JP4621743B2 - 複製欠損アデノウイルスの産生のための細胞株 - Google Patents
複製欠損アデノウイルスの産生のための細胞株 Download PDFInfo
- Publication number
- JP4621743B2 JP4621743B2 JP2007545722A JP2007545722A JP4621743B2 JP 4621743 B2 JP4621743 B2 JP 4621743B2 JP 2007545722 A JP2007545722 A JP 2007545722A JP 2007545722 A JP2007545722 A JP 2007545722A JP 4621743 B2 JP4621743 B2 JP 4621743B2
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- protein
- adenovirus
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- nucleic acid
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12N2510/00—Genetically modified cells
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10361—Methods of inactivation or attenuation
- C12N2710/10362—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63556104P | 2004-12-13 | 2004-12-13 | |
| US67448805P | 2005-04-25 | 2005-04-25 | |
| PCT/US2005/045097 WO2006065827A2 (en) | 2004-12-13 | 2005-12-12 | Cell lines for production of replication-defective adenovirus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010199416A Division JP2011015696A (ja) | 2004-12-13 | 2010-09-06 | 複製欠損アデノウイルスの産生のための細胞株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522630A JP2008522630A (ja) | 2008-07-03 |
| JP2008522630A5 JP2008522630A5 (enExample) | 2010-10-21 |
| JP4621743B2 true JP4621743B2 (ja) | 2011-01-26 |
Family
ID=36282846
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545722A Expired - Fee Related JP4621743B2 (ja) | 2004-12-13 | 2005-12-12 | 複製欠損アデノウイルスの産生のための細胞株 |
| JP2010199416A Withdrawn JP2011015696A (ja) | 2004-12-13 | 2010-09-06 | 複製欠損アデノウイルスの産生のための細胞株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010199416A Withdrawn JP2011015696A (ja) | 2004-12-13 | 2010-09-06 | 複製欠損アデノウイルスの産生のための細胞株 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7851218B2 (enExample) |
| EP (1) | EP1831352B1 (enExample) |
| JP (2) | JP4621743B2 (enExample) |
| CN (1) | CN101208425B (enExample) |
| AT (1) | ATE516343T1 (enExample) |
| CA (1) | CA2590943C (enExample) |
| MX (1) | MX2007007145A (enExample) |
| WO (1) | WO2006065827A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1655827B (zh) | 2002-05-27 | 2010-06-23 | 佩尔·松内·霍尔姆 | 腺病毒和编码其的核酸的新应用 |
| WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| JP4621743B2 (ja) | 2004-12-13 | 2011-01-26 | カンジ,インコーポレイテッド | 複製欠損アデノウイルスの産生のための細胞株 |
| EP1830864A2 (de) * | 2004-12-31 | 2007-09-12 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| US20070249043A1 (en) | 2005-12-12 | 2007-10-25 | Mayall Timothy P | Adenoviral expression vectors |
| US9913832B2 (en) * | 2009-10-12 | 2018-03-13 | Rajabrata Sarkar | Accelerating thrombus resolution through augmentation of p53 activity |
| CN103987726B (zh) | 2011-10-05 | 2017-10-03 | 金维克有限公司 | 猴(大猩猩)腺病毒或腺病毒载体及其使用方法 |
| JP6757120B2 (ja) | 2011-10-05 | 2020-09-16 | ジェンヴェック エルエルシー | アーフェンアデノウイルス(ゴリラ)又はアデノウイルスベクター、及び使用方法 |
| IN2014DN03005A (enExample) | 2011-10-05 | 2015-05-08 | Genvec Inc | |
| KR101427200B1 (ko) * | 2011-11-24 | 2014-08-07 | 주식회사 바이로메드 | 아데노바이러스 생산 신규 세포주 및 그의 용도 |
| US9676824B2 (en) | 2012-05-29 | 2017-06-13 | Genvec, Inc. | Herpes simplex virus vaccine |
| JP2016519108A (ja) | 2013-04-18 | 2016-06-30 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−10を疾病及び疾患の治療に用いる方法 |
| EP3341012B1 (en) | 2015-08-25 | 2025-07-30 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| CN110832072B (zh) * | 2017-04-21 | 2023-11-07 | 真基因太科公司 | 用于生产非复制型腺病毒的细胞系以及制备所述细胞系的方法 |
| AU2018300000B2 (en) * | 2017-07-10 | 2021-11-11 | Gen-Probe Incorporated | Analytical systems and methods for nucleic acid amplification using sample assigning parameters |
| EP3906038A4 (en) | 2018-11-21 | 2022-06-01 | Mayo Foundation for Medical Education and Research | ADENOVIRUS AND METHODS OF USE OF ADENOVIRUS |
| WO2021136347A1 (zh) * | 2019-12-30 | 2021-07-08 | 南京金斯瑞生物科技有限公司 | 一种哺乳动物表达系统使用的高表达载体 |
| AU2021251718A1 (en) | 2020-04-07 | 2022-11-10 | Lung Biotechnology Pbc | Adenoviral expression vector and methods and cell lines for production |
| CN113736780B (zh) * | 2020-05-28 | 2024-05-28 | 暨南大学 | 一种敲除p300基因的BCBL1细胞系及其构建方法与应用 |
| CN114262691A (zh) * | 2020-09-16 | 2022-04-01 | 杭州康万达医药科技有限公司 | 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途 |
| CN112156181A (zh) * | 2020-09-29 | 2021-01-01 | 广州恩宝生物医药科技有限公司 | 一种腺病毒四价疫苗 |
| CN117264902A (zh) * | 2022-06-15 | 2023-12-22 | 上海元宋生物技术有限公司 | 一种腺病毒包装与生产细胞系的构建方法及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835557B1 (en) | 1980-01-08 | 2004-12-28 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides |
| US6210939B1 (en) | 1993-10-25 | 2001-04-03 | Canji, Inc. | Recombinant adenoviral vector and methods of use |
| TW442569B (en) | 1993-10-25 | 2001-06-23 | Canji Inc | Recombinant adenoviral vector |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6392069B2 (en) | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
| US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US5891690A (en) | 1996-04-26 | 1999-04-06 | Massie; Bernard | Adenovirus E1-complementing cell lines |
| US6248514B1 (en) | 1996-07-09 | 2001-06-19 | Canji, Inc. | Methods for measuring viral infectivity |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| US6544769B1 (en) | 1996-12-13 | 2003-04-08 | Schering Corporation | Compostions comprising viruses and methods for concentrating virus preparations |
| US6146891A (en) | 1997-01-31 | 2000-11-14 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| CA2723040A1 (en) | 1998-02-17 | 1999-08-19 | Schering Corporation | Compositions comprising viruses and methods for concentrating virus preparations |
| US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US5994134A (en) | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
| US7691370B2 (en) * | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| US7001770B1 (en) | 1998-10-15 | 2006-02-21 | Canji, Inc. | Calpain inhibitors and their applications |
| US6649158B1 (en) * | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
| US6430595B1 (en) | 1999-05-20 | 2002-08-06 | Cisco Technology, Inc. | Method and apparatus for establishing a database used for correlating information gathered via SNMP |
| US20020064860A1 (en) | 2000-11-29 | 2002-05-30 | Schering Corporation | Method for purifying adenoviruses |
| KR20060012661A (ko) | 2003-06-04 | 2006-02-08 | 캔지, 인크. | 인터페론 요법을 위한 방법 및 조성물 |
| US7026164B2 (en) * | 2003-07-03 | 2006-04-11 | Cell Genesys, Inc. | Adenovirus packaging cell lines |
| CA2548100C (en) | 2003-12-10 | 2015-03-24 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
| JP4621743B2 (ja) | 2004-12-13 | 2011-01-26 | カンジ,インコーポレイテッド | 複製欠損アデノウイルスの産生のための細胞株 |
| CN101384893A (zh) | 2006-02-10 | 2009-03-11 | 柏林自由大学 | 用于制备生物样品的方法和装置 |
-
2005
- 2005-12-12 JP JP2007545722A patent/JP4621743B2/ja not_active Expired - Fee Related
- 2005-12-12 MX MX2007007145A patent/MX2007007145A/es unknown
- 2005-12-12 AT AT05853909T patent/ATE516343T1/de not_active IP Right Cessation
- 2005-12-12 WO PCT/US2005/045097 patent/WO2006065827A2/en not_active Ceased
- 2005-12-12 EP EP05853909A patent/EP1831352B1/en not_active Expired - Lifetime
- 2005-12-12 US US11/301,309 patent/US7851218B2/en active Active
- 2005-12-12 CA CA2590943A patent/CA2590943C/en not_active Expired - Fee Related
- 2005-12-12 CN CN2005800480722A patent/CN101208425B/zh not_active Expired - Fee Related
-
2010
- 2010-09-06 JP JP2010199416A patent/JP2011015696A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2590943A1 (en) | 2006-06-22 |
| EP1831352B1 (en) | 2011-07-13 |
| JP2011015696A (ja) | 2011-01-27 |
| CN101208425B (zh) | 2011-01-26 |
| MX2007007145A (es) | 2007-08-20 |
| WO2006065827A3 (en) | 2006-10-12 |
| US20060270041A1 (en) | 2006-11-30 |
| WO2006065827A9 (en) | 2006-08-24 |
| JP2008522630A (ja) | 2008-07-03 |
| CN101208425A (zh) | 2008-06-25 |
| US7851218B2 (en) | 2010-12-14 |
| EP1831352A2 (en) | 2007-09-12 |
| ATE516343T1 (de) | 2011-07-15 |
| WO2006065827A2 (en) | 2006-06-22 |
| CA2590943C (en) | 2013-10-22 |
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