8815793B2 (en) * 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) * 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
US20050107795A1 (en) * 2001-08-10 2005-05-19 John Morris Bone plating system and method of use
US7892288B2 (en) 2001-08-27 2011-02-22 Zimmer Technology, Inc. Femoral augments for use with knee joint prosthesis
US20040162619A1 (en) 2001-08-27 2004-08-19 Zimmer Technology, Inc. Tibial augments for use with knee joint prostheses, method of implanting the tibial augment, and associated tools
US20030065397A1 (en) 2001-08-27 2003-04-03 Hanssen Arlen D. Prosthetic implant support structure
US7708741B1 (en) 2001-08-28 2010-05-04 Marctec, Llc Method of preparing bones for knee replacement surgery
US6635087B2 (en) 2001-08-29 2003-10-21 Christopher M. Angelucci Laminoplasty implants and methods of use
EP1434608B1 (en) 2001-10-12 2018-08-22 Warsaw Orthopedic, Inc. Improved bone graft
US20030139812A1 (en) * 2001-11-09 2003-07-24 Javier Garcia Spinal implant
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
CA2471403A1 (en) * 2001-12-21 2003-07-10 Gensci Orthobiologics, Inc. End-capped polyalkylene glycols and compositions containing such compounds
US7205337B2 (en) * 2001-12-21 2007-04-17 Isotis Orthobiologics, Inc. End-capped polymers and compositions containing such compounds
CA2472239A1 (en) * 2002-01-22 2003-07-31 Pfizer Inc. 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases
EP1344538A1 (en) * 2002-03-14 2003-09-17 Degradable Solutions AG Porous biodegradable implant material and method for its fabrication
US20040137032A1 (en) * 2002-03-15 2004-07-15 Wang Francis W. Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US20030216777A1 (en) * 2002-05-16 2003-11-20 Yin-Chun Tien Method of enhancing healing of interfacial gap between bone and tendon or ligament
US20060204544A1 (en) * 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20050244239A1 (en) * 2002-05-30 2005-11-03 Shimp Lawrence A Method and apparatus for machining a surgical implant
EP1369092B1 (en) 2002-06-04 2008-08-20 MTF MediTech Franken GmbH Method and device for moistening non-biological medical implant material
EP1369095A3 (de) * 2002-06-04 2004-01-14 MTF MediTech Franken GmbH Verfahren und Vorrichtung zum Befeuchten eines medizinischen Implantates oder Transplantates
US7297342B2 (en) * 2002-06-10 2007-11-20 Keratec Limited Orthopaedic materials derived from keratin
JP4179495B2 (ja) * 2002-06-12 2008-11-12 松崎 浩巳 骨補填材
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US8911831B2 (en) * 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
AU2002950443A0 (en) * 2002-07-26 2002-09-12 Graeme Brazenor Pty Limited Spinal implant
SG144742A1 (en) * 2002-08-12 2008-08-28 Osteotech Inc Synthesis of a bone-polymer composite material
AU2003277325A1 (en) * 2002-10-08 2004-05-04 Osteotech, Inc. Coupling agents for orthopedic biomaterials
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US7682392B2 (en) * 2002-10-30 2010-03-23 Depuy Spine, Inc. Regenerative implants for stabilizing the spine and devices for attachment of said implants
US7582309B2 (en) * 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
EP1572258A1 (en) * 2002-11-25 2005-09-14 Yissum Research Development Company, of The Hebrew University of Jerusalem Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof
US6761739B2 (en) 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
US7291345B2 (en) * 2002-12-12 2007-11-06 Osteotech, Inc. Formable and settable polymer bone composite and method of production thereof
US7192447B2 (en) 2002-12-19 2007-03-20 Synthes (Usa) Intervertebral implant
NZ541535A (en) 2003-02-04 2009-02-28 Osteotech Inc Biodegradable polyurethane composite for osteoimplants
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
US7648509B2 (en) * 2003-03-10 2010-01-19 Ilion Medical Llc Sacroiliac joint immobilization
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
WO2004098457A1 (en) * 2003-04-30 2004-11-18 Therics, Inc. Bone void filler and method of manufacture
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
NZ544050A (en) * 2003-06-11 2009-03-31 Osteotech Inc Osteoimplants and methods for their manufacture
US20050020506A1 (en) * 2003-07-25 2005-01-27 Drapeau Susan J. Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
US7806932B2 (en) 2003-08-01 2010-10-05 Zimmer Spine, Inc. Spinal implant
US20060229627A1 (en) 2004-10-29 2006-10-12 Hunt Margaret M Variable angle spinal surgery instrument
US7118705B2 (en) 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US7163651B2 (en) * 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US6994726B2 (en) * 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
WO2005032612A2 (en) * 2003-10-02 2005-04-14 Lostec, Inc. A transplantable particulate bone composition and methods for making and using same
US20050085922A1 (en) * 2003-10-17 2005-04-21 Shappley Ben R. Shaped filler for implantation into a bone void and methods of manufacture and use thereof
EP1686934B1 (en) * 2003-11-07 2020-03-18 Vivex Biologics Group, Inc. Injectable bone substitute
CA2550431A1 (en) * 2003-12-19 2005-07-14 Osteotech, Inc. Tissue-derived mesh for orthopedic regeneration
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
WO2005072656A1 (en) 2004-01-27 2005-08-11 Osteotech, Inc. Stabilized bone graft
US20060015184A1 (en) * 2004-01-30 2006-01-19 John Winterbottom Stacking implants for spinal fusion
US7189263B2 (en) 2004-02-03 2007-03-13 Vita Special Purpose Corporation Biocompatible bone graft material
AU2005211722B2 (en) * 2004-02-05 2011-06-02 Osteobiologics, Inc. Absorbable orthopedic implants
EP1789088A4 (en) * 2004-03-24 2009-12-30 Doctor S Res Group Inc METHOD FOR IMPLEMENTING MEDICAL METHODS FOR PROMOTING BONE GROWTH, METHOD FOR PRODUCING COMPOUNDS FOR PROMOTING BONE GROWTH AND DEVICE FOR USE IN SUCH PROCEDURES
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US7942913B2 (en) 2004-04-08 2011-05-17 Ebi, Llc Bone fixation device
US7648676B2 (en) * 2004-04-20 2010-01-19 Rti Biologics, Inc. Process and apparatus for treating implants comprising soft tissue
US20060228252A1 (en) * 2004-04-20 2006-10-12 Mills C R Process and apparatus for treating implants comprising soft tissue
US7678385B2 (en) * 2004-04-28 2010-03-16 Biomet Manufacturing Corp. Irradiated implantable bone material
US20050244450A1 (en) * 2004-04-28 2005-11-03 Reddi A H Heat-treated implantable bone material
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US8163030B2 (en) * 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
WO2005110437A2 (en) * 2004-05-10 2005-11-24 Therics, Inc. Implantable biostructure comprising an osteoconductive member and an osteoinductive material
US20070009606A1 (en) 2004-05-12 2007-01-11 Serdy James G Manufacturing process, such as three dimensional printing, including binding of water-soluble material followed by softening and flowing and forming films of organic-solvent-soluble material
US7887587B2 (en) 2004-06-04 2011-02-15 Synthes Usa, Llc Soft tissue spacer
KR100750190B1 (ko) 2004-06-16 2007-08-31 요업기술원 골 수복에 효과적인 골 충전재 및 그의 제조 방법
US9220595B2 (en) 2004-06-23 2015-12-29 Orthovita, Inc. Shapeable bone graft substitute and instruments for delivery thereof
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
WO2006029270A1 (en) * 2004-09-07 2006-03-16 Smith & Nephew, Inc. Methods and devices for sterile field transfer
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20090319045A1 (en) 2004-10-12 2009-12-24 Truncale Katherine G Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20060083769A1 (en) * 2004-10-14 2006-04-20 Mukesh Kumar Method and apparatus for preparing bone
US7799754B2 (en) 2004-10-14 2010-09-21 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
US7670384B2 (en) * 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US7513866B2 (en) 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US20060111786A1 (en) * 2004-11-22 2006-05-25 Orthopedic Development Corporation Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty
US8021392B2 (en) 2004-11-22 2011-09-20 Minsurg International, Inc. Methods and surgical kits for minimally-invasive facet joint fusion
US20060111779A1 (en) 2004-11-22 2006-05-25 Orthopedic Development Corporation, A Florida Corporation Minimally invasive facet joint fusion
US20060111780A1 (en) 2004-11-22 2006-05-25 Orthopedic Development Corporation Minimally invasive facet joint hemi-arthroplasty
WO2006058153A1 (en) 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer
EP1835867A2 (en) * 2004-11-30 2007-09-26 Osteobiologics, Inc. Implants and delivery system for treating defects in articulating surfaces
US7527640B2 (en) 2004-12-22 2009-05-05 Ebi, Llc Bone fixation system
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
MX2007008561A (es) * 2005-01-14 2008-02-21 Osteotech Inc Osteoimplante expandible.
US20060216321A1 (en) * 2005-03-24 2006-09-28 Sdgi Holdings, Inc. Solvent based processing technologies for making tissue/polymer composites
US20060229723A1 (en) * 2005-04-08 2006-10-12 Sdgi Holdings, Inc. Intervertebral fusion device and method
US20060233849A1 (en) * 2005-04-13 2006-10-19 Simon Bruce J Composite bone graft material
US7621963B2 (en) * 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
EP1868539A2 (en) 2005-04-15 2007-12-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US7857853B2 (en) * 2005-04-29 2010-12-28 Sdgi Holdings, Inc Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture
US20060258578A1 (en) * 2005-05-10 2006-11-16 The University Of Zurich Pharmaceutical composition
US8070749B2 (en) 2005-05-12 2011-12-06 Stern Joseph D Revisable anterior cervical plating system
US20060271052A1 (en) * 2005-05-12 2006-11-30 Stern Joseph D Revisable anterior cervical plating system
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
US8048297B2 (en) 2005-08-23 2011-11-01 Biomet Biologics, Llc Method and apparatus for collecting biological materials
US7771590B2 (en) * 2005-08-23 2010-08-10 Biomet Manufacturing Corp. Method and apparatus for collecting biological materials
US20070074980A1 (en) * 2005-09-02 2007-04-05 Bankoski Brian R Implant rehydration packages and methods of use
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US7955364B2 (en) 2005-09-21 2011-06-07 Ebi, Llc Variable angle bone fixation assembly
US7691105B2 (en) * 2005-09-26 2010-04-06 Depuy Spine, Inc. Tissue augmentation, stabilization and regeneration technique
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
EP2431060B1 (en) * 2005-11-17 2020-04-08 BioMimetic Therapeutics, LLC Maxillofacial bone augmentation using RHPDGF-BB and a biocompatible matrix
US7901458B2 (en) * 2005-12-16 2011-03-08 Warsaw Orthopedic, Inc. Intervertebral spacer and insertion tool
US8287914B2 (en) * 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
US20100040668A1 (en) * 2006-01-12 2010-02-18 Rutgers, The State University Of New Jersey Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof
US9034356B2 (en) 2006-01-19 2015-05-19 Warsaw Orthopedic, Inc. Porous osteoimplant
CA2637616A1 (en) 2006-01-19 2007-07-26 Osteotech, Inc. Injectable and moldable bone substitute materials
US7749555B2 (en) * 2006-01-25 2010-07-06 Medtronic, Inc Modification of chemical forces of bone constructs
US7824703B2 (en) * 2006-02-01 2010-11-02 Warsaw Orthopedics, Inc. Medical implants with reservoir(s), and materials preparable from same
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
US20070270971A1 (en) * 2006-03-14 2007-11-22 Sdgi Holdings, Inc. Intervertebral prosthetic disc with improved wear resistance
US20070233246A1 (en) * 2006-03-31 2007-10-04 Sdgi Holdings, Inc. Spinal implants with improved mechanical response
US8673019B2 (en) * 2006-04-13 2014-03-18 Warsaw Orthopedic, Inc. Use of anti-inflammatory compounds with allograft tissue implantation
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US8642059B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US7806900B2 (en) 2006-04-26 2010-10-05 Illuminoss Medical, Inc. Apparatus and methods for delivery of reinforcing materials to bone
US7811290B2 (en) 2006-04-26 2010-10-12 Illuminoss Medical, Inc. Apparatus and methods for reinforcing bone
US7771741B2 (en) 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US20080262633A1 (en) 2006-05-08 2008-10-23 Williams Michelle Leroux Cancellous bone treated with collagenase and essentially free of blood cells
AU2007250080B2 (en) 2006-05-08 2011-08-18 Nuvasive, Inc. Cancellous bone treated with collagenase and essentially free of blood cells
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
EP2040765A2 (en) 2006-06-29 2009-04-01 Orthovita, INC. Bioactive bone graft substitute
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
ES2664229T3 (es) 2006-06-30 2018-04-18 Biomimetic Therapeutics, Llc Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador
US20080021462A1 (en) * 2006-07-24 2008-01-24 Warsaw Orthopedic Inc. Spinal stabilization implants
US20080021557A1 (en) * 2006-07-24 2008-01-24 Warsaw Orthopedic, Inc. Spinal motion-preserving implants
US7959683B2 (en) 2006-07-25 2011-06-14 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US20080033572A1 (en) * 2006-08-03 2008-02-07 Ebi L.P. Bone graft composites and methods of treating bone defects
US8563117B2 (en) * 2006-08-04 2013-10-22 Phillip B. Messersmith Biomimetic modular adhesive complex: materials, methods and applications therefore
JP5597836B2 (ja) 2006-08-04 2014-10-01 ケンジー ナッシュ コーポレイション バイオミメティック化合物およびその合成方法
US9066994B2 (en) * 2006-08-31 2015-06-30 Warsaw Orthopedic, Inc. Demineralized cancellous strip DBM graft
CA2667000A1 (en) 2006-09-25 2008-04-03 James P. Murphy Bioactive load-bearing composites comprising peek and bioglass particles
JP5552315B2 (ja) 2006-11-03 2014-07-16 バイオミメティック セラピューティクス， エルエルシー アースロデティック術のための組成物および方法
US8388626B2 (en) * 2006-11-08 2013-03-05 Warsaw Orthopedic, Inc. Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device
WO2008063265A1 (en) * 2006-11-10 2008-05-29 Illuminoss Medical, Inc. Systems and methods for internal bone fixation
US7879041B2 (en) 2006-11-10 2011-02-01 Illuminoss Medical, Inc. Systems and methods for internal bone fixation
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
WO2008089032A1 (en) * 2007-01-11 2008-07-24 Northwestern University Fouling resistant coatings and methods of making same
US20080195476A1 (en) * 2007-02-09 2008-08-14 Marchese Michael A Abandonment remarketing system
WO2008100856A2 (en) 2007-02-12 2008-08-21 Osteotech, Inc. Joint revision implant
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US20080206299A1 (en) * 2007-02-27 2008-08-28 Shimp Lawrence A Method for Recovering Minerals From Bone and Use of Same
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008228710A1 (en) 2007-03-22 2008-09-25 Novalign Orthopaedics, Inc. Segmented intramedullary structure
US20080230094A1 (en) * 2007-03-23 2008-09-25 Buckman Laboratories International, Inc. Method to inhibit growth of microorganisms in aqueous systems and on substrates using persulfate and a bromide
US7658940B2 (en) * 2007-03-30 2010-02-09 Skeletal Kinetics, Llc Calcium phosphate cements comprising autologous bone
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
US20090018659A1 (en) * 2007-07-10 2009-01-15 Malinin Theodore I Invertebral spinal implant and method of making the same
US20100268339A1 (en) * 2007-07-10 2010-10-21 Malinin Theodore I Intervertebral Spinal Implant and Method of Making the Same
US9125743B2 (en) * 2007-07-16 2015-09-08 Lifenet Health Devitalization and recellularization of cartilage
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US20090024174A1 (en) * 2007-07-17 2009-01-22 Stark John G Bone screws and particular applications to sacroiliac joint fusion
US8512342B2 (en) * 2007-08-11 2013-08-20 Thomas L. Meredith Portable bone grinder
WO2009026387A1 (en) * 2007-08-20 2009-02-26 Vanderbilt University Poly(ester urethane) urea foams with enhanced mechanical and biological properties
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
KR100916722B1 (ko) * 2007-10-13 2009-09-14 민병호 홍합본드를 이용한 인공치아 형성방법
CN101883663A (zh) * 2007-10-16 2010-11-10 Hkpb科技有限公司 表面涂布方法和其用途
EP2211921B1 (en) 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
US9427289B2 (en) 2007-10-31 2016-08-30 Illuminoss Medical, Inc. Light source
EP2217293B1 (en) 2007-11-09 2019-05-22 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US9056150B2 (en) 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
EP2231210A4 (en) * 2007-12-12 2013-01-23 Warsaw Orthopedic Inc BONE / COLLAGEN COMPOSITE AND ITS APPLICATIONS
US8403968B2 (en) 2007-12-26 2013-03-26 Illuminoss Medical, Inc. Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates
WO2009100454A1 (en) 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
WO2009108890A1 (en) 2008-02-27 2009-09-03 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
US8740912B2 (en) 2008-02-27 2014-06-03 Ilion Medical Llc Tools for performing less invasive orthopedic joint procedures
WO2009111338A1 (en) * 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US8840913B2 (en) 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
US20100082072A1 (en) * 2008-03-28 2010-04-01 Sybert Daryl R Bone anchors for orthopedic applications
CA2718615A1 (en) 2008-03-28 2009-10-01 Osteotech, Inc. Delivery system attachment
US20100068171A1 (en) * 2008-05-27 2010-03-18 Vanderbilt University Injectable bone/polymer composite bone void fillers
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010004057A1 (es) * 2008-07-08 2010-01-14 Histocell, S.L MATRICES TRIDIMENSIONALES DE MONETITA POROSA ESTRUCTURADA PARA INGENIERIA TISULAR Y REGENERACION OSEA, Y METODO DE PREPARACIόN DE LAS MISMAS
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
NZ602861A (en) 2008-09-09 2014-03-28 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
US8722075B2 (en) 2008-10-24 2014-05-13 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
WO2010059389A2 (en) * 2008-10-30 2010-05-27 Osteotech, Inc. Bone/polyurethane composites and methods thereof
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US12377189B2 (en) 2008-12-13 2025-08-05 Bioventus Llc Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor
CN102300594B (zh) * 2008-12-13 2014-09-17 先进生物制品有限责任公司 生物活性移植物和复合材料
US20100151114A1 (en) * 2008-12-17 2010-06-17 Zimmer, Inc. In-line treatment of yarn prior to creating a fabric
US20100168798A1 (en) 2008-12-30 2010-07-01 Clineff Theodore D Bioactive composites of polymer and glass and method for making same
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
US9821033B2 (en) * 2009-02-27 2017-11-21 Kieran Murphy Llc Modulating bone growth in treating scoliosis
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US9241798B2 (en) * 2009-03-20 2016-01-26 David A. Petersen Surgical methods and tools
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US8210729B2 (en) 2009-04-06 2012-07-03 Illuminoss Medical, Inc. Attachment system for light-conducting fibers
US8512338B2 (en) 2009-04-07 2013-08-20 Illuminoss Medical, Inc. Photodynamic bone stabilization systems and methods for reinforcing bone
US20100297082A1 (en) * 2009-05-19 2010-11-25 Osteotech, Inc. Weight-bearing polyurethane composites and methods thereof
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
USD625821S1 (en) * 2009-07-20 2010-10-19 Teknimed, S.A. Bone filler particle
USD773047S1 (en) * 2009-07-20 2016-11-29 Teknimed S.A. Bone filler particle
WO2011017284A2 (en) 2009-08-03 2011-02-10 Osteotech, Inc. Bone matrix compositions and methods
WO2011016989A2 (en) * 2009-08-07 2011-02-10 Ebi, Llc Toroid-shaped spinal disc
US20110035010A1 (en) * 2009-08-07 2011-02-10 Ebi, Llc Toroid-shaped spinal disc
US8926552B2 (en) 2009-08-12 2015-01-06 Medtronic, Inc. Particle delivery
US8870965B2 (en) 2009-08-19 2014-10-28 Illuminoss Medical, Inc. Devices and methods for bone alignment, stabilization and distraction
JP2013511357A (ja) 2009-11-20 2013-04-04 ニー・クリエイションズ・リミテッド・ライアビリティ・カンパニー 関節治療のための座標マッピングシステム
US20110125264A1 (en) * 2009-11-20 2011-05-26 Knee Creations, Llc Implantable devices for subchondral treatment of joint pain
US9259257B2 (en) 2009-11-20 2016-02-16 Zimmer Knee Creations, Inc. Instruments for targeting a joint defect
CN102740784B (zh) 2009-11-20 2015-09-09 膝部创造物有限责任公司 用于对关节的可变角度进路的仪器
US8821504B2 (en) 2009-11-20 2014-09-02 Zimmer Knee Creations, Inc. Method for treating joint pain and associated instruments
WO2011063281A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Navigation and positioning instruments for joint repair
US8951261B2 (en) 2009-11-20 2015-02-10 Zimmer Knee Creations, Inc. Subchondral treatment of joint pain
WO2011063240A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Implantable devices for subchondral treatment of joint pain
US8801800B2 (en) 2009-11-20 2014-08-12 Zimmer Knee Creations, Inc. Bone-derived implantable devices and tool for subchondral treatment of joint pain
US20110130465A1 (en) * 2009-12-01 2011-06-02 Nerites Corporation Coatings for prevention of biofilms
AU2010328427B2 (en) 2009-12-13 2014-06-05 Advanced Biologics, Inc. Bioactive grafts and composites
US8778378B2 (en) * 2009-12-21 2014-07-15 Orthovita, Inc. Bioactive antibacterial bone graft materials
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9125902B2 (en) 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US20110189253A1 (en) * 2010-01-29 2011-08-04 Warsaw Orthopedic, Inc. Biomaterial composition and method
CA2790403C (en) 2010-02-22 2019-08-27 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8684965B2 (en) 2010-06-21 2014-04-01 Illuminoss Medical, Inc. Photodynamic bone stabilization and drug delivery systems
WO2012027711A2 (en) * 2010-08-26 2012-03-01 University Of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
US20130217829A1 (en) 2010-08-27 2013-08-22 David Myung "hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same"
EP2637707A4 (en) 2010-11-09 2014-10-01 Kensey Nash Corp ADHESIVES AND METHOD OF USE FOR HERNIEREPARATUR
WO2012068135A1 (en) 2010-11-15 2012-05-24 Zimmer Orthobiologics, Inc. Bone void fillers
EP2654584A1 (en) 2010-12-22 2013-10-30 Illuminoss Medical, Inc. Systems and methods for treating conditions and diseases of the spine
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP3733099B1 (en) * 2011-02-28 2022-08-31 DePuy Synthes Products, Inc. Modular tissue scaffolds
US8673014B2 (en) 2011-04-01 2014-03-18 Kls-Martin, L.P. Method of cranial repair and cranial repair implant molding device
US20140236312A1 (en) * 2011-05-10 2014-08-21 Mark R. Appleford Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications
US8936644B2 (en) 2011-07-19 2015-01-20 Illuminoss Medical, Inc. Systems and methods for joint stabilization
CN103687645A (zh) 2011-07-19 2014-03-26 伊卢米诺斯医学有限公司 用于骨重建及稳定的装置和方法
DE102011112249A1 (de) * 2011-09-01 2013-03-07 Heinrich-Heine-Universität Düsseldorf Dentale Füllmaterialmischung zur Füllung von Wurzelkanälen
US9237957B2 (en) 2011-09-16 2016-01-19 Globus Medical, Inc. Low profile plate
US9204975B2 (en) 2011-09-16 2015-12-08 Globus Medical, Inc. Multi-piece intervertebral implants
US9398960B2 (en) 2011-09-16 2016-07-26 Globus Medical, Inc. Multi-piece intervertebral implants
US10245155B2 (en) 2011-09-16 2019-04-02 Globus Medical, Inc. Low profile plate
US9681959B2 (en) 2011-09-16 2017-06-20 Globus Medical, Inc. Low profile plate
US8961606B2 (en) 2011-09-16 2015-02-24 Globus Medical, Inc. Multi-piece intervertebral implants
US9848994B2 (en) 2011-09-16 2017-12-26 Globus Medical, Inc. Low profile plate
US9539109B2 (en) 2011-09-16 2017-01-10 Globus Medical, Inc. Low profile plate
US9149365B2 (en) 2013-03-05 2015-10-06 Globus Medical, Inc. Low profile plate
US9770340B2 (en) 2011-09-16 2017-09-26 Globus Medical, Inc. Multi-piece intervertebral implants
US10881526B2 (en) 2011-09-16 2021-01-05 Globus Medical, Inc. Low profile plate
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
US20140370094A1 (en) 2011-11-08 2014-12-18 Tufts University Silk-based scaffold platform for engineering tissue constructs
WO2013075091A1 (en) 2011-11-17 2013-05-23 Allosource Multi-piece machine graft systems and methods
AU2012340699A1 (en) 2011-11-21 2014-06-19 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
US9554914B2 (en) 2011-12-12 2017-01-31 Wright Medical Technology, Inc. Fusion implant
US8992628B2 (en) 2012-01-20 2015-03-31 Warsaw Orthopedic, Inc. Bone delivery system
US9198758B2 (en) 2012-01-26 2015-12-01 Warsaw Orthopedic, Inc. Delivery systems
US9775862B2 (en) 2012-01-30 2017-10-03 Warsaw Orthopedic, Inc. Modification of reactivity of bone constructs
US8926622B2 (en) 2012-04-03 2015-01-06 Warsaw Orthopedic, Inc. Bone delivery systems including holding and filling devices and methods
CN105561391A (zh) 2012-05-11 2016-05-11 Rti外科手术有限公司 异种移植软组织植入物及制造和使用的方法
US8939977B2 (en) 2012-07-10 2015-01-27 Illuminoss Medical, Inc. Systems and methods for separating bone fixation devices from introducer
US9655994B2 (en) 2012-07-25 2017-05-23 William F. McKay Delivery systems
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US10172651B2 (en) * 2012-10-25 2019-01-08 Warsaw Orthopedic, Inc. Cortical bone implant
US10780197B1 (en) 2012-10-29 2020-09-22 Nuvasive, Inc. Malleable, cryopreserved osteogenic compositions with viable cells
US9687281B2 (en) 2012-12-20 2017-06-27 Illuminoss Medical, Inc. Distal tip for bone fixation devices
US9265609B2 (en) 2013-01-08 2016-02-23 Warsaw Orthopedic, Inc. Osteograft implant
US9034052B2 (en) 2013-01-14 2015-05-19 Warsaw Orthopedic, Inc. Delivery systems containing bioactive materials
US9186253B2 (en) 2013-02-22 2015-11-17 Allosource Cartilage mosaic compositions and methods
US9283013B2 (en) 2013-03-14 2016-03-15 Warsaw Orthopedic, Inc. Filling systems for bone delivery devices
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
WO2014150784A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US9119732B2 (en) 2013-03-15 2015-09-01 Orthocision, Inc. Method and implant system for sacroiliac joint fixation and fusion
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
AU2014331769B2 (en) * 2013-10-09 2019-01-24 Lifenet Health Compressed bone composition and methods of use thereof
RU2557893C1 (ru) * 2014-04-10 2015-07-27 Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "ЦИТО им. Н.Н. Приорова" Минздрава России) Способ двухэтапного хирургического лечения деформации позвоночника с использованием аутоконсервации резецированного ауторебра и сухой вертикальной гало-тракции
US9364583B2 (en) 2014-04-25 2016-06-14 Warsaw Orthopedic, Inc. Osteoinductive demineralized bone implant
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN104606713B (zh) * 2015-01-04 2017-04-19 浙江大学 三维平行胶原纤维－蚕丝支架及其制备方法与应用
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
WO2016123583A1 (en) 2015-01-29 2016-08-04 Theracell, Inc. Demineralized bone fiber composition for use in minimally invasive surgery
US10006705B2 (en) 2015-02-09 2018-06-26 Warsaw Orthopedic, Inc. Methods for treating tissue materials
RU2597786C2 (ru) * 2015-02-10 2016-09-20 Общество с ограниченной ответственностью "НекстГен" Способ создания персонализированного ген-активированного имплантата для регенерации костной ткани
US10779960B2 (en) * 2015-02-27 2020-09-22 In2Bones Usa, Llc Engineered sterile cartilage allograft implant plug with sterile, specific instrument kit(s)
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US11426489B2 (en) * 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US10383731B2 (en) 2016-02-24 2019-08-20 Warsaw Orthopedic, Inc. Spinal implant system and method
ES2579305B1 (es) * 2016-04-29 2017-03-24 Optimus 3D S.L. Procedimiento de obtención de un implante activo de uso en la regeneración de masa ósea y correspondiente implante obtenido
WO2017201259A1 (en) 2016-05-18 2017-11-23 Rti Surgical, Inc. Osteoinductive nanofiber scaffold for bone regeneration
WO2018071053A1 (en) * 2016-10-14 2018-04-19 Allosource Consistent calcium content bone allograft systems and methods
EP3570787B1 (en) 2017-01-20 2022-05-04 Biomet Manufacturing, LLC Modular augment component
US10376385B2 (en) 2017-04-05 2019-08-13 Globus Medical, Inc. Decoupled spacer and plate and method of installing the same
US11452608B2 (en) 2017-04-05 2022-09-27 Globus Medical, Inc. Decoupled spacer and plate and method of installing the same
US10064726B1 (en) 2017-04-18 2018-09-04 Warsaw Orthopedic, Inc. 3D printing of mesh implants for bone delivery
US11660196B2 (en) 2017-04-21 2023-05-30 Warsaw Orthopedic, Inc. 3-D printing of bone grafts
WO2019006328A1 (en) 2017-06-30 2019-01-03 Allosource CELL BONE GRAFTS, AND METHODS OF MAKING AND USING
US11267851B2 (en) * 2017-07-18 2022-03-08 Posco Antimicrobial adhesive protein, antimicrobial nanoparticle, antimicrobial composition comprising same nanoparticle, and preparation method for same composition
US10970789B2 (en) 2018-01-23 2021-04-06 Full Circle Innovation Llc Systems and methods for facilitating insurance coverage
US11147567B2 (en) 2018-02-28 2021-10-19 Joint Restoration Foundation, Inc. Methods and devices for restoration of a bone surface
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
US12311076B1 (en) 2018-06-07 2025-05-27 Seaspine, Inc. Demineralized bone matrix composition with enhanced osteoinductivity and osteoconductivity
US11071572B2 (en) 2018-06-27 2021-07-27 Illuminoss Medical, Inc. Systems and methods for bone stabilization and fixation
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN111973797B (zh) * 2020-09-04 2022-06-03 湖南奥星生物医药股份有限公司 一种骨科用无创植入高黏度胶材料及其制备方法及应用
US12357361B2 (en) * 2021-04-15 2025-07-15 Jeremy M. Gililland Knee sizing tool and systems and methods for use in total knee replacement procedure
JP1721477S (ja) * 2021-09-13 2022-08-02 組織再生最適化用骨格の医療用充填材
US20230100859A1 (en) 2021-09-27 2023-03-30 Thomas Matthew Industries, Inc. Bone grinder promoting bone osteoinductivity
CN222510455U (zh) * 2024-04-07 2025-02-21 骨之源(广州)医疗科技有限公司 组织修复植入体和组织修复套装

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030583B1 (de) 1979-12-18 1984-06-13 Oscobal Ag Knochenersatzmaterial und Verfahren zur Herstellung eines Knochenersatzmaterials
US4637931A (en) 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US4902296A (en) 1986-10-29 1990-02-20 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4743259A (en) 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
WO1989004646A1 (en) 1987-11-13 1989-06-01 Jefferies Steven R Bone repair material and delayed drug delivery
US5219576A (en) * 1988-06-30 1993-06-15 Collagen Corporation Collagen wound healing matrices and process for their production
US5207710A (en) 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5061286A (en) * 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
JPH03131263A (ja) * 1989-10-16 1991-06-04 Nippon Electric Glass Co Ltd 生体用セメント
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
JPH0753204A (ja) * 1993-08-18 1995-02-28 S T K Ceramics Kenkyusho:Kk リン酸カルシウム系自己硬化型組成物
US5507813A (en) * 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5709683A (en) 1995-12-19 1998-01-20 Spine-Tech, Inc. Interbody bone implant having conjoining stabilization features for bony fusion
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
WO1997025941A1 (en) 1996-01-17 1997-07-24 Osteotech, Inc. Process and apparatus for producing flexible sheets from demineralized, elongate, bone particles
US5824078A (en) * 1996-03-11 1998-10-20 The Board Of Trustees Of The University Of Arkansas Composite allograft, press, and methods
US5868749A (en) 1996-04-05 1999-02-09 Reed; Thomas M. Fixation devices
JP4014698B2 (ja) * 1997-07-15 2007-11-28 ペンタックス株式会社 リン酸カルシウム系セラミックス多孔体の作製方法
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same

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